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The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

The Course of Hepatitis C Virus Infection After Liver Transplantation

Open access
Féray, Cyrille, Gigou, Michelle, Samuel, Didier, Paradis, Valérie, Wilber, Judith, David, Marie France, Urdea, Mickey, Reynes, Michel, Bréchot, Christian, Bismuth, Henri·1994·Hepatology

Abstract

Hepatitis C virus—induced liver disease is becoming a main indication for liver transplantation. Recurrence of hepatitis after transplantation has been reported, but its long–term consequences are unknown. Seventynine patients positive for hepatitis C virus (group 1) and 106 subjects negative for hepatitis C virus antibody (group 2) with a mean follow–up of 4 yr were retrospectively studied by means of serology, nested polymerase chain reaction and branched–DNA technology before and after liver transplantation. The actuarial rates of hepatitis C virus—related acute hepatitis were 72% and 20% at 4 yr in groups 1 and 2, respectively. Progression to chronic active hepatitis occurred in 61% and 36% of the subjects within 3 yr of the onset of recurrent and acquired hepatitis, respectively. No case of acute graft failure and two cases of cirrhosis were related to recurrent or acquired hepatitis C virus liver disease. Hepatitis C virus RNA levels were significantly increased in cases of hepatitis after transplantation. In contrast, the pretransplant hepatitis C virus RNA level was not predictive of recurrence. Our results establish the general persistence of hepatitis C virus infection after liver transplantation, the frequency and the severe course of recurrent liver disease. However, liver transplantation in hepatitis C virus antibody—positive patients still has a good medium–term prognosis. (Hepatology 1994;20:1137-1143).

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Crossref · 10.1002/hep.1840200506

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Metadata

Authors
Féray, C., Gigou, M., Samuel, D., Paradis, V., Wilber, J., David, M. F., Urdea, M., Reynes, M., Bréchot, C., & Bismuth, H.
Venue
Hepatology
Published
1994-11
Volume
20
Issue
5
Pages
1137-1143
ISSN
0270-9139 (ISSN-L)
OpenAlex
W2008849878
Cited by
289
References
11
FWCI
13.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Course of Hepatitis C Virus Infection After Liver Transplantation. https://app.cochat.ai/papers/10.1002/hep.1840200506
The paper
Féray, C., Gigou, M., Samuel, D., Paradis, V., Wilber, J., David, M. F., Urdea, M., Reynes, M., Bréchot, C., & Bismuth, H. (1994). The Course of Hepatitis C Virus Infection After Liver Transplantation. Hepatology. https://doi.org/10.1002/hep.1840200506

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