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Cited by 184Cancer-related molecular mechanisms researchRNA Research and SplicingLiver Disease Diagnosis and Treatment

Long noncoding RNA in liver diseases

Open access
Takahashi, Kenji, Yan, Irene, Haga, Hiroaki, Patel, Tushar·2014·Hepatology
DOI 10.1002/hep.27043PMC PMC4110118
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Abstract

The identification of the presence of large RNA transcripts that do not code for proteins but that may have biological functions has provided an important new perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms. These findings are profoundly altering our understanding of disease pathobiology and leading to the emergence of new biological concepts underlying human diseases. Strategies for the discovery and characterization of lncRNAs are highlighted. Several lncRNAs have been described in liver disease, and in liver cancers in particular. Their molecular mechanisms of action, function, and contributions to disease pathophysiology are reviewed. LncRNA genes associated with liver diseases have potential roles as biomarkers of disease diagnosis, prognosis, or therapeutic response as well as direct targets for therapeutic intervention. Conclusion: The emerging knowledge in this rapidly advancing field offers promise for new fundamental knowledge and clinical applications that will be relevant for human liver diseases. (Hepatology 2014;60:744–753)

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  • Extracellular vesicles can transfer RNAs such as non-coding RNAs from one cell to another and thereby contribute to inter-cellular communication.

    “Recent studies have confirmed that EV can transfer RNAs such as ncRNAs from one cell to another and thereby contribute to important roles in inter-cellular communication (3–9).”

    From Analysis of Extracellular RNA by Digital PCR (2014) · cites this paper as [9]

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Cited by

Sorted by citations

Authors
Takahashi, K., Yan, I., Haga, H., & Patel, T.
Affiliations
Mayo Clinic in Florida (US)
Corresponding author
Patel, Tushar
ORCID
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-08
Volume
60
Issue
2
Pages
744-753
ISSN
0270-9139 (ISSN-L)
DOI
10.1002/hep.27043
PMC
PMC4110118
OpenAlex
W2140387074
Cited by
184
References
6
Citations by year
2026: 3 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 24 · 2020: 22 · 2019: 22 · 2018: 19 · 2017: 22 · 2016: 22 · 2015: 18 · 2014: 6
FWCI
2.25
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 396 d)
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (DK069370)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
long non-coding RNA, liver disease, liver cancer, gene expression regulation, lncRNA discovery, disease biomarkers, therapeutic target, disease pathophysiology
MeSH terms
Gene Expression Regulation, Humans, Liver, Liver Diseases, RNA, Long Noncoding

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