IL‐20 and IL‐20R1 antibodies protect against liver fibrosis
Open accessAbstract
Interleukin (IL)-20 is a proinflammatory cytokine of the IL-10 family and involved in rheumatoid arthritis, atherosclerosis, stroke, and osteoporosis. However, the pathophysiological roles of IL-20 in liver injury have not been extensively studied. We explored the involvement of IL-20 in liver injury and the therapeutic potential of IL-20 antagonists for treating liver fibrosis. Compared with normal liver tissue from healthy individuals, the amount of IL-20 was much higher in hepatocytes and hepatic stellate cells in liver biopsies from patients with fibrosis, cirrhosis, and hepatocellular carcinoma. Carbon tetrachloride (CCl 4) treatment induced IL-20 that further up-regulated the expression of transforming growth factor (TGF)-β1 and p21 WAF1 and resulted in cell cycle arrest in the Clone-9 rat hepatocyte cell line. IL-20 activated quiescent rat hepatic stellate cells (HSCs) and up-regulated TGF-β1 expression. IL-20 also increased TGF-β1, tumor necrosis factor (TNF)-α, and type I collagen (Col-I) expression, and promoted the proliferation and migration of activated HSCs. Serum IL-20 was significantly elevated in mice with short-term and long-term CCl 4-induced liver injury. In mice with short-term liver injury, anti-IL-20 monoclonal antibody (7E) and anti-IL-20 receptor (IL-20R1) monoclonal antibody (51D) attenuated hepatocyte damage caused by CCl 4, TGF-β1, and chemokine production. In mice with long-term liver injury, 7E and 51D inhibited CCl 4-induced cell damage, TGF-β1 production, liver fibrosis, HSC activation, and extracellular matrix accumulation, which was caused by the reduced expression of tissue inhibitors of metalloproteinases as well as increased metalloproteinase expression and Col-I production. IL-20R1-deficient mice were protected from short-term and long-term liver injury. Conclusion: We identified a pivotal role of IL-20 in liver injury and showed that 7E and 51D may be therapeutic for liver fibrosis. (Hepatology 2014;60:1003–1014)
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Cytokine-mediated activation is indispensable for HSC profibrotic functions.
“Multiple mechanisms have been implicated in HSC profibrotic functions, but cytokine‐mediated activation is indispensable.( 72 )”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [72]
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Cites
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765 · see citing works
Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480 · see citing works
I nterleukin -10 and R elated C ytokines and R eceptors
Pestka, S., Krause, C. D., Sarkar, D., Walter, M. R., Shi, Y., & Fisher, P. B. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104622 · Cited by 1,097 · see citing works
TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
Moses, H. L., Yang, E. Y., & Pietenpol, J. A. (1990) · Cell · doi:10.1016/0092-8674(90)90155-8 · Cited by 959 · see citing works
Management of Cirrhosis and Ascites
Ginès, P., Cárdenas, A., Arroyo, V., & Rodés, J. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035021 · Cited by 768 · see citing works
Apoptosis: The nexus of liver injury and fibrosis
Canbay, A. E., Friedman, S. L., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20051 · Cited by 529 · see citing works
Moustakas, A., & Kardassis, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6733 · Cited by 354 · see citing works
Casini, A., Ceni, E., Salzano, R., Biondi, P., Parola, M., Galli, A., Foschi, M., Caligiuri, A., Pinzani, M., & Surrenti, C. (1997) · Hepatology · doi:10.1002/hep.510250218 · Cited by 302 · see citing works
Albrecht, J. H., Poon, R. Y. C., Ahonen, C. L., Rieland, B. M., Deng, C., & Crary, G. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201728 · Cited by 198 · see citing works
Monocytes and Macrophages as Cellular Targets in Liver Fibrosis
Heymann, F., Trautwein, C., & Tacke, F. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809789352230 · Cited by 187 · see citing works
Physiology and pathophysiology of liver inflammation, damage and repair.
Ramadori, G. P., Moriconi, F., Malik, I. A., & Dudás, J. (2008) · PubMed · Cited by 183 · see citing works
Pinzani, M., & Geñtilini, P. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007128 · Cited by 179 · see citing works
Wells, R. G. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g845 · Cited by 152 · see citing works
Function of interleukin‐20 as a proinflammatory molecule in rheumatoid and experimental arthritis
Hsu, Y., Li, H. H., Hsieh, M., Liu, M.-F., Huang, K., Chin, L.-S., Chen, P., Cheng, H., & Chang, M. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22039 · Cited by 145 · see citing works
Self-citationLu, X., Gilbert, L. C., He, X., Rubin, J. E., & Nanes, M. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507804200 · Cited by 135 · see citing works
Liver Transplantation: The Current Situation
Adam, R. A., & Hoti, E. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1192052 · Cited by 134 · see citing works
Interleukin-20 promotes angiogenesis in a direct and indirect manner
Hsieh, M., Chen, W.-Y., Jiang, M.-J., Cheng, B.-C., Huang, T.-Y., & Chang, M.-S. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364291 · Cited by 111 · see citing works
Self-citationDetection of IL-20 and its receptors on psoriatic skin
Wei, C.-C., Chen, W., Wang, Y.-C., Chen, P., Lee, J. Y., Wong, T., Chen, W. C., Wu, J.-C., Chen, G.-Y., Chang, M., et al. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.06.012 · Cited by 109 · see citing works
Self-citationChen, W., Cheng, B., Jiang, M. J., Hsieh, M., & Chang, M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000232502.88144.6f · Cited by 92 · see citing works
Self-citationHsu, Y., Chen, W., Chan, C.-H., Wu, C., Sun, Z., & Chang, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102234 · Cited by 86 · see citing works
Self-citationIL-20: biological functions and clinical implications
Wei, C.-C., Hsu, Y., Li, H.-H., Wang, Y.-C., Hsieh, M., Chen, W., Hsing, C., & Chang, M. (2006) · Journal of Biomedical Science · doi:10.1007/s11373-006-9087-5 · Cited by 82 · see citing works
Self-citationIL-20 Is Regulated by Hypoxia-Inducible Factor and Up-Regulated after Experimental Ischemic Stroke
Chen, W., & Chang, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803653 · Cited by 79 · see citing works
Self-citationExpression of cyclin-dependent kinase inhibitor p21 in human liver
Crary, G. S., & Albrecht, J. H. (1998) · Hepatology · doi:10.1002/hep.510280320 · Cited by 62 · see citing works
Interleukin‐20 antibody is a potential therapeutic agent for experimental arthritis
Hsu, Y., & Chang, M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27689 · Cited by 59 · see citing works
Self-citationSommerfeld, A., Reinehr, R., & Häussinger, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005355 · Cited by 53 · see citing works
Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice
Hsu, Y., Tsai, C.-F., Chuang, W.-C., Chen, W., Ho, Y., & Lu, F. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.03.039 · Cited by 51 · see citing works
Self-citationInterleukin-20 targets renal mesangial cells and is associated with lupus nephritis
Li, H.-H., Cheng, H., Sun, K., Wei, C.-C., Li, C., Chen, W.-C., Wu, W.-M., & Chang, M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.07.006 · Cited by 47 · see citing works
Self-citationLi, H. H., Hsu, Y.-H., Wei, C.-C., Lee, P.-T., Chen, W.-C., & Chang, M. S. (2008) · Genes and Immunity · doi:10.1038/gene.2008.28 · Cited by 42 · see citing works
Self-citationNeubauer, K., Ritzel, A., Saile, B., & Ramadori, G. P. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00203-0 · Cited by 32 · see citing works
Immune cell-mediated liver injury
Corazza, N., Badmann, A., & Lauer, C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0168-1 · Cited by 27 · see citing works
Oh, Y.-T., Chun, K. H., Park, B. D., Choi, J., & Lee, S. K. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0066-8 · Cited by 27 · see citing works
Interleukin-20 targets renal cells and is associated with chronic kidney disease
Wei, C.-C., Li, H.-H., Hsu, Y., Hsing, C., Sung, J., & Chang, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.039 · Cited by 27 · see citing works
Self-citationInhibiting Interleukin-19 Activity Ameliorates Esophageal Squamous Cell Carcinoma Progression
Hsing, C., Kwok, F. A., Cheng, H.-C., Li, C., & Chang, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075254 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004;4:583-594.
- Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleu- kin-10 and related cytokines and receptors. Annu Rev Immunol 2004; 22:929-979.
Cited by
Sorted by citations
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works
Hepatic inflammation and fibrosis: Functional links and key pathways
Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
Rutz, S., Wang, X., & Ouyang, W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3766 · Cited by 410 · see citing works
Fibrosis Related Inflammatory Mediators: Role of the IL‐10 Cytokine Family
Sziksz, E., Pap, D., Lippai, R., Beres, N. J., Fekete, A., Szabo, A. J., & Vannay, Á. (2015) · Mediators of Inflammation · doi:10.1155/2015/764641 · Cited by 268 · see citing works
Hepatic Stellate Cells and Hepatocarcinogenesis
Barry, A. E., Baldeosingh, R., Lamm, R. J., Patel, K., Zhang, K., Dominguez, D. A., Kirton, K. J., Shah, A. P., & Dang, H. T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00709 · Cited by 155 · see citing works
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
He, Y., Hwang, S., Ahmed, Y. A., Feng, D., Li, N., Ribeiro, M. D. C., Lafdil, F., Kisseleva, T., Szabó, G., & Gao, B. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00580-w · Cited by 136 · see citing works
The Emerging Role of B Cells in the Pathogenesis of NAFLD
Barrow, F., Khan, S., Wang, H., & Revelo, X. S. (2021) · Hepatology · doi:10.1002/hep.31889 · Cited by 126 · see citing works
Food components with antifibrotic activity and implications in prevention of liver disease
Bae, M., Park, Y., & Lee, J. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.11.003 · Cited by 93 · see citing works
Wang, K., Yang, X., Wu, Z.-J., Wang, H., Li, Q., Mei, H., You, R., & Zhang, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00240 · Cited by 85 · see citing works
Baghaei, K., Mazhari, S., Tokhanbigli, S., Parsamanesh, G., Alavifard, H., Schaafsma, D., & Ghavami, S. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.12.012 · Cited by 82 · see citing works
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
Lu, S.-W., Pan, H.-C., Hsu, Y., Chang, K., Wu, L., Chen, W., & Chang, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18244-8 · Cited by 76 · see citing works
Self-citationYu, F., Zheng, J., Mao, Y., Dong, P., Li, G., Lu, Z., Guo, C., Liu, Z., & Fan, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.124 · Cited by 76 · see citing works
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis: Updated
Dewidar, B., Soukupová, J., Fabregat, I., & Dooley, S. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0089-8 · Cited by 71 · see citing works
Interleukin-20 is involved in dry eye disease and is a potential therapeutic target
Wang, H.-H., Chen, W., Huang, Y.-H., Hsu, S., Tsao, Y., Hsu, Y., & Chang, M. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00821-2 · Cited by 67 · see citing works
Self-citationKey Players of Hepatic Fibrosis
Dawood, R. M., El-Meguid, M. A., Salum, G. M., & Awady, M. K. E. (2020) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2020.0059 · Cited by 66 · see citing works
Wu, B., Liu, J., Li, Y., & Li, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4395 · Cited by 62 · see citing works
Park, H., Lee, S.-H., Lee, J., Moon, H., & Ro, S. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813764 · Cited by 59 · see citing works
The Space of Disse: The Liver Hub in Health and Disease
Sanz-García, C., Fernández-Iglesias, A., Gracia-Sancho, J., Arráez-Aybar, L. A., Nevzorova, Y. A., & Cubero, F. J. (2021) · Livers · doi:10.3390/livers1010002 · Cited by 57 · see citing works
Xu, S., Mao, Y., Wu, J., Feng, J., Li, J., Wu, L., Yu, Q., Zhou, Y., Zhang, J., Chen, J., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15175 · Cited by 54 · see citing works
Liu, H., Wang, B., Zhang, J., Zhang, S., Wang, Y., Zhang, J., Lv, C., & Song, X. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.500 · Cited by 49 · see citing works
Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy
Chen, L.-H., Yeh, Y., Chen, Y., Hsu, Y., Wang, H.-H., Lin, P., Chang, L.-Y., Lin, C. K., Chang, M., & Shen, M. (2020) · Pain · doi:10.1097/j.pain.0000000000001831 · Cited by 41 · see citing works
Self-citationIL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target
Lin, T.-Y., & Hsu, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031009 · Cited by 38 · see citing works
Self-citationTao, Y., Tian, K., Chen, J., Tan, D., Liu, Y., Xiong, Y., Chen, Z., & Tian, Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2630357 · Cited by 36 · see citing works
He, Y., Feng, D., Hwang, S., Mackowiak, B., Wang, X., Xiang, X., Rodrigues, R. M., Fu, Y., Ma, J., Ren, T., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.02.004 · Cited by 36 · see citing works
Lee, J., Hsu, Y., Chiu, Y.-S., Jou, I., & Chang, M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01814-4 · Cited by 35 · see citing works
Self-citationNonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk
Barbarroja, N., Ruiz-Ponce, M., Cuesta-López, L., Pérez-Sánchez, C., López-Pedrera, C., de la Rosa, I. A., & Collantes‐Estévez, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997270 · Cited by 31 · see citing works
Targeting Hepatic Fibrosis in Autoimmune Hepatitis
Montaño‐Loza, A. J., Thandassery, R. B., & Czaja, A. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4254-7 · Cited by 30 · see citing works
Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation
Weng, Y.-H., Chen, W., Lin, Y.-L., Wang, J., & Chang, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00968 · Cited by 29 · see citing works
Self-citationInterleukin-19 as an Immunoregulatory Cytokine
Fujimoto, Y., Kuramoto, N., Yoneyama, M., & Azuma, Y. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200424151528 · Cited by 25 · see citing works
Interleukin-24 protects against liver injury in mouse models
Wang, H.-H., Huang, J.-H., Sue, M.-H., Ho, W.-C., Hsu, Y.-H., Chang, K., & Chang, M. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103213 · Cited by 24 · see citing works
Self-citationTargeting Certain Interleukins as Novel Treatment Options for Liver Fibrosis
An, S. Y., Petrescu, A. D., & DeMorrow, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.645703 · Cited by 21 · see citing works
The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease
Li, H., & Xia, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447391 · Cited by 20 · see citing works
Liu, C., Yuan, X., Tao, L., Cheng, Z., Dai, X., Sheng, X., & Xue, D. (2015) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-015-0733-1 · Cited by 18 · see citing works
RetractedIL-20 bone diseases involvement and therapeutic target potential
Wang, H.-H., Hsu, Y., & Chang, M. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0439-z · Cited by 18 · see citing works
Self-citationInterleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway
Wang, Y., Sun, S., Wang, K., Zhang, M., Li, M., Zan, Y., Huang, Q., Wu, S., Zhao, W., Xu, W. D., et al. (2022) · Mediators of Inflammation · doi:10.1155/2022/6755407 · Cited by 18 · see citing works
Li, X., Huang, J., Chen, X., Lai, X., Huang, Z., Li, Y., Li, S., Chang, L., & Zhang, G. (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12003 · Cited by 17 · see citing works
Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation
Dayton, J. R., Yuan, Y., Pacumio, L. P., Dorflinger, B. G., Yoo, S. C., Olson, M. J., Hernández-Suárez, S. I., McMahon, M. M., & Cruz-Orengo, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.683687 · Cited by 16 · see citing works
Zhou, L., Shang, M., Shi, M., Zhao, L., Lin, Z., Chen, T., Wu, Y., Tang, Z., Sun, H., Yu, J., et al. (2015) · Parasitology Research · doi:10.1007/s00436-015-4782-7 · Cited by 16 · see citing works
Ghanim, M. A., Amer, J., Salhab, A., & Jaradat, N. A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112942 · Cited by 12 · see citing works
Meng, B., Yang, B., Qu, Y., Liu, Y., Wu, D., Fu, C., He, Y., Chen, X., Liu, C., Kou, X., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043810 · Cited by 9 · see citing works
Mayer, C., Bergholdt, R., Cucak, H., Rolin, B. C., Sams, A. G., & Rosendahl, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131306 · Cited by 10 · see citing works
Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes
Fu, H., Xu, J., Chen, J., Li, G., Zhao, X.-B., & Chen, P. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8451 · Cited by 10 · see citing works
Bao, H., Li, X., Lai, X., Chen, X., Li, Y., Yao, Z., Huang, Z., Huang, J., Chang, L., & Zhang, G. (2022) · Inflammation Research · doi:10.1007/s00011-022-01634-7 · Cited by 9 · see citing works
Husain, H., Ahmad, R., Khan, A., Inamuddin, I., & Asiri, A. M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.168 · Cited by 9 · see citing works
Chen, L., Yu, Y., Liu, E., Duan, L., Zhu, D., Chen, J., Dai, J. M., & Duan, Y. (2018) · Parasitology Research · doi:10.1007/s00436-018-6165-3 · Cited by 9 · see citing works
Fukui, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00027-8 · Cited by 9 · see citing works
Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1
Dang, H., Hassan, Z., Jia, Z., Wu, Y., Xiao, H., Huang, W., Guo, X., Zhao, X., Li, Y., Zou, J., et al. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.11.033 · Cited by 9 · see citing works
Anti‑IL‑20 monoclonal antibody suppresses hepatocellular carcinoma progression
Ding, W., Han, G., Jin, H., Zhan, C., Ji, Y., & Huang, X. (2018) · Oncology Letters · doi:10.3892/ol.2018.9402 · Cited by 8 · see citing works
Wang, W., Huang, X., Fan, X., Yan, J., & Luan, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11516 · Cited by 7 · see citing works
Fujimoto, Y., Kuwamura, M., & Azuma, Y. (2020) · Journal of Veterinary Medical Science · doi:10.1292/jvms.20-0344 · Cited by 6 · see citing works
IL-20 contributes to low grade inflammation and weight gain in the Psammomys obesus
Cucak, H., Thomsen, L. H., & Rosendahl, A. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.01.031 · Cited by 6 · see citing works
Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats
Liu, C., Cai, J., Cheng, Z., Dai, X., Tao, L., Zhang, J., & Xue, D. (2015) · Genetics and Molecular Research · doi:10.4238/2015.september.9.15 · Cited by 5 · see citing works
Alterations in Immune Cell Profiles in the Liver in Diabetes Mellitus: A Systematic Review
Du, W., Siwan, E., Twigg, S. M., & Min, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094027 · Cited by 4 · see citing works
Un, H., Wusimanjiang, W., Zhan, W., Zhang, X., Li, M., Lei, J., Lin, R., Zhang, Y., Chen, J., & Wang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1460275 · Cited by 4 · see citing works
Moscoso, C. G., & Steer, C. J. (2019) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s213397 · Cited by 4 · see citing works
Du, X., Hua, R., He, X., Hou, W., Li, S., Yang, A., & Yang, G. (2024) · Parasites & Vectors · doi:10.1186/s13071-024-06222-8 · Cited by 3 · see citing works
Ruiz-Ponce, M., Rodríguez‐Cuenca, S., Martin-Salazar, E., Pérez‐Sánchez, C., Martinez-Moreno, J. M., Llamas-Urbano, A., Campbell, M., Romero-Zurita, L., López-Montilla, M. D., Cuesta-López, L., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118757 · Cited by 3 · see citing works
Lu, Y.-S., Chiang, P., Huang, Y.-C., Yang, S.-J., Hung, L., Medeiros, L. J., Chen, Y., Chen, T., Chang, M., & Chang, K. (2022) · Pathology · doi:10.1016/j.pathol.2022.07.007 · Cited by 3 · see citing works
Self-citationCaven, L. T., & Carabeo, R. A. (2023) · mSystems · doi:10.1128/msystems.00904-23 · Cited by 3 · see citing works
Recent progress in the pathophysiological role of interleukin-19
Fujimoto, Y., & Azuma, Y. (2019) · Folia Pharmacologica Japonica · doi:10.1254/fpj.154.66 · Cited by 2 · see citing works
The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications
Wang, K., Zhan, H.-Q., Hu, Y., Yuan, Z.-Y., Yang, J., Yang, D., Tao, L.-S., & Xu, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29853 · Cited by 2 · see citing works
Regulation of immunopathology in hepatitis B virus infection
Piconese, S., & Barnaba, V. (2015) · Nature Medicine · doi:10.1038/nm.3873 · Cited by 2 · see citing works
Karaboyun, K., Çavdar, E., İriağaç, Y., Yılmaz, A., Çelikkol, A., Avcı, O., & Seber, S. (2023) · Istanbul Medical Journal · doi:10.4274/imj.galenos.2023.59908 · Cited by 1 · see citing works
Tien, C., Wu, Y., Cheng, Y., & Hsu, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113882 · Cited by 1 · see citing works
Self-citationGuo, E., Yuan, H., Li, R., Yang, J., Liu, S., Liu, A., & Jiang, X. (2024) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2024.02.010 · Cited by 1 · see citing works
Rodrigues, P. M., Olaizola, P., & Bañales, J. M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.03.011 · Cited by 1 · see citing works
Novel approaches to identify biomechanisms in systemic sclerosis
Lopez, H. (2017) · UCL Discovery (University College London)
Az IL-10 citokincsalád szerepe a vesefibrosisban
Pap, D., Veres-Székely, A., Szebeni, B., Sziksz, E., Kiss, Z., Takács, I. M., Reusz, G., Attila, S. J., & Vannay, Á. (2019) · Hypertonia és Nephrologia · doi:10.33668/hn.23.018
Chen, S., Hung, C.-J., Hsiao, Y.-L., Tsai, Y.-P., Chang, M., Liu, H., Wang, L.-C., & Wang, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4131398/v1
Self-citationRole of Kupffer cells and other immune cells
Puengel, T., & Tacke, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00024-3
Du, J., Zhang, K., Miao, J., Yang, Y., Tian, Y., Wu, T., Tao, C., Wang, Y., & Yang, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123337
Du, X., Hua, R., He, X., Hou, W., Li, S., Yang, A., & Yang, G. (2024) · Figshare · doi:10.6084/m9.figshare.25658578
Wang, H.-H., Chen, W.-Y., Huang, Y.-H., Hsu, S.-M., Tsao, Y.-P., Hsu, Y.-H., & Chang, M.-S. (2022) · Figshare · doi:10.6084/m9.figshare.20046971
Self-citationDu, X., Hua, R., He, X., Hou, W., Li, S., Yang, A., & Yang, G. (2024) · Figshare · doi:10.6084/m9.figshare.25658666
Du, X., Hua, R., He, X., Hou, W., Li, S., Yang, A., & Yang, G. (2024) · Figshare · doi:10.6084/m9.figshare.26709251
Wang, H.-H., Chen, W.-Y., Huang, Y.-H., Hsu, S.-M., Tsao, Y.-P., Hsu, Y.-H., & Chang, M.-S. (2022) · Figshare · doi:10.6084/m9.figshare.20046968
Self-citationChen, S., Hung, C.-H., Hsiao, Y.-L., Tsai, Y.-P., Chang, M.-S., Liu, C., Wang, L.-C., & Wang, S.-M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1700154
Self-citation
- Authors
- Chiu, Y.-S., Wei, C.-C., Lin, Y.-J., Hsu, Y.-H., & Chang, M.-S.
- Affiliations
- National Cheng Kung University (TW)
- Corresponding author
- Chang, Ming-Shi
- Venue
- Hepatology
- Published
- 2014-09
- Volume
- 60
- Issue
- 3
- Pages
- 1003-1014
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2119403715
- Cited by
- 77
- References
- 35
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 12 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 1 · 2015: 8 · 2014: 2
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cheng Kung University
- Taichung Veterans General Hospital
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- IL-20, liver fibrosis, hepatocyte injury, hepatic stellate cells, TGF-β1, carbon tetrachloride, extracellular matrix accumulation, tissue inhibitors of metalloproteinases, type I collagen, hepatocellular carcinoma, liver cirrhosis
- MeSH terms
- Animals, Antibodies, Monoclonal, Carbon Tetrachloride Poisoning, Cell Line, Disease Models, Animal, Humans, Interleukins, Liver Cirrhosis, Male, Mice, Inbred C57BL, Case-Control Studies, Rats, Sprague-Dawley, Receptors, Interleukin, Mice, Rats, Chemical and Drug Induced Liver Injury
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