Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0027 · Cited by 3,889 · see citing works

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: A 5-year open-label follow-up study

Marcellin, P., Gane, E., Buti, M., Afdhal, N., Sievert, W., Jacobson, I. M., Washington, M. K., Germanidis, G., Flaherty, J. F., Schall, R. A., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61425-1 · Cited by 1,788 · see citing works

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649 · see citing works

Liver fibrosis

Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480 · see citing works

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology · doi:10.1002/hep.22950 · Cited by 782 · see citing works

Langerhans cells arise from monocytes in vivo

Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Mérad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 741 · see citing works

Comparison of gene expression profiles between human and mouse monocyte subsets

Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R. F. G., Lang, R., Haniffa, M. A., Collin, M. P., Tacke, F., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235028 · Cited by 731 · see citing works

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

Hanna, R. N., Carlin, L. M., Hubbeling, H. G., Nackiewicz, D., Green, A. M., Punt, J. A., Geissmann, F., & Hedrick, C. C. (2011) · Nature Immunology · doi:10.1038/ni.2063 · Cited by 639 · see citing works

Pharmacological Inhibition of the Chemokine CCL2 (MCP-1) Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury

Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300304 · Cited by 609 · see citing works

Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis

Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479 · see citing works

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis☆

Forbes, S. J., Russo, F. P., Rey, V., Burra, P., Rugge, M., Wright, N. A., & Alison, M. R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.025 · Cited by 436 · see citing works

CCR2 promotes hepatic fibrosis in mice #

Seki, E., Minicis, S. D., Inokuchi, S., Taura, K., Miyai, K. N., van Rooijen, N., Schwabe, R. F., & Brenner, D. A. (2009) · Hepatology · doi:10.1002/hep.22952 · Cited by 415 · see citing works

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology · doi:10.1002/hep.24315 · Cited by 346 · see citing works

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

Zimmermann, H. W., Seidler, S., Nattermann, J., Gaßler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J. W., Luedde, T., Weiskirchen, R., Trautwein, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011049 · Cited by 311 · see citing works

Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.

Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., & Geñtilini, P. (1998) · Europe PMC (PubMed Central) · Cited by 287 · see citing works

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery

Tacke, F., Ginhoux, F., Jakubzick, C., van Rooijen, N., Mérad, M., & Randolph, G. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052119 · Cited by 282 · see citing works

Functional Role of Monocytes and Macrophages for the Inflammatory Response in Acute Liver Injury

Zimmermann, H. W., Trautwein, C., & Tacke, F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00056 · Cited by 260 · see citing works

The Fractalkine Receptor CX3CR1 Protects Against Liver Fibrosis by Controlling Differentiation and Survival of Infiltrating Hepatic Monocytes

Karlmark, K. R., Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., & Tacke, F. (2010) · Hepatology · doi:10.1002/hep.23894 · Cited by 249 · see citing works

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

Liaskou, E., Zimmermann, H. W., Li, K., Oo, Y. H., Suresh, S., Stamataki, Z., Qureshi, O. S., Lalor, P. F., Shaw, J., Syn, W., et al. (2012) · Hepatology · doi:10.1002/hep.26016 · Cited by 246 · see citing works

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

Pellicoro, A., Aucott, R. L., Ramachandran, P., Robson, A. J., Fallowfield, J. A., Snowdon, V., Hartland, S. N., Vernon, M. A., Duffield, J. S., Benyon, C. R., et al. (2011) · Hepatology · doi:10.1002/hep.25567 · Cited by 190 · see citing works

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

Mitchell, C., Couton, D., Couty, J., Anson, M., Crain‐Denoyelle, A., Bizet, V., Rénia, L., Pol, S., Mallet, V. O., & Gilgenkrantz, H. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080632 · Cited by 189 · see citing works

Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease

Houlihan, D. D., & Newsome, P. N. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.040 · Cited by 189 · see citing works

Monocytes and Macrophages as Cellular Targets in Liver Fibrosis

Heymann, F., Trautwein, C., & Tacke, F. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809789352230 · Cited by 187 · see citing works

In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class

Wlotzka, B., Leva, S., Eschgfäller, B., Burmeister, J., Kleinjung, F., Kaduk, C., Muhn, P., Hess‐Stumpp, H., & Klußmann, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132067399 · Cited by 183 · see citing works

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

Heymann, F., Hammerich, L., Storch, D., Bartneck, M., Huss, S., Rüsseler, V., Gaßler, N., Lira, S. A., Luedde, T., Trautwein, C., et al. (2011) · Hepatology · doi:10.1002/hep.24764 · Cited by 178 · see citing works

Dendritic Cell Regulation of Carbon Tetrachloride–Induced Murine Liver Fibrosis Regression

Jiao, J., Sastre, D., Fiel, M. I., Lee, U. E., Ghiassi–Nejad, Z., Ginhoux, F., Vivier, E., Friedman, S. L., Merad, M., & Aloman, C. (2012) · Hepatology · doi:10.1002/hep.24621 · Cited by 154 · see citing works

Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

Ninichuk, V., Clauß, S., Kulkarni, O. P., Schmid, H., Segerer, S., Radomska, E., Eulberg, D., Buchner, K., Selve, N., Klußmann, S., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070601 · Cited by 135 · see citing works

Chronic inflammation, immune escape, and oncogenesis in the liver: A unique neighborhood for novel intersections

Stauffer, J. K., Scarzello, A. J., Jiang, Q., & Wiltrout, R. H. (2012) · Hepatology · doi:10.1002/hep.25674 · Cited by 132 · see citing works

Modification of Chemokine Pathways and Immune Cell Infiltration as a Novel Therapeutic Approach in Liver Inflammation and Fibrosis

Zimmermann, H. W., & Tacke, F. (2011) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152811798104890 · Cited by 121 · see citing works

Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo

Tacke, F. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-s1-s27 · Cited by 91 · see citing works

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

Galastri, S., Zamara, E., Milani, S., Novo, E., Provenzano, A., Delogu, W., Vizzutti, F., Sutti, S., Locatelli, I., Navari, N., et al. (2012) · Clinical Science · doi:10.1042/cs20110515 · Cited by 62 · see citing works

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works

Liver Macrophages in Tissue Homeostasis and Disease

Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works

Targeting hepatic macrophages to treat liver diseases

Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.026 · Cited by 1,003 · see citing works

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works

Pathobiology of liver fibrosis: a translational success story

Lee, Y. A., Wallace, M. C., & Friedman, S. L. (2015) · Gut · doi:10.1136/gutjnl-2014-306842 · Cited by 894 · see citing works

Roles for chemokines in liver disease

Marra, F., & Tacke, F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.043 · Cited by 829 · see citing works

Hepatic inflammatory responses in liver fibrosis

Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Wen, Y., Lambrecht, J., Ju, C., & Tacke, F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00558-8 · Cited by 695 · see citing works

Mechanisms of Organ Injury and Repair by Macrophages

Vannella, K. M., & Wynn, T. A. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034356 · Cited by 656 · see citing works

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

Hardy, T., Oakley, F., Anstee, Q. M., & Day, C. P. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044224 · Cited by 619 · see citing works

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573 · see citing works

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

Krenkel, O., Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., et al. (2018) · Hepatology · doi:10.1002/hep.29544 · Cited by 557 · see citing works

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

Ju, C., & Tacke, F. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.104 · Cited by 554 · see citing works

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Schuppan, D., Ashfaq–Khan, M., Yang, A. T., & Kim, Y. O. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.04.006 · Cited by 440 · see citing works

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Musso, G., Cassader, M., & Gambino, R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.3 · Cited by 415 · see citing works

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Mossanen, J. C., Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., et al. (2016) · Hepatology · doi:10.1002/hep.28682 · Cited by 325 · see citing works

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.038 · Cited by 321 · see citing works

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

Targher, G., & Byrne, C. D. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.16 · Cited by 313 · see citing works

Liver regeneration and inflammation: from fundamental science to clinical applications

Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works

Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology.

Weiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 269 · see citing works

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

Vater, A., & Klußmann, S. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.09.004 · Cited by 251 · see citing works

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

van der Heide, D., Weiskirchen, R., & Bansal, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02852 · Cited by 234 · see citing works

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

Yao, Y., Cai, X. T., Ren, F., Ye, Y., Wang, F., Zheng, C., Qian, Y., & Zhang, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664871 · Cited by 229 · see citing works

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy

Juban, G., Saclier, M., Yacoub‐Youssef, H., Kernou, A., Arnold, L., Boisson, C., Larbi, S. B., Magnan, M., Cuvellier, S., Théret, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.077 · Cited by 223 · see citing works

Immune mechanisms in acetaminophen-induced acute liver failure.

Krenkel, O., Mossanen, J. C., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.01 · Cited by 221 · see citing works

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Fei, L., Ren, X., Yu, H., & Zhan, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.771210 · Cited by 221 · see citing works

Mechanisms of liver fibrosis resolution

Tacke, F., & Trautwein, C. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.03.039 · Cited by 206 · see citing works

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189 · see citing works

Hepatic macrophages: Key players in the development and progression of liver fibrosis

Cheng, D., Chai, J., Wang, H., Fu, L., Peng, S., & Ni, X. (2021) · Liver International · doi:10.1111/liv.14940 · Cited by 188 · see citing works

Pathogenesis and novel treatment options for non-alcoholic steatohepatitis

Wong, V. W., Chitturi, S., Wong, G. L., Yu, J. Q., Chan, H. L., & Farrell, G. C. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30011-5 · Cited by 186 · see citing works

Fatty Liver and Chronic Kidney Disease: Novel Mechanistic Insights and Therapeutic Opportunities

Musso, G., Cassader, M., Cohney, S. J., Michieli, F. D., Pinach, S., Saba, F., & Gambino, R. (2016) · Diabetes Care · doi:10.2337/dc15-1182 · Cited by 162 · see citing works

Liver Fibrosis: From Pathogenesis to Novel Therapies

Weiskirchen, R., & Tacke, F. (2016) · Digestive Diseases · doi:10.1159/000444556 · Cited by 157 · see citing works

Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma

Ji, J., Eggert, T., Budhu, A., Forgues, M., Takai, A., Dang, H. T., Ye, Q., Lee, J., Kim, J. H., Greten, T. F., et al. (2015) · Hepatology · doi:10.1002/hep.27822 · Cited by 151 · see citing works

Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

Li, H., Shen, S. H., Fu, H., Wang, Z., Li, X., Sui, X., Yuan, M., Liu, S., Wang, G., & Guo, Q. (2019) · Stem Cells International · doi:10.1155/2019/9671206 · Cited by 151 · see citing works

Immunology of human fibrosis

Bhattacharya, M., & Ramachandran, P. (2023) · Nature Immunology · doi:10.1038/s41590-023-01551-9 · Cited by 148 · see citing works

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

Lurje, I., Gaisa, N. T., Weiskirchen, R., & Tacke, F. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101191 · Cited by 147 · see citing works

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases

Wermuth, P. J., & Jiménez, S. A. (2015) · Clinical and Translational Medicine · doi:10.1186/s40169-015-0047-4 · Cited by 138 · see citing works

Nanoparticles for the treatment of liver fibrosis

Surendran, S. P., Thomas, R. G., Moon, M. J., & Jeong, Y. Y. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s145951 · Cited by 139 · see citing works

Macrophage Phenotype in Liver Injury and Repair

Sun, Y., Li, X., Meng, X., Huang, C., Zhang, L., & Li, J. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12468 · Cited by 136 · see citing works

Adipocytokines and hepatic fibrosis

Saxena, N. K., & Anania, F. A. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.002 · Cited by 136 · see citing works

Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis

Shan, L., Wang, F., Zhai, D., Meng, X., Liu, J., & Lv, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114472 · Cited by 135 · see citing works

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Huang, E., Peng, N., Xiao, F., Hu, D., Wang, X., & Lu, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155203 · Cited by 130 · see citing works

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

She, S., Ren, L., Chen, P., Wang, M., Chen, D., Wang, Y., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812431 · Cited by 125 · see citing works

Liver fibrosis: Common mechanisms and antifibrotic therapies

Schuppan, D. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.05.005 · Cited by 122 · see citing works

Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis

Tacke, F. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1442436 · Cited by 122 · see citing works

Functional Immune Anatomy of the Liver—As an Allograft

Demetris, A. J., Bellamy, C. O. C., Gandhi, C. R., Prost, S., Nakanuma, Y., & Stolz, D. B. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13749 · Cited by 115 · see citing works

Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis

Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works

Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?

Chen, J., Deng, X., Liu, Y., Tan, Q., Huang, G., Che, Q., Guo, J., & Su, Z. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47143 · Cited by 113 · see citing works

Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury

Graubardt, N., Vugman, M., Mouhadeb, O., Caliari, G., Pasmanik‐Chor, M., Reuveni, D., Zigmond, E., Brazowski, E., David, E., Chappell‐Maor, L., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00626 · Cited by 108 · see citing works

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

Campana, L., Starkey Lewis, P. J., Pellicoro, A., Aucott, R. L., Man, J., O’Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S. N., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701247 · Cited by 107 · see citing works

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Devisscher, L., Scott, C. L., Lefere, S., Raevens, S., Bogaerts, E., Paridaens, A., Verhelst, X., Geerts, A. M., Guilliams, M., & Vlierberghe, H. V. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.006 · Cited by 104 · see citing works

Inflammatory processes in the liver: divergent roles in homeostasis and pathology

Ahmed, O., Robinson, M. W., & O’Farrelly, C. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00639-2 · Cited by 103 · see citing works

Obesity: An Immunometabolic Perspective

Ray, I., Mahata, S. K., & De, R. K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00157 · Cited by 100 · see citing works

Infiltrating monocytes in liver injury and repair

Brempelis, K. J., & Crispe, I. N. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.62 · Cited by 97 · see citing works

The Role of Myeloid-Derived Cells in the Progression of Liver Disease

Weston, C. J., Zimmermann, H. W., & Adams, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00893 · Cited by 91 · see citing works

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Habib, A., Chokr, D., Wan, J., Hegde, P., Mabire, M., Siebert, M., Ribeiro-Parenti, L., Le Gall, M., Lettéron, P., Pilard, N., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316137 · Cited by 91 · see citing works

Role of chemokine pathways in hepatobiliary cancer

Ehling, J., & Tacke, F. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.017 · Cited by 91 · see citing works

Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH

Fredrickson, G., Barrow, F., DIETSCHE, K. B., Parthiban, P., Khan, S. M., Robert, S., Demirchian, M., Rhoades, H., Wang, H., Adeyi, O. A., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101270 · Cited by 87 · see citing works

The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation

Eckert, C., Klein, N., Kornek, M., & Kornek, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00179 · Cited by 83 · see citing works

Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics

Islamuddin, M., & Qin, X.-B. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01996-3 · Cited by 81 · see citing works

Mesenchymal stromal cells and liver fibrosis: a complicated relationship

Haldar, D., Henderson, N. C., Hirschfield, G. M., & Newsome, P. N. (2016) · The FASEB Journal · doi:10.1096/fj.201600433r · Cited by 81 · see citing works

T‐Cell Immunoglobulin and Mucin Domain‐Containing Protein‐4 Is Critical for Kupffer Cell Homeostatic Function in the Activation and Resolution of Liver Ischemia Reperfusion Injury

Ni, M., Zhang, J., Sosa, R., Zhang, H., Wang, H., Jin, D., Crowley, K., Naini, B., Reed, F. E., Busuttil, R. W., et al. (2021) · Hepatology · doi:10.1002/hep.31906 · Cited by 80 · see citing works

GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties

Li, X., Huai, Q., Zhu, C., Zhang, X., Xu, W., Dai, H., & Wang, H. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.009 · Cited by 80 · see citing works

CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis

Sutti, S., Locatelli, I., Bruzzì, S., Jindal, A., Vacchiano, M., Bozzola, C., & Albano, E. (2015) · Clinical Science · doi:10.1042/cs20150053 · Cited by 80 · see citing works

Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Kang, J., Postigo, J., Kim, K., Zhu, C., Yu, J., Meroni, M., Mayfield, B., Bartolomé, A., Dapito, D. H., Ferrante, A. W., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165369 · Cited by 79 · see citing works

Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

Roohani, S., & Tacke, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147249 · Cited by 76 · see citing works

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Duriez, M., Mandouri, Y., Lekbaby, B., Wang, H., Schnuriger, A., Redelsperger, F., Guerrera, I. C., Lefèvre, M., Fauveau, V., Ahodantin, J., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.025 · Cited by 75 · see citing works

Antifibrotic Therapies in the Liver

Schuppan, D., & Mehal, W. Z. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550055 · Cited by 75 · see citing works

The SGLT2 inhibitor dapagliflozin attenuates the activity of ROS-NLRP3 inflammasome axis in steatohepatitis with diabetes mellitus

Leng, W., Wu, M., Pan, H., Lei, X., Chen, L., Wu, Q., Ouyang, X., & Liang, Z. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.03 · Cited by 75 · see citing works

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma

Tan, S., Zhao, J., Sun, Z., Cao, S., Niu, K., Zhong, Y., Wang, H., Shi, L., Pan, H., Hu, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005353117 · Cited by 75 · see citing works

Naringin prevents cyclophosphamide-induced hepatotoxicity in rats by attenuating oxidative stress, fibrosis, and inflammation

Akamo, A. J., Rotimi, S. O., Akinloye, D. I., Ugbaja, R. N., Adeleye, O. O., Dosumu, O. A., Eteng, O. E., Amah, G. H., Augustine, O., & Cole, O. E. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112266 · Cited by 75 · see citing works

Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions

Yan, M., Cui, Y., & Xiang, Q. (2025) · Theranostics · doi:10.7150/thno.106597 · Cited by 76 · see citing works

The Elusive Antifibrotic Macrophage

Adhyatmika, A., Putri, K. S. S., Beljaars, L., & Melgert, B. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00081 · Cited by 74 · see citing works

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

Oates, J. R., McKell, M. C., Moreno‐Fernandez, M. E., Damen, M. S. M. A., Deepe, G. S., Qualls, J. E., & Divanovic, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02893 · Cited by 74 · see citing works

PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target

She, S., Wu, X., Zheng, D., Pei, X., Ma, J., Sun, Y., Zhou, J., Nong, L., Guo, C., Lv, P., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.09.033 · Cited by 74 · see citing works

Increased Antiangiogenic Effect by Blocking CCL2-dependent Macrophages in a Rodent Glioblastoma Model: Correlation Study with Dynamic Susceptibility Contrast Perfusion MRI

Cho, H. R., Kumari, N., Vu, H. T., Kim, H., Park, C., & Choi, S. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-47438-4 · Cited by 72 · see citing works

Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 Pathway

Xi, S., Zheng, X.-Y., Li, X.-Y., Jiang, Y.-M., Wu, Y.-K., Gong, J., Jie, Y., Li, Z.-Y., Cao, J., Sha, L.-P., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2021.627927 · Cited by 70 · see citing works

Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage

Coelho, I., Duarte, N., Barros, A., Macedo, M. P., & Penha-Gonçalves, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616044 · Cited by 70 · see citing works

Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets

Li, H., You, H., Fan, X., & Jia, J. (2016) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2016-000079 · Cited by 69 · see citing works

Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014

Torok, N. J., Dranoff, J. A., Schuppan, D., & Friedman, S. L. (2015) · Hepatology · doi:10.1002/hep.27720 · Cited by 70 · see citing works

Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia

Sun, X., Wu, J., Liu, L., Chen, Y., Tang, Y., Liu, S., Chen, H., Jiang, Y., Liu, Y., Yuan, H., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.02.028 · Cited by 68 · see citing works

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

Tan-Garcia, A., Wai, L.-E., Zheng, D., Ceccarello, E., Jo, J., Banu, N., Khakpoor, A., Chia, A., Tham, C. Y. L., Tan, A. T., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.04.023 · Cited by 68 · see citing works

Current status and future perspectives of FGF21 analogues in clinical trials

Chui, Z. S. W., Shen, Q., & Xu, A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.001 · Cited by 68 · see citing works

Macrophages in nonalcoholic fatty liver disease: a role model of pathogenic immunometabolism

Krenkel, O., & Tacke, F. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1604480 · Cited by 66 · see citing works

Expression and cellular distribution of TLR4, MyD88, and NF-κB in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo

Liu, P., Li, F., Qiu, M.-C., & He, L.-J. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.020 · Cited by 64 · see citing works

Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy

(2024) · doi:10.1146/annurev-pharmtox-020524-012013 · Cited by 64 · see citing works

The dendritic cell–T helper 17–macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia

Lages, C. S., Simmons, J. R., Maddox, A., Jones, K. R., Karns, R. A., Sheridan, R. M., Shanmukhappa, S. K., Mohanty, S., Kofron, M. J., Russo, P., et al. (2016) · Hepatology · doi:10.1002/hep.28851 · Cited by 63 · see citing works

The role of hepatic macrophages in liver metastasis

Keirsse, J., Damme, H. V., Geeraerts, X., Beschin, A., Raes, G., & Ginderachter, J. A. V. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.03.010 · Cited by 63 · see citing works

Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling

Wu, B., Liu, J., Li, Y., & Li, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4395 · Cited by 62 · see citing works

New Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article

Ebrahimi, H., Naderian, M., & Sohrabpour, A. A. (2016) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2016.29 · Cited by 61 · see citing works

Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury

Puengel, T., Krenkel, O., Kohlhepp, M. S., Lefebvre, E. A., Luedde, T., Trautwein, C., & Tacke, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184694 · Cited by 61 · see citing works

Therapeutic inhibition of spleen tyrosine kinase in inflammatory macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis

Kurniawan, D. W., Jajoriya, A. K., Dhawan, G., Mishra, D., Argemí, J., Bataller, R. A., Storm, G., Mishra, D. P., Prakash, J., & Bansal, R. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.09.004 · Cited by 60 · see citing works

Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis

Puengel, T., Lefere, S., Hundertmark, J., Kohlhepp, M., Penners, C., Van de Velde, F., Lapauw, B., Hoorens, A., Devisscher, L., Geerts, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126696 · Cited by 59 · see citing works

Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

Conte, E. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108031 · Cited by 58 · see citing works

Dynamic plasticity of macrophage functions in diseased liver

Ritz, T., Krenkel, O., & Tacke, F. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.12.007 · Cited by 58 · see citing works

Bone Marrow-Derived Macrophage Contributes to Fibrosing Steatohepatitis Through Activating Hepatic Stellate Cells

Han, J., Zhang, X., Lau, J. K. C., Fu, K., Lau, H. C.-H., Xu, W., Chu, E. S., Lan, H. Y., & Yu, J. Q. (2018) · The Journal of Pathology · doi:10.1002/path.5275 · Cited by 58 · see citing works

Macrophages as key regulators of liver health and disease

Papachristoforou, E., & Ramachandran, P. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.006 · Cited by 55 · see citing works

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis

Barnes, M. A., McMullen, M. R., Roychowdhury, S., Madhun, N. Z., Niese, K. A., Olman, M. A., Stavitsky, A. B., Bucala, R., & Nagy, L. E. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0614-280r · Cited by 53 · see citing works

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

Azzu, V., Vacca, M., Kamzolas, I., Hall, Z., Leslie, J., Carobbio, S., Virtue, S., Davies, S. E., Lukasik, A., Dale, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101210 · Cited by 52 · see citing works

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

Mk, S., Hammerich, L., Berres, M., Trautwein, C., Tacke, F., & Wasmuth, H. (2012) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0031-1295782

Macrophage Heterogeneity in Liver Injury: You Are Now Leaving Kupffertown

Dranoff, J. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.10.020

LY-6C intermediate and LY-6C LO intrahepatic macrophage subsets orchestrate resolution of hepatic fibrosis following chronic injury

Ramachandran, P., Pellicoro, A., Vernon, M. A., Hartland, S. N., Ali, A., Aucott, R. L., Forbes, S. J., & Iredale, J. P. (2011) · Gut · doi:10.1136/gut.2011.239301.111

Pharmacological Inhibition of the Chemokine CCL2 (MCP-1) Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury

Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300304 · Cited by 609 · see citing works