C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†

Blanco‐Bose, William E., Murphy, Mark J., Ehninger, Armin, Offner, Sandra, Dubey, Christelle, Huang, Wendong, Moore, David D., Trumpp, Andreas·2008·Hepatology
DOI 10.1002/hep.22475

Cited by (140)

Items 101–140 of 140

  1. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver
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  2. Noncanonical Constitutive Androstane Receptor Signaling in Gene Regulation
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  3. Peroxisome proliferator-activated receptor γ activation inhibits liver growth through miR-122-mediated downregulation of cMyc
    Andrei A. Yarushkin, Yuliya A. Kazantseva, Vyacheslav S. Kobelev, Yuliya A. Pustylnyak, Vladimir O. Pustylnyak · 2017 · European Journal of Pharmacology
  4. Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN
    Andrei A. Yarushkin, Mark E. Mazin, Yuliya A. Pustylnyak, Elena A. Prokopyeva, Vladimir O. Pustylnyak · 2019 · Archives of Biochemistry and Biophysics
  5. Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation
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  7. Hierarchies of Transcriptional Regulation During Liver Regeneration
    Svitlana M. Kurinna, Michelle Craig Barton · 2010 · Progress in molecular biology and translational science
  8. Array-based Western-blotting reveals spatial differences in hepatic signaling and metabolism following CAR activation
    Fridolin Treindl, Elke Zabinsky, Simon Kling, Michael Schwarz, Albert Braeuning, Markus F. Templin · 2020 · Archives of Toxicology
  9. The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down‐regulation of p53 and p16INK4a genes in rat liver
    Grażyna Kostka, Katarzyna Urbanek‐Olejnik, Monika Liszewska, Alicja Winczura · 2014 · Environmental Toxicology
  10. Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer
    Sarah Da Won Bae, Romario Nguyen, Lawrence Yuen, Vincent W. T. Lam, Jacob George, Liang Qiao · 2024 · Scientific Reports
  11. Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation
    Kelly Koral, Bharat Bhushan, Anne V. Orr, John W. Stoops, William C. Bowen, Matthew A. Copeland, Joseph D. Locker, Wendy M. Mars, George K. Michalopoulos · 2022 · American Journal Of Pathology
  12. Promotion of NR1I3-mediated liver growth is accompanied by STAT3 activation
    Mark E. Mazin, Andrei A. Yarushkin, Yuliya A. Pustylnyak, Elena A. Prokopyeva, Vladimir O. Pustylnyak · 2022 · Molecular Biology Reports
  13. Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR
    Ye Feng, Dan Xu, Xinran Cai, Meishu Xu, Wojciech G. Garbacz, Songrong Ren, Michael J. Jurczak, Chaohui Yu, Hui Wang, Wen Xie · 2022 · Endocrinology
  14. Proposed reference dose for toxaphene carcinogenicity based on constitutive androstane receptor-mediated mode of action
    Brent D. Kerger, Kenneth T. Bogen, Anne E. Loccisano, James C. Lamb · 2017 · Human and Ecological Risk Assessment An International Journal
  15. CAR takes care of the injured liver
    Marc Bachofner, Sabine Werner · 2016 · Journal of Hepatology
  16. Environmental chemical TCPOBOP exposure alters milk liposomes and offspring growth trajectories in mice
    Shijia Pan, Wen Yu, Jia Zhang, Yuan Guo, Xiaoxiao Qiao, Pengfei Xu, Yonggong Zhai · 2024 · Ecotoxicology and Environmental Safety
  17. Biphasic hCAR Inhibition-Activation by Two Aminoazo Liver Carcinogens
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  18. Diminazene aceturate‐induced cytotoxicity is associated with the deregulation of cell cycle signaling and downregulation of oncogenes Furin, c‐MYC, and FOXM1 in human cervical carcinoma Hela cells
    Rajendra Gharbaran, Zouberou Sayibou, Seher Atamturktur, Jeithy Jason Ofosu‐Mensah, John Soto, Nicholas Boodhan, Saaimah Kolya, Onyekwere Onwumere, Lynne Chang, Latchman Somenarain et al. · 2023 · Journal of Biochemical and Molecular Toxicology
  19. CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production
    Miriam Doepner, Christopher A. Natale, In Young Lee, Swati Venkat, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Michael E. Feigin, Todd W. Ridky · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  20. The slow elimination of 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene in mice leads to prolonged constitutive androstane receptor activation and hepatomegaly
    Yue Gao, Chenghui Cai, Wanyu Zheng, Shicheng Fan, Yifei Zhang, Yanying Zhou, Huilin Li, Jie Yang, Shaoxing Guan, Huichang Bi · 2025 · Drug Metabolism and Disposition
  21. Constitutive Androstane Receptor
    Jiong Yan, Wen Xie · 2017 · Elsevier eBooks
  22. Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism
    Marine Huillet, Lasserre Frédéric, Marie‐Pierre Gratacap, Beatrice Engelmann, Justine Bruse, Polizzi Arnaud, Fougeray Tiffany, Martin Céline, Clémence Rives, Anne Fougerat et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration
    Zhou, Weinan, Chembazhi, Ullas Valiya, Huang, Jiansheng, Bangru, Sushant, Dean, Angela E., Asokakumar, Anjana, Kalsotra, Auinash, Rudnick, David A., Anakk, Sayeepriyadarshini · 2026 · Cellular and Molecular Gastroenterology and Hepatology
  24. Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies
    Heidrun C. Ellinger-Ziegelbauer · 2014 · Methods and principles in medicinal chemistry
  25. Functional Assessment of the Role of BORIS in Ovarian Cancer Using a Novel In Vivo Model System
    Adam R. Karpf, Michael J. Higgins · 2013
  26. Targeting Forkhead Box M1 (FOXM1) in Human Cancer
    Marianna Halasi (331069) · 2012 · Figshare
  27. Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors
    Jessica Scott, Silvia Liu, Kevin C. Klatt, Zhen Sun, Qi Guo, Sandra L. Grimm, Cristian Coarfa, Bingning Dong, David D. Moore · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation
    Huichang Bi, Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Yang Xiao, Ruimin Wang, Jianing Tian et al. · 2020
  29. Xenobiotic Receptor‐Mediated Gene Regulation in Drug Metabolism and Disposition
    Hongbing Wang, Wen Xie · 2022 · Wiley eBooks
  30. Data from ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance
    Julie Millour, Natalia de Olano, Yoshiya Horimoto, Lara J. Monteiro, Julia K. Langer, Rosa Aligué, Nabil Hajji, Eric W.‐F. Lam · 2023
  31. Supplementary Figures 1-8 from ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance
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  32. Constitutive Androstane Receptor Agonist Initiates Metabolic Activity Required for Hepatocyte Proliferation
    Mark E. Mazin, Alina M. Perevalova, Andrei A. Yarushkin, Yuliya A. Pustylnyak, Artem D. Rogachev, Elena A. Prokopyeva, Lyudmila F Gulyaeva, Vladimir O. Pustylnyak · 2023 · Biochemistry (Moscow)
  33. Liver regeneration
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  34. Additional file 3 of IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
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  35. Additional file 2 of IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
    Pei‐Yi Chu, Wei-Chieh Huang, Shiao-Lin Tung, Chung‐Ying Tsai, Chih‐Jung Chen, Yu‐Chin Liu, Chia-Wen Lee, Yang-Hsiang Lin, Hung‐Yu Lin, Cheng‐Yi Chen et al. · 2022 · Figshare
  36. Constitutive androstane receptor agonist initiates metabolic activity required for hepatocite proliferation
    Mark E. Mazin, Alina M. Perevalova, Andrei A. Yarushkin, Yuliya A. Pustylnyak, Artem D. Rogachev, Elena A. Prokopyeva, Lyudmila F Gulyaeva, Vladimir O. Pustylnyak · 2023 · Biochemistry (Moscow)
  37. Constitutive Androstane Receptor
    Jiong Yan, Wen Xie · 2018 · Elsevier eBooks
  38. Additional file 1 of IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
    Chu, Pei-Yi, Huang, Wei-Chieh, Tung, Shiao-Lin, Tsai, Chung-Ying, Chih Jung Chen, Liu, Yu-Chin, Lee, Chia-Wen, Lin, Yang-Hsiang, Lin, Hung-Yu, Chen, Cheng-Yi et al. · 2022 · Figshare
  39. Etude du rôle du récepteur nucléaire CAR, Constitutive Androstane Receptor, dans le métabolisme des lipides et la susceptibilité à l'athérosclérose
    Anne-Laure Sberna · 2011
  40. Etude des xénorécepteurs CAR (NR1I3) et PXR (NR1I2) : identification d’un nouveau gène cible de CAR (SPOT14) et d’une nouvelle isoforme de PXR (PXR-small) dans l'hépatocyte humain
    Cyril Breuker · 2010