Cited by 2,233Estrogen and related hormone effectsNuclear Receptors and SignalingGenomics and Chromatin Dynamics

The coregulator exchange in transcriptional functions of nuclear receptors

Open access
Glass, Christopher K., Rosenfeld, Michael G.·2000·Genes & Development

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gad.14.2.121

Cites

241 of 241 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Activation of type-2 nuclear receptor-heterodimer complexes by their natural ligands results in decoupling from co-repressors in the cell nucleus, subsequently initiating transcription.

    “The activation of type-2 NR-heterodimer complexes by their natural ligands results in a decoupling from the co-repressors in the cell nucleus, subsequently initiating the transcription process.[38,42]”

    From Nuclear receptors in liver fibrosis (2021) · cites this paper as [42]

  • Upon ATRA binding, co-repressors are released and co-activators including HATs, DRIP/TRAP/ARC, or mediator-containing complexes are recruited to decompress chromatin and activate transcription of target genes.

    “Upon ATRA binding, co-repressors are released and co-activators, including histone acetyltransferases (HATs), DRIP/TRAP/ARC, or mediator-containing complexes are recruited to decompress chromatin and activate transcription of target genes”

    From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Glass and Rosenfeld, 2000

  • Unliganded RARs form a complex with co-repressors such as N-CoR or SMRT and histone deacetylases (HDACs) to actively inhibit gene expression.

    “when not bound by ligand, they form a complex with co-repressors such as N-CoR (negative co-regulator) or SMRT (silencing mediator for retinoid and thyroid hormone receptors), and histone deacetylases (HDACs) to actively inhibit gene expression”

    From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Glass and Rosenfeld, 2000

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Glass, C. K., & Rosenfeld, M. G.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Genes & Development
Published
2000-01-15
Volume
14
Issue
2
Pages
121-141
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2156575042
Cited by
2,233
References
241
Citations by year
2026: 19 · 2025: 30 · 2024: 26 · 2023: 29 · 2022: 36 · 2021: 40 · 2020: 34 · 2019: 40 · 2018: 38 · 2017: 39 · 2016: 44 · 2015: 59 · 2014: 71 · 2013: 72 · 2012: 85
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
nuclear receptors, coregulators, transcriptional regulation, transcriptional coactivator
MeSH terms
Animals, Gene Expression Regulation, Humans, Transcription, Genetic, Receptors, Cytoplasmic and Nuclear

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review