Health‐related fitness and physical activity in patients with nonalcoholic fatty liver disease†‡
Open accessAbstract
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) has been referred to as the hepatic manifestation of the metabolic syndrome. There is a lower prevalence of metabolic syndrome in individuals with higher health-related fitness (HRF) and physical activity (PA) participation. The relationship between NAFLD severity and HRF or PA is unknown. Our aim was to compare measures of HRF and PA in patients with a histological spectrum of NAFLD severity. Thirty-seven patients with liver biopsy-confirmed NAFLD (18 women/19 men; age = 45.9 +/- 12.7 years) completed assessment of cardiorespiratory fitness (CRF, VO(2peak)), muscle strength (quadriceps peak torque), body composition (%fat), and PA (current and historical questionnaire). Liver histology was used to classify severity by steatosis (mild, moderate, severe), fibrosis stage (stage 1 versus stage 2/3), necroinflammatory activity (NAFLD Activity Score; or=5 NAS2) and diagnosis of NASH by Brunt criteria (NASH versus NotNASH). Analysis of variance and independent t tests were used to determine the differences among groups. Fewer than 20% of patients met recommended guidelines for PA, and 97.3% were classified at increased risk of morbidity and mortality by %fat. No differences were detected in VO(2peak) (x = 26.8 +/- 7.4 mL/g/min) or %fat (x = 38.6 +/- 8.2%) among the steatosis or fibrosis groups. Peak VO(2) was significantly higher in NAS1 versus NAS2 (30.4 +/- 8.2 versus 24.4 +/- 5.7 mL/kg/min, P = 0.013) and NotNASH versus NASH (34.0 +/- 9.5 versus 25.1 +/- 5.7 mL/kg/min, P = 0.048). CONCLUSION: Patients with NAFLD of differing histological severity have suboptimal HRF. Lifestyle interventions to improve HRF and PA may be beneficial in reducing the associated risk factors and preventing progression of NAFLD.
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Lower VO2peak is associated with increasing NAFLD activity and with disease severity by NASH diagnosis.
“Lower VO2peak was associated with increasing NAFLD activity and with disease severity by NASH diagnosis (283).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [283]
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References 39 · Cited by 148
Research works printed but not linked: 1
- American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
- Authors
- Krasnoff, J. B., Painter, P. L., Wallace, J. P., Bass, N. M., & Merriman, R. B.
- Affiliations
- University of California, San Francisco (US)
- University of Minnesota (US)
- Indiana University Bloomington (US)
- California Pacific Medical Center (US)
- Corresponding author
- Krasnoff, Joanne B.
- ORCID
- Krasnoff, Joanne B.
- Venue
- Hepatology
- Published
- 2008-04
- Volume
- 47
- Issue
- 4
- Pages
- 1158-1166
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC3096839
- OpenAlex
- W1994210784
- Cited by
- 148
- References
- 39
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 15 · 2013: 9 · 2012: 10
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5m01rr000079-42, RR024131)
- University of California, San Francisco
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK061730, U01 DK61738, U01DK061738)
- National Center for Research Resources (UL1RR024131, M01-RR000079, M01 RR-0079)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- non-alcoholic fatty liver disease, health-related physical fitness, physical activity, cardiorespiratory fitness, peak oxygen uptake, muscle strength, body fat percentage, NAFLD severity, steatosis, liver fibrosis, NAFLD activity score, NASH, metabolic syndrome, lifestyle intervention
- MeSH terms
- Adult, Aged, Body Composition, Exercise Test, Fatty Liver, Female, Fibrosis, Humans, Liver, Male, Middle Aged, Physical Fitness, Exercise, Muscle Strength
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