Cited by 482Liver physiology and pathologyLiver Disease and TransplantationLiver Disease Diagnosis and Treatment

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Liver sinusoidal endothelial cells in hepatic fibrosis

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DeLeve, Laurie D.·2015·Hepatology

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Abstract

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is also permissive for hepatic stellate cell activation and fibrosis. Thus, dysregulation of the LSEC phenotype is a critical step in the fibrotic process. Both a vascular endothelial growth factor (VEGF)‐stimulated, nitric oxide (NO)‐independent pathway and a VEGF‐stimulated NO‐dependent pathway are necessary to maintain the differentiated LSEC phenotype. The NO‐dependent pathway is impaired in capillarization and activation of this pathway downstream from NO restores LSEC differentiation in vivo . Restoration of LSEC differentiation in vivo promotes HSC quiescence, enhances regression of fibrosis, and prevents progression of cirrhosis. (H epatology 2015;61:1740–1746)

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Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · cited 1×
“In vivo studies have suggested that activated HSCs do not revert to full quiescence upon regression of fibrosis, but that HSCs that develop a quiescent phenotype after regression of fibrosis are poised to rapidly reactivate when challenged with a fibrotic stimulus.(47) These HSCs have been termed inactivated HSCs.”
Background
Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine · doi:10.1038/82161 · Cited by 758 · cited 1×
“In normal liver, LSECs are tolerogenic (44, 45).”
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613 · cited 1×
“During chronic liver disease, Kupffer cells prevent HSC apoptosis and thereby sustain the fibrotic process.(51) Thus, there is an intricate interplay among the nonparenchymal cells that either prevents or sustains HSC activation and thereby determines fibrosis (Fig.”
Capillarization of hepatic sinusoids in man
Schaffner, F., & Popper, H. (1963) · Gastroenterology · doi:10.1016/s0016-5085(63)80130-4 · Cited by 610 · cited 1×
“INTRODUCTION Capillarization, which is when liver sinusoidal endothelial cells (LSECs) lack fenestration and develop an organized basement membrane (1), is a prelude to fibrosis.”
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
Corpechot, C., Barbu, V., Wendum, D., Kinnman, N., Rey, C., Poupon, R. Y., Housset, C., & Rosmorduc, O. (2002) · Hepatology · doi:10.1053/jhep.2002.32524 · Cited by 483 · cited 1×
“VEGF is upregulated in cirrhosis (33, 34), so that total VEGF is not rate limiting in this process.”
Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.
Jarnagin, W. R., Rockey, D. C., Koteliansky, V., Wang, S. S., & Bissell, D. M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.2037 · Cited by 452 · cited 2×
“LSECs in a bile duct ligation model make increased quantities of EIIIAfibronectin.(42) HSCs cultured on matrix conditioned by LSECs isolated from the bile duct ligation model show increased activation that is blocked by antibodies to EIIIA fibronectin.”
Background
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Carreira, C. M., Nasser, S. M., di Tomaso, E., Padera, T. P., Boucher, Y., Tomarev, S. I., & Jain, R. K. (2001) · PubMed · Cited by 444
Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic
Canbay, A., Taimr, P., Torok, N., Higuchi, H., Friedman, S., & Gores, G. J. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000069036.63405.5c · Cited by 417 · cited 1×
“During resolution of fibrosis, the decline in activated HSC is due to both reversion to quiescence and apoptosis (28, 50).”
Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats
Xie, G., Wang, X., Wang, L., Wang, L., Atkinson, R. D., Kanel, G. C., Gaarde, W. A., & DeLeve, L. D. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.017 · Cited by 410
Self-citation
Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
DeLeve, L. D., Wang, X., & Guo, Y. (2008) · Hepatology · doi:10.1002/hep.22351 · Cited by 408 · cited 5×
“Hepatocytes are unable to maintain HSC quiescence unless the culture medium is supplemented with an NO-donor, but it remains to be determined whether NO contributes to the paracrine effect of LSECs on HSC quiescence or whether other paracrine factors are necessary.(36) Our group and others have reported that NO produc…”
BackgroundMethodInfluentialSelf-citation
Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension
Rockey, D. C., & Chung, J. J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70487-1 · Cited by 408 · cited 2×
“In cirrhosis, decreased production of NO by LSECs (31) and increased production of endothelin-1 by HSCs promotes contractility of HSCs (38) and”
In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.
Nagelkerke, J. F., Barto, K. P., & van Berkel, T. J. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44160-3 · Cited by 386 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L. J., Martin, T. D., Viebig, N. K., Knolle, P. A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.671 · Cited by 358 · cited 1×
“SIGN; aka CD209L or DC-SIGN-related (DC SIGNR)] (19), and LYVE-1 (20, 21).”
Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
Shah, V. H., Törüner, M., Haddad, F., Cadelina, G. W., Papapetropoulos, A., Choo, K. K., Sessa, W. C., & Groszmann, R. J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70408-7 · Cited by 340 · cited 1×
“In capillarization, eNOS protein is unchanged, but eNOS activity is diminished with low production of NO(31) due to increased binding to caveolin.(32) Thus, the VEGF-stimulated, NO-dependent pathway is impaired.”
Background
Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues
Politz, O., Gratchev, A. N., McCourt, P., Schledzewski, K., Guillot, P., Johansson, S., Svineng, G., Franke, P., Kannicht, C., Kzhyshkowska, J. G., et al. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620155 · Cited by 310
Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
Trebicka, J., Hennenberg, M., Laleman, W., Shelest, N., Biecker, E., Schepke, M., Nevens, F., Sauerbruch, T., & Heller, J. (2007) · Hepatology · doi:10.1002/hep.21673 · Cited by 307 · cited 1×
“In the bile duct ligation model, statins increase hepatic eNOS and PKG activity,(41) decrease HSC Rho-kinase activity, and reduce portal pressure with decreased intrahepatic resistance.(41) Statin-induced up-regulation of the transcription factor KLF2 in hepatic endothelial cells increases eNOS expression, presumably…”
Background
Induction of cytokine production in naive CD4+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells☆, ☆☆
KNOLLE, P., SCHMITT, E., JIN, S., GERMANN, T., DUCHMANN, R., HEGENBARTH, S., GERKEN, G., & LOHSE, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70508-1 · Cited by 298 · cited 1×
“In normal liver, LSECs are tolerogenic (44, 45).”
Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation
DeLeve, L. D., Wang, X., Hu, L., McCuskey, M. K., & McCuskey, R. S. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00017.2004 · Cited by 296
Self-citation
Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells
van Berkel, T. J. C., de Rijke, Y. B., & Kruijt, J. K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52241-9 · Cited by 277 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1).
Yamane, A., Seetharam, L., Yamaguchi, S., Gotoh, N., Takahashi, T., Neufeld, G., & Shibuya, M. (1994) · PubMed · Cited by 251
Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats
Abraldeṣ, J. G., Rodrı́guez-Vilarrupla, A., Graupera, M., Zafra, C., García‐Calderó, H., García‐Pagán, J. C., & Bosch, J. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.020 · Cited by 245 · cited 1×
“In cirrhotic liver, statins increase hepatic eNOS activity and cGMP levels.(40) In the bile duct ligation model, statins increase hepatic eNOS and PKG activity,(41) decrease HSC Rho-kinase activity, and reduce portal pressure with decreased intrahepatic resistance.”
Background
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial–stellate cell deactivation induced by statins
Marrone, G., Russo, L., Rosado, E., Hide, D., García‐Cardeña, G., García‐Pagán, J. C., Bosch, J., & Gracia‐Sancho, J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.026 · Cited by 244 · cited 2×
“Our group and others have reported that NO produced by LSECs maintains HSC quiescence: in coculture of LSECs with HSCs, inhibition of eNOS by L-NAME blocks the ability of LSECs to maintain HSC quiescence.(36,37) However, the flaw in the interpretation of these studies is that LSECs cultured in the presence of L-NAME c…”
Background
The scavenger endothelial cell: a new player in homeostasis and immunity
Sørensen, K. K., McCourt, P., Berg, T., Crossley, C., Couteur, D. G. L., Wake, K., & Smedsrød, B. H. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00686.2011 · Cited by 233
Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells
Smedsrød, B. H., Melkko, J., Araki, N., Sano, H., & Horiuchi, S. (1997) · Biochemical Journal · doi:10.1042/bj3220567 · Cited by 224 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulfate, formaldehydetreated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis(9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein,(12-14) plasma coagulation…”
Background
Stabilin-1 and −2 constitute a novel family of fasciclin-like hyaluronan receptor homologues
Politz, O., Gratchev, A. N., McCourt, P., et al. (2002) · Biochemical Journal · doi:10.1042/bj3620155 · Cited by 216 · cited 1×
“The hyaluronan/scavenger receptor, SR-H (stabilin-1 and stabilin-2), is the main functional scavenger receptor on the LSEC (6-8).”
Alcoholic liver injury: Defenestration in noncirrhotic livers—a scanning electron microscopic study
Horn, T. D., Christoffersen, P., & Henriksen, J. H. (1987) · Hepatology · doi:10.1002/hep.1840070117 · Cited by 182 · cited 1×
“In vivo, loss of the unique fenestrated phenotype has been shown to precede onset of fibrosis in alcoholic liver injury (22), non-alcoholic fatty liver disease (23), toxic liver injury (24), and the intragastric alcohol infusion model (DeLeve LD et al, unpublished observation).”
Microenvironmental Regulation of the Sinusoidal Endothelial Cell Phenotype In Vitro
March, S., Hui, E. E., Underhill, G. H., Khetani, S., & Bhatia, S. N. (2009) · Hepatology · doi:10.1002/hep.23085 · Cited by 163 · cited 3×
“FcγIIb2 (CD32b or SE-1 (16)), clears immune complexes formed with Ig G (17).”
Characterization of a hyaluronan receptor on rat sinusoidal liver endothelial cells and its functional relationship to scavenger receptors
McCourt, P., Smedsrød, B. H., Melkko, J., & Johansson, S. (1999) · Hepatology · doi:10.1002/hep.510300521 · Cited by 144 · cited 1×
“The hyaluronan/scavenger receptor, SR-H (stabilin-1 and stabilin-2), is the main functional scavenger receptor on the LSEC (6-8).”
Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding
HANSEN, B., Longati, P., Elvevold, K., Nedredal, G. I., Schledzewski, K., Olsen, R. E., Falkowski, M., Kzhyshkowska, J. G., CARLSSON, F., & JOHANSSON, S. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.017 · Cited by 144
Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces
Falkowski, M., Schledzewski, K., Hansen, B., & Goerdt, S. (2003) · Histochemistry and Cell Biology · doi:10.1007/s00418-003-0585-5 · Cited by 139 · cited 1×
“used to identify LSECs include the expression of FcγIIb2 (17) (CD32b or anti-SE1 (16)), stabilin-2 (3, 18), liver/lymph node-specific ICAM-3-grabbing integrin [L-”
Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation
Xie, G., Choi, S. S., Syn, W., Michelotti, G. A., Swiderska, M., Karaca, G., Chan, I. S., Chen, Y., & Diehl, A. M. (2012) · Gut · doi:10.1136/gutjnl-2011-301494 · Cited by 135 · cited 1×
“Hedgehog signaling is increased in LSECs that have capillarized in vitro and inhibition of hedgehog signaling blocks culture-induced capillarization.(35) It remains to be determined experimentally how the two pathways linked to capillarization, i.”
Background
Clearance of acetyl low density lipoprotein by rat liver endothelial cells. Implications for hepatic cholesterol metabolism.
Blomhoff, R., Drevon, C. A., Eskild, W., HELGERUD, P., Norum, K. R., & Berg, T. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)47239-5 · Cited by 126 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers
Gracia-Sancho, J., Laviña, B., Rodríguez-Vilarrupla, A., García-Calderó, H., Bosch, J., & García-Pagán, J. C. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.03.014 · Cited by 125 · cited 1×
“In cirrhosis, decreased production of NO by LSECs(31) and increased production of endothelin-1 by HSCs promotes contractility of HSCs(38) and increased production of prostanoids by LSECs increases portal pressure.(39) Fig.”
Background
The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor
Malovic, I., Sφrensen, K. K., Elvevold, K., Nedredal, G. I., Paulsen, S. M., Erofeev, A. V., Smedsrød, B. H., & McCourt, P. (2007) · Hepatology · doi:10.1002/hep.21639 · Cited by 122 · cited 1×
“, denatured collagen of several types of collagen, and glycoconjugates with terminal mannose, such as lysosomal enzymes, procollagen type I carboxyterminal propeptides, and tissue type plasminogen activator.(4,5) The hyaluronan/scavenger receptor, SR-H (stabilin-1 and stabilin-2), is the main functional scavenger rece…”
Background
In Hepatic Fibrosis, Liver Sinusoidal Endothelial Cells Acquire Enhanced Immunogenicity
Connolly, M. K., Bedrosian, A. S., Malhotra, A., Henning, J. R., Ibrahim, J., Vera, V., Cieza-Rubio, N. E., Hassan, B. U., Pachter, H. L., Cohen, S., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000332 · Cited by 120 · cited 1×
“However, in fibrosis, LSECs isolated from fibrotic liver secrete proinflammatory cytokines and chemokines and induce immunogenic T cells ex vivo.(46) If confirmed in vivo, this would suggest that capillarized LSECs might promote HSC activation.”
Background
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
Martens, J., Kzhyshkowska, J. G., Falkowski, M., Schledzewski, K., Gratchev, A. N., Mansmann, U., Schmuttermaier, C., Dippel, E., Koenen, W., Riedel, F., et al. (2006) · The Journal of Pathology · doi:10.1002/path.1921 · Cited by 119
Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells
Failli, P., DeFranco, R., Caligiuri, A., Gentilini, A., Romanelli, R. G., Marra, F., Batignani, G., Guerra, C. T., Laffi, G., Geñtilini, P., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.9354 · Cited by 118
Prevention of Hepatic Fibrosis in a Murine Model of Metabolic Syndrome with Nonalcoholic Steatohepatitis
DeLeve, L. D., Wang, X., Kanel, G. C., Atkinson, R., & McCuskey, R. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070720 · Cited by 115
Self-citation
Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcγRIIb2
Mousavi, S. A., Sporstφl, M., Fladeby, C., Kjeken, R., Barois, N., & Berg, T. (2007) · Hepatology · doi:10.1002/hep.21748 · Cited by 113 · cited 2×
“FcγIIb2 (CD32b or SE-1 (16)), clears immune complexes formed with Ig G (17).”
Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells
Blomhoff, R., Eskild, W., & Berg, T. (1984) · Biochemical Journal · doi:10.1042/bj2180081 · Cited by 112 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1
Géraud, C., Schledzewski, K., Demory, A., Klein, D., Kaus, M., Peyre, F., Sticht, C., Evdokimov, K., Lu, S., Schmieder, A., et al. (2010) · Hepatology · doi:10.1002/hep.23618 · Cited by 109 · cited 1×
“Both fenestration and endocytosis persist longer in vitro in the right microenvironment.(26,27) Vascular endothelial growth factor (VEGF), derived from hepatocytes and hepatic stellate cells, is a key regulator of the LSEC phenotype, as demonstrated both in vitro and in vivo.”
Background
Nitric Oxide-independent Activation of Soluble Guanylate Cyclase by BAY 60-2770 in Experimental Liver Fibrosis
Knorr, A., Hirth‐Dietrich, C., Alonso‐Alija, C., Härter, M. W., Hahn, M. G., Keim, Y., Wunder, F., & Stasch, J. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296471 · Cited by 93 · cited 1×
“This particular sGC activator prevents HSC activation in vitro (28) and prevents hepatic fibrosis if given simultaneously with the fibrotic stimulus (48).”
Regulation of Endothelin-1 Synthesis by Endothelin-converting Enzyme-1 during Wound Healing
Shao, R., Yan, W., & Rockey, D. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3228 · Cited by 92 · cited 1×
“In cirrhosis, decreased production of NO by LSECs (31) and increased production of endothelin-1 by HSCs promotes contractility of HSCs (38) and”
Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors
Nonaka, H., Tanaka, M., Suzuki, K., & Miyajima, A. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21227 · Cited by 84 · cited 2×
“Markers that have been used to identify LSECs include the expression of FccIIb2 17 (CD32b or anti-SE-116), stabilin-2,3,18 liver/lymph node-specific ICAM-3-grabbing integrin [L-SIGN; aka CD209L or DC-SIGN-related (DC SIGNR),19 and LYVE-1.”
Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity
Xie, G., Wang, L., Wang, X., Wang, L., & DeLeve, L. D. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00302.2010 · Cited by 78 · cited 1×
“Note that periportal LSECs (top panel) have fewer fenestrae per sieve plate (average 8 fenestrae per sieve plate), but larger fenestrae than centrilobular LSECs (average 24 fenestrae per sieve plate; middle panel).(2) Smaller, nonclustered holes are endocytic vesicles.”
BackgroundSelf-citation
Evaluation of hyaluronic acid binding ability of hepatic sinusoidal endothelial cells in rats with liver cirrhosis
Tamaki, S., Ueno, T., Torimura, T., Sata, M., & Tanikawa, K. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70074-4 · Cited by 75 · cited 1×
“Endocytosis is impaired in capillarization (25), but there is not yet published evidence that the decline in endocytotic capacity precedes fibrosis or a comprehensive description of which endocytotic receptors are affected in capillarization.”
Preparation of isolated liver endothelial cells and Kupffer cells in high yield by means of an enterotoxin
Blomhoff, R., Smedsrød, B. H., Eskild, W., Granum, P. E., & Berg, T. (1984) · Experimental Cell Research · doi:10.1016/0014-4827(84)90714-6 · Cited by 67 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
A Transgenic Model for Conditional Induction and Rescue of Portal Hypertension Reveals a Role of VEGF-Mediated Regulation of Sinusoidal Fenestrations
May, D., Djonov, V., Zamir, G. A., Bala, M., Safadi, R., Sklair‐Levy, M., & Keshet, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021478 · Cited by 54 · cited 1×
“Similarly, conditional induction of a VEGF decoy receptor that sequesters VEGF and precludes VEGF signaling leads to loss of LSEC fenestration.(29) After early cirrhosis is induced in an experimental model of toxin-induced parenchymal fibrosis, the thioacetamide model, a 1-week treatment with sGC activator, normalizes…”
Background
Fibronectin Extra Domain-A Promotes Hepatic Stellate Cell Motility but Not Differentiation Into Myofibroblasts
Olsen, A. L., Sackey, B. K., Marcinkiewicz, C., Boettiger, D. C., & Wells, R. G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.038 · Cited by 50 · cited 2×
“However, recent studies suggest that EIIIA fibronectin does not play an essential role in HSC activation in vitro or in vivo, but does contribute to HSC motility.(43) The effect on HSC may contribute to a modest profibrotic effect of EIIIA in a toxin-induced model of parenchymal fibrosis, but EIIIA does not appear to…”
Background
Intracellular transport of formaldehyde-treated serum albumin in liver endothelial cells after uptake via scavenger receptors
Eskild, W., Kindberg, G. M., Smedsrød, B. H., Blomhoff, R., Norum, K. R., & Berg, T. (1989) · Biochemical Journal · doi:10.1042/bj2580511 · Cited by 45 · cited 1×
“The hyaluronan/scavenger receptor clears hyaluronan, chondroitin sulphate, formaldehyde treated serum albumin (FSA, used as a test ligand for scavenger receptor-mediated endocytosis (9-11)), procollagen type I and III N-terminal peptides, nidogen, acetylated and oxidized low density lipoprotein (12-14), plasma coagula…”
Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma
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Authors: DeLeve, L. D.
Affiliations: University of Southern California (US)
Corresponding author: DeLeve, Laurie D.
ORCID: DeLeve, Laurie D.
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-03-23
Volume: 61
Issue: 5
Pages: 1740-1746
ISSN: 0270-9139 (ISSN-L)
1527-3350
DOI: 10.1002/hep.27376
PMC: PMC4333127
OpenAlex: W1781806439
Cited by: 482
References: 50
Citations by year: 2026: 45 · 2025: 44 · 2024: 60 · 2023: 40 · 2022: 39 · 2021: 51 · 2020: 49 · 2019: 37 · 2018: 46 · 2017: 35 · 2016: 26 · 2015: 9
FWCI: 3.08
Type: journal article
Language: en
Update notices: correction (2015-07-01)
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 162 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100580, DK-66423, R01DK066423)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: liver sinusoidal endothelial cells, liver fibrosis, capillarization, endothelial fenestrations, basement membrane formation, hepatic stellate cell activation, VEGF signaling, nitric oxide, HSC quiescence, fibrosis regression, liver cirrhosis
MeSH terms: Cell Differentiation, Humans, Liver Cirrhosis, Endothelial Cells

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Liver sinusoidal endothelial cells in hepatic fibrosis

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