Cingulate cortex projections to the parahippocampal region and hippocampal formation in the rat
Abstract
In the present study we aimed to determine the topographical and laminar characteristics of cingulate projections to the parahippocampal region and hippocampal formation in the rat, using the anterograde tracers Phaseolus vulgaris-leucoagglutinin and biotinylated dextranamine. The results show that all areas of the cingulate cortex project extensively to the parahippocampal region but not to the hippocampal formation. Rostral cingulate areas (infralimbic-, prelimbic cortices, rostral 1/3 of the dorsal anterior cingulate cortex) primarily project to the perirhinal and lateral entorhinal cortices. Projections from the remaining cingulate areas preferentially target the postrhinal and medial entorhinal cortices as well as the presubiculum and parasubiculum. At a more detailed level the projections show differences in topographical specificities according to their site of origin within the cingulate cortex suggesting the functional contribution of cingulate areas may differ at an individual level. This organization of the cingulate-parahippocampal projections relates to the overall organization of postulated parallel parahippocampal-hippocampal processing streams mediated through the lateral and medial entorhinal cortex respectively. The mid-rostrocaudal part of the dorsal anterior cingulate cortex appears to be connected to both networks as well as to rostral and caudal parts of the cingulate cortex. This region may therefore responsible for integrating information across these…
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The cingulum is the principal route for anterior cingulate and retrosplenial projections, as well as lighter pregenual cortical projections, to the parahippocampal region, including inputs to the entorhinal cortex, postrhinal cortex, parasubiculum, and presubiculum.
“The cingulum is also the principal route for anterior cingulate and retrosplenial projections (as well as the lighter pregenual cortical projections) to the parahippocampal region, including inputs to the entorhinal cortex, postrhinal cortex, parasubiculum, and presubiculum (Jones and Witter, 2007).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Jones and Witter, 2007
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References 85 · Cited by 201
- Authors
- Jones, B. F., & Witter, M. P.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Witter, Menno P.
- ORCID
- Witter, Menno P.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2007-06-27
- Volume
- 17
- Issue
- 10
- Pages
- 957-976
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W1983083547
- Cited by
- 201
- References
- 85
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 13 · 2023: 11 · 2022: 12 · 2021: 16 · 2020: 12 · 2019: 7 · 2018: 21 · 2017: 11 · 2016: 15 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 10
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cingulate cortex, parahippocampal region, hippocampal formation, corticocortical connections, entorhinal cortex, perirhinal cortex, postrhinal cortex, presubiculum, parasubiculum, dorsal anterior cingulate cortex, infralimbic cortex, prelimbic cortex, rats
- MeSH terms
- Afferent Pathways, Animals, Biotin, Brain Mapping, Dextrans, Female, Gyrus Cinguli, Hippocampus, Iontophoresis, Phytohemagglutinins, Rats, Wistar, Parahippocampal Gyrus, Rats
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