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Cited by 26Lymphoma Diagnosis and TreatmentReliability and Agreement in MeasurementMedical Imaging Techniques and Applications

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Training improves the interobserver agreement of the expert positron emission tomography review panel in primary mediastinal B‐cell lymphoma: interim analysis in the ongoing International Extranodal Lymphoma Study Group‐37 study

Ceriani, Luca, Barrington, Sally, Biggi, Alberto, Malkowski, Bogdan, Metser, Ur, Versari, Annibale, Martelli, Maurizio, Davies, Andrew, Johnson, Peter W., Zucca, Emanuele, Chauvie, Stéphane·2017·Hematological Oncology
DOI 10.1002/hon.2339
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Abstract

The International Extranodal Lymphoma Study Group (IELSG)-37 is a prospective randomized trial assessing the role of consolidation mediastinal radiotherapy after immunochemotherapy to patients with newly diagnosed primary mediastinal large B-cell lymphoma (PMBCL). It is a positron emission tomography (PET) response-guided study where patients obtaining a complete metabolic response on an end-of-therapy PET-computed tomography (CT) scan evaluated by a central review are randomized to receive radiotherapy or no further treatment. The aims of this study were to measure agreement between reviewers reporting PET-CT scans for this trial and to determine the effect of training upon concordance rates. The review panel comprised 6 experienced nuclear physicians who read PET-CT scans using the 5-point Deauville scale. Interobserver agreement (IOA) was measured at 4 time points: after a blinded review of a "training set" of 20 patients with PMBCL from the previous IELSG-26 study (phase 1); after the first 10 clinical cases enrolled in the IELSG-37 (phase 2); and after 2 further groups of 50 (phase 3) and 40 clinical cases (phase 4). After feedback from the training set and the first 10 cases, a meeting was held to discuss interpretation, and a detailed set of instructions for the review procedure was agreed and acted upon. Between 2012 and 2014, the first 100 patients were reviewed. Using Deauville score 3 as the cutoff for a complete metabolic response, the overall IOA among the review…

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  • Reader training and discussions over divergent assessments increase agreement even among expert readers.

    “It has been shown that reader training and discussions over divergent assessments increase agreement even among “expert” readers [213].”

    From Influences on PET Quantification and Interpretation (2022) · cites this paper as [213]

  • In a setting in which several lesions of interest are present, additional inter-reader variability can result from a divergent choice of the decisive target lesion.

    “Furthermore, besides the reader’s subjective assessment of a certain lesion, in a setting in which several lesions of interest are present (e.g., in restaging in lymphoma or metastatic tumors), additional inter-reader variability can result from a divergent choice of the decisive target lesion [213].”

    From Influences on PET Quantification and Interpretation (2022) · cites this paper as [213]

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References 26 · Cited by 26

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Metadata

Authors
Ceriani, L., Barrington, S., Biggi, A., Malkowski, B., Metser, U., Versari, A., Martelli, M., Davies, A., Johnson, P. W., Zucca, E., & Chauvie, S.
Affiliations
  • Istituto Oncologico della Svizzera Italiana (CH)
  • St Thomas' Hospital (GB)
  • Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
  • Department of Nuclear Medicine, Oncology Center, Bydgoszcz, PET and Molecular Imaging Department Collegium Medicum, Nicolaus Copernicus University Toruń Poland
  • Princess Margaret Cancer Centre (CA)
  • Santa Maria Nuova Hospital (IT)
  • Sapienza University of Rome (IT)
  • Cancer Research UK (GB)
Corresponding author
Ceriani, Luca
ORCID
Venue
Hematological Oncology
Publisher
Wiley
Published
2016-08-22
Volume
35
Issue
4
Pages
548-553
ISSN
  • 0278-0232 (ISSN-L)
  • 1099-1069
DOI
10.1002/hon.2339
OpenAlex
W2515380104
Cited by
26
References
26
Citations by year
2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 1
FWCI
3.63
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Hematological Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (acceptedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Swiss National Science Foundation (32003B-146931)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
primary mediastinal B-cell lymphoma, interobserver agreement, PET/CT interpretation, Deauville score, central review, radiology education, complete metabolic response, mediastinal irradiation, chemoimmunotherapy, non-Hodgkin lymphoma, Krippendorff's alpha
MeSH terms
Positron Emission Tomography Computed Tomography, B-Lymphocytes, Humans, Mediastinal Neoplasms, Prospective Studies, Observer Variation

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