Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108 · see citing works

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696 · see citing works

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Long non-coding RNAs: insights into functions

Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654 · see citing works

Prediction of complete gene structures in human genomic DNA

Burge, C., & Karlin, S. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0951 · Cited by 4,211 · see citing works

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

Pan, Q., Shai, O., Lee, L. J., Frey, B. J., & Blencowe, B. J. (2008) · Nature Genetics · doi:10.1038/ng.259 · Cited by 3,951 · see citing works

Causes and consequences of microRNA dysregulation in cancer

Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,003 · see citing works

Ultraconserved Elements in the Human Genome

Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W. J., Mattick, J. S., & Haussler, D. (2004) · Science · doi:10.1126/science.1098119 · Cited by 1,732 · see citing works

Genetic variation in microRNA networks: the implications for cancer research

Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,253 · see citing works

Exosomes: A Common Pathway for a Specialized Function

van Niel, G., Porto-Carreiro, I., Simoes, S., & Raposo, G. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj128 · Cited by 922 · see citing works

Characterization of HULC, a Novel Gene With Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA

Panzitt, K., Tschernatsch, M. M. O., Guelly, C., Moustafa, T., Stradner, M. H., Strohmaier, H. M., Buck, C. R., Denk, H., Schroeder, R., Trauner, M. A., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.026 · Cited by 771 · see citing works

Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas

Calin, G. A., Liu, C., Ferracin, M., Hyslop, T., Spizzo, R., Sevignani, C., Fabbri, M., Cimmino, A., Lee, E. J., Wojcik, S. E., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.027 · Cited by 714 · see citing works

The H19 Non-Coding RNA Is Essential for Human Tumor Growth

Matouk, I., de-Groot, N., Mezan, S., Ayesh, S. K., Abu-lail, R., Hochberg, A., & Galun, E. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000845 · Cited by 649 · see citing works

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

Braconi, C., Kogure, T., Valeri, N., Huang, N., Nuovo, G., Costinean, S., Negrini, M., Miotto, E., Croce, C. M., & Patel, T. (2011) · Oncogene · doi:10.1038/onc.2011.193 · Cited by 642 · see citing works

Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation

Lai, M.-C., Yang, Z., Zhou, L., Zhu, Q., Xie, H., Zhang, F., Wu, L., Chen, L.-M., & Zheng, S. (2011) · Medical Oncology · doi:10.1007/s12032-011-0004-z · Cited by 596 · see citing works

Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

Kogure, T., Lin, W.-L., Yan, I. K., Braconi, C., & Patel, T. (2011) · Hepatology · doi:10.1002/hep.24504 · Cited by 551 · see citing works

The Centrality of RNA

Sharp, P. A. (2009) · Cell · doi:10.1016/j.cell.2009.02.007 · Cited by 452 · see citing works

Tumor-Released Microvesicles as Vehicles of Immunosuppression

Valenti, R., Huber, V., Iero, M., Filipazzi, P., Parmiani, G., & Rivoltini, L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0520 · Cited by 409 · see citing works

Micromechanical control of cell–cell interactions

Hui, E. E., & Bhatia, S. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608660104 · Cited by 392 · see citing works

Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells

Mohamed, J. S., Gaughwin, P. M., Lim, B., Robson, P., & Lipovich, L. (2009) · RNA · doi:10.1261/rna.1441510 · Cited by 335 · see citing works

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma

Braconi, C., Valeri, N., Kogure, T., Gasparini, P., Huang, N., Nuovo, G. J., Terracciano, L., Croce, C. M., & Patel, T. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011098108 · Cited by 214 · see citing works

Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis

Matouk, I., Abbasi, I., Hochberg, A., Galun, E., Dweik, H., & Akkawi, M. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328306a3a2 · Cited by 190 · see citing works

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works

Exosomes: biogenesis, biologic function and clinical potential

Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119 · see citing works

LNCcation: lncRNA localization and function

Bridges, M. C., Daulagala, A. C., & Kourtidis, A. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202009045 · Cited by 1,556 · see citing works

Exosome-based liquid biopsies in cancer: opportunities and challenges

Wang, Y., Hurley, J. D., Roberts, D., Chakrabortty, S. K., Enderle, D., Noerholm, M., Breakefield, X. O., & Skog, J. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.01.074 · Cited by 871 · see citing works

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782 · see citing works

Exosomes in cancer: small particle, big player

Zhang, X., Yuan, X., Shi, H., Wu, L., Qian, H., & Xu, W. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0181-x · Cited by 783 · see citing works

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551 · see citing works

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Rashed, M. H., Bayraktar, E., Helal, G. K., Abd‐Ellah, M. F., Amero, P., Chávez‐Reyes, A., & Rodriguez‐Aguayo, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030538 · Cited by 525 · see citing works

Clinical utility of circulating non-coding RNAs — an update

Anfossi, S., Babayan, A., Pantel, K., & Călin, G. A. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0035-x · Cited by 453 · see citing works

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

Conigliaro, A., Costa, V., Dico, A. L., Saieva, L., Buccheri, S., Dieli, F., Manno, M., Raccosta, S., Mancone, C., Tripodi, M., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0426-x · Cited by 435 · see citing works

Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

Yang, J., Xu, J., Wang, W. T., Zhang, B., Yu, X., & Shi, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01480-x · Cited by 404 · see citing works

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

Xiao, J., Pan, Y., Li, X. H., Yang, X. Y., Feng, Y. L., Tan, H. H., Jiang, L., Feng, J., & Yu, X. Y. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.181 · Cited by 373 · see citing works

Aortic Valve Stenosis

Goody, P. R., Hosen, M. R., Christmann, D., Niepmann, S. T., Zietzer, A., Adam, M., Bönner, F., Zimmer, S., Nickenig, G., & Jansen, F. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313067 · Cited by 339 · see citing works

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 325 · see citing works

Circular RNA: a novel biomarker and therapeutic target for human cancers

Lei, B., Tian, Z., Fan, W., & Ni, B. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.28047 · Cited by 315 · see citing works

Circulating long non-coding RNAs in cancer: current status and future perspectives

Qi, P., Zhou, X.-Y., & Du, X. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0524-4 · Cited by 313 · see citing works

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301 · see citing works

Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy

Takahashi, K., Yan, I. K., Wood, J. D., Haga, H., & Patel, T. C. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0636 · Cited by 281 · see citing works

Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration

Fu, Y., Karbaat, L., Wu, L., Leijten, J., Both, S. K., & Karperien, M. (2017) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0365 · Cited by 276 · see citing works

Long noncoding RNAs: a potential novel class of cancer biomarkers

Yarmishyn, A. A., & Kurochkin, I. V. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00145 · Cited by 273 · see citing works

Regulation of Macrophage Activation and Polarization by HCC-Derived Exosomal lncRNA TUC339

Li, X., Lei, Y., Wu, M., & Li, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102958 · Cited by 254 · see citing works

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes

Berrondo, C., Flax, J. D., Kucherov, V., Siebert, A. L., Osinski, T. L., Rosenberg, A. F., Fucile, C., Richheimer, S., & Beckham, C. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147236 · Cited by 267 · see citing works

Transcriptome of Extracellular Vesicles: State-of-the-Art

Turchinovich, A. A., Drapkina, O. M., & Tonevitsky, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00202 · Cited by 254 · see citing works

Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges

Lane, R. E., Korbie, D. J., Hill, M. M. C., & Trau, M. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0192-7 · Cited by 245 · see citing works

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)

Sato-Kuwabara, Y., Melo, S. A., Soares, F. A., & Călin, G. A. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2712 · Cited by 244 · see citing works

Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification

Fang, S., Tian, H., Li, X., Jin, D., Li, X., Kong, J., Yang, C., Yang, X., Lu, Y., Luo, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175050 · Cited by 234 · see citing works

Modulation of hypoxia-signaling pathways by extracellular long non-coding RNA regulator of reprogramming

Takahashi, K., Yan, I. K., Haga, H., & Patel, T. C. (2014) · Journal of Cell Science · doi:10.1242/jcs.141069 · Cited by 231 · see citing works

Emerging roles of exosomes during epithelial–mesenchymal transition and cancer progression

Greening, D. W., Gopal, S. K., Mathias, R. A., Liu, L., Sheng, J., Zhu, H., & Simpson, R. J. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.008 · Cited by 220 · see citing works

Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

Grammatikakis, I., Panda, A., Abdelmohsen, K., & Gorospe, M. (2014) · Aging · doi:10.18632/aging.100710 · Cited by 207 · see citing works

LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions

Barbagallo, C., Brex, D., Caponnetto, A., Cirnigliaro, M., Scalia, M., Magnano, A., Caltabiano, R., Barbagallo, D., Biondi, A., Cappellani, A., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.009 · Cited by 222 · see citing works

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Sahoo, S., Adamiak, M., Mathiyalagan, P., Kenneweg, F., Kafert-Kasting, S., & Thum, T. (2021) · Circulation · doi:10.1161/circulationaha.120.049254 · Cited by 212 · see citing works

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

Parasramka, M. A., Maji, S., Matsuda, A., Yan, I. K., & Patel, T. C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.004 · Cited by 209 · see citing works

Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease

Koeck, E. S., Iordanskaia, T., Sevilla, S., Ferrante, S. C., Hubal, M. J., Freishtat, R. J., & Nadler, E. P. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.06.050 · Cited by 210 · see citing works

Non-coding RNAs regulation of macrophage polarization in cancer

Mohapatra, S., Pioppini, C., Özpolat, B., & Călin, G. A. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01313-x · Cited by 206 · see citing works

LncRNAs regulate metabolism in cancer

Lin, W., Zhou, Q., Wang, C., Zhu, L., Bi, C., Zhang, S., Wang, X., & Jin, H. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.40769 · Cited by 202 · see citing works

Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2

Lang, H., Hu, G., Zhang, B., Kuang, W., Chen, Y., Wu, L., & Xu, G. (2017) · Oncology Reports · doi:10.3892/or.2017.5742 · Cited by 201 · see citing works

Circulating lncRNA H19 in plasma as a novel biomarker for breast cancer

Zhang, K., Luo, Z., Zhang, Y., Zhang, L., Wu, L., Liu, L., Yang, J., Song, X., & Liu, J. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160630 · Cited by 199 · see citing works

Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer

Weber, D. G., Johnen, G., Casjens, S., Bryk, O., Pesch, B., Jöckel, K., Kollmeier, J., & Brüning, T. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-518 · Cited by 196 · see citing works

Exosomal lncRNAs as new players in cell-to-cell communication

Dragomir, M. P., Chen, B., & Călin, G. A. (2018) · Translational Cancer Research · doi:10.21037/tcr.2017.10.46 · Cited by 194 · see citing works

Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer

Zhang, K., Shi, H., Xi, H., Wu, X., Cui, J., Gao, Y., Liang, W., Hu, C., Liu, Y., Li, J., et al. (2016) · Theranostics · doi:10.7150/thno.16044 · Cited by 192 · see citing works

Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression

Wu, L.-J., Zhang, X., Zhang, B., Shi, H., Yuan, X., Sun, Y., Pan, Z.-J., Qian, H., & Xu, W.-R. (2016) · Tumor Biology · doi:10.1007/s13277-016-5071-5 · Cited by 177 · see citing works

Long noncoding RNA in liver diseases

Takahashi, K., Yan, I., Haga, H., & Patel, T. (2014) · Hepatology · doi:10.1002/hep.27043 · Cited by 184 · see citing works

Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice

Haga, H., Yan, I. K., Takahashi, K., Matsuda, A., & Patel, T. C. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0226 · Cited by 181 · see citing works

Progress and Prospects of Long Noncoding RNAs (lncRNAs) in Hepatocellular Carcinoma

Li, C., Chen, J., Zhang, K., Feng, B., Wang, R., & Chen, L. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430109 · Cited by 179 · see citing works

The therapeutic and diagnostic role of exosomes in cardiovascular diseases

Zamani, P., Fereydouni, N., Butler, A. E., Navashenaq, J. G., & Sahebkar, A. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.10.010 · Cited by 177 · see citing works

Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs

Lee, H., Zhang, D., Zhu, Z., Cruz, C. S. D., & Jin, Y. (2016) · Scientific Reports · doi:10.1038/srep35250 · Cited by 173 · see citing works

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

Xavier, C. P. R., Caires, H. R., Barbosa, M. A. G., Bergantim, R., Guimarães, J. E., & Vasconcelos, M. H. (2020) · Cells · doi:10.3390/cells9051141 · Cited by 175 · see citing works

Circulating CUDR , LSINCT ‐5 and PTENP 1 long noncoding RNA s in sera distinguish patients with gastric cancer from healthy controls

Dong, L., Qi, P., Xu, M., Ni, S., Huang, D., Xu, Q., Weng, W., Tan, C., Sheng, W., Zhou, X., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29484 · Cited by 167 · see citing works

RNA Biomarkers: Frontier of Precision Medicine for Cancer

Xi, X., Li, T., Huang, Y., Sun, J., Zhu, Y., Yang, Y., & Lu, Z. J. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010009 · Cited by 160 · see citing works

Tumour cell–derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth

Haga, H., Yan, I. K., Takahashi, K., Wood, J. D., Zubair, A. C., & Patel, T. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.24900 · Cited by 159 · see citing works

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Ahmadi, M., & Rezaie, J. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02426-5 · Cited by 158 · see citing works

Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats

Alzahrani, F. A., El‐Magd, M. A., Abdelfattah‐Hassan, A., Saleh, A. A., Saadeldin, I. M., El‐Shetry, E. S., Badawy, A. A., & Alkarim, S. (2018) · Stem Cells International · doi:10.1155/2018/8058979 · Cited by 157 · see citing works

Circulating RNAs as new biomarkers for detecting pancreatic cancer

Kishikawa, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8527 · Cited by 152 · see citing works

MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease

Xue, M., Zhuo, Y., & Shan, B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7046-9_1 · Cited by 154 · see citing works

The Clinical Relevance of Long Non-Coding RNAs in Cancer

da Silva, A. M., Bullock, M. D., & Călin, G. A. (2015) · Cancers · doi:10.3390/cancers7040884 · Cited by 150 · see citing works

Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease

Jansen, F., Li, Q., Pfeifer, A., & Werner, N. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.08.004 · Cited by 146 · see citing works

Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies

Fatima, F., & Nawaz, M. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010010 · Cited by 144 · see citing works

Identification of Cancer-Related Long Non-Coding RNAs Using XGBoost With High Accuracy

Zhang, X., Li, T., Wang, J., Li, J., Chen, L., & Liu, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00735 · Cited by 142 · see citing works

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

Sutaria, D. S., Badawi, M., Phelps, M. A., & Schmittgen, T. D. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2123-5 · Cited by 140 · see citing works

Circulating biomarkers to monitor cancer progression and treatment

Rapisuwon, S., Vietsch, E. E., & Wellstein, A. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.004 · Cited by 138 · see citing works

SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming

Li, Y., Zhao, Z., Liu, W., & Li, X. (2020) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-020-03244-7 · Cited by 137 · see citing works

Novel Genetic and Epigenetic Biomarkers of Prognostic and Predictive Significance in Stage II/III Colorectal Cancer

Luo, X.-J., Zhao, Q., Liu, J. S., Zheng, J., Qiu, M., Ju, H., & Xu, R. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.12.017 · Cited by 137 · see citing works

Unpacking extracellular vesicles: RNA cargo loading and function

Dellar, E. R., Hill, C., Melling, G. E., Carter, D. R. F., & Baena-López, L. A. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.40 · Cited by 138 · see citing works

Exosome: Function and Role in Cancer Metastasis and Drug Resistance

Zhang, C., Ji, Q., Yang, Y., Li, Q., & Wang, Z. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818763450 · Cited by 134 · see citing works

Exosomes in hepatocellular carcinoma: a new horizon

Chen, R., Xu, X., Tao, Y., Qian, Z., & Yu, Y. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-018-0315-1 · Cited by 136 · see citing works

Exosomes and Their Role in Cancer Progression

Osaki, M., & Okada, F. (2019) · Yonago acta medica · doi:10.33160/yam.2019.06.002 · Cited by 134 · see citing works

The functional roles of exosomal long non-coding RNAs in cancer

Wang, M., Zhou, L., Yu, F., Zhang, Y., Li, P., & Wang, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03018-3 · Cited by 132 · see citing works

Exosomes and Hepatocellular Carcinoma: From Bench to Bedside

Sasaki, R., Kanda, T., Yokosuka, O., Kato, N., Matsuoka, S., & Moriyama, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061406 · Cited by 128 · see citing works

Sources and Functions of Extracellular Small RNAs in Human Circulation

Fritz, J. V., Heintz‐Buschart, A., Ghosal, A., Wampach, L., Etheridge, A., Galas, D. J., & Wilmes, P. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050711 · Cited by 124 · see citing works

CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression

Wang, Z., Zhao, K., Hackert, T., & Zöller, M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00097 · Cited by 123 · see citing works

A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls

Wu, Y., Yq, W., Weng, W.-W., Zhang, Q.-Y., Xq, Y., Gan, H.-L., Yang, Y.-S., Zhang, P.-P., Sun, M., Xu, M.-D., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.48 · Cited by 118 · see citing works

HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape

Han, Q., Zhao, H., Yu, J., Yin, C., & Zhang, J. (2019) · Cells · doi:10.3390/cells8060558 · Cited by 119 · see citing works

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

Devhare, P. B., & Ray, R. B. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.001 · Cited by 114 · see citing works

Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

Kosaka, N., Kogure, A., Yamamoto, T., Urabe, F., Usuba, W., Prieto‐Vila, M., & Ochiya, T. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0219-1 · Cited by 110 · see citing works

Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment

Chen, H., Zhang, C., Wang, H., & Zhao, L. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1887552 · Cited by 111 · see citing works

Upregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma

Shi, W., Wu, Q., Li, S., Yang, T., Liu, Z.-H., Tong, Y., Tuo, L., Wang, S., & Cao, X. (2015) · Tumor Biology · doi:10.1007/s13277-014-2863-3 · Cited by 108 · see citing works

Blockade of lncRNA‐ASLNCS5088–enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation

Chen, J., Zhou, R.-P., Liang, Y.-M., Fu, X.-J., Wang, D.-R., & Wang, C. (2019) · The FASEB Journal · doi:10.1096/fj.201901610 · Cited by 97 · see citing works

The Role of Extracellular Vesicles: An Epigenetic View of the Cancer Microenvironment

Qian, Z., Shen, Q., Yang, X., Qiu, Y., & Zhang, W. (2015) · BioMed Research International · doi:10.1155/2015/649161 · Cited by 106 · see citing works

Droplet digital PCR improves urinary exosomal miRNA detection compared to real-time PCR

Wang, C., Ding, Q., Plant, P. J., Basheer, M. F., Yang, C., Tawedrous, E., Krizova, A., Boulos, C., Farag, M. S., Cheng, Y., et al. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.03.008 · Cited by 105 · see citing works

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Sutaria, D. S., Jiang, J., Elgamal, O. A., Pomeroy, S. M., Badawi, M. A., Zhu, X., Pavlovicz, R. E., Azevedo‐Pouly, A. C. P., Chalmers, J. J., Li, C., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1333882 · Cited by 104 · see citing works

Long non-coding RNAs as biomarkers and therapeutic targets: Recent insights into hepatocellular carcinoma

Qiu, L., Tang, Q., Li, G., & Chen, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.007 · Cited by 102 · see citing works

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

Carotenuto, P., Fassan, M., Pandolfo, R., Lampis, A., Vicentini, C., Cascione, L., Paulus-Hock, V., Boulter, L., Guest, R. V., Quagliata, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312278 · Cited by 101 · see citing works

Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

Lee, H., Abston, E. D., Zhang, D., Rai, A., & Jin, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00924 · Cited by 100 · see citing works

The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma

Yang, N., Li, S., Li, G., Zhang, S., Tang, X., Ni, S., Jian, X.-M., Xu, C., Zhu, J., & Lu, M. (2016) · Oncotarget · doi:10.18632/oncotarget.12465 · Cited by 101 · see citing works

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer

Mohankumar, S., & Patel, T. C. (2015) · Briefings in Functional Genomics · doi:10.1093/bfgp/elv058 · Cited by 98 · see citing works

Herpesviruses hijack host exosomes for viral pathogenesis

Sadeghipour, S., & Mathias, R. A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.03.005 · Cited by 97 · see citing works

The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer

Ke, D., Li, H., Zhang, Y., An, Y., Fu, H., Fang, X., & Zheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15628 · Cited by 94 · see citing works

Pancreatic cancer stem cell markers and exosomes - the incentive push

Heiler, S., Wang, Z., & Zöller, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i26.5971 · Cited by 91 · see citing works

Role of extracellular vesicles in liver diseases and their therapeutic potential

Kostallari, E., Valainathan, S. R., Biquard, L., Shah, V. H., & Rautou, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.026 · Cited by 92 · see citing works

New Insights into the Epigenetics of Hepatocellular Carcinoma

Wahid, B., Ali, A., Rafique, S., & Idrees, M. (2017) · BioMed Research International · doi:10.1155/2017/1609575 · Cited by 91 · see citing works

Extracellular RNAs: A New Awareness of Old Perspectives

Sadik, N., Cruz, L., Gurtner, A., Rodosthenous, R. S., Dusoswa, S. A., Ziegler, O., van Solinge, T. S., Wei, Z., Salvador, A. M., György, B., et al. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7652-2_1 · Cited by 90 · see citing works

Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability

Hewson, C., Capraro, D., Burdach, J., Whitaker, N. J., & Morris, K. V. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.06.001 · Cited by 90 · see citing works

Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis

Xu, J.-S., Liao, K.-L., & Zhou, W.-M. (2018) · Stem Cells International · doi:10.1155/2018/4837370 · Cited by 87 · see citing works

Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry

Danielson, K., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., Khoory, J. A., Kreimer, S. D., Ivanov, A. R., Mantel, P., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144678 · Cited by 84 · see citing works

Characters, functions and clinical perspectives of long non-coding RNAs

Wu, R., Su, Y., Wu, H., Dai, Y., Zhao, M., & Lu, Q. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1179-y · Cited by 84 · see citing works

LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential

Begolli, R., Sideris, N., & Giakountis, A. (2019) · Cancers · doi:10.3390/cancers11101524 · Cited by 84 · see citing works

The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis

Yu, J., Han, J., Zhang, J., Li, G., Liu, H., Cui, X., Xu, Y., Li, T., Liu, J., & Wang, C. (2016) · Medicine · doi:10.1097/md.0000000000004436 · Cited by 79 · see citing works

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

Chen, X., Tang, F. R., Arfuso, F., Cai, W.-Q., Ma, Z., Yang, J., & Sethi, G. (2019) · Biomolecules · doi:10.3390/biom10010066 · Cited by 79 · see citing works

Exosome-Based Treatment for Atherosclerosis

Heo, J., & Kang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23021002 · Cited by 79 · see citing works

Papillary thyroid cancer–derived exosomes contain miRNA-146b and miRNA-222

Lee, J. C., Zhao, J., Gundara, J. S., Serpell, J. W., Bach, L. A., & Sidhu, S. B. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.02.027 · Cited by 79 · see citing works

Extracellular vesicle–derived LINC02313 stabilizes HNRNPC to drive PKM2-dependent glycolytic reprogramming and proliferation in hepatocellular carcinoma

Xie, L., Zhang, W., Ning, K., Pan, C., Lv, L., Wang, R., Liu, B., Tang, Y., Song, D., Yang, Y., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08808-5

[Advances in the role of exosome-derived long non-coding RNAs in hepatocellular carcinoma].

Zhou, C., & Wang, C. (2019) · PubMed · doi:10.3760/cma.j.issn.1007-3418.2019.01.019

Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles

Zhang, W., Liu, Y., Jiang, J. D., Tang, Y., Tang, Y., & Liang, X. (2020) · Cancer Science · doi:10.1111/cas.14494 · Cited by 45 · see citing works

Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion

Cao, S., Zheng, H., Sun, B., Wang, Z., Liu, T., Guo, D., & Shen, Z. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i35.5283 · Cited by 58 · see citing works

Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies

Fatima, F., & Nawaz, M. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010010 · Cited by 144 · see citing works