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Serum alanine aminotransferase in skeletal muscle diseases†
Abstract
Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibited markedly elevated creatine kinase and lactate dehydrogenase levels consistent with muscle injury. In acute cases, aspartate aminotransferase (AST) and ALT were both elevated, and the AST/ALT ratio was greater than 3, but this ratio approached 1 after a few days because of a faster decline in AST. In conclusion, this difference in half-life accounts for the comparable AST and ALT levels in our cases with chronic muscle injury.
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Cited by
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Zhang, Y., Jia, Y., Zheng, R., Guo, Y., Wang, Y., Guo, H., Fei, M., & Sun, S. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147850 · Cited by 415
Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men
van Wijck, K., Lenaerts, K., van Loon, L. J. C., Peters, W. H. M., Buurman, W. A., & Dejong, C. H. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022366 · Cited by 359
“Alternatively, muscle transaminase release is expected in response to (exerciseinduced) muscle injury [23,24], while L-FABP release could be due to intestinal damage.”
BackgroundReview article: the gastrointestinal complications of myositis
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Sridhar, S. B., Xu, F., Darbinian, J., Quesenberry, C. P., Ferrara, A., & Hedderson, M. M. (2014) · Diabetes Care · doi:10.2337/dc13-2229 · Cited by 59
Metadata
- Authors
- Nathwani, R. A., Pais, S., Reynolds, T. B., & Kaplowitz, N.
- Venue
- Hepatology
- Published
- 2005-02
- Volume
- 41
- Issue
- 2
- Pages
- 380-382
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2020508492
- Cited by
- 398
- References
- 0
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nathwani, R. A., Pais, S., Reynolds, T. B., & Kaplowitz, N. (2005). Serum alanine aminotransferase in skeletal muscle diseases†. Hepatology. https://doi.org/10.1002/hep.20548
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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