The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Prognostic impact of tumour‐infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
Open accessAbstract
Classical Hodgkin Lymphoma (cHL) is morphologically characterized by a small number of tumour cells, Hodgkin and Reed–Sternberg (HRS) cells, surrounded by numerous tumour‐infiltrating lymphocytes (TIL). The functional role of these TIL is still controversial. While generally considered to represent an anti‐tumour immune response, TIL in cHL might result from the profoundly deregulated immunity of cHL patients. Eighty‐seven cases of cHL were available to evaluate the prognostical significance of tumour‐infiltrating cytotoxic T lymphocytes (CTL), T helper 1 (Th1) cells, T helper 2 (Th2) cells and regulatory T cells (Treg). We confirm that in cHL the microenvironment is dominated by Th2 cells and Treg and show that large numbers of Th2 cells are associated with significantly improved disease‐free survival (p = 0.021) and event‐free survival (p = 0.012). Furthermore, a high ratio of Treg over Th2 cells resulted in a significantly shortened disease‐free survival (p = 0.025). These observations suggest that Treg may exert inhibitory effects on anti‐tumour immune responses mediated through Th2 cells and that Th2 cells may be more important for effective anti‐tumour immunity than anticipated. Copyright © 2008 John Wiley & Sons, Ltd.
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Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
The Central Role of CD4+ T Cells in the Antitumor Immune Response
Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D., & Levitsky, H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2357 · Cited by 1,345
Tumor-infiltrating T lymphocytes: Friends or foes?
Yu, P., & Fu, Y.-X. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700389 · Cited by 299
PRALL, F. (2004) · Human Pathology · doi:10.1016/j.humpath.2004.01.022 · Cited by 226
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The immune contexture in human tumours: impact on clinical outcome
Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
Bruni, D., Angell, H. K., & Galon, J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0285-7 · Cited by 1,586
From mice to humans: developments in cancer immunoediting
Teng, M. W. L., Galon, J., Fridman, W.-H., & Smyth, M. J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80004 · Cited by 337
Aldinucci, D., Gloghini, A., Pinto, A., De Filippi, R., & Carbone, A. (2010) · The Journal of Pathology · doi:10.1002/path.2711 · Cited by 275
Targeting regulatory T cells in tumors
Liu, C., Workman, C. J., & Vignali, D. A. A. (2016) · The FEBS Journal · doi:10.1111/febs.13656 · Cited by 228
Metadata
- Authors
- Schreck, S., Friebel, D., Buettner, M., Distel, L., Grabenbauer, G., Young, L. S., & Niedobitek, G.
- Venue
- Hematological Oncology
- Publisher
- Wiley
- Published
- 2008-10-15
- Volume
- 27
- Issue
- 1
- Pages
- 31-39
- ISSN
- 0278-0232 (ISSN-L)
- 1099-1069
- OpenAlex
- W1993349395
- Cited by
- 188
- References
- 5
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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