The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects
Abstract
The Ayurvedic medicine Bacopa monniera (Brahmi) has been shown to exert cognitive enhancing effects in animals. The current study examined the acute effects of an extract of Bacopa monniera on cognitive function in normal healthy human subjects. The study was a double-blind, placebo-controlled independent group design in which subjects were randomly allocated to one of two treatment conditions, Bacopa monniera (300 mg) (n = 18) or placebo (n = 20). Neuropsychological testing was conducted before and 2 h after drug administration. No significant changes were found on any of the tests. The findings suggest that Bacopa monniera, at least for the dose administered, has no acute effects on cognitive functioning in normal healthy subjects. Copyright 2001 John Wiley & Sons, Ltd.
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A single dose of 300 mg Bacopa monniera extract containing 55% combined bacosides A and B did not cause any significant change in cognitive function at 2 h in healthy volunteers aged 18-60 years.
“In a double-blind, placebo-controlled trial in 38 healthy volunteers (ages 18–60 years), single dose of 300 mg B. monniera extract (containing 55% combined bacosides A and B) did not cause any significant change in cognitive function at 2 h [87].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [87]
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References 33 · Cited by 103
- Authors
- Nathan, P. J., Clarke, J., Lloyd, J., Hutchison, C. W., Downey, L., & Stough, C.
- Affiliations
- Swinburne University of Technology (AU)
- Corresponding author
- Nathan, P. J.
- Venue
- Human Psychopharmacology Clinical and Experimental
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 16
- Issue
- 4
- Pages
- 345-351
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W1991932520
- Cited by
- 103
- References
- 33
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 11
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Bacopa monnieri, Ayurveda, cognitive function, acute effects, plant extracts, healthy volunteers, neuropsychological performance
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