Cited by 7,745T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisSignaling Pathways in Disease

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, Jason D., Gavin, Marc A., Rudensky, Alexander Y.·2003·Nature Immunology

Abstract

CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4+CD25+ regulatory T cell deficiency and not from a cell-intrinsic defect of CD4+CD25- T cells. CD4+CD25+ regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3-deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function.

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Crossref · 10.1038/ni904

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2 of 2 references verified0 citation errors · 0 not checkable

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Authors
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Rudensky, Alexander Y.
Venue
Nature Immunology
Published
2003-03-03
Volume
4
Issue
4
Pages
330-336
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2097811455
Cited by
7,745
References
2
Citations by year
2026: 168 · 2025: 199 · 2024: 237 · 2023: 230 · 2022: 306 · 2021: 323 · 2020: 326 · 2019: 318 · 2018: 287 · 2017: 307 · 2016: 296 · 2015: 303 · 2014: 351 · 2013: 392 · 2012: 414
FWCI
106.35
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
Foxp3, regulatory T cells, CD4+CD25+ T cells, Treg development, autoimmunity, scurfy mice, Treg suppressive function, transcription factors
MeSH terms
Animals, DNA-Binding Proteins, Female, Receptors, Interleukin-2, CD4-Positive T-Lymphocytes, Down-Regulation, Gene Targeting, Mice, Forkhead Transcription Factors

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