The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection†‡
Abstract
Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to HBV. Regulatory T cells (T(reg)) can suppress the function of effector T cells and may thus be key players in this impaired immune response. Changes in the functionality or number of T(reg) could explain the decreased antiviral response in chronic HBV patients. To investigate the role of T(reg) in chronic HBV infection, we compared the proportional frequency and functionality of T(reg) in peripheral blood of 50 chronic HBV patients, 23 healthy controls, and 9 individuals with a resolved HBV infection. A higher percentage of T(reg), defined as CD4, CD25, CD45RO, and cytotoxic T-lymphocyte-associated antigen 4-positive cells, was detected within the population of CD4(+) cells in peripheral blood of chronic HBV patients compared with healthy controls and individuals with a resolved HBV infection. Accordingly, chronic HBV patients displayed a higher FoxP3 messenger RNA level than healthy controls. Depletion of CD25(+) cells from peripheral blood mononuclear cells (PBMC) of chronic HBV patients resulted in an enhanced proliferation after stimulation with HBV core antigen. Reconstitution of these depleted PBMC with CD4(+)CD25(+) T(reg) resulted in a dose-dependent reduction of both HBV-specific proliferation and interferon gamma production. In conclusion, chronic HBV patients harbor an increased percentage of T(reg) in peripheral blood compared with controls. T(reg) have an immunosuppressive effect on HBV-specific T helper cells. The presence of HBV-specific T(reg) could contribute to an inadequate immune response against the virus, leading to chronic infection.
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Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Sakaguchi, S. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,306
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,856
CD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri821 · Cited by 2,110
CD4+CD25high Regulatory Cells in Human Peripheral Blood
Baecher-Allan, C., Brown, J. A., Freeman, G. J., & Hafler, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1245 · Cited by 1,859
Hepatitis B Virus Immunopathogenesis
Chisari, F. V. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.29 · Cited by 1,609
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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
R.Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bènard, A., Van Landeghen, M., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,245
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Cited by
Fu, J., Xu, D., Liu, Z., Shi, M., Zhao, P., Fu, B., Zhang, Z., Yang, H., Zhang, H., Zhou, C., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.102 · Cited by 897
Bertoletti, A., & Ferrari, C. (2012) · Gut · doi:10.1136/gutjnl-2011-301073 · Cited by 477
Regulatory T Cells Are Expanded in Blood and Disease Sites in Patients with Tuberculosis
Guyot-Revol, V., Innes, J. A., Hackforth, S., Hinks, T., & Lalvani, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1294oc · Cited by 444
FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis
Kobayashi, N., Hiraoka, N., Yamagami, W., Ojima, H., Kanai, Y., Kosuge, T., Nakajima, A., & Hirohashi, S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2363 · Cited by 431
Immune responses and immunopathology in acute and chronic viral hepatitis
Shin, E.-C., Sung, P. S., & Park, S.-H. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.69 · Cited by 365
Metadata
- Authors
- Stoop, J. N., van der Molen, R. G., Baan, C. C., van der Laan, L. J. W., Kuipers, E. J., Kusters, J. G., & Janssen, H. L. A.
- Venue
- Hepatology
- Published
- 2005-04
- Volume
- 41
- Issue
- 4
- Pages
- 771-778
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2048056516
- Cited by
- 506
- References
- 34
- FWCI
- 19.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stoop, J. N., van der Molen, R. G., Baan, C. C., van der Laan, L. J. W., Kuipers, E. J., Kusters, J. G., & Janssen, H. L. A. (2005). Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection†‡. Hepatology. https://doi.org/10.1002/hep.20649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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