Liver regeneration

Fausto, Nelson; Campbell, Jean S.; Riehle, Kimberly J.

doi:10.1002/hep.20969

Cited by 1,378Liver physiology and pathologyTissue Engineering and Regenerative MedicineOrgan Transplantation Techniques and Outcomes

Liver regeneration

Fausto, Nelson, Campbell, Jean S., Riehle, Kimberly J.·2006·Hepatology

DOI 10.1002/hep.20969

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Abstract

During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia. A large number of genes are involved in liver regeneration, but the essential circuitry required for the process may be categorized into three networks: cytokine, growth factor and metabolic. There is much redundancy within each network, and intricate interactions exist between them. Thus, loss of function from a single gene rarely leads to complete blockage of liver regeneration. The innate immune system plays an important role in the initiation of liver regeneration after partial hepatectomy, and new cytokines and receptors that participate in initiation mechanisms have been identified. Hepatocytes primed by these agents readily respond to growth factors and enter the cell cycle. Presumably, the increased metabolic demands placed on hepatocytes of the regenerating liver are linked to the machinery needed for hepatocyte replication, and may function as a sensor that calibrates the regenerative response according to body demands. In contrast to the regenerative process after partial hepatectomy, which is driven by the replication of existing hepatocytes, liver repopulation after acute liver failure depends on the differentiation of progenitor cells. Such cells are also present in chronic liver diseases, but their contribution to the production of hepatocytes in those conditions is unkno…

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Serum lactate, CRP, and antithrombin III were demonstrated to identify imminent PHLF as early as within 24 h of surgery.
“More recently, markers such as serum lactate, CRP, and antithrombin III were demonstrated to identify imminent PHLF as early as within 24 h of surgery [11,12,13].”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [12]

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Authors: Fausto, N., Campbell, J. S., & Riehle, K. J.
Affiliations: University of Washington (US)
ORCID: Campbell, Jean S.
Riehle, Kimberly J.
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-02
Volume: 43
Issue: Supplement 1
Pages: S45-S53
ISSN: 0270-9139 (ISSN-L)
DOI: 10.1002/hep.20969
OpenAlex: W4254164242
Cited by: 1,378
References: 8
Citations by year: 2026: 25 · 2025: 46 · 2024: 42 · 2023: 83 · 2022: 66 · 2021: 52 · 2020: 64 · 2019: 47 · 2018: 75 · 2017: 63 · 2016: 75 · 2015: 86 · 2014: 76 · 2013: 88 · 2012: 87
FWCI: 10.44
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3499 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 23226, CA 074131, R01CA074131)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: liver regeneration, partial hepatectomy, compensatory hyperplasia, hepatocyte proliferation, cytokines, growth factors, innate immunity, hepatocyte cell cycle, liver repopulation, acute liver failure, progenitor cells, chronic liver disease
MeSH terms: Animals, Cell Cycle, Growth Substances, Hepatectomy, Humans, Immunity, Innate, Liver, Liver Regeneration, Signal Transduction, Cytokines

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Liver regeneration

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