The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Chemische Aspekte der Penicillin‐Allergie: Die direkte Penicilloylierung von ϵ‐Aminogruppen durch Penicilline bei pH 7, 4
Abstract
Abstract The aminolysis of penicillins by ε‐amino groups at pH 7,4 is demonstrated. It is shown that penicillenic acid, formed spontaneously under these conditions from penicillins, does not contribute significantly to the penicilloylations observed. Penicillin therefore can directly form penicilloylamides under physiological conditions.
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“Beta-lactams are known to be able to act as haptens and bind to amino groups of amino acids, such as lysine [105].”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [105]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
STUDIES ON THE MECHANISM OF THE FORMATION OF THE PENICILLIN ANTIGEN
Levine, B. B., & Óváry, Z. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.114.6.875 · Cited by 332
HYPERSENSITIVITY TO PENICILLENIC ACID DERIVATIVES IN HUMAN BEINGS WITH PENICILLIN ALLERGY
Parker, C. W., Shapiro, J. M., Kern, M., & Eisen, H. N. (1962) · The Journal of Experimental Medicine · doi:10.1084/jem.115.4.821 · Cited by 221
Parser, C. W., deWeck, A. L., Kern, M., & Eisen, H. N. (1962) · The Journal of Experimental Medicine · doi:10.1084/jem.115.4.803 · Cited by 128
Self-citationLevine, B. B. (1962) · Journal of Medicinal Chemistry · doi:10.1021/jm01240a016 · Cited by 93
The specificity of hemagglutination reactions in human and experimental penicillin hypersensitivity
Thiel, J. A., Mitchell, S., & Parker, C. W. (1964) · Journal of Allergy · doi:10.1016/0021-8707(64)90067-x · Cited by 72
Microbiological Aspects of Penicillin: VI. Procedure for the Cup Assay for Penicillin
Foster, J. W., & Woodruff, H. B. (1944) · Journal of Bacteriology · doi:10.1128/jb.47.1.43-58.1944 · Cited by 67
Levine, B. B. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90314-9 · Cited by 67
A New Chemical Aspect of Penicillin Allergy: The Direct Reaction of Penicillin with ɛ-Amino-Groups
SCHNEIDER, C. H., & WECK, A. L. D. (1965) · Nature · doi:10.1038/208057a0 · Cited by 66
Self-citationStudies on Penicillin Hypersensitivity
WECK, A. L. D. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000229312 · Cited by 54
Cited by
Idsøe, O., GUTHE, T., Willcox, R. R., & WECK, A. L. D. (1968) · Europe PMC (PubMed Central) · Cited by 540
Mauri-Hellweg, D., Bettens, F., Mauri, D., Brander, C., Hunziker, T., & Pichler, W. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.1.462 · Cited by 352
Zanni, M. P., von Greyerz, S., Schnyder, B., Brander, K. A., Frutig, K., Hari, Y., Valitutti, S., & Pichler, W. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3544 · Cited by 246
Involvement of Drug-Specific T Cells in Acute Drug-Induced Interstitial Nephritis
Spanou, Z., Keller, M., Britschgi, M., Yawalkar, N., Fehr, T., Neuweiler, J., Gugger, M., Mohaupt, M., & Pichler, W. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050418 · Cited by 151
The Mechanisms of Reactions of β-Lactam Antibiotics
Page, M. I. (1987) · Advances in physical organic chemistry · doi:10.1016/s0065-3160(08)60204-x · Cited by 128
Metadata
- Authors
- Schneider, C. H., & De Weck, A. L.
- Affiliations
- University of Bern (CH)
- Venue
- Helvetica Chimica Acta
- Publisher
- Wiley
- Published
- 1966-01
- Volume
- 49
- Issue
- 5
- Pages
- 1695-1707
- ISSN
- 0018-019X (ISSN-L)
- 1522-2675
- OpenAlex
- W2088264825
- Cited by
- 37
- References
- 16
- Citations by year
- 2024: 1 · 2017: 1 · 2014: 1
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Helvetica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of β-Lactam Compounds
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- penicillin allergy, aminolysis, penicillin, pH 7.4, physiological conditions
- MeSH terms
- Animals, Chemistry, Drug Hypersensitivity, Penicillins, Rabbits, Chemical Phenomena
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- This page
- CoChat. (2026). Citation check: Chemische Aspekte der Penicillin‐Allergie: Die direkte Penicilloylierung von ϵ‐Aminogruppen durch Penicilline bei pH 7, 4. https://app.cochat.ai/papers/10.1002/hlca.19660490532
- The paper
- Schneider, C. H., & De Weck, A. L. (1966). Chemische Aspekte der Penicillin‐Allergie: Die direkte Penicilloylierung von ϵ‐Aminogruppen durch Penicilline bei pH 7, 4. Helvetica Chimica Acta. https://doi.org/10.1002/hlca.19660490532
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
