Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice

Baeck, Christer, Wei, Xiao, Bartneck, Matthias, Fech, Viktor, Heymann, Felix, Gassler, Nikolaus, Hittatiya, Kanishka, Eulberg, Dirk +3 more·2014·Hepatology

Cited by (271)

Items 201–271 of 271

  1. In search of the magic bullet: can liver inflammation and fibrosis be reversed with medications?
    Henning Wolfgang Zimmermann, Frank Tacke · 2015 · Expert Review of Gastroenterology & Hepatology
  2. Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis
    Mingjun Wang, Wenwu Ling, Hong Wang, Ling-Wei Meng, He Cai, Bing Peng · 2016 · World Journal of Gastroenterology
  3. Role of macrophages in liver cirrhosis: fibrogenesis and resolution
    Sherine Ahmed Elsherif, Ahmed Salah Alm · 2022 · Anatomy & Cell Biology
  4. Is There a Place for Somatostatin Analogues for the Systemic Treatment of Hepatocellular Carcinoma in the Immunotherapy Era?
    Elias Kouroumalis, Ioannis Tsomidis, Argryro Voumvouraki · 2022 · Livers
  5. Healing the scars of life-targeting redox imbalance in fibrotic disorders of the elderly.
    Anke Liepelt, Frank Tacke · 2015 · PubMed Central
  6. <i>Tet2</i> deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis
    Feng, Jiuxing, Wu, Baitong, Li, Yu, Sun, Pengli, Liu, Qian, Xiao, Qianxue, Cai, Jia-Bin, Zheng, Yimin, Chen, Haonan, Xu, Yichi et al. · 2026 · Journal of Experimental Medicine
  7. Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages
    Eline Geervliet, Sahil Arora, Dagmara S. Donohue, Carlos Antônio de Albuquerque Pinheiro, Leon W.M.M. Terstappen, Richard B. M. Schasfoort, Julieta I. Paez, Raj Kumar, Ruchi Bansal · 2025 · Acta Pharmaceutica Sinica B
  8. Functions of two distinct Kupffer cells in the liver
    Chun-Ye Zhang, Shuai Liu, Ming Yang · 2021 · Exploration of Medicine
  9. Macrophage Polarization in Skin Wound Healing: Progress in Biology and Therapeutics
    Lu Chen, Li-Ying Cheng, Tian Chen, Yu-Guang Zhang, Jianming Zhang · 2021 · Journal of Shanghai Jiaotong University (Science)
  10. Visualisation of kupffer cells in the rat liver with poly- and monoclonal antibodies against microglial-specific protein Iba-1
    Inga A. Nikitina, Valeria A. Razenkova, Olga V. Kirik, Dmitriy E. Korzhevsky · 2023 · Medical academic journal
  11. Pien Tze Huang plus entecavir improves hepatic fibrosis in Chinese patients with chronic hepatitis B
    Xin Zhang, Liwen Zhang, Longshan Ji, Suthat Liangpunsakul, Jinghao Zhang, Fei Hong, Hua Lyu, Seonghwan Hwang, Chunyan Gou, Yuyong Jiang et al. · 2025 · Phytomedicine
  12. Integrated bioinformatics analysis reveals potential mechanisms associated with intestinal flora intervention in nonalcoholic fatty liver disease
    Yingying Liu, Xinkui Liu, Wei Zhou, Jingyuan Zhang, Jiarui Wu, Siyu Guo, Shanshan Jia, Haojia Wang, Jialin Li, Yingying Tan · 2022 · Medicine
  13. Extracellular Matrix Metabolism and Fibrotic Disease
    Lara Campana, John Peter Iredale · 2014 · Current Pathobiology Reports
  14. BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH
    Yi Chen, Kang-Jie Xie, Caiyang Chen, Xi-Hui Wang, Chen-Chen Ma, Zhang-Xiang Huang, Y. Jiao, Wei-Feng Yu · 2025 · Molecular Medicine
  15. Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice
    S. Eswaran, Laura Gebert, Sarah Schraven, N. Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, S. Dreschers et al. · 2025 · Scientific Reports
  16. Pathogenesis, diagnosis and management of chronic hepatitis B related liver fibrosis
    Mehmet Ali Kösekli, Gülali Aktaş · 2025 · Minerva Gastroenterology
  17. Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response
    Cristina Baquero, Minerva Iniesta‐González, Nerea Palao, Cristina Fernández‐Infante, Mateo Cueto‐Remacha, Jaime Mancebo, Samuel de la Cámara Fuentes, María Rodrigo‐Faus, M. Pilar Valdecantos, Ángela M. Valverde et al. · 2025 · The Journal of Pathology
  18. Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis
    Joseph P. Cornish, Ian N. Moore, Donna L. Perry, Abigail Lara, Mahnaz Minai, Dominique Promeneur, Katie R. Hagen, Kimmo I. Virtaneva, Monica Paneru, Connor R. Buechler et al. · 2019 · Viruses
  19. Kupffer cells and liver
    Muhammad Jahangir Hossen, Md. Abdul Matin, Mahmudul Hasan Sikder, Md. Selim Ahmed, Moizur Rahman · 2022 · Elsevier eBooks
  20. Chronic Liver Failure and Hepatic Cirrhosis
    Lauren Tal Grinspan, Elizabeth C. Verna · 2018 · Springer eBooks
  21. Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure
    Frank Tacke, Thomas A. Wynn · 2015 · Gastroenterology
  22. Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis
    Rebecca A. Sosa, Allyson Q. Terry, Takahiro Ito, Bita V. Naini, Ying Yi Zheng, Harry C. Pickering, Jessica Nevarez‐Mejia, Ronald W. Busuttil, David W. Gjertson, Jerzy W. Kupiec‐Weglinski et al. · 2023 · Transplantation Direct
  23. Hepatic Fibrosis and its Regression: The Pursuit of Treatment
    Subhrajit Biswas · 2016 · Journal of Liver Research Disorders & Therapy
  24. Astragaloside IV Alleviates Acute Liver Failure Induced by D-GalN/LPS by Upregulating Autophagy and Reducing Inflammation
    Meng Hong, Wenwen Lian, Ying Yang, Zhi Chen · 2024 · Infectious Microbes & Diseases
  25. Hepatic Stellate Cells as Target for Reversal of Fibrosis/Cirrhosis
    Sophie Lotersztajn, Ariane Mallat · 2015 · Elsevier eBooks
  26. Intrahepatic Expression of C-C Motif ligand 5 in Patients with Chronic Hepatitis B
    Xiang‐An Zhao, Jian Wang, Haiyan Chang, Yong Liu, Yuxin Chen, Guangmei Chen, Rui Huang, Chao Wu · 2020 · The Turkish Journal of Gastroenterology
  27. Glucagon-Like Peptide-1 Receptor Agonist Use and Liver-Related Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes in the All of Us Research Program
    Erik Almazan, Jonggi Choi, Tushar Kamath, Vy H. Nguyen, Eric M. Przybyszewski, Jiunn Song, Allison Carroll, Megan Michta, Tracey G. Simon, Raymond T. Chung · 2026 · The American Journal of Gastroenterology
  28. Pathogenetic substantiation of approaches to the treatment of non-alcoholic fatty liver disease.
    Pavel Bogomolov, М. В. Мациевич, Kseniya Yu. Kokina, Alexander Yur'evich Mayorov, Ekaterina Е. Mishina · 2018 · Clinical Medicine (Russian Journal)
  29. Trem-2 modulation of gut microbiota is blunted during hepatotoxic injury and uncoupled from liver repair responses
    Inês Coelho, Nádia Duarte, Maria Paula Macedo, Carlos Penha‐Gonçalves · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages
    Aquino, Jorge Benjamin · 2026 · Frontiers in Immunology
  31. Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19 −/− mouse model
    Li Wang, Yue Yu, Jiayan feng, Yanan Zhang, Renxue Wang, Huiyu She, T Liu, Victor Wei Teik Ling, Jianshe Wang · 2026 · Pediatric Investigation
  32. Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII.
    Man-Man Yuan, Bingfeng Zheng, Jing-Lin Wang, Shuai-Qi Xu, Shenglan Wang, Yang Tan, Yong Feng, Xianchi Dong, Qi-Hua Zhu, Jie Yan et al. · 2026 · Acta Pharmacologica Sinica
  33. Revisiting macrophage metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: mechanisms, regulation, and therapeutic breakthroughs
    Li Zhu, Bo Wu · 2026 · Frontiers in Immunology
  34. Mechanistic Insights into the Role of MCP-1 in Diverse Liver Pathological Conditions: A Recent Update
    Sahil Dhengle, Krushna Ch Maharana, Sarasa Meenakshi, Sanjiv Singh · 2025 · Current Pharmaceutical Design
  35. Monocyte Chemotactic Protein-1 (Cytokine, Receptors, and Gene Polymorphisms) in Hepatitis
    Alicja Ewa Grzegorzewska, Adrianna Mostowska · 2017 · Biomarkers in disease
  36. CMC Aspects for the Clinical Development of Spiegelmers
    Stefan Vonhoff · 2018
  37. Understanding heterotopic ossification after spinal cord injury
    Irina Kulina · 2015 · The University of Queensland
  38. Monocyte Chemotactic Protein-1 (Cytokine, Receptors, and Gene Polymorphisms) in Hepatitis
    Alicja Ewa Grzegorzewska, Adrianna Mostowska · 2015 · Exposure and Health
  39. Targeting liver inflammatory myeloid cells with immunomodulatory liposomes improves nonalcoholic steatohepatitis in mice
    Muralidhara Rao Maradana · 2016 · The University of Queensland
  40. Pathways for kidney triglyceride accumulation
    Diego A. Scerbo · 2017
  41. General Discussion and Future Perspectives
    Chiara Cassarini · 2019 · CRC Press eBooks
  42. Antifibrotic Therapy for Liver Cirrhosis
    Lê Thị Thanh Thủy, Hoang Hai, Vu Ngoc Hieu, Ninh Quoc Dat, Dinh Viet Hoang, Norifumi Kawada · 2019 · Springer eBooks
  43. Molecular Basis of Fibrogenesis and Angiogenesis During Chronic Liver Disease: Impact of TGF-β and VEGF on Pathogenic Pathways
    Shinya Mizuno, Eriko Osaki · 2020 · Springer eBooks
  44. The versatile nature of MIF (macrophage migration inhibitory factor) in chronic lung diseases
    Laura Florez‐Sampedro · 2020
  45. Mesenchymal stromal cell therapy for liver fibrosis
    Debashis Haldar · 2019 · University of Birmingham Institutional Research Archive (University of Birmingham)
  46. Reversal of Cirrhosis
    Gemma Òdena, Eva J. Stein, Ramon A. Bataller · 2015 · Springer eBooks
  47. TNF signaling
    Amrit Mann, Mark J. Czaja, Jörn Markus Schattenberg · 2015 · Wiley eBooks
  48. Research Progress of New Serological Markers of Chronic Hepatitis B Liver Inflammation and Fibrosis
    唤 木 · 2020 · Advances in Clinical Medicine
  49. The Role of Myeloid-Derived Cells in the Progression of Liver Disease
    2020 · Frontiers research topics
  50. From inflammation to fibrosis
    Pablo Muriel · 2022 · Elsevier eBooks
  51. Role of Kupffer cells and other immune cells
    Tobias Puengel, Frank Tacke · 2024 · Elsevier eBooks
  52. Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in mice
    Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Simone Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian M. Kiessling, Thomas Clavel, Norbert Wagner et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization
    Jiaxin Wang, Ning Li, Xueyu Cang, Xuerong Liu, Ranyan Gao, Lingyi Xu, Fengchun Li, Xinyu Jiang, Hongliang Chen, Xinyu Geng et al. · 2025 · Scientific Reports
  54. Additional file 1 of Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
    Zhang, Kun, Zhang, Meng-Xia, Meng, Xiao-Xiang, Zhu, Jing, Wang, Jia-Jun, Yifan He, Li, Ye-Hua, Zhao, Si-Cong, Shi, Zhe-Min, Zheng, Li-Na et al. · 2023 · Figshare
  55. Additional file 2 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  56. Additional file 6 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  57. Additional file 3 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  58. Additional file 1 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  59. Additional file 5 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  60. Additional file 2 of Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
    Zhang, Kun, Zhang, Meng-Xia, Xiaoxiang Meng, Zhu, Jing, Wang, Jia-Jun, Yifan He, Li, Ye-Hua, Zhao, Si-Cong, Shi, Zhe-Min, Zheng, Li-Na et al. · 2024 · Figshare
  61. Additional file 4 of TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
    Qiang Liu, Xiaohua Lei, Cao, Zhenyu, Zhang, Ju, Yan, Likun, Fu, Jie, Tong, Qing, Qin, Wei, Yaoli Shao, Liu, Chun et al. · 2022 · Figshare
  62. Macrophage Heterogeneity in Liver Ischemia-Reperfusion Injury
    Yuan Zhai, Yue Wang, Cheng Zhong, Jackson L. Chin, Nan L. Xia, Yi-Chu Kao, Tori Huey, Hesham El-Shewy, Dirk J. van der Windt, Kristi L. Helke et al. · 2025 · Research Square
  63. Influence de la réponse IL-17 dans la physiopathologie du foie
    Adrien Guillot · 2014
  64. Alteration of alternative splicing in the pathogenesis of liver disease
    Hualin Wang · 2017 · theses.fr (ABES)
  65. Monoacylglycerol Lipase, a new anti-inflammatory and anti-fibrogenic target in the liver
    Dina Chokr · 2018 · theses.fr (ABES)
  66. Myeloperoxidase regulates hypoxia-induced inflammation and oxidative stress in liver-spleen axis
    Yonggui Li, Xiaoli Liu, Lingming Zhang, Xiaoluan Li, Zeyi Zuo, Qiao Gao, Qinfang Zhu · 2026 · Journal of Inflammation
  67. Peptide hormone-based combinational pharmacotherapies for chronic metabolic diseases
    Zara Siu Wa Chui, Yaqian Xue, Xiaoping Wu, Aimin Xu · 2026 · Pharmacological Reviews
  68. Serum CC-Chemokine Profiling in Alcohol-Associated Liver Disease: Focus on MIP-3α/CCL20 as a Biomarker of Disease Severity
    A. Szczerbińska, Jacek Roliński, Agata Surdacka, H. Cichoż-Lach · 2026 · Diagnostics
  69. Ferroptosis, immune activation and MASH-related HCC.
    M. Kuchay, F. J. Cubero, B. Ramos-Molina · 2026 · Gut
  70. ADAM17 as a proteolytic rheostat linking inflammation, tissue repair, and failure of inflammatory resolution in liver injury and fibrosis
    Xiaodan Jiang, Jinxin Ma, Zhejun Liu, Jiang Chen · 2026 · Frontiers in Pharmacology
  71. The Crosstalk Between Macrophages and Hepatic Energy Metabolic Reprogramming and the Modulation by Natural Products: An Overview
    Bingxin Huangfu, Jia Xu, Xianghui Huang, Kaida Huang, Xiaoyun He, Baiqiang Zhai · 2026 · ACS Nutrition Science