Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

Kong, Bo, Wang, Li, Chiang, John Y.L., Zhang, Youcai, Klaassen, Curtis D., Guo, Grace L.·2012·Hepatology

DOI 10.1002/hep.25740

Cited by (457)

Items 201–300 of 457

Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE−/− mice
Tian Lan, Jamie Haywood, Paul A. Dawson · 2013 · Atherosclerosis
Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling
Tian Shuxia, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen · 2020 · Annals of Hepatology
The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease
Stefano Fiorucci, Michele Biagioli, Monia Baldoni, Patrizia Ricci, Valentina Sepe, Angela Zampella, Eleonora Distrutti · 2021 · Expert Opinion on Drug Discovery
Modulation of gut microbiota and intestinal immune response in gilthead seabream (Sparus aurata) by dietary bile salt supplementation
Alberto Ruiz, Karl Blyth Andree, Dolors Furones, Paul George Holhorea, Josep À. Calduch-Giner, Marc Viñas, Jaume Pérez‐Sánchez, Enric Gisbert · 2023 · Frontiers in Microbiology
Perfluorooctanoic acid (PFOA) and its alternative perfluorobutanoic acid (PFBA) alter hepatic bile acid profiles via different pathways
Xiaoyuan Wang, Yinchuan Lv, Xin Qiang, Shumin Liang, Ruosi Li, Jing Zhan, Jiaying Liu · 2024 · The Science of The Total Environment
GLP-1 receptor agonists and gallbladder disease risk: insights into molecular mechanisms and clinical implications
Mariana Michelle Ramírez-Mejía, Guadalupe Ponciano‐Rodríguez, Mohammed Eslam, Nahúm Méndez-Sánchez · 2025 · Therapeutic Advances in Endocrinology and Metabolism
Dysregulation of bile acid homeostasis in parenteral nutrition mouse model
Le Zhan, Ill Yang, Bo Kong, Jianliang Shen, Ludwik Gorczyca, Naureen Memon, Brian Buckley, Grace Liejun Guo · 2015 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in C57BL6/mice through AMPK–FXR–TGR5 cross‐talk
Zhenya Zhai, Kai‐Min Niu, Huiping Liu, Chong Lin, Yue Tu, Yi‐Chun Liu, Lichuang Cai, Ouyang Kexian, Jianping Liu · 2021 · Journal of Food Science
Diammonium Glycyrrhizinate Ameliorates Obesity Through Modulation of Gut Microbiota-Conjugated BAs-FXR Signaling
Yun Li, Huiqin Hou, Xianglu Wang, Xin Dai, Wanru Zhang, Qiang Tang, Yue Dong, Chen Yan, Bangmao Wang, Zhengxiang Li et al. · 2021 · Frontiers in Pharmacology
Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064
Jamie E. Moscovitz, Bo Kong, Kyle Buckley, Brian Buckley, Grace Liejun Guo, Lauren M. Aleksunes · 2016 · Toxicology and Applied Pharmacology
Exploring Advanced Therapies for Primary Biliary Cholangitis: Insights from the Gut Microbiota–Bile Acid–Immunity Network
Ziqi Guo, Kun He, Ke Pang, Daiyu Yang, Chengzhen Lyu, Haifeng Xu, Dong Wu · 2024 · International Journal of Molecular Sciences
Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet
Yanliu Lu, Yimei Du, Lin Qin, Di Wu, Wei Wang, Lei Ling, Feifei Ma, Hua Ling, Li Yang, Changhong Wang et al. · 2018 · Evidence-based Complementary and Alternative Medicine
Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease
Tim van Zutphen, Anna Bertolini, Hilde D. de Vries, Vincent W. Bloks, Jan Freark de Boer, Johan W. Jonker, Folkert Kuipers · 2019 · Handbook of experimental pharmacology
ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis
Lihua Hao, In Hyuk Bang, Jie Wang, Yuancheng Mao, Jae Do Yang, Soon‐Young Na, Jeong Kon Seo, Hueng‐Sik Choi, Eun Ju Bae, Byung‐Hyun Park · 2020 · JCI Insight
Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity
Yanan Chen, Jingkai Zhou, Shansen Xu, Mei Liu, Minglu Wang, Yiyi Ma, Mingming Zhao, Zhan‐You Wang, Yingjie Guo, Limei Zhao · 2019 · Biochemical Pharmacology
Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease
Michael A Trauner, Saul J. Karpen, Paul A. Dawson · 2025 · Hepatology
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease
Justine Gillard, Isabelle Anne Leclercq · 2023 · Clinical Science
Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice
Mei Li, Ding Cheng, Chuan Peng, Yujiao Huang, Jie Geng, Guangrui Huang, Ting Wang, Anlong Xu · 2023 · Chinese Medicine
FXR Deletion in Hepatocytes does not Affect the Severity of Alcoholic Liver Disease in Mice
Min Zhang, B. Kong, Ming-Xing Huang, Rui-Xuan Wan, Laura E. Armstrong, Justin D. Schumacher, D. Rizzolo, Monica D. Chow, Yi-Horng Lee, Grace L. Guo · 2018 · Digestive and Liver Disease
Activation of Constitutive Androstane Receptor (CAR) in mice results in maintained biliary excretion of bile acids despite a marked decrease of bile acids in liver
Lickteig, Andrew J., Csanaky, Iván L., Pratt-Hyatt, Matthew, Klaassen, Curtis D. · 2016 · Toxicological Sciences
Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice
Minghua Yang, Haoyang Wang, Ihtisham Bukhari, Zhao Ye, Huang Huang, Yong Yu, Xiangdong Sun, Yang Mi, Mei Lü, Pengyuan Zheng · 2023 · Frontiers in Nutrition
Bile salt dietary supplementation promotes growth and reduces body adiposity in gilthead seabream (Sparus aurata)
Alberto Ruiz, Karl Blyth Andree, Ignasi Sanahuja, Paul George Holhorea, Josep À. Calduch-Giner, Sofía Morais, José J. Pastor, Jaume Pérez‐Sánchez, Enric Gisbert · 2022 · Aquaculture
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr −/− mice
Jiesi Xu, Yang Xu, Yanyong Xu, Liya Yin, Yanqiao Zhang · 2017 · Scientific Reports
Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation
Zouyan He, Lin Lei, Erika Kwek, Yimin Zhao, Jianhui Liu, Wangjun Hao, Hanyue Zhu, Ning Nan Liang, Ka Ying Ma, Hing‐Man Ho et al. · 2018 · Journal of Functional Foods
Metabolomic and transcriptomic profiling of hepatocellular carcinomas in Hras12V transgenic mice
Tingting Fan, Zhuona Rong, Jianyi Dong, Juan Li, Kangwei Wang, Xinxin Wang, Huiling Li, Jun Chen, Fujin Wang, Jingyu Wang et al. · 2017 · Cancer Medicine
Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets
Syeda Maliha, Grace Liejun Guo · 2021 · Liver Research
Enterobacter aerogenes ZDY01 inhibits choline-induced atherosclerosis through CDCA-FXR-FGF15 axis
Jinghui Tang, Manman Qin, Le Min Tang, Dan Shan, Cheng Zhang, Yifeng Zhang, Hua Wei, Liang Qiu, Jun Yu · 2021 · Food & Function
Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction
Meng Yan, Li Hou, Yaoyao Cai, Hanfei Wang, Yujun Ma, Qiming Geng, Weiwei Jiang, Weibing Tang · 2022 · Frontiers in Pharmacology
The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice
Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian, Yuanxiang Jin · 2022 · Chemosphere
Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT- and BDL-induced cholestasis
YueHua Zhou, YunZhong Zhou, Yifei Li, Wei Sun, Zhaolong Wang, Long Chen, Ye He, XiaoLong Niu, Jialiang Chen, Guangtao Yao · 2022 · Frontiers in Pharmacology
Developmental regulation of the gut–liver (FGF19-CYP7A1) axis in neonates
Naureen Memon, Ian J. Griffin, Chris W. Lee, Aimee R. Herdt, Barry I. Weinberger, Thomas Hegyi, Mary O. Carayannopoulos, Lauren M. Aleksunes, Grace Liejun Guo · 2018 · The Journal of Maternal-Fetal & Neonatal Medicine
Bile acid malabsorption is associated with diarrhea in acute phase of colitis
Ruigang Hou, Lei Fan, Junjin Liu, Yao Cheng, Zhuang‐peng Chang, Bei Wu, Yun‐yun Shao · 2018 · Canadian Journal of Physiology and Pharmacology
Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis
Yu Wang, Jing Yu, Binqin Chen, Wenqi Jin, Meili Wang, Xuenan Chen, Mengqiong Jian, Liwei Sun, Chunli Piao · 2024 · Frontiers in Endocrinology
Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis
Chang Hun Lee, Yun‐Jung Choi, Hyewon Cho, In Hyuk Bang, Lihua Hao, Seungok Lee, Raok Jeon, Eun Ju Bae, Byung‐Hyun Park · 2020 · Biochemical Pharmacology
Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner
Dan Huang, Shuang Shen, Qian Zhuang, Xin Ye, Yueqin Qian, Zhixia Dong, Xinjian Wan · 2024 · Chinese Medicine
Characterization of the Mitochondrial Localization of the Nuclear Receptor SHP and Regulation of Its Subcellular Distribution by Interaction with Bcl2 and HNF4α
Yuxia Zhang, Li Wang · 2013 · PLoS ONE
Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification
Hyun Ju, Youn Sue Lee, Min Jin Ha, Yoonsu Cho, Hana Yi, Yu-Jin Hwang, Geum‐Sook Hwang, Min‐Jeong Shin · 2016 · Endocrine Journal
Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway
Lili Ding, Binfeng Zhang, Jinmei Li, Li Yang, Zhengtao Wang · 2017 · Molecular Medicine Reports
Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats
Hanxiang Sun, Xiujuan Su, Yang Liu, Guohua Li, Qiaoling Du · 2023 · iScience
Disentangling the nutrition-microbiota liaison in inflammatory bowel disease
Marilina Florio, Lucilla Crudele, Fabio Sallustio, Antonio Moschetta, Marica Cariello, Raffaella Maria Gadaleta · 2025 · Molecular Aspects of Medicine
Bile acid signaling in MASLD: From pathogenesis to therapeutic applications
Benedikt Simbrunner, Rafael Paternostro, Thomas Reiberger, Michael Trauner · 2025 · Hepatology
Bile Acids—A Peek Into Their History and Signaling
James ThienToan Nguyen, Ryan Philip Henry Shaw, Sayeepriyadarshini Anakk · 2022 · Endocrinology
The regulatory role of bile acid microbiota in the progression of liver cirrhosis
Feng Zhu, Shudan Zheng, Mei Zhao, Fan Shi, Lihong Zheng, Haiqiang Wang · 2023 · Frontiers in Pharmacology
Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han et al. · 2023 · Journal of Ethnopharmacology
Regulation of bile acid homeostasis by the intestinal Diet1–FGF15/19 axis
Karen Reue, Jessica M. Lee, Laurent Vergnes · 2014 · Current Opinion in Lipidology
The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism
Marica Cariello, Marilidia Piglionica, Raffaella Maria Gadaleta, Antonio Moschetta · 2019 · Handbook of experimental pharmacology
Probiotic Lactobacillus rhamnosus GG prevents progesterone metabolite epiallaopregnanolone sulfate-induced hepatic bile acid accumulation and liver injury
Li Ren, Qing Song, Yunhuan Liu, Lihua Zhang, Zhiming Hao, Wenke Feng · 2019 · Biochemical and Biophysical Research Communications
A Novel Sialoglycopeptide from Gadus morhua Eggs Prevents Liver Fibrosis Induced by CCl 4 via Downregulating FXR/FGF15 and TLR4/TGF-β/Smad Pathways
Hao Yue, Weizhen Cai, Yanqi Li, Xiaoxuan Feng, Ping Dong, Changhu Xue, Jingfeng Wang · 2021 · Journal of Agricultural and Food Chemistry
Hyodeoxycholic acid attenuates cholesterol gallstone formation via modulation of bile acid metabolism and gut microbiota
Shuang Shen, Dan Huang, Shengnan Qian, Xin Ye, Qian Zhuang, Xinjian Wan, Zhixia Dong · 2023 · European Journal of Pharmacology
Fucogalactan Sulfate (FS) from Laminaria japonica Regulates Lipid Metabolism in Diet-Induced Humanized Dyslipidemia Mice via an Intestinal FXR-FGF19-CYP7A1/CYP8B1 Pathway
Jiangping Song, Xingyu Lu, Denghong Liu, Yuwei Zhang, Xiaoning Zhai, Liuyang Zhou, Jie Gao · 2023 · Journal of Agricultural and Food Chemistry
Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice
Rachel M. Golonka, Beng San Yeoh, Piu Saha, Yuan Tian, John Y.L. Chiang, Andrew D. Patterson, Andrew T. Gewirtz, Bina Joe, Matam Vijay–Kumar · 2024 · Cellular and Molecular Gastroenterology and Hepatology
Effects of maternal T-2 toxin exposure on the hepatic glycolipid metabolism in young mice
Ruifen Kang, Aneela Perveen, Chunmei Li · 2020 · Ecotoxicology and Environmental Safety
Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma
Haider M. Hassan, Majdina Isovic, Bart Kolendowski, Natasha Bauer-Maison, Oladapo Onabote, Matthew J. Cecchini, Aaron R. Haig, Saman Maleki Vareki, T. Michael Underhill, Joseph Torchia · 2020 · Cell Reports
Upregulation of hepatic bile acid synthesis via fibroblast growth factor 19 is defective in gallstone disease but functional in overweight individuals
Olga Renner, Simone Harsch, Silke Matysik, Dieter Lütjohann, Gerd Schmitz, Eduard Friedrich Stange · 2014 · United European Gastroenterology Journal
Pectin Penta‐Oligogalacturonide Suppresses Intestinal Bile Acids Absorption and Downregulates the FXR‐FGF15 Axis in High‐Cholesterol Fed Mice
Rugang Zhu, Yuting Hou, Yandi Sun, Tuoping Li, Jungang Fan, Gang Chen, Junxiu Wei · 2017 · Lipids
Involvement of Bile Acid Metabolism and Gut Microbiota in the Amelioration of Experimental Metabolism-Associated Fatty Liver Disease by Nobiletin
Hongling Xu, Mingming Yuan, Kailin Niu, Wei Jennifer Yang, Maoyuan Jiang, Lei Zhang, Jing Zhou · 2024 · Molecules
Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity
Peixia Li, Rui Zhang, Jinping Zhou, Pengpeng Guo, Yani Liu, Shaojun Shi · 2024 · Gut Microbes
Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis
Elena Bellafante, Saraid McIlvride, Vanya Nikolova, Hei Man Fan, Luiza Borges Manna, Jenny Chambers, Mavis Machirori, Anita Banerjee, Kevin G. Murphy, Marcus Martineau et al. · 2020 · Scientific Reports
Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow
Marinella Marzano, Bruno Fosso, Carolina Colliva, Elisabetta Notario, Daniela Passeri, Marianna Intranuovo, Antimo Gioiello, Luciano Adorini, Graziano Pesole, Roberto Pellicciari et al. · 2022 · Biomedicine & Pharmacotherapy
Salidroside ameliorates liver metabonomics in relation to modified gut-liver FXR signaling in furan-induced mice
Yuan Yuan, Xuan Wu, Yilin Hong, Xu Zhang, Ziyue Wang, Haiyang Yan · 2020 · Food and Chemical Toxicology
The crosstalk between cell death and pregnancy related diseases: A narrative review
Xiaowen Xie, Jiayu Liu, Jingyi Gao, Chenwei Shang, Ying Jiang, Lingyan Chen, Zhiwen Qian, Lu Liu, Danping Wu, Yun Zhang et al. · 2024 · Biomedicine & Pharmacotherapy
Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity
Zijing Zhang, Zuo Du, Qinhui Liu, Tong Wu, Qin Tang, Jinhang Zhang, Cuiyuan Huang, Ya Huang, Rui Li, Yanping Li et al. · 2021 · Metabolism
In vivo mouse models to study bile acid synthesis and signaling
Anisha Bhattacharya, Rulaiha E. Taylor, Grace Liejun Guo · 2023 · Hepatobiliary & pancreatic diseases international
Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway
Ji Wang, Meng-yu Zhong, Yunxia Liu, Jia-Yu Yu, Yibin Wang, Xuejiao Zhang, Haipeng Sun · 2024 · Acta Pharmacologica Sinica
Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols
Charlotte Lefort, Matthias Van Hul, Nathalie M. Delzenne, Amandine Everard, Patrice D. Cani · 2019 · American Journal of Physiology-Endocrinology and Metabolism
Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice
Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J. C. Bijvelds · 2019 · Cellular and Molecular Gastroenterology and Hepatology
Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus
Yi Xin Sun, Minxia Zhu, Hui Zhao, Xiaoqing Ni, Renan Chang, Jianyou Su, Hua Huang, Shiwei Cui, Xinlei Wang, Jin Yuan et al. · 2020 · BioMed Research International
The glucose-lowering effects of α-glucosidase inhibitor require a bile acid signal in mice
Yixuan Qiu, Linyan Shen, Lihong Fu, Jie Yang, Canqi Cui, Tingting Li, Xuelin Li, Chenyang Fu, Xianfu Gao, Weiqing Wang et al. · 2020 · Diabetologia
Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease
Ravi Vats, Silvia Liu, Junjie Zhu, Dhanunjay Mukhi, Egemen Tütüncüoğlu, Nayra Cárdenes, Sucha Singh, Tomasz Brzóska, Karis Kosar, Mikhil N. Bamne et al. · 2020 · Hepatology
CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia
Yasuhiro Hasegawa, Masanobu Kawai, Kazuhiko Bessho, Kie Yasuda, Takehisa Ueno, Yoshinori Satomura, Akiko Konishi, Takeshi Kimura, Kayo Ikeda, Makiko Tachibana et al. · 2018 · Hepatology Research
Signal Transduction and Molecular Regulation in Fatty Liver Disease
Xiaocheng Charlie Dong, Kushan Chowdhury, Menghao Huang, Hyeong-Geug Kim · 2021 · Antioxidants and Redox Signaling
Gut microbiome responses in the metabolism of human dietary components: Implications in health and homeostasis
Riya Rajeev, P. S. Seethalakshmi, Prasant Kumar Jena, Ragothaman Prathiviraj, George Seghal Kiran, Joseph Selvin · 2021 · Critical Reviews in Food Science and Nutrition
Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid
András Gregor, Marc Pignitter, Slave Trajanoski, Sandra Auernigg‐Haselmaier, Veronika Somoza, Jürgen S. König, Kalina Duszka · 2021 · Gut Microbes
Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3‐mediated hepatocyte nuclear receptor 4α/cholesterol 7α‐hydroxylase pathway in mice
Shuai Yan, Juan Tang, Yuyao Zhang, Yuanyang Wang, Shengkai Zuo, Yujun Shen, Qianqian Zhang, Di Chen, Yu Yu, Kai Wang et al. · 2016 · Hepatology
Microbial bile acid modifications: current understandings, key problems, and future perspectives
Haobo Zhang, Jiejie Wen, Xiang Liu, Yu‐Qi Feng, Xin Liu, Kang Ning · 2025 · Science China Life Sciences
Intermittent Fasting Alleviates Non‐Alcoholic Steatohepatitis by Regulating Bile Acid Metabolism and Promoting Fecal Bile Acid Excretion in High‐Fat and High‐Cholesterol Diet Fed Mice
Xiaozhuan Lin, Xuan Zhu, Yan Xin, Peiwen Zhang, Yunjun Xiao, Taiping He, Honghui Guo · 2023 · Molecular Nutrition & Food Research
Endocrine Adiponectin‐FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury
Min You, Zhou Zhou, Michael J. Daniels, Alvin P. Jogasuria · 2017 · Gene Expression
Porcine bile acids improve performance by altering hepatic lipid metabolism and amino acid metabolism with different protein level diets in late laying hens
Ronghui Xing, Kefeng Fan, Zongze Fan, Longfei Wang, Yanqun Huang, Huaiyong Zhang, Wen Chen, Xuemeng Si · 2025 · Poultry Science
Pathological and therapeutic roles of bile acid metabolism and signaling in hepatocellular carcinoma: Insights from human and mouse studies
Xue Wang, Curtis D. Klaassen, Xin Chen, Youcai Zhang · 2025 · Pharmacological Reviews
Targeted microbiome metabolomics reveals flaxseed oil supplementation regulated the gut microbiota and farnesoid X receptor pathway in high-fat diet mice
Chen Yang, Zhenxia Xu, Qingde Huang, Xu Wang, Fenghong Huang, Qianchun Deng · 2023 · Food Science and Human Wellness
Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease
Clavia Ruth Wooton‐Kee · 2023 · Pharmacology & Therapeutics
Energy and macronutrient restriction regulate bile acid homeostasis
András Gregor, Valeriya Panteva, Stefan Bruckberger, Arturo Auñon-Lopez, Sara Blahova, Viktoria Blahova, Julia Tevini, Daniela D. Weber, Barbara Kofler, Marc Pignitter et al. · 2023 · The Journal of Nutritional Biochemistry
Circulating Bile Acid Profiles: A Need for Further Examination
Qi Li, Yu Tian, Yongsheng Chen · 2021 · The Journal of Clinical Endocrinology & Metabolism
Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase
Vinay Sachdev, Madalina Duta-Mare, Melanie Korbelius, Nemanja Vujić, Christina Leopold, Jan Freark de Boer, Silvia Rainer, Peter Fickert, Dagmar Kolb, Folkert Kuipers et al. · 2021 · Cells
Bile acid receptors link nutrient sensing to metabolic regulation
Jibiao Li, Tiangang Li · 2017 · Liver Research
FXR overexpression alleviates cholestasis via NLRC4 inflammasome suppression and bile acid homeostasis regulation.
Wenyu Wang, Lin Li, Xia Li, Jia-Qi Chen, Rui Wang, Qi Yang, Yi-Fan Qu, Chang-Yuan Wang, Ting Fu, Qiang Meng · 2025 · Free Radical Biology & Medicine
Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration
Kiran V.K. Koelfat, Kim M.C. van Mierlo, Toine M. Lodewick, Johanne G. Bloemen, Gregory van der Kroft, Iakovos Amygdalos, Ulf P. Neumann, Cornelis H.C. Dejong, Peter L. M. Jansen, Steven W.M. Olde Damink et al. · 2021 · Hepatology Communications
Dietary deoxycholic acid decreases fat accumulation by activating liver farnesoid X receptor in grass crap (Ctenopharyngodon idella)
Yihui Du, Guangjun Wang, Ermeng Yu, Jun Xie, Yun Long Xia, Hongyan Li, Kai Zhang, Wangbao Gong, Zhifei Li, Wenping Xie et al. · 2023 · Aquaculture
Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease
Kiran V.K. Koelfat, Frank G. Schaap, Caroline M.I.M. Hodin, Ruben G.J. Visschers, Björn I. Svavarsson, Martin Leníček, Ronit Shiri‐Sverdlov, Kaatje Lenaerts, Steven W.M. Olde Damink · 2016 · Clinical Nutrition
Armillaria luteo-virens Sacc Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
Na-Na Zhang, Jianlin Liu, Xinxin Guo, Shuying Li, Fengzhong Wang, Minjie Wang · 2021 · Nutrients
Association of FXR gene variants with cholelithiasis
Satoko Hirobe-Jahn, Simone Harsch, Olga Renner, Dominique Richter, Oliver Josef Müller, Eduard Friedrich Stange · 2014 · Clinics and Research in Hepatology and Gastroenterology
Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice
Mingxing Huang, Jessica A. R. Williams, Bo Kong, Yan Zhu, Guodong Li, Zhe Zhu, Grace Liejun Guo · 2017 · Digestive and Liver Disease
Chlorhexidine-containing chewing gum. Clinical documentation
Thomas N. Imfeld · 2006 · PubMed
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Xiao-Xin Jiang, Jing-Yi Ren, Ge-Jun Yu, Wen-Tao Wu, Mengyuan Chen, Yun Zhao, Can-Xia He · 2025 · Nutrients
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis
Li-Shan Yan, Jian-Ying Kang, Chun-Yu Gu, Xinyu Qiu, Jiajia Li, Brian Chi‐Yan Cheng, Yiwei Wang, Gan Luo, Yi Zhang · 2025 · Journal of Ethnopharmacology
Bile Acid Network and Vascular Calcification-Associated Diseases: Unraveling the Intricate Connections and Therapeutic Potential
Cui Wang, Qing Ma, Xijie Yu · 2023 · Clinical Interventions in Aging
FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels
Quan Shang, Grace Liejun Guo, Akira Honda, Monica Saumoy, Gerald Salen, Guorong Xu · 2013 · Journal of Lipid Research
Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis
Soyeon Shim, Maddeboina Krishnaiah, Madhusudana Reddy Sankham, Inha Kim, Yoseob Lee, Irin Shin, Areum Oh, Hwa Jeong Lee, Thi Ngoc Lan Vu, Jongmi Park et al. · 2022 · Journal of Medicinal Chemistry
c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice
Ayantika Ghosh, Frank Chen, Swati Banerjee, Ming Xu, Benjamin L. Shneider · 2013 · American Journal of Physiology-Gastrointestinal and Liver Physiology
FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR‐B1‐deficient mice fed a high‐fat and high‐cholesterol diet
Amar Bahadur Singh, Bin Dong, Fredric B. Kraemer, Jingwen Liu · 2020 · Physiological Reports