Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Schneeberger, Kerstin, Sánchez‐Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G., Oosterhoff, Loes A., Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E. +13 more·2020·Hepatology

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  2. High-throughput human microfluidic organoid-on-a-chip platform for modeling liver diseases and screening nanotherapeutics.
    Kong, Defu, Yu, Shihang, Heegsma, Janette, Blokzijl, Tjasso, Qin, Tian, Pan, Yixiao, Blokzijl, Hans, de Meijer, Vincent E., Duan, Yourong, Faber, Klaas Nico et al. · 2026 · Journal of nanobiotechnology
  3. Liver Organoid and Liver‐On‐A‐Chip Platforms for Modeling Alcoholic Liver Disease: A Comparative Review
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  4. Recapitulating the liver niche in vitro
    Kiryu K. Yap, Geraldine M. Mitchell · 2022 · Advances in stem cells and their niches
  5. A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research
    Amanda B. T. Hill, Yanet Murphy, Kathryn M. Polkoff, Laura Edwards, Derek M. Walker, Adele Moatti, Alon Greenbaum, Jorge A. Piedrahita · 2024 · Frontiers in Genome Editing
  6. Global landscape of hepatic organoid research: A bibliometric and visual study
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  7. Mini liver organoid models emulating metabolic dysfunction-associated steatotic disease development: gradually emerging beneath the iceberg
    Ting Feng, Junmin Li, Xiaoyi Ma, Junzhao Ye · 2025 · Metabolism and Target Organ Damage
  8. The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins
    Souvik Ghosh, Anastasiya Börsch, Shreemoyee Ghosh, Mihaela Zavolan · 2021 · BMC Genomics
  9. Platform-Agnostic CellNet (PACNet) enables cross-study meta-analysis of cell fate engineering protocols
    Emily K.W. Lo, Jeremy J. Velazquez, Da Peng, Chulan Kwon, Mo R. Ebrahimkhani, Patrick Cahan · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Construction of liver organoid models by hepatobiliary differentiation from human induced pluripotent stem cells: state of the art, challenges and improving strategies
    Yihang Wu, Yi Wang, Wei Zhang, Li-Li Yuan, Yan Chen · 2026 · Stem Cell Research & Therapy
  11. Engineering Organoid Platforms for Pathogenesis Research
    Xiang Gao, Xiaolu Han, Jiahui Bai, Weiming Tian, Jie Zhou, Lihua Ding, Xiang Gao · 2026 · Research
  12. Controlling cellular plasticity to improve in vitro models for kidney regeneration
    Carla Pou Casellas, Maarten B. Rookmaaker, Marianne Christina Verhaar · 2021 · Current Opinion in Biomedical Engineering
  13. Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity
    Luc J. W. van der Laan, Floris J.M. Roos, Monique M. A. Verstegen · 2021 · Hepatology
  14. Organoid-based platforms for oncolytic virus discovery and optimization: Bridging in vitro innovation and clinical translation
    Fan Yang, Hui Wang, Yigang Wang · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  15. The liver organoid's past, present and future: a personalized medicine strategy
    Mariam Mahmoud Abady, Ibrahim A Zahran, Yasmin Mohamed Elmokhtar · 2024 · International Journal of Health Sciences
  16. Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts
    Katsuhiro Tomofuji, Ken Fukumitsu, Jumpei Kondo, Hiroshi Horie, Kenta Makino, Satoshi Wakama, Takashi Ito, Yu Oshima, Satoshi Ogiso, Takamichi Ishii et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Advances in strategies for liver regeneration and replacement
    Savneet Kaur, Pedro M. Baptista · 2024 · Current Opinion in Biomedical Engineering
  18. The Authors’ Reply: Organoid Technology: Are Human Cholangiocyte Organoids Immune Protected?
    Ivo J. Schurink, Jeroen de Jonge, Luc J. W. van der Laan · 2022 · Transplantation
  19. Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors
    Katsuhiro Tomofuji, Jumpei Kondo, Kunishige Onuma, Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii, Etsuro Hatano, Masahiro Inoue · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Activated Hepatic Stellate Cells Promote Expansion of LGR5-Positive Progenitor Cells in Fibrotic Human Liver Disease
    Defu Kong, Natalia Smith‐Cortinez, Janette Heegsma, Hans Blokzijl, Vincent Erwin de Meijer, Klaas Nico Faber · 2023 · Research Square
  21. The vascularised chamber device significantly enhances the survival of transplanted liver organoids
    Denis D. Shi, Evelyn Makris, Yi-Wen Gerrand, Pu‐Han Lo, George C. Yeoh, Wayne A. Morrison, Geraldine M. Mitchell, Kiryu K. Yap · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Liver Organoid Research: Present Situation, limiting Factors and Future Therapeutical Potential in Pediatric Diseases
    Stefan Bittmann, Gloria Villalon, Elena Moschüring-Alieva, Lara Bittmann, Elisabeth Luchter · 2023 · Asian Journal of Pediatric Research
  23. Recent Advances in Regenerative Medicine of the Liver and Bile Duct System by Chemically Induced Liver Progenitor Cells (CLiPs) in Nagasaki Experience
    Masaaki Hidaka, Daisuke Miyamoto, Susumu Eguchi · 2023 · Springer eBooks
  24. Curing Classical Homocysteinuria with Pediatric in vitro engineered Liver Organoid Transplantation?
    Stefan Bittmann, Elisabeth Luchter, Lara Bittmann, Elena Moschüring-Alieva, Gloria Villalon · 2023 · Neurology and Neuroscience
  25. The vascularised chamber device significantly enhances the survival of transplanted liver organoids
    Denis D. Shi, Evelyn Makris, Yi-Wen Gerrand, Pu‐Han Lo, George C. Yeoh, Wayne A. Morrison, Geraldine M. Mitchell, Kiryu K. Yap · 2024 · eLife
  26. The vascularised chamber device significantly enhances the survival of transplanted liver organoids
    Denis D. Shi, Evelyn Makris, Yi-Wen Gerrand, Pu‐Han Lo, George C. Yeoh, Wayne A. Morrison, Geraldine M. Mitchell, Kiryu K. Yap · 2024 · eLife
  27. Misidentification of neural cell identity in liver-derived organoid systems
    Imre Firmin Schene, Arif Ibrahim Ardisasmita, Sabine A. Fuchs · 2024 · Stem Cell Reports
  28. Recent Advances in Regenerative Medicine of the Liver and Bile Duct System by Chemically Induced Liver Progenitor Cells (CLiPs) in Nagasaki Experience
    Masaaki Hidaka, Daisuke Miyamoto, Susumu Eguchi · 2024 · Springer eBooks
  29. Generation of Human Liver Organoids (HLOs) on Pillar/Perfusion Platform via Microarray 3D Bioprinting and Study of Genetic Diversity in DILI
    Sunil Shrestha · 2024
  30. Biliary tree stem cell transplantation
    Savino Paradiso, Federica Cremisini, Matteo Franchitto, Guido Carpino, Vincenzo Cardinale · 2025 · Elsevier eBooks
  31. Hepatobiliary organoids and large-scale expansion for regenerative therapies
    Kerstin Schneeberger, Sara Morini, Bart Spee · 2025 · Elsevier eBooks
  32. Whole-liver bioengineering: The future of transplantation medicine
    Diogo Marques, Natalia Sánchez Romero, Sandra Melitón Barbancho, Álvaro Blanes-Rodríguez, P Arnal, Helen Almeida, Pablo Royo Dachary, Pedro M. Baptista · 2025 · Elsevier eBooks
  33. Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function
    Shicheng Ye, Zhenguo Wang, Maarten Dirk Delemarre, Nalan Liv, Antoinette van den Dikkenberg, Tina Vermonden, Luc J. W. van der Laan, Jos Malda, Bart Spee, Frank G. van Steenbeek et al. · 2026 · Materials Today Bio
  34. Additional file 1 of Cholangiocyte organoids to study drug-induced injury
    Zhenguo Wang, Xing, Chen, Luc J. W. van der Laan, Verstegen, Monique M. A., Bart Spee, Rosalinde Masereeuw · 2024 · Figshare
  35. Additional file 1 of The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins
    Ghosh, Souvik, Anastasiya Börsch, Shreemoyee Ghosh, Mihaela Zavolan · 2021 · Figshare
  36. Future of Regenerative Hepatology
    Javier Martínez-García, Álvaro Blanes-Rodríguez, Sandra Melitón Barbancho, Marta Sáinz Viartola, Pedro M. Baptista · 2026 · Springer eBooks
  37. Liver Tissue Engineering
    Kartik Mitra Venkat, Zhiyi Zhang, Kexiao Zheng, Vishnu Goutham Kota, Hwa Liang Leo, Lingyu Sun, Hanry Yu · 2026 · Elsevier eBooks
  38. Triclocarban drives intrahepatic cholangiocyte injury by triggering ferroptosis via the SLC7A11/GSH/GPX4 axis
    Jiadi Zhao, Lin Ma, Xueting Gao, Shengmin Xu, Lijun Wu · 2026 · Toxicology
  39. Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing
    Yu Tao, Paulina Núñez Bernal, Núria Ginés Rodriguez, Manon Bouwmeester, Tom Walraven, Dave Wanders, Linda M. Kock, Nura van Heck, Kerstin Schneeberger, Luc J. W. van der Laan et al. · 2026 · Cells
  40. Scalable generation of human stem cell-derived ureteric bud and collecting duct organoids in stirred bioreactors
    Kayla J. Wolf, Jonathan E. Rubins, Ronald C. van Gaal, Kyles Stevens, Aline N. Klaus, Pooja Nair, Jennifer A. Lewis · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Organoids in drug discovery and development: emerging technologies to transition beyond animal models
    Jolene Phelps, Amanda Orr, Stephanie Michelle Willerth · 2026 · Expert Opinion on Drug Discovery