The coregulator exchange in transcriptional functions of nuclear receptors
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Activation of type-2 nuclear receptor-heterodimer complexes by their natural ligands results in decoupling from co-repressors in the cell nucleus, subsequently initiating transcription.
“The activation of type-2 NR-heterodimer complexes by their natural ligands results in a decoupling from the co-repressors in the cell nucleus, subsequently initiating the transcription process.[38,42]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [42]
Upon ATRA binding, co-repressors are released and co-activators including HATs, DRIP/TRAP/ARC, or mediator-containing complexes are recruited to decompress chromatin and activate transcription of target genes.
“Upon ATRA binding, co-repressors are released and co-activators, including histone acetyltransferases (HATs), DRIP/TRAP/ARC, or mediator-containing complexes are recruited to decompress chromatin and activate transcription of target genes”
From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Glass and Rosenfeld, 2000
Unliganded RARs form a complex with co-repressors such as N-CoR or SMRT and histone deacetylases (HDACs) to actively inhibit gene expression.
“when not bound by ligand, they form a complex with co-repressors such as N-CoR (negative co-regulator) or SMRT (silencing mediator for retinoid and thyroid hormone receptors), and histone deacetylases (HDACs) to actively inhibit gene expression”
From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Glass and Rosenfeld, 2000
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Königshofer, P., Brusilovskaya, K., Petrenko, O., Hofer, B. S., Schwabl, P., Trauner, M., & Reiberger, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166235 · Cited by 45 · see citing works
DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia
Glasow, A., Barrett, A., Petrie, K., Gupta, R., Boix-Chornet, M., Zhou, D.-C., Grimwade, D., Gallagher, R., von Lindern, M., Waxman, S., et al. (2008) · Blood · doi:10.1182/blood-2007-05-088344 · Cited by 44 · see citing works
Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells
Racanicchi, S., Maccherani, C., Liberatore, C., Billi, M., Gelmetti, V., Panigada, M., Rizzo, G., Nervi, C., & Grignani, F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600593 · Cited by 36 · see citing works
McKenna, N. J. (2012) · Nuclear Receptor Signaling · doi:10.1621/nrs.10003 · Cited by 33 · see citing works
Kambhampati, S., Verma, A., Li, Y., Parmar, S., Sassano, A., & Platanias, L. (2004) · Leukemia & Lymphoma · doi:10.1080/10428190410001722053 · Cited by 29 · see citing works
The helix 1–3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones
Cluning, C., Ward, B. K., Rea, S. L., Arulpragasam, A., Fuller, P. J., & Ratajczak, T. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1023 · Cited by 26 · see citing works
Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
Varlakhanova, N., Hahm, J. B., & Privalsky, M. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.10.010 · Cited by 24 · see citing works
Ferry, C., Gianni, M., Lalevée, S., Bruck, N., Plassat, J.-L., Raska, I., Garattini, E., & Rochette-Egly, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808815200 · Cited by 24 · see citing works
- Authors
- Glass, C. K., & Rosenfeld, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-01-15
- Volume
- 14
- Issue
- 2
- Pages
- 121-141
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2156575042
- Cited by
- 2,233
- References
- 241
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 26 · 2023: 29 · 2022: 36 · 2021: 40 · 2020: 34 · 2019: 40 · 2018: 38 · 2017: 39 · 2016: 44 · 2015: 59 · 2014: 71 · 2013: 72 · 2012: 85
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- nuclear receptors, coregulators, transcriptional regulation, transcriptional coactivator
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Transcription, Genetic, Receptors, Cytoplasmic and Nuclear
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