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Liver stiffness in nonalcoholic fatty liver disease: A comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy

Open access
Cassinotto, Christophe, Boursier, Jérome, de Lédinghen, Victor, Lebigot, Jérome, Lapuyade, Bruno, Cales, Paul, Hiriart, Jean‐Baptiste, Michalak, Sophie, Bail, Brigitte Le, Cartier, Victoire, Mouries, Amaury, Oberti, Frédéric, Fouchard‐Hubert, Isabelle, Vergniol, Julien, Aubé, Christophe·2016·Hepatology

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue. The goal of this study was to assess the clinical use of liver stiffness measurement (LSM) evaluated by supersonic shear imaging (SSI), FibroScan, and acoustic radiation force impulse (ARFI) in a cohort of NAFLD patients who underwent liver biopsy. A total of 291 NAFLD patients were prospectively enrolled from November 2011 to February 2015 at 2 French university hospitals. LSM was assessed by SSI, FibroScan (M probe), and ARFI within two weeks prior to liver biopsy. Calculations of the area under the receiver operating curve (AUROC) were performed and compared for the staging of liver fibrosis. AUROC for SSI, FibroScan, and ARFI were 0.86, 0.82, and 0.77 for diagnoses of ≥F2; 0.89, 0.86, and 0.84 for ≥F3; and 0.88, 0.87, and 0.84 for F4, respectively. SSI had a higher accuracy than ARFI for diagnoses of significant fibrosis (≥F2) (P= 0.004). Clinical factors related to obesity such as body mass index ≥ 30 kg/m 2, waist circumference ≥102 cm or increased parietal wall thickness were associated with LSM failures when using SSI or FibroScan and with unreliable results when using ARFI. In univariate analysis, FibroScan values were slightly correlated with NAFLD activity score and steatosis (R = 0.28 and 0.22, respectively), whereas SSI and ARFI were not; however, these components of NAFLD did not affect LSM results in multivariate analysis. The cutoff values for SSI and FibroScan for staging fibrosis with a sensitivity ≥90% were very close: 6.3/6.2 kPa for ≥F2, 8.3/8.2 kPa for ≥F3, and 10.5/9.5 kPa for F4.Conclusion:Although obesity is associated with an increase in LSM failure, the studied techniques and especially SSI provide high value for the diagnosis of liver fibrosis in NAFLD patients. (H epatology 2016;63:1817‐1827)

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Metadata

Authors
Cassinotto, C., Boursier, J., de Lédinghen, V., Lebigot, J., Lapuyade, B., Cales, P., Hiriart, J., Michalak, S., Bail, B. L., Cartier, V., Mouries, A., Oberti, F., Fouchard‐Hubert, I., Vergniol, J., & Aubé, C.
Venue
Hepatology
Published
2016-01-22
Volume
63
Issue
6
Pages
1817-1827
ISSN
  • 0270-9139 (ISSN-L)
  • 1527-3350
OpenAlex
W2282195703
Cited by
521
References
28
FWCI
24.31
Type
journal article
Language
en
Open access
bronze

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Cassinotto, C., Boursier, J., de Lédinghen, V., Lebigot, J., Lapuyade, B., Cales, P., Hiriart, J., Michalak, S., Bail, B. L., Cartier, V., Mouries, A., Oberti, F., Fouchard‐Hubert, I., Vergniol, J., & Aubé, C. (2016). Liver stiffness in nonalcoholic fatty liver disease: A comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy. Hepatology. https://doi.org/10.1002/hep.28394

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