The DOI matches its Crossref record; 50 of the 53 references it cites were found in a registry or an index.
Tumor Necrosis Factor–Like Weak Inducer of Apoptosis Is a Mitogen for Liver Progenitor Cells
Open accessAbstract
Liver progenitor cells (LPCs) represent the cell compartment facilitating hepatic regeneration during chronic injury while hepatocyte-mediated repair mechanisms are compromised. LPC proliferation is frequently observed in human chronic liver diseases such as hereditary hemochromatosis, fatty liver disease, and chronic hepatitis. In vivo studies have suggested that a tumor necrosis factor family member, tumor necrosis factor–like weak inducer of apoptosis (TWEAK), is promitotic for LPCs; whether it acts directly is not known. In our murine choline-deficient, ethionine-supplemented (CDE) model of chronic liver injury, TWEAK receptor [fibroblast growth factor-inducible 14 (Fn14)] expression in the whole liver is massively upregulated. We therefore set out to investigate whether TWEAK/Fn14 signaling promotes the regenerative response in CDE-induced chronic liver injury by mitotic stimulation of LPCs. Fn14 knockout (KO) mice showed significantly reduced LPC numbers and attenuated inflammation and cytokine production after 2 weeks of CDE feeding. The close association between LPC proliferation and activation of hepatic stellate cells in chronic liver injury prompted us to investigate whether fibrogenesis was also modulated in Fn14 KO animals. Collagen deposition and expression of key fibrogenesis mediators were reduced after 2 weeks of injury, and this correlated with LPC numbers. Furthermore, the injection of 2-week-CDE-treated wildtype animals with TWEAK led to increased proliferation of nonparenchymal pan cytokeratin–positive cells. Stimulation of an Fn14-positive LPC line with TWEAK led to nuclear factor kappa light chain enhancer of activated B cells (NFκB) activation and dose-dependent proliferation, which was diminished after targeting of the p50 NFκB subunit by RNA interference. Conclusion: TWEAK acts directly and stimulates LPC mitosis in an Fn14-dependent and NFκB-dependent fashion, and signaling via this pathway mediates the LPC response to CDE-induced injury and regeneration. (Hepatology 2010)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fn14 has been identified as a critical receptor for mitogenic stimulation of HPCs31-34.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [33]
In the citing paper
“HPCs had a corresponding reduction in NFκB activity (Figure 5g), a downstream mediator of TWEAK-Fn14 signalling33.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rapid colorimetric assay for cell growth and survival
Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,935
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378
Grisham, J. W. (1962) · PubMed · Cited by 769
TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis
Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu, Y., Scott, H. S., Hession, C. A., Garcia, I., & Browning, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32401 · Cited by 690
The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting
Winkles, J. A. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2488 · Cited by 610
Richardson, M. M., Jonsson, J. R., Powell, E. E., Brunt, E. M., Neuschwander–Tetri, B. A., Bhathal, P. S., Dixon, J. B., Weltman, M. D., Tilg, H., Moschen, A. R., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.012 · Cited by 482
Oval Cell Numbers in Human Chronic Liver Diseases Are Directly Related to Disease Severity
Lowes, K. N., Brennan, B. A., Yeoh, G. C., & Olynyk, J. K. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65299-6 · Cited by 453
Self-citationA precursor—product relationship exists between oval cells and hepatocytes in rat liver
Evarts, R. P., Nagy, P., Marsden, E. R., & Thorgeirsson, S. S. (1987) · Carcinogenesis · doi:10.1093/carcin/8.11.1737 · Cited by 447
Flagged first, then by citations
3 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Brown, 2003, The Fn14 cytoplasmic tail binds tumournecrosisfactorreceptorassociated factors 1, 2, 3 and 5 and mediates nuclear factorkappaB activation., Biochem J, 371, 395403
- TirnitzParker, 2007, Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a cholinedeficient, ethioninesupplemented diet., Int J Biochem Cell Biol, 39, 22262239
Cited by
Sorted by citations
Items 101–177 of 177
Qian, Y., Shang, Z., Gao, Y., Wu, H., & Kong, X. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.014 · Cited by 18
Temporal histopathological changes in biliary atresia: A perspective for rapid fibrosis progression
El-Araby, H. A., Saber, M. A., Radwan, N. M., Taie, D. M., Adawy, N. M., & Sıra, A. M. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.09.007 · Cited by 18
Strazzabosco, M., & Fabris, L. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.006 · Cited by 18
“For example, the tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF)-a family and produced by natural killer cells and macrophages, induces a selective expansion of HPC in both DDC and CDE toxicity models [9,10].”
BackgroundRole of Fn14 in acute alcoholic steatohepatitis in mice
Karaca, G., Xie, G., Moylan, C. A., Swiderska‐Syn, M., Guy, C. D., Krüger, L., Machado, M. V., Choi, S. S., Michelotti, G. A., Burkly, L. C., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00429.2013 · Cited by 17
Acute kidney injury transcriptomics unveils a relationship between inflammation and ageing.
Izquierdo, M. C., Sanz, A. B., Sánchez-Niño, M. D., Pérez-Gómez, M. V., Ruiz‐Ortega, M., Poveda, J., Ruiz‐Andrés, O., Ramos, A. M., Moreno, J. A., Egido, J., et al. (2012) · PubMed · doi:10.3265/nefrologia.pre2012.aug.11667 · Cited by 16
Tyrosine Kinase Inhibitors in the Treatment of Hepatocellular Carcinoma
Khoo, T. S. W. L., Rehman, A., & Olynyk, J. K. (2019) · Codon Publications eBooks · doi:10.15586/hepatocellularcarcinoma.2019.ch7 · Cited by 17
Self-citationTWEAK–Fn14 as a common pathway in the heart and the kidneys in cardiorenal syndrome
Poveda, J., Vázquez‐Sánchez, S., Sanz, A. B., Ortíz, A., Ruilope, L. M., & Ruiz‐Hurtado, G. (2021) · The Journal of Pathology · doi:10.1002/path.5631 · Cited by 18
Adult Hepatic Progenitor Cell Niche: How it affects the Progenitor Cell Fate.
Katoonizadeh, A., & Poustchi, H. (2014) · Europe PMC (PubMed Central) · Cited by 17
Current Challenges and Future Directions
Matthews, D., & Gerritsen, M. E. (2010) · Wiley eBooks · doi:10.1002/9780470555293.ch11 · Cited by 21
Ceulemans, A., Verhulst, S., Haele, M. V., Govaere, O., Ventura, J., van Grunsven, L. A., & Roskams, T. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.543 · Cited by 16
“Thus, we demonstrate that in human livers, EpCAM and TROP-2 are both markers of cholangiocytes and activated HPCs. Marker clustering, PCA/Pearson's analysis and immuno- histochemical validation indicated the successful isolation of HPC-enriched populations from human ASH livers, which were used for further analysis.”
BackgroundInfluentialThe role of stem cells in liver injury and repair
Boyd, A., Newsome, P. N., & Lu, W. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1618186 · Cited by 16
“3,5-diethocarbonyl-1,4-dihydrocollidine (DDC) model [87] whereas administration of TWEAK to wild-type mice resulted in enhanced HPC response [88].”
The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
Gogoi-Tiwari, J., Köhn‐Gaone, J., Giles, C., Schmidt‐Arras, D., Gratte, F. D., Elsegood, C. L., McCaughan, G. W., Ramm, G. A., Olynyk, J. K., & Tirnitz‐Parker, J. E. E. (2017) · Journal of Visualized Experiments · doi:10.3791/56138 · Cited by 18
Self-citationMouse Models of Hepatocellular Carcinoma
Carlessi, R., Köhn‐Gaone, J., Olynyk, J. K., & Tirnitz‐Parker, J. E. E. (2019) · Codon Publications eBooks · doi:10.15586/hepatocellularcarcinoma.2019.ch4 · Cited by 17
“In order to significantly reduce the time to carcinogenesis, ethionine, a non-proteinogenic cytotoxic methionine analogue, can be added to the CD diet (CDE) and induce severe hepatic inflammation with a strong proliferation of liver progenitor cells and activation of fibrosis-driving hepatic stellate cells in as early…”
BackgroundSelf-citationLiver progenitor cells-mediated liver regeneration in liver cirrhosis
Shang, H., Wang, Z., & Song, Y. (2016) · Hepatology International · doi:10.1007/s12072-015-9693-2 · Cited by 14
The canine hepatic progenitor cell niche: Molecular characterisation in health and disease
Kruitwagen, H. S., Spee, B., Viebahn, C. S., Venema, H. B., Penning, L. C., Grinwis, G. C. M., Favier, R. P., van den Ingh, T. S. G. A. M., Rothuizen, J. J., & Schotanus, B. A. (2014) · The Veterinary Journal · doi:10.1016/j.tvjl.2014.05.024 · Cited by 15
Self-citationLi, X., Zhou, X., Ping, X., Zhao, X. Y., Kang, H., Zhang, Y., Ma, Y., Ge, H., Liu, L., Li, R., et al. (2024) · Inflammation · doi:10.1007/s10753-024-01993-9 · Cited by 13
Tsuruya, K., Chikada, H., Ida, K., Anzai, K., Kagawa, T., Inagaki, Y., Mine, T., & Kamiya, A. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0479 · Cited by 13
Inflammatory and Non-Inflammatory Mechanisms Controlling Cirrhosis Development
Sánchez, P. S., Rigual, M. D. M., & Djouder, N. (2021) · Cancers · doi:10.3390/cancers13205045 · Cited by 13
“HPCs reportedly express the TWEAK receptor Fn14 and TWEAK induces oval cell expansion in a Fn14 dependent manner via NF-kB activation [36].”
BackgroundWang, S., Li, L., Cook, C., Zhang, Y., Xia, Y., & Liu, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02930-z · Cited by 13
“Prolonged TWEAK/Fn14 activation selectively exerts a mitogenic effect on LPCs and can drive chronic liver damage such as chronic hepatitis, nonalcoholic steatohepatitis, and alcoholic liver disease [3, 34].”
BackgroundInfluentialMacrophage heterogeneity and plasticity in liver injury and repair mechanisms
Zhang, T., Horn, P., Peiseler, M., & Tacke, F. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf072 · Cited by 14
Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases
Clerbaux, L., Hul, N. V., Gouw, A. S. H., Manco, R., Español‐Suñer, R., & Leclercq, I. A. (2018) · InTech eBooks · doi:10.5772/intechopen.69533 · Cited by 14
“Although low choline dietary content could be used [31], we will describe here a model using dietary choline deficiency.”
BackgroundMethodKatoonizadeh, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00007-2 · Cited by 12
TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis
Bakar, N. D. B. A., Carlessi, R., Gogoi-Tiwari, J., Köhn‐Gaone, J., Williams, V. M., Falasca, M., Olynyk, J. K., Ramm, G. A., & Tirnitz‐Parker, J. E. E. (2023) · Cancers · doi:10.3390/cancers15061807 · Cited by 11
Self-citationXu, M., Zhang, F., Wang, A., Wang, C., Cao, Y. Q., Zhang, M., Zhang, M., Su, M., Zou, X., Xu, G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167658 · Cited by 11
Woo, K. H., Stewart, S. G., Kong, G., Finch‐Edmondson, M., Dwyer, B. J., Yeung, S. Y., Abraham, L. J., Kampmann, S. S., Diepeveen, L. A., Passman, A. M., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.03.015 · Cited by 11
“Secondly, there is extensive evidence to support the view that some hepatocellular carcinomas (HCC) may be derived from liver progenitor cells (LPCs) [10] and growth of these cells is stimulated by TNF [11, 12] and TNF-related cytokines such as tumour necrosis factor-like weak inducer of apoptosis (TWEAK) [13] as well…”
BackgroundSelf-citationM1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice
Rachakonda, V. P., Jadeja, R. N., Urrunaga, N. H., Shah, N., Ahmad, D., Cheng, K., Twaddell, W. S., Raufman, J., & Khurana, S. (2015) · Scientific Reports · doi:10.1038/srep14110 · Cited by 11
DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells
Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J. M., Toussaint, M. J. M., Schotanus, B. A., et al. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0139 · Cited by 10
Self-citationRegeneration and activation of liver progenitor cells in liver cirrhosis
Yin, Y., Kong, D., He, K., & Xia, Q. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.016 · Cited by 11
Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia
Zheng, L., Lv, Z., Gong, Z., Sheng, Q., Gao, Z., Zhang, Y., Yu, S., Zhou, J., Xi, Z., & Wang, X. (2017) · Pediatric Surgery International · doi:10.1007/s00383-017-4068-5 · Cited by 9
“Fn14 knockout mouse in murine chronic liver injury showed that reduced HPCs were correlated with declined CD45+ leukocytes, F4/80+ macrophages, which indicate a general inflammation, and also with fell down key inflammation cytokines, such as TNF, IL-6 (interleukin 6), IFN(Interferon), and LT- (lymphotoxin) [14].”
BackgroundTWEAK is an activator of Hippo-YAP signaling protecting against hepatic Ischemia/ reperfusion injury
Tong, W., Zhu, L., Han, P., Bai, Y., Wang, T., Chen, D., Li, Z., Chi, H., Deng, X., Zhang, Y., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113567 · Cited by 7
Gratte, F. D., Pasic, S., Bakar, N. D. B. A., Gogoi-Tiwari, J., Liu, X., Carlessi, R., Kisseleva, T., Brenner, D. A., Ramm, G. A., Olynyk, J. K., et al. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.105933 · Cited by 7
Self-citationAsıl, M., & Dertli, R. (2016) · Medicine · doi:10.1097/md.0000000000004763 · Cited by 7
“Division of Gastroenterology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Meram, Konya, Turkey.”
BackgroundMerimi, M., Lagneaux, L., Lombard, C. A., Agha, D. M., Bron, D., Lewalle, P., Meuleman, N., Najimi, M., Sokal, E. M., & Najar, M. (2021) · Inflammation Research · doi:10.1007/s00011-020-01428-9 · Cited by 6
Xu, J., He, J., Huang, H., Peng, R., & Xi, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0248-x · Cited by 5
“Previous studies also indicated that the TNF-like weak inducer of apoptosis (TWEAK) was involved in various cellular activities including cell proliferation, apoptosis, and migration [9, 10].”
BackgroundRetractedWang, G., Garcia, V., Lee, J., Yanum, J. A., Lin, J., Jiang, H., & Dai, G. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269383 · Cited by 5
The Pathophysiology of Alcoholic Liver Disease ∗
French, S. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00010-2 · Cited by 5
Hepatic progenitor cell activation is induced by the depletion of the gut microbiome in mice
Wang, F., Sun, N., Li, L., Zhu, W., Xiu, J., Shen, Y., & Xu, Q. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.873 · Cited by 5
Khalaf, A. T., & Liu, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115699 · Cited by 5
Designing Stem Cell Niche for Liver Development and Regeneration
Haque, A., Guild, J., & Revzin, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00036-6 · Cited by 4
Chen, X., Farrokhi, V., Singh, P., Ocaña, M. F., Patel, J. R., Lin, L., Neubert, H., & Brodfuehrer, J. (2017) · mAbs · doi:10.1080/19420862.2017.1398873 · Cited by 4
To TWEAK, or Not to TWEAK: that Is the Question
Shafritz, D. A. (2010) · Hepatology · doi:10.1002/hep.23750 · Cited by 5
Cellular Homeostasis and Repair in the Biliary Tree
Wang, W., Chen, D., Wang, J., & Wen, L. (2022) · Seminars in Liver Disease · doi:10.1055/a-1869-7714 · Cited by 4
Liver Progenitor Cells, Cancer Stem Cells and Hepatocellular Carcinoma
Janina, E. E., George, C. T., & John, K. (2012) · InTech eBooks · doi:10.5772/48005 · Cited by 3
“interferon gamma (IFNγ), and transforming growth factor beta (TGFβ) among others (Knight et al., 2000; Akhurst et al., 2005; Knight et al., 2005; Knight & Yeoh, 2005; Knight et al., 2007; Tirnitz-Parker et al., 2010).”
BackgroundAdeniyi, O. O., Lenstra, J. A., Mastrangelo, S., & Lühken, G. (2024) · animal · doi:10.1016/j.animal.2024.101329 · Cited by 3
“Moreover, Tirnitz-Parker et al. (2010) reported that TWEAK in conjunction with FN14 facilitates hepatic regeneration during chronic injury via the NF-j B pathway.”
BackgroundRomero-Suárez, D. E., Solana-Tinoco, J. B., Espiñeira, M. C. G., Lambis-Anaya, L., & Causado, A. S. (2024) · Revista de Gastroenterología del Perú · doi:10.47892/rgp.2024.443.1718 · Cited by 3
“…has been suggested by studies in murine and cellular models, which may be related to the severity and progression of steatosis and with the possible activation and proliferation of liver progenitor cells in healthy liver undergoing partial hepatectomy and under pathological conditions (5,6,27) .”
BackgroundKaushal, S., Bhattacharya, D., Kumar, S., Herr, W., Dhanjal, J. K., & Minocha, S. (2025) · BMC Genomics · doi:10.1186/s12864-025-11786-5 · Cited by 4
“Also, the extent and efficiency of regeneration can be affected if the liver is damaged and scarred, for example, during the course of NAFLD [81, 87–90].”
Xu, J., He, J., Huang, H., Peng, R., & Xi, J. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02424-8 · Cited by 2
RetractedGrant, C. R., Liberal, R., Holder, B. S., Yuan-fang Ma, A., Mieli‐Vergani, G., Vergani, D., & Longhi, M. S. (2012) · Gut · doi:10.1136/gutjnl-2012-302514b.114 · Cited by 1
Bartlett, D. C., Aldridge, V., Wilhelm, A., Davies, N., Youster, J., Adams, D., & Newsome, P. N. (2012) · Gut · doi:10.1136/gutjnl-2012-302514b.115 · Cited by 1
Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis
Schnabl, B., & Brenner, D. A. (2012) · Gut · doi:10.1136/gutjnl-2012-302644 · Cited by 1
Immunopathogenesis of Liver Cirrhosis
Guillot, A., & Gao, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_35 · Cited by 1
Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease
Younes, R., Burgoyne, R. A., TINIAKOS, D. G., & Govaere, O. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2020.119 · Cited by 1
Munir, M. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Liver Regeneration and Fibrosis
Forbes, S. J., & Alison, M. R. (2013) · Wiley eBooks · doi:10.1002/9781118637272.ch1
Introduction to Hepatic Progenitor Cells
Robinson, P. M., Pi, L., Brown, A. R., Sullivan, D. C., & Petersen, B. E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00017-8
Diehl, A. M. (2014) · Hepatology · doi:10.1002/hep.27676
“The ductular reaction also seems to be a prerequisite for eventual liver regeneration because various interventions that prevent the response block recovery.(3) The latter observation prompted speculation that oval and/or ductular cells are liver progenitors.”
BackgroundLiver Regeneration in Health and Disease
Alison, M. R., & Islam, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7696-2_22
940 LOSS OF KERATIN 19 PREDISPOSES TO THE DEVELOPMENT OF CHOLESTATIC LIVER DISEASE
Chen, Y., Güldiken, N., Omary, M. B., Haybäck, J., & Strnad, P. (2012) · Journal of Hepatology · doi:10.1016/s0168-8278(12)60952-0
Clinical Studies of Cell Therapy for Liver Cirrhosis
Thomas, J. A., & Forbes, S. J. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-098-4_11
Role of liver progenitor cell in liver regeneration: Cellular cross-talks and signals
Chen, L.-L., Zhang, Q.-F., & Kong, X. (2015) · Journal of Shanghai Jiaotong University (Science) · doi:10.1007/s12204-015-1615-x
Itoh, T. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21705-5_5
Stephenson, B., Humphreys, E. H., Muirhead, G., Wilhelm, A., Munir, M., Burkly, L. C., Adams, D., & Afford, S. C. (2012) · Gut · doi:10.1136/gutjnl-2012-302514b.113
Boulter, L., Radulescu, S., Ramachandran, P., Pellicoro, A., Ra, R., & Sansom, O. J. (2013)
Wang, G., Garcia, V., Lee, J., Yanum, J. A., Jiang, H., & Dai, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.26.441515
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TNFSFS12)
Blanco‐Colio, L. M. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101976-1
Martín‐Sánchez, D., Fontecha‐Barriuso, M., Sánchez-Niño, M. D., Izquierdo, M. C., Ucero, A. C., Ortíz, A., & Sanz, A. B. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_594-1
Sanz, A. B., Izquierdo, M. C., Niño, M. D. S., Ucero, A. C., & Ortíz, A. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_594
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TNFSFS12)
Blanco‐Colio, L. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101976
Martín‐Sánchez, D., Fontecha‐Barriuso, M., Sánchez-Niño, M. D., Izquierdo, M. C., Ucero, A. C., Ortíz, A., & Sanz, A. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_594
Mechanisms of ductular reaction in non-alcoholic steatohepatitis
Chen, Y., Gao, W.-K., Shu, Y.-Y., & Ye, J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i19.0000 · Cited by 29
Wöhner, B., Müller, M., Pearen, M. A., Köhn‐Gaone, J., Gorki, L., Philippsen, R., Gogoi-Tiwari, J., John, C., Scheja, L., Krause, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.14.607697
Self-citationАнтонова, Е. И., Omarova, D. I., Firsova, N. V., & Ачилов, А. Б. (2025) · Biological Communications · doi:10.21638/spbu03.2024.403
Influence de la réponse IL-17 dans la physiopathologie du foie
Guillot, A. (2014) · theses.fr (ABES) · doi:10.70675/93867442zef10z413bz8ac0z49dbe1889857
The biliary tree: A new frontier in mucosal immunology?
Guo, Y., Chouik, Y., Hao, Y., Kohlhepp, M. S., & Guillot, A. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.04.006
Metadata
- Authors
- Tirnitz-Parker, J. E. E., Viebahn, C. S., Jakubowski, A., Klopcic, B. R. S., Olynyk, J. K., Yeoh, G. C. T., & Knight, B.
- Affiliations
- The University of Western Australia (AU)
- Biogen (United States) (US)
- Centre for Inflammation Research (GB)
- Venue
- Hepatology
- Published
- 2010-07
- Volume
- 52
- Issue
- 1
- Pages
- 291-302
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2005176562
- Cited by
- 177
- References
- 53
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 7 · 2018: 6 · 2017: 18 · 2016: 18 · 2015: 15 · 2014: 18 · 2013: 20 · 2012: 16
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Murdoch University Research Portal (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Funders
- University of Edinburgh
- Gastroenterological Society of Australia
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- TWEAK, Fn14, liver progenitor cells, chronic liver injury, liver regeneration, cell proliferation, NF-κB signaling, p50 subunit, hepatic stellate cells, liver fibrosis, choline-deficient ethionine-supplemented diet, cytokine production, inflammation
- MeSH terms
- Cytokine TWEAK, TWEAK Receptor, Animals, Choline Deficiency, Collagen, Ethionine, Liver, Liver Regeneration, Male, Mice, Inbred C57BL, Mitogens, Mitosis, Recombinant Proteins, Stem Cells, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice, Knockout, Tumor Necrosis Factors, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
