Exosome-mediated activation of Toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis

Cited by (175)

Items 101–175 of 175

1. Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis
   Mishghan Zehra, James C Curry, Sneha S. Pillai, Hari Vishal Lakhani, Cory E. Edwards, Komal Sodhi · 2020 · International Journal of Molecular Sciences
2. The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution
   Qing Duo Liang, Yudi Hu, Meina Zhang, Chunjie Lin, Wei Zhang, Ying Li, Ping Zhu, Pengxin Xue, Yujie Chen, Qiyuan Li et al. · 2020 · Frontiers in Immunology
3. New Aspect of Liver IL-17+ γδ T Cells
   Xi Chen, Zhenghu Jia, Xiaoli Wu, Na Zhao, Weifeng He, Jianlei Hao · 2019 · Molecular Immunology
4. Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)
   Dongdong Xue, Jingzhao Han, Yifan Liu, Hongfang Tuo, Yanhui Peng · 2021 · Cancer Biology & Therapy
5. TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis
   Qifeng He, Yijun Lu, Wenfang Tian, Runqiu Jiang, Weiwei Yu, Yong Liu, Meiling Sun, Fei Wang, Haitian Zhang, Ning Wu et al. · 2022 · Cellular and Molecular Immunology
6. Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production
   Reo Kawata, Shingo Oda, Yoshihiro Koya, Hiroaki Kajiyama, Tsuyoshi Yokoi · 2020 · Toxicology
7. Clinical implications of exosome-derived noncoding RNAs in liver
   Zhe Zhou, Wei Zheng, Zheng Xiang, Cunsi Ye, Qiao qiao Yin, Shou Hao Wang, Cheng Xu, Wen Hao Wu, Tian Chen Hui, Qing Wu et al. · 2022 · Laboratory Investigation
8. New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways☆
   Tom Ryu, Kyurae Kim, Sung Eun Choi, Katherine Po Sin Chung, Won‐Il Jeong · 2022 · Liver Research
9. Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases
   Kun-Li Yin, Ming Li, Peipei Song, Yuxin Duan, Wen-Tao Ye, Wei Tang, Norihiro Kokudo, Qiang Gao, Rui Liao · 2022 · Journal of Clinical and Translational Hepatology
10. Hepatocyte‐derived exosomes deliver the lncRNA CYTOR to hepatic stellate cells and promote liver fibrosis
    Wenqiang Xu, Wenhui Mo, Dengyu Han, Weiqi Dai, Xiaorong Xu, Jingjing Li, Xuanfu Xu · 2024 · Journal of Cellular and Molecular Medicine
11. Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
    Dong‐Kyu Kim, Gun-Sik Cho, Choongseong Han, Dong‐Hyuk Park, Heekyung Park, Dong‐Hun Woo, Jong‐Hoon Kim · 2017 · Tissue Engineering and Regenerative Medicine
12. γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy
    Stavros P. Papadakos, Konstantinos Arvanitakis, Ioanna Ε. Stergiou, Maria-Loukia Koutsompina, Georgios S. Germanidis, Stamatios E Theocharis · 2024 · International Journal of Molecular Sciences
13. Diverse Functions of γδ T Cells in the Progression of Hepatitis B Virus and Hepatitis C Virus Infection
    Wen Hou, Xiaoli Wu · 2021 · Frontiers in Immunology
14. Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
    Cristina Zivko, Gregor Fuhrmann, Paola Luciani · 2020 · Biochimica et Biophysica Acta (BBA) - General Subjects
15. IL-17A-producing γδ T cells promote liver pathology in acute murine schistosomiasis
    Lei Sun, Wenci Gong, Yujuan Shen, Le Liang, Xiaofan Zhang, Teng Li, Tina Tuwen Chen, Yuan Hu, Jianping Cao · 2020 · Parasites & Vectors
16. Therapeutic potential of exosomes in periodontal regeneration: Immunomodulatory and tissue-repair mechanisms
    Shuang Yang, Chunyu Han, Qihui Wang, Yue Ai, Dezhou Wang, Wenzhi Song · 2025 · Frontiers in Immunology
17. Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells
    Maria Teresa Koenen, Elisa Fabiana Brandt, Dawid Kaczor, Tim Caspers, Alexandra C.A. Heinzmann, Petra Fischer, Daniel Heinrichs, Theresa Hildegard Wirtz, Christian Trautwein, Rory R. Koenen et al. · 2022 · Biomolecules
18. Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis
    Luping Wang, Yi Huang, Jingrong Chen, Jialu Gao, Sihan Chen, Mingqi Zhao, Jiguo Lin, Shunqing Zhou, Yan Shen, Yunyun Cheng · 2025 · Frontiers in Cell and Developmental Biology
19. Targeting Gut–Liver Axis for Treatment of Liver Fibrosis and Portal Hypertension
    Eric Kalo, Scott A. Read, Golo Ahlenstiel · 2021 · Livers
20. Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease.
    Won‐Mook Choi, Hyuk Soo Eun, Young‐Sun Lee, Sun Jun Kim, Myung Ho Kim, Jun Hee Lee, Young‐Ri Shim, Hee‐Hoon Kim, Ye Eun Kim, Hyon‐Seung Yi et al. · 2019 · Europe PMC (PubMed Central)
21. TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue‐bound HGF
    Christian Stöß, Melanie Laschinger, Baocai Wang, Miao Lu, Felicitas Altmayr, Daniel Hartmann, Norbert Hüser, Bernhard Holzmann · 2020 · The FASEB Journal
22. Targeting extracellular vesicles‐mediated hepatic inflammation as a therapeutic strategy in liver diseases
    Dakai Yang, Jing Liu · 2020 · Liver International
23. LPS ‐induced macrophage exosomes promote the activation of hepatic stellate cells and the intervention study of total astragalus saponins combined with glycyrrhizic acid
    Kaili Deng, Ze Dai, Ping Yang, Dongxue Yang, Yuping Zhou · 2022 · The Anatomical Record
24. T cells and liver fibrosis
    Ruonan Sun, Zheng Xiang, Bin-Jiao Wu · 2022 · Portal Hypertension & Cirrhosis
25. Contribution of Hepatic Steatosis–Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice
    Xinxu Yuan, Owais Mohammad Bhat, Yao Zou, Yang Zhang, Pin‐Lan Li · 2023 · American Journal Of Pathology
26. Organ Crosstalk: The Role of Spleen
    Yidan Gao, Shiwei Shen, YongJun Wang, Mei Tian · 2024 · Phenomics
27. Extracellular Vesicles in Viral Liver Diseases
    Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki · 2024 · Viruses
28. Cutting-edge insights into liver fibrosis: advanced therapeutic strategies and future perspectives using engineered mesenchymal stem cell-derived exosomes
    Didamoony, Manar A., Soubh, Ayman A., Ahmed, Lamiaa A. · 2025 · Drug Delivery and Translational Research
29. Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice
    Wenyi Chen, Xinyi Chen, Feiqiong Gao, Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Guanghua Ma, Jintao Gong et al. · 2025 · Journal of Nanobiotechnology
30. Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis
    Zheng Li, Lixia Wang, Yuan Hu, Jia Yi, Lun Wan, Yujuan Shen, Si Liu, Xiaorong Zhou, Jianping Cao · 2021 · Parasite Immunology
31. Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements
    Kunli Yin, Kai-Jian Chu, Ming Li, Yu-Xin Duan, Yanxi Yu, Meiqing Kang, Da Fu, Rui Liao · 2024 · Journal of Clinical and Translational Hepatology
32. Extracellular vesicles
    Mariana Ottaiano Gonçalves, Juliana Fortes Di Iório, Gabriela Villa Marin, Paula Meneghetti, Náthani Gabrielly Silva Negreiros, Ana Cláudia Torrecilhas · 2024 · Current topics in membranes
33. Advances in the pharmacological mechanisms of berberine in the treatment of fibrosis
    Xiaoqin Liu, Qingzhi Liang, Yifan Wang, Shuai Xiong, Rensong Yue · 2024 · Frontiers in Pharmacology
34. The Role of Extracellular Vesicles in Liver Fibrosis: Friends or Foes?
    Xiang Tao, Can Chen, Mei Liu · 2024 · Biomedicines
35. Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation
    Tingting Chen, Yan Zhang, Yijie Zhang, Zuowei Ning, Qihan Xu, Ying H. Lin, Jiacheng Gong, Jierui Li, Zhuoer Chen, Ying Meng et al. · 2023 · Hepatology International
36. Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis
    Hongwu Meng, Lingfeng Jiang, Pengcheng Jia, Ruowen Niu, Fangtian Bu, Yan Yu Zhu, Xue‐Yin Pan, Juanjuan Li, Jinyu Liu, Yilong Zhang et al. · 2023 · Biochemical Pharmacology
37. Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives
    Alka Singh, Ansab Akhtar, Prashant Shukla · 2025 · ADMET & DMPK
38. γδ T cells: The potential role in liver disease and implications for cancer immunotherapy
    He Ren, WanJing Li, Xin Liu, Na Zhao · 2022 · Journal of Leukocyte Biology
39. Diverse Subsets of γδT Cells and Their Specific Functions Across Liver Diseases
    Chenjie Zhan, Chun-Xiu Peng, Huaxiu Wei, Ke Wei, Yangzhi Ou, Zhiyong Zhang · 2025 · International Journal of Molecular Sciences
40. Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein
    Xiaohua Wang, Yuting Li, Xin Li, Lei Yan, Huilin Guan, Ruijie Han, Yang Han, Jinqiu Gui, Xiaoyan Xu, Yan Dong et al. · 2018 · World Journal of Microbiology and Biotechnology
41. Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome
    Carolina Castillo-Castro, Alexandro J. Martagón, Rocio Ortı́z-López, Luis Garrido-Trevino, Melissa Villegas-Albo, Francisco Bosques‐Padilla · 2021 · World Journal of Hepatology
42. HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells
    Yang Gao, Li Li, Shengning Zhang, Yuanyi Mang, Xi-Bing Zhang, Shi‐Ming Feng · 2024 · World Journal of Gastroenterology
43. Role of ncRNAs in modulation of liver fibrosis by extracellular vesicles
    Giulia Chiabotto, Giovanni Camussi, Stefania Bruno · 2020 · ExRNA
44. Functions of hepatic non-parenchymal cells in alcoholic liver disease
    Won‐Mook Choi, Myung‐Ho Kim, Won‐Il Jeong · 2019 · Liver Research
45. Hepatic-derived extracellular vesicles in late pregnancy promote mammary gland development by stimulating prolactin receptor-mediated JAK2/STAT5/mTOR signalling
    Jiahao Zhu, Lekai Yang, Haibin Deng, Junyi Luo, Ting Chen, Jiajie Sun, Yongliang Zhang, Qianyun Xi · 2024 · International Journal of Biological Macromolecules
46. γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response
    Anna Ruta, Kavita Krishnan, JiWon Woo, Joscelyn C. Mejías, Elise F. Gray-Gaillard, David R. Maestas, Helen Hieu Nguyen, Alexandra N. Rindone, Christopher Cherry, Michael Patatanian et al. · 2026 · Nature Communications
47. Gamma Delta T Cells: Role in Immunotherapy of Hepatocellular Carcinoma
    Krishna Chaitanya Amajala, Indu Priya Gudivada, Rama Rao Malla · 2023 · Critical Reviews™ in Oncogenesis
48. Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
    Zhengyuan Xie, Heng-Wei Cao, Qing Wang, Hui Juan Lu, Wen Du · 2022 · Journal of Cell Communication and Signaling
49. Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis
    Jie Sun, Yi Shen, Xiaoze Wang, Ruoting Men, Xian Xing, Linling Lv, Fan Yang, Mengyi Shen, Yanyi Zheng, Xiaoli Fan et al. · 2025 · Journal of Nanobiotechnology
50. Nucleic acids and proteins carried by exosomes from various sources: Potential role in liver diseases
    Danna Xie, Baolin Qian, Xun� Li · 2022 · Frontiers in Physiology
51. Tissue damage from chronic liver injury inhibits peripheral NK cell abundance and proinflammatory function
    Zonghao You, Shaoxue Ling, Shuwu Zhao, Haixing Han, Yuhong Bian, Yongzhi He, Xi Chen · 2024 · Journal of Leukocyte Biology
52. Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model
    Zhixian Zhu, Sen Liang, Nan Zhao, Huiling Zou, Liangjun Zhang, Xiaoxun Zhang, Jin Chai · 2025 · Liver Research
53. The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?
    Nourhan Badwei · 2024 · iLiver
54. Toll‐like Receptors in Liver Disease
    So Yeon Kim, Ekihiro Seki · 2020
55. Acute bacterial and viral infections
    Oriol Juanola, Esther Caparrós, Rubén Francés · 2024 · Elsevier eBooks
56. Sinusoidal cell interactions—From soluble factors to exosomes
    Martí Ortega‐Ribera, Mrigya Babuta, Gyöngyi Szabó · 2024 · Elsevier eBooks
57. Role of extracellular vesicles in diagnosis and treatment of liver fibrosis
    Jiawei Zhao, Yugang Wang, Min Yan Shi · 2019 · World Chinese Journal of Digestology
58. Immunopathogenesis of Liver Cirrhosis
    Adrien Guillot, Bin Gao · 2020 · Springer eBooks
59. TLR3 Mediates Senescence and Immunosurveillance of Hepatic Stellate Cells
    Guo Feng Zhou, Jiaxin Bei, Tianyang Li, Kangshun Zhu, Zhengkun Tu · 2021 · Hepatitis Monthly
60. Mechanisms of action of extracellular miRNAs
    А.Е. Абатуров, V.L. Babуch · 2023 · CHILD`S HEALTH
61. Therapeutic Actions of Hepatocyte Extracellular Vesicles in a Murine Model of Diet-Induced Steatohepatitis with Fibrosis
    Xinlei Li, Ruju Chen, Sherri Kemper, Zhaohui Xu, David R. Brigstock · 2025 · Biomedicines
62. Isolation of Hepatic Stellate Cells and Lymphocytes for Co-culture Systems
    Hee‐Hoon Kim, Kyurae Kim, Song Hwa Hong, Won‐Il Jeong · 2023 · Methods in molecular biology
63. Reply
    Wonhyo Seo, Eunjung Jo, Won‐Il Jeong · 2016 · Hepatology
64. ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells
    Menglin Zheng, Satoshi Okawa, Miren Bravo, Fei Chen, Maria Luz Martínez‐Chantar, Antonio del Sol · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
65. The Relationship between Intestinal Dysbacteriosis and Liver Cirrhosis
    丹 雷 · 2022 · Advances in Clinical Medicine
66. Role of gut dysbiosis in chronic liver disease leading to fibrosis
    Pablo Muriel · 2022 · Elsevier eBooks
67. Hepatic Nonparenchymal Cells and Liver-Associated Lymphoid Cells
    Carol R. Gardner, Jeffrey D. Laskin, Debra L. Laskin · 2025 · Elsevier eBooks
68. Pro-inflammatory effects of endogenous and recombinant MDA-7/IL-24 with RGD peptide on human hepatic stellate cells
    Afrooz Daneshparvar, Seyed Younes Hosseini, Nasrin Hamidizadeh, Mohabbat Jamhiri, Nader Tanideh, Maryam Sadat Sadati, Iman Jamhiri · 2025 · Scientific Reports
69. Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization
    Jiaxin Wang, Ning Li, Xueyu Cang, Xuerong Liu, Ranyan Gao, Lingyi Xu, Fengchun Li, Xinyu Jiang, Hongliang Chen, Xinyu Geng et al. · 2025 · Scientific Reports
70. Immunological liver-skin axis: a systemic Vγ4 + γδT17 cell response links psoriasis-like inflammation and MASLD
    Janik Fleissner, Yamila Rocca, Lukas Freund, Thomas Ossner, Fabian Imdahl, Rémi Doucet-Ladevèze, Florian Kurz, Andreas Geier, M. Goebeler, Georg Gasteiger et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
71. Harnessing the power of the gut microbiome: a review of supplementation diagnosis and therapy for liver cirrhosis
    Yuanqing Zhu, Wenkang Gao, Mingjian Cheng, Xuyang Li, Kailin Cai, Liuying Chen, Huikuan Chu · 2026 · Cellular and Molecular Life Sciences
72. Les vésicules extracellulaires dans l'hépatotoxicité des hydrocarbures aromatiques polycycliques : biomarqueurs et/ou vecteurs ?
    Nettie van Meteren · 2020 · theses.fr (ABES)
73. The Role of MicroRNA Networks in Alcohol-associated Liver Disease
    Seol Hee Park, Wonhyo Seo · 2026 · Journal of Digestive Cancer Research
74. Dual regulatory roles and mechanisms of Gamma delta T cells in organ fibrosis
    Yongrong Li, Mingli Chen, Chaochao Chen, Dongchun Liang, Deming Sun, Zhoutao He, 蓝程 · 2026 · Tissue and Cell
75. AURKA regulates HBV-induced hepatic stellate cell inflammation and liver fibrosis by modulating K48-linked ubiquitination and proteasomal degradation of TLR3
    Hongjie Wu, 王天宝, Fang Yang, Mingqiang Yue, Aihui Li, Changyun Si · 2026 · Journal of Bioenergetics and Biomembranes