Alcoholic hepatitis: Translational approaches to develop targeted therapies
Open accessAbstract
Alcoholic liver disease is a leading cause of liver‐related mortality worldwide. In contrast to recent advances in therapeutic strategies for patients with viral hepatitis, there is a significant lack of novel therapeutic options for patients with alcoholic liver disease. In particular, there is an urgent need to focus our efforts on effective therapeutic interventions for alcoholic hepatitis (AH), the most severe form of alcoholic liver disease. AH is characterized by an abrupt development of jaundice and complications related to liver insufficiency and portal hypertension in patients with heavy alcohol intake. The mortality of patients with AH is very high (20%‐50% at 3 months). Available therapies are not effective in many patients, and targeted approaches are imminently needed. The development of such therapies requires translational studies in human samples and suitable animal models that reproduce the clinical and histological features of AH. In recent years, new animal models that simulate some of the features of human AH have been developed, and translational studies using human samples have identified potential pathogenic factors and histological parameters that predict survival. Conclusion: This review summarizes the unmet needs for translational studies on the pathogenesis of AH, preclinical translational tools, and emerging drug targets to benefit the AH patient. (H epatology 2016;64:1343‐1355)
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Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (AFLD) to more advanced liver disease such as ASH, fibrosis/cirrhosis, hepatic cancer, liver failure, and death.
“Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (simple fat accumulation in so-called alcoholic fatty liver disease, AFLD) to more advanced liver disease such as inflammation (alcoholic steatohepatitis, ASH), fibrosis/cirrhosis, hepatic cancer, liver failure, and death203–213.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [209]
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Self-citation
- Authors
- Mandrekar, P., Bataller, R., Tsukamoto, H., & Gao, B.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- National Institutes of Health (US)
- Corresponding author
- Mandrekar, Pranoti
- Bataller, Ramon
- Tsukamoto, Hidekazu
- Gao, Bin
- Venue
- Hepatology
- Published
- 2016-04-15
- Volume
- 64
- Issue
- 4
- Pages
- 1343-1355
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC5010788
- OpenAlex
- W2291262197
- Cited by
- 115
- References
- 62
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 16 · 2017: 12 · 2016: 6
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- UNC Libraries
- Funders
- U.S. Department of Veterans Affairs (5I01BX001991, I01 BX001991, 5P50AA011999)
- American Association for the Study of Liver Diseases
- National Institute on Alcohol Abuse and Alcoholism (R21AA022770, U01AA021908, U01AA020821, U01AA018663, R01AA017986, R24AA012885, P50AA011999)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- alcoholic hepatitis, alcoholic liver disease, targeted therapy, translational research, pathogenesis, therapeutic target, survival prediction, portal hypertension, liver insufficiency, jaundice
- MeSH terms
- Animals, Disease Models, Animal, Forecasting, Health Services Needs and Demand, Hepatitis, Alcoholic, Humans, Translational Research, Biomedical, Molecular Targeted Therapy
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