Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

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Items 101–200 of 532

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2. Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?
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3. TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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4. Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond
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5. Liver‐Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer
   Elizabeth P. Newberry, Zoe Hall, Yan Xie, Elizabeth A. Molitor, Peter O. Bayguinov, Gregory W. Strout, James A. J. Fitzpatrick, Elizabeth M. Brunt, Julian Leether Griffin, Nicholas O. Davidson · 2021 · Hepatology
6. Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial
   Eleonora Scorletti, Annette L. West, Lokpal S. Bhatia, Samuel P. Hoile, Keith G. McCormick, Graham C. Burdge, Karen A. Lillycrop, Geraldine Frances Clough, Philip C. Calder, Christopher D. Byrne · 2015 · Journal of Hepatology
7. Additive effects of PNPLA3 and TM6SF2 on the histological severity of non‐alcoholic fatty liver disease
   Bo Kyung Koo, Sae Kyung Joo, Donghee Kim, Jeong Mo Bae, Jeong Hwan Park, Jung Ho Kim, Won Kyum Kim · 2017 · Journal of Gastroenterology and Hepatology
8. Genetic and Epigenetic Modifiers of Alcoholic Liver Disease
   Marica Meroni, Miriam Longo, Raffaela Rametta, Paola Dongiovanni · 2018 · International Journal of Molecular Sciences
9. Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker
   Guido Baselli, Paola Dongiovanni, Raffaela Rametta, Marica Meroni, Serena Pelusi, Marco Maggioni, Sara Badiali, Piero Pingitore, Samantha Maurotti, Tiziana Montalcini et al. · 2020 · Gut
10. MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy
    Yingxin Xian, Jianping Weng, Fen Liang Xu · 2020 · Chinese Medical Journal
11. Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease
    Anders Mellemkjær, Mikkel Breinholt Kjær, David Haldrup, Henning Grønbæk, Karen Louise Thomsen · 2023 · European Journal of Internal Medicine
12. Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review
    Tyler J Severson, Siddesh V. Besur, Herbert L. Bonkovsky · 2016 · World Journal of Gastroenterology
13. Non-Alcoholic Fatty Liver Disease: From Pathogenesis to Clinical Impact
    Alfredo Caturano, Carlo Acierno, Riccardo Nevola, Pia Clara Pafundi, Raffaele Galiero, Luca Rinaldi, Teresa Salvatore, Luigi Elio Adinolfi, Ferdinando Carlo Sasso · 2021 · Processes
14. Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity
    Marco A. Arrese, Juan Pablo Arab, Francisco Barrera M., Benedikt K. Kaufmann, Luca V. C. Valenti, Ariel E. Feldstein · 2021 · Seminars in Liver Disease
15. Diagnosis of non-alcoholic fatty liver disease (NAFLD)
    Hannele Yki‐Järvinen · 2016 · Diabetologia
16. Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges
    Mohammad Shafi Kuchay, José Ignacio Martínez‐Montoro, Narendra Singh Choudhary, José Carlos Fernández‐García, Bruno Ramos‐Molina · 2021 · Biomedicines
17. Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population
    Salvatore Petta, Vito Di Marco, Rosaria Maria Pipitone, Stefania Grimaudo, Carola Buscemi, Antonio Craxı̀, Silvio Buscemi · 2018 · Liver International
18. Noninvasive fatty liver markers predict liver disease mortality in the U.S. population
    Aynur Ünalp–Arida, Constance E. Ruhl · 2015 · Hepatology
19. Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD?
    Amalia Gastaldelli · 2017 · Clinical Science
20. Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
    Serena Pelusi, Annalisa Cespiati, Raffaela Rametta, Grazia Pennisi, Ville Männistö, Chiara Rosso, Guido Baselli, Paola Dongiovanni, Anna Ludovica Fracanzani, Sara Badiali et al. · 2019 · Clinical Gastroenterology and Hepatology
21. Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease
    Mohammad Shafi Kuchay, Narendra Singh Choudhary, Bruno Ramos‐Molina · 2025 · American Journal of Physiology-Cell Physiology
22. Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice
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23. TM6SF2 rs58542926 impacts lipid processing in liver and small intestine
    Elizabeth A. O’Hare, Rongze Yang, Laura M. Yerges‐Armstrong, Urmila Sreenivasan, Rebecca J. McFarland, Carmen C. Leitch, Meredith H. Wilson, Shilpa Narina, Alexis Gorden, Kathy A. Ryan et al. · 2016 · Hepatology
24. MBOAT7 Down-Regulation by Hyperinsulinemia Induces Fat Accumulation in Hepatocytes
    Marica Meroni, Paola Dongiovanni, Miriam Longo, Fabrizia Carli, Guido Baselli, Raffaela Rametta, Serena Pelusi, Sara Badiali, Marco Maggioni, Melania Gaggini et al. · 2019 · EBioMedicine
25. A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals
    Mitra Ahadi, Kasra Molooghi, Negin Masoudifar, Ali Beheshti Namdar, Hassan Vossoughinia, Mohammadreza Farzanehfar · 2020 · Journal of Gastroenterology and Hepatology
26. Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease
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27. PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis
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28. Significant positive association of endotoxemia with histological severity in 237 patients with non‐alcoholic fatty liver disease
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29. TM6SF2: Catch-22 in the Fight Against Nonalcoholic Fatty Liver Disease and Cardiovascular Disease?
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30. Emerging role of genomic analysis in clinical evaluation of lean individuals with NAFLD
    Vilarinho, Sílvia, Ajmera, Veeral, Zheng, Melanie, Loomba, Rohit · 2021 · Hepatology
31. TM6SF2 G lu167 L ys polymorphism is associated with low levels of LDL ‐cholesterol and increased liver injury in obese children
    Anna Grandone, D. Cozzolino, Pierluigi Marzuillo, Grazia Cirillo, Anna Di Sessa, L. Ruggiero, M. R. Di Palma, Laura Perrone, Emanuele Miraglia del Giudice · 2015 · Pediatric Obesity
32. Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity
    Carlos Jose Pirola, Silvia C. Sookoian · 2018 · World Journal of Gastroenterology
33. Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy
    Alessia Di Costanzo, Francesca Belardinilli, Diego Bailetti, Marialuisa Sponziello, Laura D’Erasmo, Licia Polimeni, Francesco Baratta, Daniele Pastori, Fabrizio Ceci, Anna Montali et al. · 2018 · Scientific Reports
34. Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy
    Yu‐Cheng Lin, Pi‐Feng Chang, Hsueh-Fang Lin, Kevin G. Liu, Mei‐Hwei Chang, Yen‐Hsuan Ni · 2016 · Journal of Hepatology
35. A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease
    Paola Dongiovanni, Luca V. C. Valenti · 2017 · International Journal of Molecular Sciences
36. Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting
    Albert Blanco‐Grau, Pablo Gabriel-Medina, Francisco Rodríguez-Algarra, Yolanda Villena-Ortiz, Rosa María López, Salvador Augustín, Mònica Pons, Luz-Maria Cruz, Ariadna Rando‐Segura, Belén Enfedaque et al. · 2021 · Diagnostics
37. Renin-Angiotensin System Inhibitors, Type 2 Diabetes and Fibrosis Progression: An Observational Study in Patients with Nonalcoholic Fatty Liver Disease
    Serena Pelusi, Salvatore Petta, Chiara Rosso, Vittorio Natale Borroni, Anna Ludovica Fracanzani, Paola Dongiovanni, Antonio Craxı̀, Elisabetta Bugianesi, Silvia Rossana Fargion, Luca V. C. Valenti · 2016 · PLoS ONE
38. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study
    Jeffrey Y. Cui, Chi‐Hua Chen, Min‐Tzu Lo, Nicholas J. Schork, Ricki Bettencourt, Monica P. Gonzalez, Archana Bhatt, Jonathan C. Hooker, Katherine M. Shaffer, Karen E. Nelson et al. · 2016 · Hepatology
39. Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis
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40. AASLD Practice Statement on the evaluation and management of metabolic dysfunction–associated steatotic liver disease in children
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41. Genetic background in nonalcoholic fatty liver disease: A comprehensive review
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42. Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)
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43. Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease
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44. Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease
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45. β-Klotho gene variation is associated with liver damage in children with NAFLD
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46. Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
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49. The intersection of nonalcoholic fatty liver disease and obesity
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50. PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery
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52. Genetic and hormonal control of hepatic steatosis in female and male mice
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53. Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to Therapeutics
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54. Nonalcoholic fatty liver disease or metabolic dysfunction‐associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches
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55. Hepatic Fat—Genetic Risk Score Predicts Hepatocellular Carcinoma in Patients With Cirrhotic HCV Treated With DAAs
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56. Genetics Is of the Essence to Face NAFLD
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57. Genetic and epigenetic mechanisms of NASH
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58. Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review
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59. Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study
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60. Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology
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61. Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
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62. Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population
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63. A “systems medicine” approach to the study of non-alcoholic fatty liver disease
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64. Validation of PNPLA3 polymorphisms as risk factor for NAFLD and liver fibrosis in an admixed population
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65. Disruption of the ERLIN–TM6SF2–APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease
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66. Epidemiologic, Genetic, Pathogenic, Metabolic, Epigenetic Aspects Involved in NASH-HCC: Current Therapeutic Strategies
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67. From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention
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68. Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis
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69. Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients
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70. From sugar to liver fat and public health: systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis
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71. Pathology and Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease-Associated Hepatic Tumors
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72. PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients
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73. PNPLA3 rs738409 and TM6SF2 rs58542926 gene variants affect renal disease and function in nonalcoholic fatty liver disease
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74. Lack of evidence supporting a role of TMC4-rs641738 missense variant—MBOAT7- intergenic downstream variant—in the Susceptibility to Nonalcoholic Fatty Liver Disease
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75. Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD
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76. TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis
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77. PCSK9 rs11591147 R46L loss‐of‐function variant protects against liver damage in individuals with NAFLD
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78. TM 6 SF 2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA 3 polymorphism
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80. The genetic backgrounds in nonalcoholic fatty liver disease
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81. TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease
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82. Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
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83. The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease
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84. Epicardial Adipose Tissue (EAT) Thickness Is Associated with Cardiovascular and Liver Damage in Nonalcoholic Fatty Liver Disease
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85. Human-based systems: Mechanistic NASH modelling just around the corner?
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86. Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease
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87. Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review
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88. Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play
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94. Risk for hepatic and extra-hepatic outcomes in nonalcoholic fatty liver disease
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97. The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development – a potential therapeutic target?
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99. miRNA Dysregulation in the Development of Non-Alcoholic Fatty Liver Disease and the Related Disorders Type 2 Diabetes Mellitus and Cardiovascular Disease
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100. Shared Mechanisms between Cardiovascular Disease and NAFLD
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