Oxygen: Modulator of metabolic zonation and disease of the liver

Metabolic zonation of the liver: Regulation and implications for liver function

Gebhardt, R. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90055-5 · Cited by 607 · see citing works

Hypoxic control of metastasis

Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works

Hypoxia and Metabolic Adaptation of Cancer Cells

Eales, K. L., Hollinshead, K. E. R., & Tennant, D. A. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.50 · Cited by 724 · see citing works

Metabolic zonation of the liver: The oxygen gradient revisited

Kietzmann, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.012 · Cited by 499 · see citing works

Extracellular Metabolic Energetics Can Promote Cancer Progression

Loo, J. M., Scherl, A., Nguyen, A., Man, F. Y., Weinberg, E., Zeng, Z., Saltz, L., Paty, P. B., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2014.12.018 · Cited by 393 · see citing works

Orchestrating liver development

Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375 · see citing works

Molecular Physiology of Mammalian Glucokinase

Iynedjian, P. B. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8322-9 · Cited by 365 · see citing works

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338 · see citing works

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275 · see citing works

Formation of steady‐state oxygen gradients in vitro: <i>Application to liver zonation</i>

Allen, J. W., & Bhatia, S. N. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10569 · Cited by 269 · see citing works

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

Glick, D., Zhang, W., Beaton, M., Marsboom, G., Gruber, M., Simon, M. C., Hart, J., Dorn, G. W., Brady, M. J., & Macleod, K. F. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00167-12 · Cited by 251 · see citing works

Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis

Natarajan, S., Foreman, K. M., Soriano, M. I., Rossen, N. S., Shehade, H., Fregoso, D. R., Eggold, J. T., Krishnan, V., Dorigo, O., Krieg, A. J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2616 · Cited by 129 · see citing works

The role of hypoxia-inducible factor-2 in digestive system cancers

Zhao, J., Du, F., Shen, G., Zheng, F., & Xu, B. (2015) · Cell Death &amp; Disease · doi:10.1038/cddis.2014.565 · Cited by 122 · see citing works

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

Yamaguchi, N., Weinberg, E. M., Nguyen, A., Liberti, M. V., Goodarzi, H., Janjigian, Y. Y., Paty, P. B., Saltz, L. B., Kingham, T. P., Loo, J. M., et al. (2019) · eLife · doi:10.7554/elife.52135 · Cited by 91 · see citing works

Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine

Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909553 · Cited by 65 · see citing works

Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations

Rivera, K. R., Yokus, M. A., Erb, P. D., Pozdin, V. A., & Daniele, M. (2019) · The Analyst · doi:10.1039/c8an02201a · Cited by 57 · see citing works

3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation

Wesseler, M. F., Taebnia, N., Harrison, S., Youhanna, S., Preiss, L. C., Kemas, A. M., Vegvari, A., Mokry, J., Sullivan, G. J., Lauschke, V. M., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.09.022 · Cited by 39 · see citing works

Mimicking physiologically relevant hepatocyte zonation using immunomodulatory silk liver extracellular matrix scaffolds toward a bioartificial liver platform

Janani, G., & Mandal, B. B. (2021) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.1c00719 · Cited by 31 · see citing works

Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver

Tsukada, K., Tajima, T., Hori, S., Matsuura, T., Johnson, R. S., Goda, N., & Suematsu, M. (2013) · Microcirculation · doi:10.1111/micc.12033 · Cited by 18 · see citing works

From NAFLD to MAFLD: Aligning Translational In Vitro Research to Clinical Insights

Gatzios, A., Rombaut, M., Buyl, K., De Kock, J., Rodrigues, R. M., Rogiers, V., Vanhaecke, T., & Boeckmans, J. (2022) · Biomedicines · doi:10.3390/biomedicines10010161 · Cited by 15 · see citing works