The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nuclear Receptors in Liver Disease Δ
Open accessAbstract
Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver regeneration, inflammation, fibrosis, cell differentiation, and tumor formation. Derangements of nuclear receptor regulation and genetic variants may contribute to the pathogenesis and progression of liver diseases. This places nuclear receptors into the frontline for novel therapeutic approaches for a broad range of hepatic disorders and diseases including cholestatic and fatty liver disease, drug hepatotoxicity, viral hepatitis, liver fibrosis, and cancer. (Hepatology 2011;.)
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“The retinoid X receptor (RXR) usually forms heterodimers with several other NRs (e.g., FXR, PPAR, LXR) and thereby has broad implications for fibrogenesis.[169]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [169]
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Cites
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,165
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Principles for modulation of the nuclear receptor superfamily
Gronemeyer, H., Gustafsson, J.-Å., & Laudet, V. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1551 · Cited by 1,285
Nuclear Receptor Coregulators and Human Disease
Lonard, D. M., Lanz, R. B., & O’Malley, B. W. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0012 · Cited by 318
Nuclear receptors: Decoding metabolic disease
Sonoda, J., Pei, L., & Evans, R. M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.016 · Cited by 313
Nuclear receptor regulation of hepatic function
Karpen, S. J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00129-0 · Cited by 173
Arrese, M., & Karpen, S. J. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.2 · Cited by 54
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Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392
Triggering and resolution of inflammation in NASH
Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Bile acid transporters and regulatory nuclear receptors in the liver and beyond
Halilbasic, E., Claudel, T., & Trauner, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 415
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Metadata
- Authors
- Wagner, M., Zollner, G., & Trauner, M.
- Affiliations
- Baylor College of Medicine (US)
- Medical University of Graz (AT)
- Medical University of Vienna (AT)
- Corresponding author
- Trauner, Michael
- Venue
- Hepatology
- Published
- 2011-03
- Volume
- 53
- Issue
- 3
- Pages
- 1023-1034
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1966064283
- Cited by
- 260
- References
- 7
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 8 · 2023: 4 · 2022: 17 · 2021: 23 · 2020: 12 · 2019: 17 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 22 · 2014: 24 · 2013: 29 · 2012: 19
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion)
- Funders
- Austrian Science Foundation and funding from the European Community's Seventh Framework Programme (P18613-B05, F3008-B05)
- FLIP (FP7/2007-2013, HEALTH-F2-2009-241762)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- nuclear receptors, liver disease, hepatic lipid metabolism, bile acid homeostasis, drug disposition, liver regeneration, liver fibrosis, liver inflammation, hepatic steatosis, cholestatic liver disease, drug-induced liver injury, viral hepatitis, liver cancer, transcriptional regulation
- MeSH terms
- Bile Acids and Salts, Cholestasis, Fatty Liver, Glucose, Hepatitis, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Humans, Cholesterol, HDL, Liver, Liver Cirrhosis, Liver Diseases, Liver Regeneration, Transcription, Genetic, Triglycerides, Receptors, Cytoplasmic and Nuclear, Lipid Metabolism, Chemical and Drug Induced Liver Injury, Non-alcoholic Fatty Liver Disease
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