CoChat
Sign Up
Cited by 113Gallbladder and Bile Duct DisordersBariatric Surgery and OutcomesDiet and metabolism studies

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

The Role of Gallbladder Emptying in Gallstone Formation During Diet–Induced Rapid Weight Loss

Gebhard, R L, Prigge, W F, Ansel, H J, Schlasner, L, Ketover, S R, Sande, D, Holtmeier, K, Peterson, F J·1996·Hepatology
DOI 10.1002/hep.510240313
Open this paper in CoChat — free account

Abstract

Obese persons are at risk for cholesterol gallstones because their bile is saturated with cholesterol. The risk increases during rapid weight loss by means of certain very–low–calorie diets or gastric bypass surgery. Gallstone risk factors during rapid weight loss include increased bile cholesterol saturation index and gallbladder stasis. Obese subjects were randomized to one of two low–calorie liquid diets for rapid weight loss: a 520–kcal diet with less than 2 g fat/d, and a 900–kcal diet with 30 g fat/d (including one 10–g fat meal to stimulate maximal gallbladder emptying). Bile and blood lipids, saturation index, leukocyte 3–hydroxy–3–methylglutaryl coenzyme A (HMG CoA) reductase activity, and ultrasonographic gallbladder emptying were measured repeatedly during dietary treatment. Both diets produced comparable weight loss of 22%. Bile cholesterol saturation index increased during both diets (26%), but fell to 15% below prediet level after weight loss. Compared with subjects' maximal gallbladder emptying fraction of 66%, the 520–kcal diet provided poor gallbladder emptying (35%), whereas the 10–g fat meal of the 900–kcal diet provided maximal emptying. Gallstones developed in four of six 520–kcal subjects and none of seven 900–kcal subjects ( P = .021), an unanticipated difference that resulted in premature study termination for ethical reasons. Blood lipids and HMG CoA reductase activity in mononuclear leukocytes fell at week 8 during both diets, but recovered while weight was still being lost. The findings suggest that gallstone risk during rapid weight loss may be reduced by maintenance of gallbladder emptying with a small amount of dietary fat. Ultimately, weight loss reduced bile cholesterol saturation and improved highdensity lipoprotein (HDL) levels.

Overview

Integrity signals

Registry

Crossref · 10.1002/hep.510240313

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 32 references

Cited by

Sorted by citations

Items 101–112 of 112

Related

See all

Metadata

Authors
Gebhard, R. L., Prigge, W. F., Ansel, H. J., Schlasner, L., Ketover, S. R., Sande, D., Holtmeier, K., & Peterson, F. J.
Affiliations
Minneapolis VA Medical Center (US)
ORCID
Ansel, H J
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-09
Volume
24
Issue
3
Pages
544-548
ISSN
0270-9139 (ISSN-L)
DOI
10.1002/hep.510240313
OpenAlex
W2020577433
Cited by
113
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 3
FWCI
2.13
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 6939 d)
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords
gallstone formation, gallbladder emptying, rapid weight loss, very low calorie diet, cholesterol gallstones, gallbladder stasis, dietary fat, leukocytes, serum lipids, HDL cholesterol, obesity, gastric bypass
MeSH terms
Adult, Cholelithiasis, Diet, Reducing, Dietary Fats, Female, Humans, Male, Middle Aged, Obesity, Reference Values, Time Factors, Weight Loss, Gallbladder Emptying

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review