Incidence of cancer in primary biliary cirrhosis: the Mayo experience

Nijhawan, Pardeep K.; Therneau, Terry M.; Dickson, Rolland E.; Boynton, Jessica; Lindor, Keith D.

doi:10.1002/hep.510290511

Cited by 99Liver Diseases and ImmunityCholangiocarcinoma and Gallbladder Cancer StudiesPediatric Hepatobiliary Diseases and Treatments

Incidence of cancer in primary biliary cirrhosis: the Mayo experience

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Nijhawan, Pardeep K., Therneau, Terry M., Dickson, Rolland E., Boynton, Jessica, Lindor, Keith D.·1999·Hepatology

DOI 10.1002/hep.510290511

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Abstract

Patients with primary biliary cirrhosis (PBC) may be at increased risk for malignancies. Several studies have addressed the risk of specific malignancies; however, there is little information about overall incidences of malignancies in these patients. We hypothesize that these patients may be at an increased risk for cancer. We performed a retrospective chart review evaluating patients with the diagnosis of PBC and malignancies. We reviewed records of patients with PBC presenting to the Mayo Clinic between 1976 and 1985. The diagnosis of PBC was made using evidence of cholestasis, positive antimitochondrial antibody titers and liver biopsy findings consistent with PBC. The incidence of malignancies were then compared with published data by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. Of the 1,692 patients with PBC in the Mayo Clinic data base, 114 patients were identified with primary cancer. The number of malignancies was higher than would be anticipated by chance alone; with 93 observed versus 62.4 expected events (P < .001). Hepatobiliary malignancies had a relative risk of 46 (P < .0001) for women and 55 (P < .0001) in men. There was a dramatic increased risk for development of hepatobiliary malignancies. PBC patients might benefit from more aggressive surveillance for hepatobiliary malignancies during their lifetime

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Regular imaging surveillance is linked to improved clinical outcomes in PBC patients who develop HCC.
“Surveillance with regular imaging was associated with better clinical outcome of PBC patients who develop HCC.(227)(228)(229)(230)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [228]
The Discussion recommends that PBC patients might benefit from more aggressive surveillance for hepatobiliary malignancies. It does not specify regular imaging or report that surveillance was associated with better outcomes among patients who developed HCC. (LLM, conf=0.85)
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Authors: Nijhawan, P. K., Therneau, T. M., Dickson, R. E., Boynton, J., & Lindor, K. D.
Affiliations: Mayo Clinic (US)
Corresponding author: Lindor, Keith D.
ORCID: Therneau, Terry M.
Lindor, Keith D.
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-05
Volume: 29
Issue: 5
Pages: 1396-1398
ISSN: 0270-9139 (ISSN-L)
DOI: 10.1002/hep.510290511
OpenAlex: W2021512776
Cited by: 99
References: 20
Citations by year: 2024: 2 · 2023: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 5
FWCI: 2.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 5967 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords: primary biliary cirrhosis, cancer incidence, hepatobiliary malignancies, cancer risk, cholestatic liver disease, antimitochondrial antibodies, cancer surveillance, sex differences in cancer risk
MeSH terms: Adolescent, Adult, Aged, Bile Duct Neoplasms, Child, Child, Preschool, Female, Humans, Infant, Liver Cirrhosis, Biliary, Liver Neoplasms, Male, Medical Records, Neoplasms, Retrospective Studies, Risk Factors, Incidence, Sex Distribution

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