The widespread regulation of microRNA biogenesis, function and decay

MicroRNAs: Target Recognition and Regulatory Functions

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Untitled work

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Origins and Mechanisms of miRNAs and siRNAs

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Regulation of mRNA Translation and Stability by microRNAs

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Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

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c-Myc-regulated microRNAs modulate E2F1 expression

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Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

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The Microprocessor complex mediates the genesis of microRNAs

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A microRNA component of the p53 tumour suppressor network

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Many roads to maturity: microRNA biogenesis pathways and their regulation

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Origin, Biogenesis, and Activity of Plant MicroRNAs

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

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Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

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A brain-specific microRNA regulates dendritic spine development

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

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Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA

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Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

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Selective Blockade of MicroRNA Processing by Lin28

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Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

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MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

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Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

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miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

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P bodies and the control of mRNA translation and degradation

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Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

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The let-7 family of microRNAs

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Widespread microRNA repression by Myc contributes to tumorigenesis

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SMAD proteins control DROSHA-mediated microRNA maturation

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

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Modulation of microRNA processing by p53

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A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,026 · see citing works

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

Gibbings, D., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 990 · see citing works

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

Heo, I., Joo, C., Cho, J., Ha, M., Han, J., & Kim, V. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.014 · Cited by 947 · see citing works

P bodies: at the crossroads of post-transcriptional pathways

Eulálio, A., Behm‐Ansmant, I., & Izaurralde, E. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2080 · Cited by 939 · see citing works

Cell Signalling by MicroRNA165/6 Directs Gene Dose-Dependent Root Cell Fate

Carlsbecker, A., Lee, J.-Y., Roberts, C. J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M. A., Vatén, A., Thitamadee, S., et al. (2010) · Nature · doi:10.1038/nature08977 · Cited by 861 · see citing works

A Human snoRNA with MicroRNA-Like Functions

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A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

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Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works

Lin28 promotes transformation and is associated with advanced human malignancies

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Methylation Protects miRNAs and siRNAs from a 3′-End Uridylation Activity in Arabidopsis

Li, J., Yang, Z., Yu, B., Liu, J., & Chen, X. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.029 · Cited by 809 · see citing works

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 788 · see citing works

Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs

Kawahara, Y., Zinshteyn, B., Sethupathy, P., Iizasa, H., Hatzigeorgiou, A. G., & Nishikura, K. (2007) · Science · doi:10.1126/science.1138050 · Cited by 785 · see citing works

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

Heo, I., Joo, C., Kim, Y.-K., Ha, M., Yoon, M.-J., Cho, J., Yeom, K.-H., Han, J., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.08.002 · Cited by 748 · see citing works

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

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RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA

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Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

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P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

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MicroRNA-directed transcriptional gene silencing in mammalian cells

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A Hexanucleotide Element Directs MicroRNA Nuclear Import

Hwang, H., Wentzel, E. A., & Mendell, J. T. (2007) · Science · doi:10.1126/science.1136235 · Cited by 698 · see citing works

Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression

Diederichs, S., & Haber, D. A. (2007) · Cell · doi:10.1016/j.cell.2007.10.032 · Cited by 687 · see citing works

microRNA‐122 stimulates translation of hepatitis C virus RNA

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Chromatin structure analyses identify miRNA promotersPreprint

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AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2

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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

Trabucchi, M., Briata, P., García‐Mayoral, M. F., Haase, A. D. D., Filipowicz, W., Ramos, A., Gherzi, R., & Rosenfeld, M. G. (2009) · Nature · doi:10.1038/nature08025 · Cited by 652 · see citing works

Reciprocal actions of REST and a microRNA promote neuronal identity

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DNA Methylation Mediated by a MicroRNA Pathway

Wu, L., Zhou, H., Zhang, Q., Zhang, J., Ni, F., Liu, C., & Qi, Y. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.008 · Cited by 638 · see citing works

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

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Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Frank, F., Sonenberg, N., & Nagar, B. (2010) · Nature · doi:10.1038/nature09039 · Cited by 625 · see citing works

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

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Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

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A search for conserved sequences in coding regions reveals that the <i>let-7</i> microRNA targets Dicer within its coding sequence

Forman, J. J., Legesse-Miller, A., & Coller, H. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803230105 · Cited by 581 · see citing works

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

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HuR recruits let-7/RISC to repress c-Myc expressionPreprint

Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 544 · see citing works

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., & Patel, D. J. (2009) · Nature · doi:10.1038/nature08434 · Cited by 542 · see citing works

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

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Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

Iwasaki, S., Kobayashi, M., Yoda, M., Sakaguchi, Y., Katsuma, S., Suzuki, T., & Tomari, Y. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.015 · Cited by 507 · see citing works

Transcriptional Control of Gene Expression by MicroRNAs

Khraiwesh, B., Arif, M. A., Seumel, G. I., Ossowski, S., Weigel, D., Reski, R., & Frank, W. (2010) · Cell · doi:10.1016/j.cell.2009.12.023 · Cited by 494 · see citing works

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

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An mRNA m7G Cap Binding-like Motif within Human Ago2 Represses Translation

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Posttranscriptional Crossregulation between Drosha and DGCR8

Han, J., Pedersen, J. S., Kwon, S. C., Belair, C. D., Kim, Y. K., Yeom, K., Yang, W., Haussler, D. H., Blelloch, R. H., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2008.10.053 · Cited by 459 · see citing works

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

Hagan, J. P., Piskounova, E., & Gregory, R. I. (2009) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1676 · Cited by 454 · see citing works

Synaptic Protein Synthesis Associated with Memory Is Regulated by the RISC Pathway in Drosophila

Ashraf, S. I., McLoon, A. L., Sclarsic, S. M., & Kunes, S. M. (2006) · Cell · doi:10.1016/j.cell.2005.12.017 · Cited by 446 · see citing works

Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2Preprint

Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T., & Suzuki, T. (2009) · Genes & Development · doi:10.1101/gad.1761509 · Cited by 438 · see citing works

MicroRNA Function Is Globally Suppressed in Mouse Oocytes and Early Embryos

Suh, N., Baehner, L., Moltzahn, F., Melton, C. A., Shenoy, A., Chen, J., & Blelloch, R. H. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.044 · Cited by 435 · see citing works

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

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Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis

Ramachandran, V., & Chen, X. (2008) · Science · doi:10.1126/science.1163728 · Cited by 423 · see citing works

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1405 · Cited by 414 · see citing works

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

Schwamborn, J. C., Berezikov, E., & Knoblich, J. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.024 · Cited by 408 · see citing works

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

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Lin28: A MicroRNA Regulator with a Macro Role

Viswanathan, S. R., & Daley, G. Q. (2010) · Cell · doi:10.1016/j.cell.2010.02.007 · Cited by 406 · see citing works

MicroRNA Binding Sites in Arabidopsis Class III HD-ZIP mRNAs Are Required for Methylation of the Template Chromosome

Bao, N., Lye, K.-W., & Barton, M. K. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.003 · Cited by 401 · see citing works

The Control of mRNA Decapping and P-Body Formation

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RNA editing of the microRNA‐151 precursor blocks cleavage by the Dicer–TRBP complex

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Integration of microRNA miR-122 in hepatic circadian gene expressionPreprint

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Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana

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Cellular MicroRNA and P Bodies Modulate Host-HIV-1 Interactions

Nathans, R. S., Chu, C., Serquiña, A., Lu, C., Cao, H., & Rana, T. M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.003 · Cited by 373 · see citing works

RISC Assembly Defects in the Drosophila RNAi Mutant armitage

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Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

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Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

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