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Cited by 28

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Prediction of biochemical nonresolution in patients with chronic drug‐induced liver injury: A large multicenter study

Wang, Chun‐Yan, Deng, Ya, Li, Ping, Zheng, Sujun, Chen, Guofeng, Zhou, Guangde, Xu, Jing, Chen, Yan‐Ping, Wang, Zheng, Jin, Xueyuan, Tang, Jin‐Mo, Hu, Kun‐Peng, Bi, Jing‐Feng, Zhang, Ping, Li, Chun‐Xia, Huang, Ang, Lv, Gui‐Ji, Xiao, Xiao‐He, Zou, Zhengsheng, Ji, Dong·2022·Hepatology
DOI 10.1002/hep.32283
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Abstract

Background and Aims: To clarify high‐risk factors and develop a nomogram model to predict biochemical resolution or biochemical nonresolution (BNR) in patients with chronic DILI. Approach and Results: Retrospectively, 3655 of 5326 patients with chronic DILI were enrolled from nine participating hospitals, of whom 2866 underwent liver biopsy. All of these patients were followed up for over 1 year and their clinical characteristics were retrieved from electronic medical records. The endpoint was BNR, defined as alanine aminotransferase or aspartate aminotransferase >1.5× upper limit of normal or alkaline phosphatase >1.1× ULN, at 12 months from chronic DILI diagnosis. The noninvasive high‐risk factors for BNR identified by multivariable logistic regression were used to establish a nomogram, which was validated in an independent external cohort. Finally, 19.3% (707 of 3655) patients presented with BNR. Histologically, with the increase in liver inflammation grades and fibrosis stages, the proportion of BNR significantly increased. The risk of BNR was increased by 21.3‐fold in patients with significant inflammation compared to none or mild inflammation (p < 0.001). Biochemically, aspartate aminotransferase and total bilirubin, platelets, prothrombin time, sex, and age were associated with BNR and incorporated to construct a nomogram model (BNR‐6) with a concordance index of 0.824 (95% CI, 0.798–0.849), which was highly consistent with liver histology. These results were successfully validated both in the internal cohort and external cohort. Conclusions: Significant liver inflammation is a robust predictor associated with biochemical nonresolution. The established BNR‐6 model provides an easy‐to‐use approach to assess the outcome of chronic DILI.

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Crossref · 10.1002/hep.32283

Cites

8 of 8 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • High TBil and ALP levels in the second month after an acute DILI episode and the biochemical nonresolution-6 model may help predict the risk of chronic injury and delayed recovery.

    “High TBil and ALP levels in the second month after an acute DILI episode and the biochemical nonresolution-6 model may help predict the risk of chronic injury and delayed recovery [26,72].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [72]

Citations

Cites

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Research works printed but not linked: 31

  1. 2020, Managing the challenge of drug‐induced liver injury: a roadmap for the development and deployment of preclinical predictive models, Nat Rev Drug Discov, 19, 131, 10.1038/s41573-019-0048-x · DOI
  2. 2021, Chronic drug‐induced liver injury: updates and future challenges, Front Pharmacol, 12, 627133, 10.3389/fphar.2021.627133 · DOI
  3. 2017, Drug‐induced liver injury: recent advances in diagnosis and risk assessment, Gut, 66, 1154, 10.1136/gutjnl-2016-313369 · DOI · Paper page
  4. 2021, The LAC score indicates significant fibrosis in patients with chronic drug‐induced liver injury: a large biopsy‐based study, Front Pharmacol, 12, 734090, 10.3389/fphar.2021.734090 · DOI
  5. 2014, Idiosyncratic drug‐induced liver injury is associated with substantial morbidity and mortality within 6 months from onset, Gastroenterology, 147, 96, 10.1053/j.gastro.2014.03.045 · DOI · Paper page
  6. 2015, Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury, Am J Gastroenterol, 110, 1450, 10.1038/ajg.2015.283 · DOI
  7. 2016, Definition and risk factors for chronicity following acute idiosyncratic drug‐induced liver injury, J Hepatol, 65, 532, 10.1016/j.jhep.2016.05.003 · DOI · Paper page
  8. 2015, Features and outcomes of 899 patients with drug‐induced liver injury: the DILIN prospective study, Gastroenterology, 148, 1340, 10.1053/j.gastro.2015.03.006 · DOI · Paper page
  9. 2014, Practice parameters committee of the American college of gastroenterology. ACG clinical guideline: the diagnosis and management of idiosyncratic drug‐induced liver injury, Am J Gastroenterol, 109, 950, 10.1038/ajg.2014.131 · DOI · Paper page
  10. 2015, Risk of acute liver failure in patients with drug‐induced liver injury: evaluation of Hy’s Law and a new prognostic model, Clin Gastroenterol Hepatol, 13, 2360, 10.1016/j.cgh.2015.06.020 · DOI
  11. 2015, Clinical and histologic features of azithromycin‐induced liver injury, Clin Gastroenterol Hepatol, 13, 369, 10.1016/j.cgh.2014.07.054 · DOI
  12. 2019, Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: an international collaborative effort, Hepatology, 69, 760, 10.1002/hep.29802 · DOI · Paper page
  13. 2018, Herbal and dietary supplement‐induced liver injuries in the Spanish DILI registry, Clin Gastroenterol Hepatol, 16, 1495, 10.1016/j.cgh.2017.12.051 · DOI · Paper page
  14. 2021, A high serum level of taurocholic acid is correlated with the severity and resolution of drug‐induced liver injury, Clin Gastroenterol Hepatol, 19, 1009, 10.1016/j.cgh.2020.06.067 · DOI
  15. 2018, Development and validation of a test to identify drugs that cause idiosyncratic drug‐induced liver injury, Clin Gastroenterol Hepatol, 16, 1488, 10.1016/j.cgh.2018.04.049 · DOI · Paper page
  16. 2017, The histopathological evaluation of drug‐induced liver injury, Histopathology, 70, 81, 10.1111/his.13082 · DOI
  17. 2017, New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment, Hepatology, 65, 1438, 10.1002/hep.29009 · DOI
  18. 1981, Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis, Hepatology, 1, 431, 10.1002/hep.1840010511 · DOI
  19. 1995, Histological grading and staging of chronic hepatitis, J Hepatol, 22, 696, 10.1016/0168-8278(95)80226-6 · DOI
  20. 2021, Risk stratification based on chronic liver failure consortium acute decompensation score in patients with Child‐Pugh B cirrhosis and acute variceal bleeding, Hepatology, 73, 1478, 10.1002/hep.31478 · DOI
  21. 2021, Refitting the model for end‐stage liver disease for the Eurotransplant region, Hepatology, 74, 351, 10.1002/hep.31677 · DOI
  22. 2019, Development and validation of NTCP models for acute side‐effects resulting from proton beam therapy of brain tumours, Radiother Oncol, 130, 164, 10.1016/j.radonc.2018.06.036 · DOI
  23. 2017, Death and liver transplantation within 2 years of onset of drug‐induced liver injury, Hepatology, 66, 1275, 10.1002/hep.29283 · DOI · Paper page
  24. 2017, Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements, Hepatology, 65, 1267, 10.1002/hep.28967 · DOI · Paper page
  25. 2014, Hepatic histological findings in suspected drug‐induced liver injury: systematic evaluation and clinical associations, Hepatology, 59, 661, 10.1002/hep.26709 · DOI · Paper page
  26. 2014, Use of Hy’s law and a new composite algorithm to predict acute liver failure in patients with drug‐induced liver injury, Gastroenterology, 147, 109, 10.1053/j.gastro.2014.03.050 · DOI · Paper page
  27. 2010, Pharmacogenetics of drug‐induced liver injury, Hepatology, 52, 748, 10.1002/hep.23720 · DOI
  28. 2021, Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI, J Hepatol, 75, 333, 10.1016/j.jhep.2021.03.021 · DOI
  29. 2017, Acetaminophen (APAP) hepatotoxicity—isn’t it time for APAP to go away?, J Hepatol, 67, 1324, 10.1016/j.jhep.2017.07.005 · DOI
  30. 2017, Idiosyncratic drug induced liver injury in African‐Americans is associated with greater morbidity and mortality compared to Caucasians: a randomized controlled trial, Am J Gastroenterol, 112, 1382, 10.1038/ajg.2017.215 · DOI · Paper page
  31. 2019, Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease, Gastroenterology, 156, 1264, 10.1053/j.gastro.2018.12.036 · DOI · Paper page

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Metadata

Authors
Wang, C., Deng, Y., Li, P., Zheng, S., Chen, G., Zhou, G., Xu, J., Chen, Y., Wang, Z., Jin, X., Tang, J., Hu, K., Bi, J., Zhang, P., Li, C., Huang, A., Lv, G., Xiao, X., Zou, Z., & Ji, D.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2022-01-06
Volume
75
Issue
6
Pages
1373-1385
ISSN
  • 0270-9139
  • 1527-3350
DOI
10.1002/hep.32283
Cited by
28
References
8
Language
en
Licence

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