Cited by 482Liver physiology and pathologyLiver Disease and TransplantationLiver Disease Diagnosis and Treatment

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Liver sinusoidal endothelial cells in hepatic fibrosis

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DeLeve, Laurie D.·2015·Hepatology

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Abstract

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is also permissive for hepatic stellate cell activation and fibrosis. Thus, dysregulation of the LSEC phenotype is a critical step in the fibrotic process. Both a vascular endothelial growth factor (VEGF)‐stimulated, nitric oxide (NO)‐independent pathway and a VEGF‐stimulated NO‐dependent pathway are necessary to maintain the differentiated LSEC phenotype. The NO‐dependent pathway is impaired in capillarization and activation of this pathway downstream from NO restores LSEC differentiation in vivo . Restoration of LSEC differentiation in vivo promotes HSC quiescence, enhances regression of fibrosis, and prevents progression of cirrhosis. (H epatology 2015;61:1740–1746)

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“28 Meanwhile, LSECs can also stimulate neovascularization by secreting angiogenic factors, thereby fostering the fibrotic process.”
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Authors: DeLeve, L. D.
Affiliations: University of Southern California (US)
Corresponding author: DeLeve, Laurie D.
ORCID: DeLeve, Laurie D.
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-03-23
Volume: 61
Issue: 5
Pages: 1740-1746
ISSN: 0270-9139 (ISSN-L)
1527-3350
DOI: 10.1002/hep.27376
PMC: PMC4333127
OpenAlex: W1781806439
Cited by: 482
References: 50
Citations by year: 2026: 45 · 2025: 44 · 2024: 60 · 2023: 40 · 2022: 39 · 2021: 51 · 2020: 49 · 2019: 37 · 2018: 46 · 2017: 35 · 2016: 26 · 2015: 9
FWCI: 3.08
Type: journal article
Language: en
Update notices: correction (2015-07-01)
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 162 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100580, DK-66423, R01DK066423)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: liver sinusoidal endothelial cells, liver fibrosis, capillarization, endothelial fenestrations, basement membrane formation, hepatic stellate cell activation, VEGF signaling, nitric oxide, HSC quiescence, fibrosis regression, liver cirrhosis
MeSH terms: Cell Differentiation, Humans, Liver Cirrhosis, Endothelial Cells

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Liver sinusoidal endothelial cells in hepatic fibrosis

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