Retinoic Acid Receptor‐β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin‐Driven Activation and Durotaxis in Hepatic Stellate Cells

The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Edge, S. B., & Compton, C. C. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-0985-4 · Cited by 9,055 · see citing works

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works

Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692 · see citing works

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works

Overview of retinoid metabolism and function

Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 948 · see citing works

Atomic force microscopy probing of cell elasticity

Kuznetsova, T. G., Starodubtseva, M. N., Yegorenkov, N. I., et al. (2007) · Micron · doi:10.1016/j.micron.2007.06.011 · Cited by 806 · see citing works

Non-alcoholic fatty liver disease: An expanded review

Benedict, M., & Zhang, X. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i16.715 · Cited by 754 · see citing works

The pancreatic stellate cell: a star on the rise in pancreatic diseases

Omary, M. B., Lugea, A., Lowe, A. W., & Pandol, S. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30082 · Cited by 693 · see citing works

Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells

Wang, N., Tolić-Nørrelykke, I. M., Chen, J., Mijailovich, S. M., Butler, J. P., Fredberg, J. J., & Stamenović, D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00269.2001 · Cited by 669 · see citing works

Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

Liu, C., Lin, H., Tang, M., & Wang, Y.-K. (2015) · Oncotarget · doi:10.18632/oncotarget.3862 · Cited by 537 · see citing works

Cancer associated fibroblasts: the dark side of the coin.

Cirri, P., & Chiarugi, P. (2011) · Europe PMC (PubMed Central) · Cited by 501 · see citing works

Hepatic Stellate Cells and Liver Fibrosis

Moreira, R. K. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-1728-hscalf · Cited by 452 · see citing works

Liver stiffness: a novel parameter for the diagnosis of liver disease

Mueller, S. (2010) · Hepatic Medicine: Evidence and Research · doi:10.2147/hmer.s7394 · Cited by 434 · see citing works

The carbon tetrachloride model in mice

Scholten, D., Trebicka, J., Liedtke, C., & Weiskirchen, R. (2015) · Laboratory Animals · doi:10.1177/0023677215571192 · Cited by 417 · see citing works

Clinical evidence for the regression of liver fibrosis

Ellis, E. L., & Mann, D. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.024 · Cited by 411 · see citing works

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

Guilluy, C., Swaminathan, V., García‐Mata, R., O’Brien, E. T., Superfine, R., & Burridge, K. (2011) · Nature Cell Biology · doi:10.1038/ncb2254 · Cited by 369 · see citing works

Fibrosis—a lethal component of systemic sclerosis

Ho, Y. Y., Lagares, D., Tager, A. M., & Kapoor, M. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.53 · Cited by 307 · see citing works

Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors

Yang, C., Zeisberg, M., Mosterman, B., Sudhakar, A., Yerramalla, U. L., Holthaus, K. A., Xu, L.-M., Eng, F. J., Afdhal, N. H., & Kalluri, R. (2003) · Gastroenterology · doi:10.1053/gast.2003.50012 · Cited by 282 · see citing works

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

Amann, T., Bataille, F., Spruß, T., Mühlbauer, M., Gäbele, E., Schölmerich, J., Kiefer, P., Bosserhoff, A., & Hellerbrand, C. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01087.x · Cited by 277 · see citing works

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Chronopoulos, A., Robinson, B. K., Sarper, M., Cortés, E., Auernheimer, V., Lachowski, D., Attwood, S. J., García, R., Ghassemi, S., Fabry, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12630 · Cited by 275 · see citing works

Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

Wobser, H., Dorn, C., Weiß, T. S., Amann, T., Bollheimer, C., Büttner, R., Schölmerich, J., & Hellerbrand, C. (2009) · Cell Research · doi:10.1038/cr.2009.73 · Cited by 235 · see citing works

The Role of Matrix Stiffness in Hepatic Stellate Cell Activation and Liver Fibrosis

Wells, R. G. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000155516.02468.0f · Cited by 232 · see citing works

Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma

Coulouarn, C., Corlu, A., Glaise, D., Guénon, I., Thorgeirsson, S. S., & Clément, B. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3317 · Cited by 222 · see citing works

The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases

Rybak, J., Roesli, C., Kaspar, M., Villa, A., & Neri, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1436 · Cited by 212 · see citing works

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

Lachowski, D., Cortes, E., Robinson, B., Rice, A., Rombouts, K., & Del Río Hernández, A. E. (2018) · The FASEB Journal · doi:10.1096/fj.201700721r · Cited by 175 · see citing works

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever

Carloni, V., Luong, T. V., & Rombouts, K. (2014) · Liver International · doi:10.1111/liv.12465 · Cited by 174 · see citing works

Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine

Jesnowski, R., Furst, D. E., Ringel, J., Chen, Y., Schrödel, A., Kleeff, J. H., Kolb, A., Schareck, W. D., & Löhr, M. J. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700329 · Cited by 161 · see citing works

Molecular regulation of pancreatic stellate cell function.

Jaster, R. (2004) · Molecular Cancer · doi:10.1186/1476-4598-3-26 · Cited by 151 · see citing works

Tumor-suppressive activity of retinoic acid receptor-β in cancer

Xu, X.-C. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.11.019 · Cited by 127 · see citing works

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis

Ohata, M., Lin, M. P., Satre, M. A., & Tsukamoto, H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.3.g589 · Cited by 117 · see citing works

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

Lachowski, D., Cortés, E., Pink, D., Chronopoulos, A., Karim, S. A., Morton, J. P., & Hernández, A. E. D. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-02689-x · Cited by 105 · see citing works

Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro.

Fukuda, T., Yoshida, N., Kataoka, Y., Manabe, R., Mizuno-Horikawa, Y., Sato, M., Kuriyama, K., Yasui, N., & Sekiguchi, K. (2002) · PubMed · Cited by 104 · see citing works

Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids

Hellemans, K., Verbuyst, P., Quartier, E., Schuit, F., Rombouts, K., Chandraratna, R. A. S., Schuppan, D., & Geerts, A. (2004) · Hepatology · doi:10.1002/hep.20015 · Cited by 102 · see citing works

Effects of cytoskeletal prestress on cell rheological behavior

Stamenović, D. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.01.004 · Cited by 89 · see citing works

The contractome – a systems view of actomyosin contractility in non-muscle cells

Zaidel‐Bar, R., Zhenhuan, G., & Luxenburg, C. (2015) · Journal of Cell Science · doi:10.1242/jcs.170068 · Cited by 86 · see citing works

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells

Sarper, M., Cortés, E., Lieberthal, T. J., & Hernández, A. E. D. R. (2016) · Scientific Reports · doi:10.1038/srep27639 · Cited by 80 · see citing works

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

Ablain, J., & de Thé, H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29081 · Cited by 76 · see citing works

Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior

Pinato, D. J., Black, J. R., Trousil, S., Dina, R. E., Trivedi, P. S., Mauri, F. A., & Sharma, R. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1358332 · Cited by 72 · see citing works

Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis

Zhubanchaliyev, A., Temirbekuly, A., Kongrtay, K., Wanshura, L. C., & Kunz, J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00462 · Cited by 61 · see citing works

Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma

Sakurai, T., & Kudo, M. (2013) · Liver Cancer · doi:10.1159/000343851 · Cited by 58 · see citing works

Contraction of human hepatic stellate cells activated in culture: A role for voltage-operated calcium channels

Bataller, R. A., Nicolás, J. M., Ginès, P., Görbis, M. N., García-Ramallo, E., Lario, S., Tobías, E., Pinzani, M., Thomas, A. P., Arroyo, V., et al. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80057-3 · Cited by 54 · see citing works

Fibronectin Extra Domain-A Promotes Hepatic Stellate Cell Motility but Not Differentiation Into Myofibroblasts

Olsen, A. L., Sackey, B. K., Marcinkiewicz, C., Boettiger, D. C., & Wells, R. G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.038 · Cited by 49 · see citing works

F-actin cytoskeleton reorganization is associated with hepatic stellate cell activation

Cui, X., Zhang, X., Yin, Q.-L., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2036 · Cited by 45 · see citing works

A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease

Trasino, S. E., Tang, X., Jessurun, J., & Gudas, L. J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1434-z · Cited by 41 · see citing works

Retinoic Acid Differentially Up-Regulates the Gene Expression of Retinoic Acid Receptor α and γ Isoforms in Embryo and Adult Rats

Takeyama, K.-I., Kojima, R., Ohashi, T., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0755 · Cited by 28 · see citing works

Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid

Takami, Y., Yamamoto, I., Tsubouchi, H., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.08.006 · Cited by 12 · see citing works

Hepatic fibrosis: A convergent response to liver injury that is reversible

Wang, S., & Friedman, S. L. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.011 · Cited by 62 · see citing works

Nuclear receptors in liver fibrosis

Königshofer, P., Brusilovskaya, K., Petrenko, O., Hofer, B. S., Schwabl, P., Trauner, M., & Reiberger, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166235 · Cited by 45 · see citing works

[Evidence for retinoic acid modulating expression of cyclin-dependent kinase inhibitors in rat hepatic stellate cells].

Huang, G., Zhang, J., & Zhang, Y. (2001) · PubMed

Direct Channeling of Retinoic Acid between Cellular Retinoic Acid-Binding Protein II and Retinoic Acid Receptor Sensitizes Mammary Carcinoma Cells to Retinoic Acid-Induced Growth Arrest

Budhu, A. S., & Noy, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2632-2641.2002 · Cited by 296 · see citing works

Table of Contents

(2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00477-0

EXPRESSION OF A RETINOIC ACID-RECEPTOR GENE IS REGULATED BY RETINOIC ACID ITSELF

(2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1990.tb02982.x

Retinoic acid receptor transcripts in human umbilical vein endothelial cells

Fésüs, L., Nagy, L. T., Basilion, J. P., et al. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91329-b · Cited by 11 · see citing works