The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
Abstract
In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain largely unknown. Differentially expressed lncRNAs between HBV-related HCC and paired peritumoral tissues were identified by microarray and validated using quantitative real-time polymerase chain reaction. Liver samples from patients with HBV-related HCC were analyzed for levels of a specific differentially expressed lncRNA High Expression In HCC (termed lncRNA-HEIH); data were compared with survival data using the Kaplan-Meier method and compared between groups by the log-rank test. The effects of lncRNA-HEIH were assessed by silencing and overexpressing the lncRNA in vitro and in vivo . The expression level of lncRNA-HEIH in HBV-related HCC is significantly associated with recurrence and is an independent prognostic factor for survival. We also found that lncRNA-HEIH plays a key role in G 0 /G 1 arrest, and further demonstrated that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Conclusions: Together, these results indicate that lncRNA-HEIH is an oncogenic lncRNA that promotes tumor progression and leads us to propose that lncRNAs may serve as key regulatory hubs in HCC progression. (Hepatology 2011
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Cited by
Mechanisms of HBV-induced hepatocellular carcinoma
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Metadata
- Authors
- Yang, F., Zhang, L., Huo, X.-S., Yuan, J.-H., Xu, D., Yuan, S.-X., Zhu, N., Zhou, W.-P., Yang, G.-S., Wang, Y.-Z., Shang, J.-L., Gao, C.-F., Zhang, F.-R., Wang, F., & Sun, S.-H.
- Venue
- Hepatology
- Published
- 2011-11
- Volume
- 54
- Issue
- 5
- Pages
- 1679-1689
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2024303499
- Cited by
- 632
- References
- 32
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, F., Zhang, L., Huo, X.-S., Yuan, J.-H., Xu, D., Yuan, S.-X., Zhu, N., Zhou, W.-P., Yang, G.-S., Wang, Y.-Z., Shang, J.-L., Gao, C.-F., Zhang, F.-R., Wang, F., & Sun, S.-H. (2011). Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. https://doi.org/10.1002/hep.24563
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