C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†
Open accessAbstract
Unlabelled In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury. In this study, we identify c-Myc as a gene induced by CAR and demonstrate that TCPOBOP-induced proliferation of hepatocytes depends on c-Myc function. Moreover, the TCPOBOP-induced cell cycle program (Cdc2, cyclins, MCM proteins, Cdc20, and genes implicated in the spindle assembly checkpoint) is severely impaired in c-Myc mutant livers. Strikingly, many of these genes overlap with a program controlled by the forkhead transcription factor FoxM1, known to control progression through S-phase and mitosis. Indeed, FoxM1 is also induced by TCPOBOP. Moreover, we show that c-Myc binds to the FoxM1 promoter in a TCPOBOP-dependent manner, suggesting a CAR --> c-Myc --> FoxM1 pathway downstream of TCPOBOP. Conclusion Collectively, this study identifies c-Myc and FoxM1 mediated proliferative programs as key mediators of TCPOBOP-CAR induced direct liver hyperplasia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CAR's pro-proliferative role in liver is mediated through induction of c-Myc, Foxm1, and cyclin D1, and modulation of β-catenin and YAP signaling pathways.
“Prior studies have focused primarily on the pro-proliferative role of CAR in the liver, mediated through the induction of factors such as cellular-myelocytomatosis oncogene (c-Myc),15 forkhead box m1 (Foxm1),15 and cyclin D1 (Ccnd1),16 as well as modulation of β-catenin17,18 and Yes-associated protein19, 20, 21, 22 signaling pathways.”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [15]
Cites
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
Morgan, D. O. (1995) · Nature · doi:10.1038/374131a0 · Cited by 3,288 · see citing works
From genomics to chemical genomics: new developments in KEGG
Kanehisa, M. I. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj102 · Cited by 3,126 · see citing works
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works
Transcriptional regulation and transformation by Myc proteins
Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,122 · see citing works
Genomic targets of the human c-Myc proteinPreprint
Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963 · see citing works
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874 · see citing works
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823 · see citing works
Self-citationFoxM1 is required for execution of the mitotic programme and chromosome stability
Laoukili, J., Kooistra, M. R. H., Brás, A., Kauw, J. J. W., Kerkhoven, R. M., Morrison, A. J., Clevers, H. C., & Medema, R. H. (2005) · Nature Cell Biology · doi:10.1038/ncb1217 · Cited by 808 · see citing works
Waxman, D. J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1351 · Cited by 754 · see citing works
Preventing re-replication of chromosomal DNA
Blow, J. J., & Dutta, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1663 · Cited by 664 · see citing works
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., & Moore, D. D. (2000) · Nature · doi:10.1038/35038112 · Cited by 654 · see citing works
Self-citationMaglich, J. M., Stoltz, C. M., Goodwin, B. J., Hawkins‐Brown, D., Moore, J. T., & Kliewer, S. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.638 · Cited by 652 · see citing works
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645 · see citing works
Self-citationA global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
Li, Z., Calcar, S. V., Qu, C., Cavenee, W. K., Zhang, M. Q., & Ren, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332764100 · Cited by 524 · see citing works
c-Myc regulates mammalian body size by controlling cell number but not cell size
Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434 · see citing works
Self-citationKalinichenko, V. V., Major, M. L., Wang, X., Petrovic, V., Kuechle, J., Yoder, H. M., Dennewitz, M. B., Shin, B., Datta, A., Raychaudhuri, P., et al. (2004) · Genes & Development · doi:10.1101/gad.1200704 · Cited by 358 · see citing works
Wang, X., Kiyokawa, H., Dennewitz, M. B., & Costa, R. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252570299 · Cited by 328 · see citing works
Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J. M., Lozano, G., & Moore, D. D. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0520 · Cited by 284 · see citing works
Self-citationGetting in and out of mitosis with Polo-like kinase-1
van Vugt, M. A. T. M., & Medema, R. H. (2005) · Oncogene · doi:10.1038/sj.onc.1208617 · Cited by 271 · see citing works
Identification of c-myc responsive genes using rat cDNA microarray.
Guo, Q., Malek, R. L., Kim, H., Chiao, C., He, M., Ruffy, M., Sanka, K., Lee, N. H., Dang, C. V., & Liu, E. T. (2000) · PubMed · Cited by 265 · see citing works
Assem, M., Schuetz, E. G., Leggas, M. L., Sun, D., Yasuda, K., Reid, G., Zelcer, N., Adachi, M., Strom, S. C., Evans, R. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314111200 · Cited by 240 · see citing works
Self-citationMiao, J., Fang, S., Bae, Y., & Kemper, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510713200 · Cited by 197 · see citing works
More than just proliferation: Myc function in stem cells
Murphy, M., Wilson, A., & Trumpp, A. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.01.008 · Cited by 183 · see citing works
Self-citationCAR, The Continuously Advancing Receptor, in Drug Metabolism and Disease
Qatanani, M., & Moore, D. D. (2005) · Current Drug Metabolism · doi:10.2174/1389200054633899 · Cited by 167 · see citing works
Self-citationHow Do so Few Control so Many?
Nasmyth, K. (2005) · Cell · doi:10.1016/j.cell.2005.03.006 · Cited by 158 · see citing works
Developmental Context Determines Latency of MYC-Induced Tumorigenesis
Beer, S., Zetterberg, A., Ihrie, R. A., McTaggart, R., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L. D., Feng, S., Ruebner, B. H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020332 · Cited by 142 · see citing works
The Myc trilogy: lord of RNA polymerases
Óskarsson, T., & Trumpp, A. (2005) · Nature Cell Biology · doi:10.1038/ncb0305-215 · Cited by 135 · see citing works
Self-citationc-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409260102 · Cited by 104 · see citing works
Fernández, L. Á., Winkler, M., & Grosschedl, R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.196-208.2001 · Cited by 97 · see citing works
Gadd45β Is Induced Through a CAR-Dependent, TNF-Independent Pathway in Murine Liver Hyperplasia * #
Columbano, A., Ledda‐Columbano, G. M., Pibiri, M., Cossu, C., Menegazzi, M., Moore, D. D., Huang, W., Tian, J., & Locker, J. D. (2005) · Hepatology · doi:10.1002/hep.20883 · Cited by 91 · see citing works
Self-citationA Common Set of Immediate–Early Response Genes in Liver Regeneration and Hyperplasia
Locker, J. D., Tian, J., Carver, R. S., Concas, D., Cossu, C., Ledda‐Columbano, G. M., & Columbano, A. (2003) · Hepatology · doi:10.1053/jhep.2003.50299 · Cited by 89 · see citing works
Óskarsson, T., Essers, M. A. G., Dubois, N. C., Offner, S. E., Dubey, C., Roger, C., METZGER, D., Chambon, P., Hümmler, E., Beard, P., et al. (2006) · Genes & Development · doi:10.1101/gad.381206 · Cited by 82 · see citing works
Self-citationCYTOCHROME P450-BASED CANCER GENE THERAPY: RECENT ADVANCES AND FUTURE PROSPECTS
Waxman, D. J., Chen, L., Hecht, J. E. D., & Jounaïdi, Y. (1999) · Drug Metabolism Reviews · doi:10.1081/dmr-100101933 · Cited by 67 · see citing works
Interaction and Assembly of Murine Pre-replicative Complex Proteins in Yeast and Mouse Cells
Kneißl, M., Pütter, V., Szalay, A. A., & Grummt, F. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00079-2 · Cited by 64 · see citing works
RACE: Remote Analysis Computation for gene Expression data
Psarros, M., Heber, S., Sick, M., Thoppae, G., Harshman, K., & Sick, B. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki490 · Cited by 61 · see citing works
FOXM1c transactivates the human c‐myc promoter directly via the two TATA boxes P1 and P2
Wierstra, I., & Alves, J. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05468.x · Cited by 57 · see citing works
Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP
Ledda‐Columbano, G. M., Pibiri, M., Cossu, C., Molotzu, F., Locker, J. D., & Columbano, A. (2004) · Hepatology · doi:10.1002/hep.1840400429 · Cited by 48 · see citing works
Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli
Ledda-Columbano, G. M., Pibiri, M., Concas, D., Cossu, C., Tripodi, M., & Columbano, A. (2002) · Hepatology · doi:10.1053/jhep.2002.36159 · Cited by 45 · see citing works
Diwan, B. A., Lubet, R. A., Ward, J. M., Hrabie, J. A., & Rice, J. M. (1992) · Carcinogenesis · doi:10.1093/carcin/13.10.1893 · Cited by 45 · see citing works
The CAR Nuclear Receptor and Hepatocyte Proliferation * #
Costa, R. H., Kalinchenko, V. V., Tan, Y., & Wang, I. (2005) · Hepatology · doi:10.1002/hep.20953 · Cited by 35 · see citing works
FOXM1c and Sp1 transactivate the P1 and P2 promoters of human c-myc synergistically
Wierstra, I., & Alves, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.151 · Cited by 28 · see citing works
Bub1 and the multilayered inhibition of Cdc20–APC/C in mitosis
Vanoosthuyse, V., & Hardwick, K. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.003 · Cited by 26 · see citing works
Brezillon, N., Lambert-Blot, M., Morosan, S., Couton, D., Mitchell, C., Kremsdorf, D., Costa, R. H., Gilgenkrantz, H., & Guidotti, J. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300232 · Cited by 19 · see citing works
Vincent, S. D., & Robertson, E. J. (2004) · genesis · doi:10.1002/gene.20047 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of the master regulator FOXM1 in cancer
Liao, G., Li, X., Zeng, S., Liu, C., Yang, S., Li, Y., Hu, C.-J., & Bai, J. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0266-6 · Cited by 412 · see citing works
Target gene-independent functions of MYC oncoproteins
Baluapuri, A., Wolf, E., & Eilers, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0215-2 · Cited by 310 · see citing works
A Positive Feedback Loop of lncRNA- PVT1 and FOXM1 Facilitates Gastric Cancer Growth and Invasion
Xu, M., Wang, Y., Weng, W., Wei, P., Qi, P., Zhang, Q., Tan, C., Ni, S., Dong, L., Yang, Y., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0742 · Cited by 249 · see citing works
Halasi, M., & Gartel, A. L. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0712 · Cited by 210 · see citing works
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
Ahmadi, S. E., Rahimi, S., Zarandi, B., Chegeni, R., & Safa, M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01111-4 · Cited by 211 · see citing works
ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance
Millour, J., de Olano, N., Horimoto, Y., Monteiro, L. J., Langer, J. K., Aligué, R., Hajji, N., & Lam, E. W. ‐. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0024 · Cited by 184 · see citing works
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works
Pro-proliferative FoxM1 is a target of p53-mediated repression
Barsotti, A. M., & Prives, C. L. (2009) · Oncogene · doi:10.1038/onc.2009.282 · Cited by 166 · see citing works
Hernandez, J., Mota, L. C., & Baldwin, W. S. (2009) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569209788654005 · Cited by 159 · see citing works
Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover
Popov, N., Schülein‐Völk, C., Jaenicke, L. A., & Eilers, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2104 · Cited by 151 · see citing works
The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
Mackowiak, B., Hodge, J., Stern, S., & Wang, H. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.081042 · Cited by 116 · see citing works
Chen, W.-D., Wang, Y.-D., Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B. M., & Huang, W. (2010) · Hepatology · doi:10.1002/hep.23390 · Cited by 115 · see citing works
Self-citationXu, X., Chen, W., Miao, R., Zhou, Y., Wang, Z., Zhang, L., Wan, Y., Dong, Y., Qu, K., & Liu, C. (2015) · Oncotarget · doi:10.18632/oncotarget.2905 · Cited by 111 · see citing works
Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1
Gemenetzidis, E., Costea, D. E., Parkinson, E. K., Waseem, A., Wan, H., & Teh, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2173 · Cited by 105 · see citing works
Myc's other life: stem cells and beyond
Laurenti, E., Wilson, A., & Trumpp, A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.09.006 · Cited by 101 · see citing works
Self-citationActivating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis
Dong, B., Lee, J.-S., Park, Y.-Y., Yang, F., Xu, G., Huang, W., Finegold, M. J., & Moore, D. D. (2015) · Nature Communications · doi:10.1038/ncomms6944 · Cited by 97 · see citing works
Self-citationFOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic Target in Ovarian Cancer
Liu, C., Barger, C. J., & Karpf, A. R. (2021) · Cancers · doi:10.3390/cancers13123065 · Cited by 97 · see citing works
Paxton, J. W. (2012) · InTech eBooks · doi:10.5772/1180 · Cited by 88 · see citing works
Zhang, Q., Huang, H., Liu, A., Jiang, L., Liu, C., Sun, B., Chen, L., Gao, Y., Xu, D., & Su, C. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.032 · Cited by 85 · see citing works
The xenobiotic receptors PXR and CAR in liver physiology, an update
Cai, X., Young, G. M., & Xie, W. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166101 · Cited by 84 · see citing works
Barger, C. J., Zhang, W., Hillman, J. C., Stablewski, A. B., Higgins, M. J., Vanderhyden, B. C., Odunsi, K. O., & Karpf, A. R. (2015) · Oncotarget · doi:10.18632/oncotarget.4546 · Cited by 80 · see citing works
Wang, I., Zhang, Y., Snyder, J. E., Sutherland, M. J., Burhans, M. S., Shannon, J. M., Park, H. J., Whitsett, J. A., & Kalinichenko, V. V. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.027 · Cited by 69 · see citing works
Zhou, Z., Chen, H., Xie, R., Wang, H., Li, S., Xu, Q., Xu, N., Cheng, Q., Qian, Y., Huang, R., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12443 · Cited by 69 · see citing works
High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass
GANNON, M. A. (2010) · The Open Endocrinology Journal · doi:10.2174/1874216501004010066 · Cited by 71 · see citing works
Tschuor, C., Kachaylo, E., Limani, P., Raptis, D. A., Linecker, M., Tian, Y., Herrmann, U., Grabliauskaite, K., Weber, A., Columbano, A., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.040 · Cited by 68 · see citing works
Oxidative stress in melanocyte senescence and melanoma transformation
Meierjohann, S. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.11.005 · Cited by 67 · see citing works
Wang, Y., Zhou, X., Xu, M., Weng, W., Zhang, Q., Yang, Y., Wei, P., & Du, X. (2016) · Oncotarget · doi:10.18632/oncotarget.9160 · Cited by 65 · see citing works
Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice
Feng, G. J., Cotta, W., Wei, X., Poetz, O., Evans, R., Jardé, T., Reed, K. R., Méniel, V. S., Williams, G. T., Clarke, A. R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.047 · Cited by 64 · see citing works
Kopec, A. K., Burgoon, L. D., Aibo, D. I., Mets, B. D., Tashiro, C. H. M., Potter, D., Sharratt, B., Harkema, J. R., & Zacharewski, T. R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.12.003 · Cited by 63 · see citing works
Chen, W., Fu, X., Dong, B., Wang, Y., Shiah, S., Moore, D. D., & Huang, W. (2012) · Hepatology · doi:10.1002/hep.25766 · Cited by 60 · see citing works
Self-citationEffect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
Režen, T., Tamási, V., Lövgren‐Sandblom, A., Björkhem, I., Meyer, U., & Rozman, D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-384 · Cited by 59 · see citing works
Zhi, Y., Abudoureyimu, M., Zhou, H., Wang, T., Feng, B., Wang, R., & Chu, X. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.04.008 · Cited by 56 · see citing works
Chakraborty, S., Kanakasabai, S., & Bright, J. J. (2011) · British Journal of Cancer · doi:10.1038/sj.bjc.6606064 · Cited by 54 · see citing works
Shizu, R., Benoki, S., Numakura, Y., Kodama, S., Miyata, M., Yamazoe, Y., & Yoshinari, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061802 · Cited by 52 · see citing works
Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR
Tojima, H., Kakizaki, S., Yamazaki, Y., Takizawa, D., Horiguchi, N., Sato, K., & Mori, M. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.06.001 · Cited by 50 · see citing works
Bhushan, B., Stoops, J. W., Mars, W. M., Orr, A., Bowen, W. C., Paranjpe, S., & Michalopoulos, G. K. (2019) · Hepatology · doi:10.1002/hep.30109 · Cited by 49 · see citing works
Jiao, T., Yao, X., Zhao, Y.-Y., Zhou, Y., Gao, Y., Fan, S., Chen, P., Li, X., Jiang, Y., Xiao, Y., et al. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000061 · Cited by 49 · see citing works
Oncogenic MYC amplifies mitotic perturbations
Littler, S., Sloss, O., Geary, B., Pierce, A., Whetton, A. D., & Taylor, S. S. (2019) · Open Biology · doi:10.1098/rsob.190136 · Cited by 45 · see citing works
Zhang, X., Cheng, L., Minn, K. T., Madan, R., Godwin, A. K., Shridhar, V., & CHIEN, J. R. (2014) · Oncotarget · doi:10.18632/oncotarget.2497 · Cited by 45 · see citing works
MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products
Chan, K. I., Zhang, S., Li, G., Xu, Y., Cui, L., Wang, Y., Su, H., Tan, W., & Zhong, Z. (2024) · Aging and Disease · doi:10.14336/ad.2023.0520 · Cited by 45 · see citing works
Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches
Akhdar, H., Legendre, C., Aninat, C., & More, F. (2012) · InTech eBooks · doi:10.5772/30015 · Cited by 44 · see citing works
Yoshinari, K. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00267 · Cited by 41 · see citing works
Gao, Y., Fan, S., Li, H., Jiang, Y., Yao, X., Zhu, S., Yang, X., Wang, R., Tian, J., Gonzalez, F. J., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.021 · Cited by 41 · see citing works
Mechanisms of RAS/β-catenin interactions
Zeller, E., Hammer, K., Kirschnick, M., & Braeuning, A. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1035-3 · Cited by 39 · see citing works
Braeuning, A., Heubach, Y., Knorpp, T., Kowalik, M. A., Templin, M., Columbano, A., & Schwarz, M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr166 · Cited by 40 · see citing works
c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
Stoelzle, T., Schwarb, P., Trumpp, A., & Hynes, N. E. (2009) · BMC Biology · doi:10.1186/1741-7007-7-63 · Cited by 38 · see citing works
Self-citationNiu, B., Coslo, D. M., Bataille, A. R., Albert, I., Pugh, B. F., & Omiecinski, C. J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky692 · Cited by 37 · see citing works
Chu, P., Huang, W.-C., Tung, S.-L., Tsai, C., Chen, C., Liu, Y., Lee, C.-W., Lin, Y.-H., Lin, H., Chen, C., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00858-8 · Cited by 37 · see citing works
Self-citationTakizawa, D., Kakizaki, S., Horiguchi, N., Yamazaki, Y., Tojima, H., & Mori, M. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq277 · Cited by 34 · see citing works
de Haan, L. R., van der Lely, S. J., Warps, A. K., Hofsink, Q., Olthof, P. B., de Keijzer, M. J., Lionarons, D. A., Dias, L. M., Bruinsma, B. G., Uygun, K., et al. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.04.201801.001 · Cited by 33 · see citing works
Cystathionase mediates senescence evasion in melanocytes and melanoma cells
Leikam, C., Hufnagel, A., Walz, S., Kneitz, S., Fekete, Á., Müller, M., Eilers, M., Schartl, M., & Meierjohann, S. (2013) · Oncogene · doi:10.1038/onc.2012.641 · Cited by 34 · see citing works
Role of YAP activation in nuclear receptor CAR-mediated proliferation of mouse hepatocytes
Abe, T., Amaike, Y., Shizu, R., Takahashi, M., Kano, M., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., & Yoshinari, K. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy149 · Cited by 36 · see citing works
Kazantseva, Y. A., Yarushkin, A. A., & Pustylnyak, V. O. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.008 · Cited by 33 · see citing works
A Cdh1–FoxM1–Apc axis controls muscle development and regeneration
Chen, Z., Li, L., Xu, S., Liu, Z., Zhou, C., Li, Z., Liu, Y., Wu, W., Huang, Y., Kuang, M., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2375-6 · Cited by 31 · see citing works
Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice
Zhao, Y.-Y., Yao, X., Jiao, T., Tian, J., Gao, Y., Fan, S., Chen, P., Jiang, Y., Zhou, Y., Chen, Y., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153520 · Cited by 31 · see citing works
Huynh, K. M., Soh, J., Dash, R., Sarkar, D., Fisher, P. B., & Kang, D. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22326 · Cited by 31 · see citing works
Boix, L., López-Oliva, J. M., Rhodes, A. C., & Bruix, J. (2016) · Oncotarget · doi:10.18632/oncotarget.11885 · Cited by 30 · see citing works
Clinical Relevance of the Constitutive Androstane Receptor
Stern, S., Kurian, R., & Wang, H. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000483 · Cited by 29 · see citing works
Donthamsetty, S., Bhave, V., Kliment, C. R., Bowen, W. C., Mars, W. M., Bell, A. W., Stewart, R. E., Orr, A. V., Wu, C., & Michalopoulos, G. K. (2010) · Hepatology · doi:10.1002/hep.24040 · Cited by 30 · see citing works
Lin, C., Mars, W. M., Paranjpe, S., Donthamsetty, S., Bhave, V., Kang, L., Orr, A. V., Bowen, W. C., Bell, A. W., & Michalopoulos, G. K. (2011) · Hepatology · doi:10.1002/hep.24417 · Cited by 29 · see citing works
Nuclear receptor CAR-mediated liver cancer and its species differences
Shizu, R., & Yoshinari, K. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1746268 · Cited by 29 · see citing works
Ganzenberg, K., Singh, Y., & Braeuning, A. (2013) · Toxicology · doi:10.1016/j.tox.2013.03.019 · Cited by 29 · see citing works
Zhang, Z., Zhu, P., Zhou, Y. H., Sheng, Y., Hong, Y., Xiang, D., Qian, Z., Mosenson, J. A., & Wu, W.-S. (2016) · Leukemia · doi:10.1038/leu.2016.201 · Cited by 29 · see citing works
Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver
Kazantseva, Y. A., Yarushkin, A. A., Mostovich, L. A., Pustylnyak, Y. A., & Pustylnyak, V. O. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.004 · Cited by 27 · see citing works
Kim, K. H., Choi, J. M., Li, F., Dong, B., Wooton‐Kee, C. R., Arizpe, A., Anakk, S., Jung, S. Y., Hartig, S. M., & Moore, D. D. (2019) · Hepatology Communications · doi:10.1002/hep4.1274 · Cited by 27 · see citing works
Self-citationLentiviral-Mediated RNAi Knockdown Yields a Novel Mouse Model for Studying Cyp2b Function
Damiri, B., Holle, E., Yu, X., & Baldwin, W. S. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr309 · Cited by 27 · see citing works
Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development
Yoshinari, K., & Shizu, R. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000481 · Cited by 26 · see citing works
von Hippel, F. A., Miller, P. K., Carpenter, D. O., Dillon, D. M., Smayda, L. C., Katsiadaki, I. G., Titus, T. A., Batzel, P., Postlethwait, J. H., & Buck, C. L. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.054 · Cited by 24 · see citing works
SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism
Chen, T., Chen, Q., Xu, Y., Zhou, Q., Zhu, J., Zhang, H., Wu, Q., Xu, J., & Yu, C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.015 · Cited by 23 · see citing works
Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD
Prokopec, S. D., Watson, J. D., Lee, J., Pohjanvirta, R., & Boutros, P. C. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.02.012 · Cited by 23 · see citing works
Identification of Candidate B-Lymphoma Genes by Cross-Species Gene Expression Profiling
Tompkins, V. S., Han, S., Olivier, A. K., Syrbu, S., Bair, T., Button, A. M., Jacobus, L., Wang, Z., Lifton, S., Raychaudhuri, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076889 · Cited by 23 · see citing works
Role of the constitutive androstane receptor (CAR) in human liver cancer
Bae, S. D. W., Nguyen, R., Qiao, L., & George, J. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188516 · Cited by 22 · see citing works
Yoshinari, K., Ohno, H., Benoki, S., & Yamazoe, Y. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.11.003 · Cited by 21 · see citing works
PXR mediates mifepristone-induced hepatomegaly in mice
Yao, X., Jiao, T., Jiang, Y., Fan, S., Zhao, Y.-Y., Xiao, Y., Gao, Y., Li, F., Zhou, Y., Chen, P., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00633-4 · Cited by 21 · see citing works
Sakamoto, Y., Inoue, K., Takahashi, M., Taketa, Y., Kodama, Y., Nemoto, K., Degawa, M., Gamou, T., Ozawa, S., Nishikawa, A., et al. (2013) · Toxicologic Pathology · doi:10.1177/0192623313482055 · Cited by 20 · see citing works
Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update
Zhao, P., Fan, S., Gao, Y., Huang, M., & Bi, H. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000454 · Cited by 20 · see citing works
Bhushan, B., Molina, L., Koral, K., Stoops, J. W., Mars, W. M., Banerjee, S., Orr, A., Paranjpe, S., Monga, S. P., Locker, J., et al. (2021) · Hepatology · doi:10.1002/hep.31521 · Cited by 20 · see citing works
Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors
Wang, Z., Neal, B. H., Lamb, J. C., & Klaunig, J. E. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv151 · Cited by 19 · see citing works
Regulation of type 3 deiodinase in rodent liver and adipose tissue during fasting
de Vries, E. M., van Beeren, H. C., van Wijk, A. C. W. A., Kalsbeek, A., Romijn, J. A., Fliers, E., & Boelen, A. (2020) · Endocrine Connections · doi:10.1530/ec-20-0189 · Cited by 20 · see citing works
Retinoic Acid-mediated Nuclear Receptor Activation and Hepatocyte Proliferation
Bushue, N., & Wan, Y. Y. (2009) · Journal of Experimental & Clinical Medicine · doi:10.1016/s1878-3317(09)60007-3 · Cited by 19 · see citing works
Chen, F., Zamule, S. M., Coslo, D. M., Chen, T., & Omiecinski, C. J. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.10.012 · Cited by 18 · see citing works
FOXM1 transcriptional regulation
Li, M., Gao, X., Su, Y., Shan, S., Qian, W., Zhang, Z., & Zhu, D. (2024) · Biology of the Cell · doi:10.1111/boc.202400012 · Cited by 17 · see citing works
Imai, J., Yamazoe, Y., & Yoshinari, K. (2012) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.dmpk-12-rg-112 · Cited by 17 · see citing works
Kazantseva, Y. A., Pustylnyak, Y. A., & Pustylnyak, V. O. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916040040 · Cited by 17 · see citing works
Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice
Li, L., Bao, X., Zhang, Q.-Y., Negishi, M., & Ding, X. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.076406 · Cited by 17 · see citing works
Abe, T., Shizu, R., Sasaki, T., Shimizu, Y., Hosaka, T., Kodama, S., Matsuzawa, A., & Yoshinari, K. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.258632 · Cited by 16 · see citing works
Saito, K., Moore, R., & Negishi, M. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kfs338 · Cited by 15 · see citing works
Hao, R., Su, S., Wan, Y., Shen, F. H., Niu, B., Coslo, D. M., Albert, I. U., Han, X., & Omiecinski, C. J. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.04.002 · Cited by 14 · see citing works
Kazantseva, Y. A., Yarushkin, A. A., & Pustylnyak, V. O. (2014) · Toxicology · doi:10.1016/j.tox.2014.04.003 · Cited by 14 · see citing works
Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver
Sprenger, H., Rasinger, J. D., Hammer, H., Naboulsi, W., Zabinsky, E., Planatscher, H., Schwarz, M., Poetz, O., & Braeuning, A. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03338-7 · Cited by 12 · see citing works
CAR-mediated repression of Cdkn1a(p21) is accompanied by the Akt activation
Yarushkin, A. A., Mazin, M. E., Yunusova, A. Y., Korchagina, K. V., Pustylnyak, Y. A., Prokopyeva, E. A., & Pustylnyak, V. O. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.032 · Cited by 12 · see citing works
Škoda, J., Dohnalová, K., Chalupský, K., Stahl, A., Templin, M. F., Maixnerová, J., Mičuda, S., Grøntved, L., Braeuning, A., & Pávek, P. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114905 · Cited by 11 · see citing works
Wang, B., Hikosaka, K., Sultana, N., Sharkar, M. T. K., Noritake, H., Kimura, W., Wu, Y., Kobayashi, Y., Uezato, T., & Miura, N. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.014 · Cited by 10 · see citing works
Boix, L., López-Oliva, J. M., Rhodes, A. C., & Bruix, J. (2016) · Journal of Hepatology · doi:10.1016/s0168-8278(16)01032-1 · Cited by 10 · see citing works
Constitutive androstane receptor activation evokes the expression of glycolytic genes
Yarushkin, A. A., Kazantseva, Y. A., Prokopyeva, E. A., Markova, D. N., Pustylnyak, Y. A., & Pustylnyak, V. O. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.075 · Cited by 9 · see citing works
Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks
Ghasemi, N., & Azizi, H. (2024) · Gene · doi:10.1016/j.gene.2024.148447 · Cited by 9 · see citing works
Smetanina, M. A., Pakharukova, M. Y., Kurinna, S. M., Dong, B., Hernandez, J. P., Moore, D. D., & Merkulova, T. I. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.05.019 · Cited by 9 · see citing works
Self-citationYarushkin, A., Mazin, M. E., Pustylnyak, Y. A., Prokopyeva, E., & Pustylnyak, V. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173135 · Cited by 8 · see citing works
Huillet, M., Lasserre, F., Gratacap, M., Engelmann, B., Bruse, J., Polizzi, A., Fougeray, T., Martin, C. M. P., Rives, C., Fougerat, A., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100930 · Cited by 9 · see citing works
- Authors
- Blanco‐Bose, W. E., Murphy, M. J., Ehninger, A., Offner, S., Dubey, C., Huang, W., Moore, D. D., & Trumpp, A.
- Affiliations
- ISREC Foundation (CH)
- City Of Hope National Medical Center (US)
- Baylor College of Medicine (US)
- German Cancer Research Center (DE)
- Corresponding author
- Trumpp, Andreas
- Venue
- Hepatology
- Published
- 2008-10
- Volume
- 48
- Issue
- 4
- Pages
- 1302-1311
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2158113492
- Cited by
- 138
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 5 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 14 · 2012: 7
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK046546, F32DK063780, U19 DK-62434, R01 DK46546, U19DK062434)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- c-Myc, FOXM1, constitutive androstane receptor, TCPOBOP, hepatocyte proliferation, hepatomegaly, cell cycle regulation, spindle assembly checkpoint, cdc2, cyclins, MCM proteins, CDC20, transcriptional regulation, nuclear receptor signaling
- MeSH terms
- Forkhead Box Protein M1, Constitutive Androstane Receptor, Animals, Disease Models, Animal, Hyperplasia, Liver, Mice, Transgenic, Pyridines, Transcription Factors, Signal Transduction, Proto-Oncogene Proteins c-myc, Receptors, Cytoplasmic and Nuclear, Hepatocytes, Cell Proliferation, Mice, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
