Effect of distal splenorenal shunt on survival of patients with primary biliary cirrhosis
Open accessAbstract
Distal splenorenal shunt is known to effectively control bleeding from esophageal and gastric varices; however, the effect of this selective shunt on liver function is less well understood. We examined retrospectively the effect of distal splenorenal shunt on the survival of 19 patients with primary biliary cirrhosis subjected to surgery for bleeding varices over a 20-yr period and had been followed for at least 1 yr. Actual Kaplan-Meier survival curve was compared with predicted survival curve based on the Mayo Clinic model using clinical data collected at the time of surgery. The patients median length of follow-up was 65.9 mo. Ten of the 19 patients died or underwent orthotopic liver transplantation during the period of observation. The actual Kaplan-Meier and predicted Mayo Clinic model survival curves were similar and did not differ significantly. Survival was best in patients with good liver function (i.e., low Mayo risk scores). Distal splenorenal shunt, therefore, did not appear to have an adverse effect on the survival of patients with primary biliary cirrhosis. We conclude that variceal bleeding in primary biliary cirrhosis patients with good liver function should not be considered an indication for liver transplantation. Instead, if treatment with sclerotherapy or β-blockers fails then distal splenorenal shunt will prevent recurrent bleeding in 90% of patients and leave them with an excellent prognosis. (Hepatology 1994;20:1482-1486).
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Distal splenorenal shunts have not been linked to faster liver failure in PBC patients.
“Distal splenorenal shunts are rarely used but have not been associated with accelerated liver failure in patients with PBC.(237)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [237]
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- Authors
- Boyer, T. D., Kokenes, D. D., Hertzler, G., Kutner, M. H., & Henderson, M. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Boyer, Thomas D.
- Venue
- Hepatology
- Published
- 1994-12
- Volume
- 20
- Issue
- 6
- Pages
- 1482-1486
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2118839487
- Cited by
- 20
- References
- 30
- Citations by year
- 2021: 1 · 2018: 3 · 2016: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- distal splenorenal shunt, primary biliary cirrhosis, variceal bleeding, esophageal varices, gastric varices, survival, liver transplantation, liver function, sclerotherapy, beta-blockers, portal hypertension
- MeSH terms
- Adult, Aged, Aged, 80 and over, Esophageal and Gastric Varices, Female, Follow-Up Studies, Gastrointestinal Hemorrhage, Humans, Liver, Liver Cirrhosis, Biliary, Liver Function Tests, Male, Middle Aged, Prognosis, Retrospective Studies, Splenorenal Shunt, Surgical, Survival Rate
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