Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

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Items 201–300 of 432

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2. The plasma degradome reflects later development of NASH fibrosis after liver transplant
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3. Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract
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4. The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2
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5. Hepatic venous pressure gradient: Inaccurately estimates portal venous pressure gradient in alcoholic cirrhosis and portal hypertension
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6. HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells
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7. Emerging synthetic drugs for the treatment of hepatic cirrhosis: a 2024 update
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8. <i>Tet2</i> deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis
   Feng, Jiuxing, Wu, Baitong, Li, Yu, Sun, Pengli, Liu, Qian, Xiao, Qianxue, Cai, Jia-Bin, Zheng, Yimin, Chen, Haonan, Xu, Yichi et al. · 2026 · Journal of Experimental Medicine
9. Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis
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10. Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis
    Ying Zhu, Shi-Yu Geng, Yao Chen, Qingjing Ru, Yi Zhou Zheng, Na Jiang, Fei-Ye Zhu, Yongsheng Zhang · 2025 · World Journal of Gastroenterology
11. Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism
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12. New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review)
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13. FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism
    Wujun Wei, Cheng Lin, Shihua Luo, Jingjing Huang, Ren-Tong Hu, Jiaxing Li, Hong Ma, Jia-Zhu Wei, Chunfang Wang, Crystale-Siew-Ying Lim et al. · 2025 · Biochemical and Biophysical Research Communications
14. Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis
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15. Combination of silybin and carvedilol synergistically alleviates liver fibrosis by inhibiting Wnt/β-catenin signaling
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16. Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B
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17. A machine learning based algorithm accurately stages liver disease by quantification of arteries
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18. Aryl Hydrocarbon Receptor Activation Limits the Fatty Acid Synthesis and Subsequent “miR-193a-3p-HDAC3-FASN” Signals to Alleviate Intestinal Fibrosis
    Xiaoqian Wu, Xiaohong Miao, Xinru Xue, Simiao Qiao, Yue Dai, Zhifeng Wei · 2024 · Journal of Agricultural and Food Chemistry
19. CT-based artificial intelligence system complementing deep learning model and radiologist for liver fibrosis staging
    Shuang Zheng, Wenao Ma, Lin Mu, Kan He, Jianfeng Cao, Tiffany Y. So, Lei Zhang, Mingyang Li, Zhai Yanan, Feng Liu et al. · 2025 · iScience
20. Histone methyltransferase SMYD2 regulates the activation of hepatic stellate cells by activating TLR4 signaling
    Kai-Ze Ding, R. Xie, Bing Han, Hui-Ling Zheng, Tian Tian · 2025 · Scientific Reports
21. Luteolin for the Treatment of Organ Fibrosis: A Mini Review
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22. Nanotherapy targeting liver sinusoidal endothelial cells in liver fibrosis
    Lingfeng Zhang, Jia-Wen Ru, Su-Qing Liang, Meng-Meng Zhang, Chun-Yu Zhang, Jia-Qi Liu, Yi Wang, Tian‐Jiao Zhou, Xian Wu Cheng, Lei Xing et al. · 2026 · Journal of Controlled Release
23. Role of artificial intelligence in staging and assessing of treatment response in MASH patients
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24. Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients
    Qiyao Wei, Jing Zhao · 2025 · BMC Gastroenterology
25. Challenges and opportunities in nonalcoholic steatohepatitis
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26. Clinical trials reimagined
    Paul Yien Kwo, Tushar C. Patel · 2023 · Hepatology
27. SERPINB3 in fibrogenic chronic liver diseases and primary liver cancers
    Patrizia Pontisso, Maurizio Parola · 2024 · Exploration of Digestive Diseases
28. CTHRC1 serves as an indicator in biliary atresia for evaluating the stage of liver fibrosis and predicting prognosis
    Zequan Ding, Ruyi Zhang, Wei Zhu, Yao Lu, Zhongxian Zhu, Hua Qiang Xie, Weibing Tang · 2024 · Digestive and Liver Disease
29. Promotion of liver fibrosis by Y-box binding protein 1 via the attenuation of transforming growth factor-beta 3 transcription
    Qiong Liao, Yuwei Dong, Binghang Li, Jie Qin, Yangwei Cao, Wenjuan Tu, Lungen Lu · 2023 · Annals of Translational Medicine
30. Association of weight-adjusted waist index with all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease: a national population-based cohort study
    Fan Zhang, Yan Han, Yong-Hua Mao, Wenjian Li · 2025 · BMC Cardiovascular Disorders
31. Pathogenesis, diagnosis and management of chronic hepatitis B related liver fibrosis
    Mehmet Ali Kösekli, Gülali Aktaş · 2025 · Minerva Gastroenterology
32. Obesity and risk for liver disease: a two-sample Mendelian randomisation study
    Wen An, Jing Luo, Zhe Yu, Mengqi Li, Herui Wei, Aqian Song, Yuanpeng Mao, Hao Bian, Lingling He, Fan Xiao et al. · 2024 · British Journal Of Nutrition
33. Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway
    Guanqi Dai, Junhao Lin, Yuchuan Jiang, Xinhui Liu, Peng Chen, Yixiao Zhang, Zhenghui Song, Xuefen Zhuang, Jinge Cong, Yingchun Li et al. · 2025 · Frontiers in Oncology
34. Alterations in the “Gut–Liver Axis” on Rats with Immunological Hepatic Fibrosis
    Zhaoyao Qi, Xinxin Qi, Yuanhui Xu, Hongguang Sun, Dengfeng Li, Jincun Liu, Meili Cong, Tao Liu · 2023 · Journal of Immunology Research
35. Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis
    Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Li Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu · 2023 · International Journal of Nanomedicine
36. Role and new insights of microfibrillar‐associated protein 4 in fibrotic diseases
    Long Zhu, Wenqun Gou, Lijia Ou, Binjie Liu, Manyi Liu, Hui Feng · 2023 · Apmis
37. Label‐free Raman spectroscopy for the assessment of liver fibrosis
    Huiying Cao, Chen Ma, Zhitao Wu, Lin Sun, Wenjing Liu, Chenhui Ma, Feihong Chen, Zhaoliang Peng, Lijiang Xuan, Ruimin Huang et al. · 2023 · MedComm – Future Medicine
38. Personalized translational medicine: Investigating YKL-40 as early biomarker for clinical risk stratification in hepatocellular carcinoma recurrence post-liver transplantation
    Ileana Lulić, Dinka Lulić, Jadranka Pavičić Šarić, Iva Bačak Kocman, Dunja Rogić · 2025 · World Journal of Transplantation
39. Viscoelasticity assessment for in vivo quantification of muscle contusion injury in rats using shear wave elastography
    Yuwei Xin, Fei‐Fei Liu, Diancheng Li, Jiaan Zhu · 2022 · Ultrasound in Medicine & Biology
40. Machine Learning Models to Classify Normal and Fibrotic Mouse Liver Model using Dielectric Properties
    Poulami Samaddar, Poushali Samadder, Bhavana Baraskar, Priyanka Anvekar, Shalil Khanal, Sunil Gaddam, Sayan Kumar Roy, Dipankar Mitra, Enis Kostallari, Shivaram P. Arunachalam · 2022 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
41. A májbetegségek súlyosságának és prognózisának nem invazív vizsgálómódszerei
    Gabriella Pár · 2023 · Orvosi Hetilap
42. Digitizing DILI: Who can? RUCAM? RECAM?
    James H. Lewis · 2022 · Hepatology
43. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease
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44. YKL-40 in Virus-Associated Liver Disease: A Translational Biomarker Linking Fibrosis, Hepatocarcinogenesis, and Liver Transplantation
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45. Supramolecular carrier-free biological nanofibers for treatment of liver fibrosis
    Chen Jiang, Bowen Li, Zhiyi Xu, Xueli Li, Huixian Li, Qianli Zou · 2025 · Colloids and Surfaces A Physicochemical and Engineering Aspects
46. A novel cell-permeable LOXL2 inhibitor PAT-1251 potently suppresses biliary liver fibrosis via collagen crosslinking-dependent and -independent mechanisms
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47. Bystander Effects and Profibrotic Interactions in Hepatic Stellate Cells during HIV and HCV Coinfection
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48. Association Between Bioimpedance-Determined Metabolic Age and MASLD Risk Scores in Spanish Workers
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49. Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease
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50. Hepatocyte uptake ratio derived from T1 mapping for quantitative assessment of liver fibrosis
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51. Single Cell Secretome Analyses of Hepatic Stellate Cells: Aiming for Single Cell Phenomics
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52. The Current Proceedings of PSC-Based Liver Fibrosis Therapy
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53. Cellular and Molecular Mechanisms of Toxic Liver Fibrosis in Rats Depending on the Stages of Its Development
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54. Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice
    Jie Gao, Miaoye Bao, Yuanming Xing, Yiming Ding, Tuo Han, Ergang Wen, Jun Liu, Shaoyun Yue, Rong Wang, Ling Wang et al. · 2023 · American Journal of Physiology-Gastrointestinal and Liver Physiology
55. Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe
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56. Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
    Elena Ivanovna Lebedeva, Anatoliy T. Shchastniy, Andrei S. Babenka, Dmitry Aleksandrovich Zinovkin · 2024 · Molecular Biology
57. Network pharmacology combined with metabolomics to reveal the anti-fibrotic mechanism of Polygoni Orientalis Fructus in CCl4-induced hepatic fibrosis rats
    Lizhou Ma, Yu Chen, Rong Yue, Ziyu Li, Yibo Wang, Yanggang Bian, Miao Wang · 2024 · Journal of Proteomics
58. Serum‐free light chains as a dependable biomarker for stratifying patients with metabolic dysfunction‐associated steatotic liver disease
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59. Experimental study on H2O2 activation of HSC-T6 and hepatic fibrosis in cholestatic mice by "Yajieshaba"
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60. The Causal Relationship between Inflammatory Cytokines and Liver Cirrhosis in European Descent: A Bidirectional Two-Sample Mendelian Randomization Study and the First Conclusions
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61. Multi‐Scale Spatial Heterogeneity of Liver Fibrosis Evaluated by MR Elastography in Rat Models
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62. Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells
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63. A single-cell fixed RNA profiling of liver fibrosis progression and regression reveals SEMA4D and LMCD1 as key mediators of fibrogenesis
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64. Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells
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65. Targeting macrophages in liver fibrosis
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66. Portal vein computed tomography imaging characteristics and their relationship with bleeding risk in patients with liver cirrhosis undergoing interventional therapy
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67. The role of macrophage-derived exosomes in noncancer liver diseases: From intercellular crosstalk to clinical potential
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68. Non-Invasive Kupffer-CEUS Enhances the Accuracy of Focal Liver Lesions Diagnosis in Patients with Liver Cirrhosis or Fibrosis: A Prospective Multicenter Study from China
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69. Modulation of γδ T cells by USF3: Implications for liver fibrosis and immune regulation.
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70. Protective effects of Scutellaria barbata against hepatocyte apoptosis during hepatic fibrosis progression
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71. Discovery of Novel Cyclic Peptides as SMAD2-SMAD4 Interaction Inhibitors for the Treatment of Hepatic Fibrosis.
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72. Biomedical applications of organoids derived from the digestive system
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73. Associations Between Shift Work, Sociodemographic and Lifestyle Characteristics, Body Measurements, and MASLD
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74. Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis
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75. Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms
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76. CCN1: a SASPy protein that plays multifaceted roles in fibrogenesis
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77. Clinical implications of fibrosis marker dynamics after hepatitis C cure: Insights from paired biopsies
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78. TRIM26 deficiency promotes liver fibrosis progression by mediating macrophage polarization via the EZH2-STAT1 axis
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79. Single-cell fixed RNA profiling uncovers SEMA4D and LMCD1 as therapeutic targets in a liver fibrosis model
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80. Platelet-mediated progression of fatty liver disease in metabolic dysfunction-associated steatohepatitis: a pathophysiological review
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81. Proteolytic remodelling of the extracellular matrix by pericytes
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82. Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus Trichoderma harzianum
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83. Immune surveillance and immune evasion of senescent cells
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84. 3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
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85. FDRdb: a manually curated database of fibrotic disease–associated RNAome and high-throughput datasets
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86. Model of toxic fibrosis in Wistar rats: morphological and molecular-genetic parameters of the transition point to cirrhosis
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87. Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy
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88. Staging of Liver Fibrosis Based on Energy Valley Optimization Multiple Stacking (EVO-MS) Model
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89. Non-Invasive Biomarkers for Differentiating Alcohol Associated Hepatitis from Acute Decompensation in Patients with ALD
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90. Liver fibrosis: Our evolving understanding
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91. Plasma microRNA-15a/16-1 serves as a non-invasive indicator of liver fibrosis severity in individuals with chronic hepatitis B
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92. Effects of Bushen Huayu Decoction combined with entecavir on liver function and hepatic fibrosis in patients with compensated cirrhosis
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93. Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies
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94. Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids
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95. A spatial map of human liver cirrhosis reveals the patho-architecture and gene signatures associated with cell state transitions during liver disease
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96. Follistatin-like protein 1 and chronic liver disease progression: a novel pro-inflammatory and pro-fibrogenic mediator?
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97. Therapeutic Effect of Hydrodynamics-Based Delivery of Matrix Metalloproteinase-13 Gene on Thioacetamide-Induced Liver Fibrosis in Rats
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98. Decompensated liver cirrhosis: assessment of complications and mortality in hospitalised patients
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99. Liver sinusoidal cells in the diagnosis and treatment of liver diseases: Role of hepatic stellate cells
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100. Mechanism of Si Ni San Combined with Astragalus in Treating Hepatic Fibrosis: A Network Pharmacology and Molecular Docking Study
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