The role of hypoxia-inducible factor-2 in digestive system cancers

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

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HIF activation identifies early lesions in VHL kidneys

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

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The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

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The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

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The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

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HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression

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Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1α

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Regulation of E-cadherin Expression by <i>VHL</i> and Hypoxia-Inducible Factor

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Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α

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HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

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Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

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Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients

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Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

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HIF‐1α and HIF‐2α have divergent roles in colon cancer

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Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

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Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

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Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells

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Roles of Hypoxia-Inducible Factor-1α (Hif-1α) Versus Hif-2α in the Survival of Hepatocellular Tumor Spheroids

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HIF-2α deletion promotes Kras-driven lung tumor development

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Human cancers converge at the HIF-2α oncogenic axis

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A Mouse Model of Cholestasis-Associated Cholangiocarcinoma and Transcription Factors Involved in Progression

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Hypoxia‐inducible factors in stem cells and cancer

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Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

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Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth

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Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

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Prognostic significance of HIF-2α/EPAS1 expression in hepatocellular carcinoma

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Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

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The relation between hypoxia‐inducible factor (HIF)‐1α and HIF‐2α expression with anemia and outcome in surgically treated head and neck cancer

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Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes

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Hypoxia Induces Vascular Endothelial Growth Factor Gene Transcription in Human Osteoblast-Like Cells through the Hypoxia-Inducible Factor-2α

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Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells

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Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control

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Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration

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Cellular prion protein promotes glucose uptake through the Fyn‐HIF‐2α‐Glut1 pathway to support colorectal cancer cell survival

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HIF‐2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

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The Correlation of Expression Levels of HIF-1 and HIF-2 in Hepatocellular Carcinoma with Capsular Invasion, Portal Vein Tumor Thrombi and Patients' Clinical Outcome

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Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses

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Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment

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Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice

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HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer

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Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

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PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis

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Downregulation of PHLPP Expression Contributes to Hypoxia-Induced Resistance to Chemotherapy in Colon Cancer Cells

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HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

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Anti-Ri-associated paraneoplastic opsoclonus-ataxia syndrome in a man with transitional cell carcinoma

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New Agents and New Targets for Renal Cell Carcinoma

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Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression

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Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

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A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

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Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis

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Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

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Hypoxia inducible factor as a therapeutic target for atherosclerosis

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Role of OCT4 in cancer stem-like cells and chemotherapy resistance

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Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews

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Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction

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The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability

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Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

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Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects

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COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment

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Targeted Therapies for Pancreatic Cancer and Hurdles Ahead

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Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression

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HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

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The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors

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Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer

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Hypoxia‐sensitive LINC 01436 is regulated by E2F6 and acts as an oncogene by targeting miR‐30a‐3p in non‐small cell lung cancer

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Anticancer Activity of Garcinia morella on T-Cell Murine Lymphoma Via Apoptotic Induction

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Hypoxia/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation

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Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study

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USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α

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Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan

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Selenium targets resistance biomarkers enhancing efficacy while reducing toxicity of anti-cancer drugs: preclinical and clinical development

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Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy

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MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells

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High Altitude and Cancer Mortality

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Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing

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Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia

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The regulatory mechanisms of oncomiRs in cancer

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CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

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Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods

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PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia

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Combined over-expression of the hypoxia-inducible factor 2α gene and its long non-coding RNA predicts unfavorable prognosis of patients with osteosarcoma

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HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases

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Hypoxia-inducible factor-2α is crucial for proper brain development

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Dietary luteolin protects against renal anemia in mice

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RelSim: An integrated method to identify disease genes using gene expression profiles and PPIN based similarity measure

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Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer

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Regulation of the HIF switch in human endothelial and cancer cells

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Novel Approaches with HIF-2α Targeted Therapies in Metastatic Renal Cell Carcinoma

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Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes

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hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients

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HIF-2α, acting via miR-191, is involved in angiogenesis and metastasis of arsenite-transformed HBE cells

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