Haematological toxicity of drugs used in psychiatry
Open accessAbstract
Almost all classes of psychotropic agents have been reported to cause blood dyscrasias. Mechanisms include direct toxic effects upon the bone marrow, the formation of antibodies against haematopoietic precursors or involve peripheral destruction of cells. Agranulocytosis is probably the most important drug-related blood dyscrasia. The mortality from drug-induced agranulocytosis is 5-10% in Western countries. The manifestations of agranulocytosis are secondary to infection. Aggressive treatment with intravenous broad-spectrum antimicrobials and bone marrow stimulants may be required. Of drugs encountered in psychiatry, antipsychotics including clozapine (risk of agranulocytosis approximately 0.8%, predominantly in the first year of treatment) and phenothiazines (chlorpromazine agranulocytosis risk approximately 0.13%), and antiepileptics (notably carbamazepine, neutropenia risk approximately 0.5%) are the most common causes of drug-related neutropenia/agranulocytosis. Drugs known to cause neutropenia should not be used concomitantly with other drugs known to cause this problem. High temperature and other indicators of possible infection should be looked for routinely during treatment. Clozapine is well known as a drug that can cause blood dyscrasias, but olanzapine and other atypicals may also cause similar problems. In addition to genetic factors, there are likely to be dose-related and immunological components to these phenomena. Important lessons have been learnt from the haematological monitoring that is necessary with clozapine and the monitoring has been very successful in preventing deaths related to clozapine-induced agranulocytosis. Continuing research into the mechanisms of drug-induced neutropenia and agranulocytosis may serve to further enhance the safe use not only of clozapine, but also of other agents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
With appropriate management, the mortality from drug-induced agranulocytosis in Western countries is 5-10% (before the use of antibiotics this percentage was 80%).
“With appropriate management, the mortality from drug-induced agranulocytosis in Western countries is 5-10% (before the use of antibiotics this percentage was 80%) (582).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [582]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Clozapine-induced agranulocytosis. incidence and risk factors in the united states
Alvir, J. M. J., Lieberman, J. A., Safferman, A. Z., Schwimmer, J. L., & Schaaf, J. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307153290303 · Cited by 967 · see citing works
Pharmacological and Therapeutic Properties of Valproate
Perucca, E. (2002) · CNS Drugs · doi:10.2165/00023210-200216100-00004 · Cited by 690 · see citing works
Neutropenia and Agranulocytosis in Patients Receiving Clozapine in the UK and Ireland
Atkin, K., Kendall, F., Gould, D. C., Freeman, H. L., Lieberman, J. A., & O'Sullivan, D. P. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.169.4.483 · Cited by 293 · see citing works
Active monitoring of 12760 clozapine recipients in the UK and Ireland
Munro, J., O'Sullivan, D. P., Andrews, C., Arana, A., Mortimer, A. M., & Kerwin, R. W. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.175.6.576 · Cited by 286 · see citing works
Influence of antidepressants on hemostasis
Halperin, D., & Reber, G. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.1/dhalperin · Cited by 245 · see citing works
Hematologic Toxicity of Sodium Valproate
Acharya, S. S., & Bussel, J. B. (2000) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-200001000-00012 · Cited by 220 · see citing works
Honigfeld, G., Arellano, F. M., Sethi, J., Bianchini, A., & Schein, J. R. (1998) · PubMed · Cited by 216 · see citing works
Selective Serotonin Reuptake Inhibitors and Increased Bleeding Risk: Are We Missing Something?
Serebruany, V. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.03.044 · Cited by 162 · see citing works
Rechallenge with clozapine following leucopenia or neutropenia during previous therapy
Dunk, L., Annan, L. J., & Andrews, C. D. M. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.188.3.255 · Cited by 154 · see citing works
Self-citationCongenital and Acquired Neutropenia
Berliner, N., Horwitz, M. S., & Loughran, T. P. (2004) · Hematology · doi:10.1182/asheducation-2004.1.63 · Cited by 141 · see citing works
Hematologic Side Effects of Psychotropics
Oyesanmi, O., Kunkel, E. J. S., Monti, D., & Field, H. L. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71206-5 · Cited by 117 · see citing works
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.413 · Cited by 112 · see citing works
Review: Drug-induced neutropenia--pathophysiology, clinical features, and management.
Bhatt, V. R., & Saleem, A. (2004) · PubMed · Cited by 111 · see citing works
Apparent Neuroleptic Malignant Syndrome with Clozapine and Lithium
Pope, H. G., Cole, J. O., Choras, P., & Fulwiler, C. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198608000-00010 · Cited by 109 · see citing works
Mechanism of Clozapine-Induced Agranulocytosis
Pirmohamed, M., & Park, K. (1997) · CNS Drugs · doi:10.2165/00023210-199707020-00005 · Cited by 103 · see citing works
Clozapine-induced transient white blood count disorders.
Hummer, M., Kurz, M., Barnas, C., Saria, A., & Fleischhacker, W. W. (1994) · PubMed · Cited by 101 · see citing works
Antiepileptics and Blood Dyscrasias: A Cohort Study
Blackburn, S. C. F., Oliart, A. D., Rodríguez, L. A. G., & Gutthann, S. P. (1998) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1998.tb03148.x · Cited by 101 · see citing works
Clozapine Underutilization and Discontinuation in African Americans Due to Leucopenia
Kelly, D. L., Kreyenbuhl, J. A., Dixon, L. B., Love, R. C., Medoff, D., & Conley, R. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl068 · Cited by 101 · see citing works
Blood Dyscrasias Induced by Psychotropic Drugs
(2004) · Pharmacopsychiatry · doi:10.1055/s-2004-815513 · Cited by 100 · see citing works
WESSINGER, S., KAPLAN, M., CHOI, L., WILLIAMS, M., LAU, C., SHARP, L., CROWELL, M. D., KESHAVARZIAN, A., & JONES, M. P. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02859.x · Cited by 96 · see citing works
Clozapine, agranulocytosis, and benign ethnic neutropenia
Rajagopal, S. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.031161 · Cited by 94 · see citing works
Restarting Clozapine after Neutropenia
Whiskey, E., & Taylor, D. M. (2007) · CNS Drugs · doi:10.2165/00023210-200721010-00003 · Cited by 94 · see citing works
Benign familial leukopenia and neutropenia in different ethnic groups
Shoenfeld, Y., Alkan, M., Asaly, A., Carmeli, Y., & Katz, M. E. (1988) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1988.tb01192.x · Cited by 90 · see citing works
Lithium and Clozapine Rechallenge: A Retrospective Case Analysis
Kanaan, R., & Kerwin, R. W. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0509 · Cited by 81 · see citing works
Fitzsimons, J., Berk, M., Lambert, T., Bourin, M., & Dodd, S. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.4.731 · Cited by 80 · see citing works
Assessing cardiovascular risks versus clinical benefits of atypical antipsychotic drug treatment.
Meltzer, H. Y., Davidson, M., Glassman, A. H., & Vieweg, W. V. R. (2002) · PubMed · Cited by 74 · see citing works
Olanzapine-Induced Neutropenia
Gajwani, P., & Tesar, G. E. (2000) · Psychosomatics · doi:10.1176/appi.psy.41.2.150 · Cited by 68 · see citing works
Hematological Adverse Events in Clozapine-Treated Children and Adolescents
Gerbino-Rosen, G., Roofeh, D., Tompkins, D. A., Feryo, D., Nusser, L., Kranzler, H. N., Napolitano, B. A., Frederickson, A. M., Henderson, I., Rhinewine, J., et al. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000171904.23947.54 · Cited by 66 · see citing works
Risk and Protective Factors in the Development of Psychopathology
Tohen, M. F., & Tsuang, M. T. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.287 · Cited by 65 · see citing works
Gelenberg, A. J. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0101 · Cited by 65 · see citing works
Impact of Myeloperoxidase and NADPH-Oxidase Polymorphisms in Drug-Induced Agranulocytosis
Mosyagin, I., Dettling, M., Roots, I., Müller-Oerlinghausen, B., & Cascorbi, I. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000144891.52858.a6 · Cited by 63 · see citing works
Leukopenia and neutropenia induced by quetiapine
Cowan, C., & Oakley, Ç. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.003 · Cited by 63 · see citing works
Clozapine treatment in Australia: a review of haematological monitoring
Copolov, D., Bell, W. R., Keks, N. A., Strazzeri, D. C., Benson, W., & Johnson, G. F. S. (1998) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1998.tb141414.x · Cited by 60 · see citing works
HLA‐B38 and clozapine‐induced agranulocytosis in Israeli Jewish schizophrenic patients
Valevski, A., Klein, T., Gazit, E., Meged, S., Stein, D. J., Elizur, A., Narinsky, E. R., Kutzuk, D., & Weizman, A. (1998) · European Journal of Immunogenetics · doi:10.1046/j.1365-2370.1998.00091.x · Cited by 60 · see citing works
Clozapine-Induced Neutropenia in Children: Management with Lithium Carbonate
Sporn, A. L., Gogtay, N., Ortiz‐Aguayo, R., Alfaro, C. L., Tossell, J. W., Lenane, M., Gochman, P., & Rapoport, J. L. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603322572697 · Cited by 57 · see citing works
Hägg, S., Rosenius, S., & Spigset, O. (2003) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000062800.74434.6c · Cited by 53 · see citing works
Pereira, A. M., & Dean, B. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.006 · Cited by 51 · see citing works
Circadian rhythm of white blood cells during clozapine treatment
Ahokas, A., & Elonen, E. (1999) · Psychopharmacology · doi:10.1007/s002130051008 · Cited by 49 · see citing works
Oxidation of Clozapine and Ascorbate by Myeloperoxidase
Hsuanyu, Y., & Dunford, H. B. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1328 · Cited by 49 · see citing works
Drug Adherence: Effects of Decreased Visit Frequency on Adherence to Clozapine Therapy
Patel, N. C., Crismon, M. L., Miller, A. L., & Johnsrud, M. T. (2005) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.2005.25.9.1242 · Cited by 49 · see citing works
Continuing clozapine treatment despite neutropenia
Esposito, D., Rouillon, F., & Limosin, F. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0835-z · Cited by 48 · see citing works
G-CSF and the management of clozapine-induced agranulocytosis.
Gerson, S. L. (1994) · PubMed · Cited by 47 · see citing works
Gardner, I. B., Popović, M., ZAHID, N. D., & Uetrecht, J. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050095o · Cited by 46 · see citing works
High risk of eosinophilia in women treated with clozapine.
Banov, M. D., Tohen, M. F., & Friedberg, J. W. (1993) · PubMed · Cited by 44 · see citing works
Dettling, M., Sachse, C., Müller-Oerlinghausen, B., Roots, I., Brockmöller, J., Rolfs, A., & Cascorbi, I. (2000) · Pharmacopsychiatry · doi:10.1055/s-2000-8359 · Cited by 43 · see citing works
Eosinophilia after Commencement of Clozapine Treatment
Chatterton, R. (1997) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679709065515 · Cited by 43 · see citing works
Sudden Late Onset of Clozapine-Induced Agranulocytosis
Patel, N. C., Dorson, P. G., & Bettinger, T. L. (2002) · Annals of Pharmacotherapy · doi:10.1345/aph.1a417 · Cited by 43 · see citing works
Kang, B., Cho, M., Oh, J., Lee, Y., Chae, B.-J., & Ko, J. (2006) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.779 · Cited by 42 · see citing works
Psychotropic drug-induced neutropenia
Duggal, H. S., & Singh, I. (2005) · Drugs of today · doi:10.1358/dot.2005.41.8.893629 · Cited by 41 · see citing works
Risperidone-induced leucopenia and neutropenia: a case report
Sluys, M., Güzelcan, Y., Casteelen, G., & de Haan, L. (2004) · European Psychiatry · doi:10.1016/j.eurpsy.2003.03.009 · Cited by 41 · see citing works
Haematological safety of antipsychotic drugs
King, D. J., & Wager, E. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200309 · Cited by 39 · see citing works
Lithium-induced hematologic changes in patients with bipolar affective disorder
Özdemır, M. A., Sofuoǧlu, S., Tanrikulu, G., ALDANMAZ, F., Eşel, E., & Dündar, S. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91155-x · Cited by 37 · see citing works
Plasma Clozapine and Desmethylclozapine Levels in Clozapine-Induced Agranulocytosis
Hasegawa, M., Cola, P. A., & Meltzer, H. Y. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.34 · Cited by 37 · see citing works
Saletu-Zyhlarz, G. M., Anderer, P., Berger, P., Gruber, G., Oberndorfer, S., & Saletu, B. (2000) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/1099-1077(200006)15:4 · Cited by 36 · see citing works
Valproic Acid–Induced Neutropenia
Vesta, K. S., & Medina, P. J. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1c381 · Cited by 36 · see citing works
Managing clozapine-induced neutropenia with lithium
Paton, C., & Esop, R. (2005) · Psychiatric Bulletin · doi:10.1192/pb.29.5.186 · Cited by 35 · see citing works
Boshes, R. A., Manschreck, T. C., Desrosiers, J., Candela, S. F., & Hanrahan-Boshes, M. (2001) · Annals of Clinical Psychiatry · doi:10.3109/10401230109147387 · Cited by 35 · see citing works
Pantelis, C., & Adesanya, A. (2001) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.0911f.x · Cited by 34 · see citing works
Olanzapine-Induced Neutropenia
Duggal, H. S., Gates, C., & Pathak, P. C. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000117428.05703.16 · Cited by 34 · see citing works
Thrombotic Thrombocytopenic Purpura Associated with Quetiapine
Huynh, M., Chee, K. G., & Lau, D. H. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g067 · Cited by 34 · see citing works
Acute Neutropenia in a Patient Treated With Quetiapine
Croarkin, P. E., & Rayner, T. (2001) · Psychosomatics · doi:10.1176/appi.psy.42.4.368 · Cited by 32 · see citing works
An alternative to interruption of treatment in recurrent clozapine-induced severe neutropenia
Conus, P., Nanzer, N., & Baumann, P. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.2.180 · Cited by 32 · see citing works
Life-Threatening Idiosyncratic Drug-Induced Agranulocytosis in Elderly Patients
s, E. A., Noël, E., Kurtz, J., Loukili, N., Kaltenbach, G., & Maloisel, F. (2004) · Drugs & Aging · doi:10.2165/00002512-200421070-00002 · Cited by 32 · see citing works
Ziprasidone-related agranulocytosis following olanzapine-induced neutropenia
Montgomery, J. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.08.005 · Cited by 31 · see citing works
Lithium counteracts carbamazepine-induced leukopenia while increasing its therapeutic effect
Brewerton, T. D. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90130-7 · Cited by 29 · see citing works
Olanzapine-induced leucopenia and neutropenia
Stergiou, V., Bozikas, V. P., Garyfallos, G., Nikolaidis, N., Lavrentiadis, G., & Fokas, K. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.025 · Cited by 28 · see citing works
Pessina, A., Turlizzi, E., Bonomi, A., Guizzardi, F., Cavicchini, L., Croera, C., & Bareggi, S. R. (2006) · Pharmacopsychiatry · doi:10.1055/s-2006-931475 · Cited by 28 · see citing works
Husain, Z., Almeciga, I., Delgado, J. C., Clavijo, O. P., Castro, J. E., Belalcázar, V., Pinto, C., Zúñiga, J., Romero, V. A., & Yunis, E. J. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.008 · Cited by 27 · see citing works
Heat Stroke in Schizophrenia During Clozapine Treatment: Rapid Recognition and Management
Kerwin, R. W., Osborne, S., & Sáinz‐Fuertes, R. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040250 · Cited by 27 · see citing works
Nielsen, H. J. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00789.x · Cited by 25 · see citing works
Meged, S., Stein, D. J., Sitrota, P., Melamed, Y., Elizur, A., Shmuelian, I., & Gazit, E. (1999) · International Clinical Psychopharmacology · doi:10.1097/00004850-199909000-00005 · Cited by 25 · see citing works
Leukopenia in clozapine treated patients may be induced by other drugs: a case series
Imbarlina, M. J., Sarkar, S., Marwah, S., Parepally, H., Johnston, P. R., Brar, J. S., & Chengappa, K. N. R. (2004) · European Psychiatry · doi:10.1016/j.eurpsy.2004.09.007 · Cited by 25 · see citing works
Filgrastim treatment of three patients with clozapine-induced agranulocytosis.
Lamberti, J. S., Bellnier, T. J., Schwarzkopf, S. B., & Schneider, E. M. (1995) · PubMed · Cited by 24 · see citing works
Delieu, J., Badawoud, M. H., Williams, M. A., Horobin, R. W., & Duguid, J. K. M. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500306 · Cited by 24 · see citing works
Psychotropic Medications and Leukopenia
Sedky, K., & Lippmann, S. (2006) · Current Drug Targets · doi:10.2174/138945006778226642 · Cited by 24 · see citing works
Ahn, Y. M., Jeong, S. H., Jang, H. S., Koo, Y. J., Kang, U. G., Lee, K. Y., & Kim, Y. S. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00007 · Cited by 24 · see citing works
Delieu, J., Horobin, R. W., & Duguid, J. K. M. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106061112 · Cited by 22 · see citing works
Haematological safety of antipsychotic drugs
Hall, R., Smith, A. M., & Edwards, J. G. (2003) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2.4.395 · Cited by 22 · see citing works
Esposito, D., Aouillé, J., Rouillon, F., & Limosin, F. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0918a · Cited by 21 · see citing works
G-CSF plasma levels in clozapine-induced neutropenia
Jauss, M., Pantel, J., Werle, E., & Schröder, J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00963-x · Cited by 20 · see citing works
Prolongation of clozapine-induced leukopenia with olanzapine treatment
Sayin, A., & Çoşar, B. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.11.032 · Cited by 20 · see citing works
Risperidone-Induced Morning Pseudoneutropenia
Esposito, D., Corruble, E., Hardy, P., & Chouinard, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.397 · Cited by 20 · see citing works
Do white-cell count spikes predict agranulocytosis in clozapine recipients?
Alvir, J. M., Lieberman, P., & Safferman, A. Z. (1995) · PubMed · Cited by 20 · see citing works
Reversible Neutropenia during Treatment with Olanzapine: Three Case Reports
Cordes, J., Streit, M., Loeffler, S., von Wilmsdorff, M., Agelink, M. W., & Klimke, A. (2004) · The World Journal of Biological Psychiatry · doi:10.1080/15622970410029938 · Cited by 18 · see citing works
Murry, P., & Laurent, A. (2001) · Psychopharmacology · doi:10.1007/s002130100922 · Cited by 18 · see citing works
Reversible Neutropenia With Olanzapine Following Clozapine-Induced Neutropenia
Thangadurai, P., Jyothi, K. S., Gopalakrishnan, R. M., Kuruvilla, A., & Jacob, K. S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.7.1298 · Cited by 17 · see citing works
Successful initiation of clozapine treatment despite morning pseudoneutropenia
Esposito, D., Chouinard, G., Hardy, P., & Corruble, E. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570500605x · Cited by 16 · see citing works
A Review of Cyclic Antidepressant-Induced Blood Dyscrasias
Hartshorn, E. A., Levin, G. M., & DeVane, C. L. (1992) · Annals of Pharmacotherapy · doi:10.1177/106002809202600313 · Cited by 16 · see citing works
Eosinophilia Indicating Subclinical Clozapine-Induced Pericarditis
Körtner, K., Neuhaus, A. H., Schürer, F., & Dettling, M. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0726d · Cited by 14 · see citing works
Diurnal variation of neutropenia during clozapine treatment
PORTER, R. J., & Mohamed, A. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006061 · Cited by 14 · see citing works
Paradoxical pattern of haematological risk with clozapine
Gillman, P. K. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.1.88 · Cited by 13 · see citing works
SSRIs & the Risk of Abnormal Bleeding
Reeves, R. R., Wise, P. M., & Cox, S. K. (2007) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20070401-06 · Cited by 13 · see citing works
Selective Serotonin Reuptake Inhibitors in the Context of Hepatitis C Infection
Martin, K. A., Krahn, L. E., Balan, V., & Rosati, M. J. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0707 · Cited by 12 · see citing works
Vieweg, W. V. R., Yank, G. R., Rowe, W. T., Hovermale, L. S., & Clayton, A. H. (1986) · Psychiatric Quarterly · doi:10.1007/bf01064735 · Cited by 12 · see citing works
Fatal agranulocytosis: The use of olanzapine in a patient with schizophrenia and myelodysplasia
Stip, É., Langlois, R., Thuot, C., & Mancini-Marı̈e, A. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.005 · Cited by 12 · see citing works
Neutropenia Following Acute Chlorpromazine Ingestion
Burckart, G. J., Snidow, J. W., & Bruce, W. (1981) · Clinical Toxicology · doi:10.3109/15563658108990307 · Cited by 10 · see citing works
The effects of lithium on the functions of human neutrophils and lymphocytes in vitro and in vivo.
Anderson, R., Walters, L., Grabow, G., van der Merwe, M., & Ce, V. R. (1982) · PubMed · Cited by 8 · see citing works
Yen, C., Chong, M., Kuo, M., & Chang, C.-S. (1997) · PubMed · Cited by 4 · see citing works
Gómez-Estrada, H., Hernández-Delgado, J., & Díaz-Esquivel, P. (1985) · PubMed · Cited by 4 · see citing works
Biochemical investigation of leukocyte functions during lithium therapy
Türközkan, N., Durmuş, O., & Boran, N. (1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90697-d · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Bhatt V, Saleem A. 2004. Review: drug-induced neutropeniapathophysiology, clinical features, and management. Ann Clin Lab Sci 34 : 131-137.
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842 · see citing works
Schizophrenia: overview and treatment options.
(2014) · PubMed Central · Cited by 533 · see citing works
Termination of Clozapine Treatment Due to Medical Reasons
Nielsen, J., Correll, C. U., Manu, P., & Kane, J. M. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r08064 · Cited by 232 · see citing works
Ng, F., Mammen, O. K., Wilting, I., Sachs, G. S., Ferrier, I. N., Cassidy, F., Beaulieu, S., Yatham, L. N., & Berk, M. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00737.x · Cited by 192 · see citing works
Couchman, L., Morgan, P. E., Spencer, E. P., & Flanagan, R. J. (2010) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e3181dad1fb · Cited by 173 · see citing works
Self-citationImmunomodulatory effects of clozapine and their clinical implications: What have we learned so far?
Røge, R., Møller, B. K., Andersen, C. R., Correll, C. U., & Nielsen, J. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.020 · Cited by 165 · see citing works
Correll, C. U., Agid, O., Crespo‐Facorro, B., de Bartolomeis, A., Fagiolini, A. M., Seppälä, N., & Howes, O. D. (2022) · CNS Drugs · doi:10.1007/s40263-022-00932-2 · Cited by 164 · see citing works
Clozapine-induced agranulocytosis
Mijović, A., & MacCabe, J. H. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04215-y · Cited by 160 · see citing works
Idiosyncratic drug‐induced agranulocytosis: Possible mechanisms and management
Tesfa, D., Keisu, M., & Palmblad, J. E. W. (2009) · American Journal of Hematology · doi:10.1002/ajh.21433 · Cited by 124 · see citing works
Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring
Wiciński, M., & Węclewicz, M. M. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000391 · Cited by 95 · see citing works
Hematological Markers of In Vivo Toxicity
Arika, W. M., & Nyamai, D. W. (2016) · Journal of Hematology & Thromboembolic Diseases · doi:10.4172/2329-8790.1000236 · Cited by 93 · see citing works
Ostuzzi, G., Papola, D., Gastaldon, C., Schoretsanitis, G., Bertolini, F., Amaddeo, F., Cuomo, A., Emsley, R. A., Fagiolini, A. M., Imperadore, G., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01685-9 · Cited by 93 · see citing works
Chabot‐Richards, D., & George, T. I. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12212 · Cited by 89 · see citing works
DNA Methylation Signatures of Mood Stabilizers and Antipsychotics in Bipolar Disorder
Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 87 · see citing works
Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia
Yoshida, K., & Takeuchi, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113098 · Cited by 80 · see citing works
Genetics of Clozapine-Associated Neutropenia: Recent Advances, Challenges and Future Perspective
Legge, S. E., & Walters, J. (2019) · Pharmacogenomics · doi:10.2217/pgs-2018-0188 · Cited by 70 · see citing works
Kwan, W., Cortes, M., Frost, I. M., Esain, V., Theodore, L. N., Liu, S. Y., Budrow, N., Goessling, W., & North, T. E. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.004 · Cited by 69 · see citing works
Haematological toxicity of clozapine and some other drugs used in psychiatry
Nooijen, P. M. M., Carvalho, F. D., & Flanagan, R. J. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1181 · Cited by 69 · see citing works
Self-citationPharmacological Mechanism-Based Drug Safety Assessment and Prediction
Abernethy, D. R., Woodcock, J., & Lesko, L. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.55 · Cited by 64 · see citing works
Genetics of Antipsychotic-induced Side Effects and Agranulocytosis
Chowdhury, N. I., Remington, G. J., & Kennedy, J. L. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0185-3 · Cited by 59 · see citing works
Ozolua, R. I., Anaka, O. N., Okpo, S., & Idogun, S. (2010) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v6i4.57214 · Cited by 58 · see citing works
Humbert‐Claude, M., Davenas, E., Gbahou, F., Vincent, L., & Arrang, J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2471-5 · Cited by 57 · see citing works
Appl, H., Holzammer, T., Dove, S., Haen, E., Straßer, A., & Seifert, R. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0704-0 · Cited by 55 · see citing works
Gastrointestinal hypomotility: An under-recognised life-threatening adverse effect of clozapine
Flanagan, R. J., & Ball, R. Y. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.07.021 · Cited by 55 · see citing works
Self-citationOptimizing Outcomes in Clozapine Rechallenge Following Neutropenia
Meyer, N., Gee, S., Whiskey, E., Taylor, D. M., Mijović, A., Gaughran, F., Shergill, S. S., & MacCabe, J. H. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09326 · Cited by 51 · see citing works
Nonchemotherapy Drug-Induced Neutropenia and Agranulocytosis
Pick, A. M., & Nystrom, K. K. (2014) · Journal of Pharmacy Practice · doi:10.1177/0897190014546115 · Cited by 48 · see citing works
Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics
Álvarez-Herrera, S., Escamilla-Orozco, R. I., Contreras, O. M., Saracco, R., Flores-Medina, Y., Hurtado‐Alvarado, G., Maldonado-García, J. L., Becerril‐Villanueva, E., Pérez‐Sánchez, G., & Pavón, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00195 · Cited by 47 · see citing works
Safety and efficacy of commonly used antiemetics
Hendren, G., Aponte-Feliciano, A., & Kovac, A. L. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1080688 · Cited by 44 · see citing works
Fabrazzo, M., Prisco, V., Sampogna, G., Perris, F., Catapano, F., Monteleone, A. M., & Maj, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.06.068 · Cited by 35 · see citing works
Is Anticonvulsant Treatment of Mania a Class Effect? Data from Randomized Clinical Trials
Rosa, A. R., Fountoulakis, K. Ν., Siamouli, M., Gonda, X., & Vieta, E. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00089.x · Cited by 35 · see citing works
Phenothiazines and their Evolving Roles in Clinical Practice: A Narrative Review
Edinoff, A. N., Armistead, G., Rosa, C. A., Anderson, A., Patil, R., Cornett, E. M., Murnane, K. S., Kaye, A. M., & Kaye, A. D. (2022) · Health Psychology Research · doi:10.52965/001c.38930 · Cited by 33 · see citing works
Idiosyncratic Drug-Induced Agranulocytosis: The Paradigm of Deferiprone
Pontikoglou, C. G., & Papadaki, H. Α. (2010) · Hemoglobin · doi:10.3109/03630269.2010.484791 · Cited by 33 · see citing works
Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia
Qubad, M., & Bittner, R. A. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231158152 · Cited by 33 · see citing works
Neutropenia Associated with Quetiapine, Olanzapine, and Aripiprazole
Lander, M., & Bastiampillai, T. J. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048674.2010.524624 · Cited by 33 · see citing works
Maher, K. N., Tan, M. P. J., Tossell, J. W., Weisinger, B., Gochman, P., Miller, R., GREENSTEIN, D. K., Overman, G. P., Rapoport, J. L., & Gogtay, N. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0136 · Cited by 33 · see citing works
Martínez, S. A. H., Melchor-Martínez, E. M., González-González, R. B., Sosa-Hernández, J. E., Araújo, R., Rodríguez-Hernández, J. A., Barceló, D., Parra-Saldívar, R., & Iqbal, H. M. N. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115892 · Cited by 23 · see citing works
Antidepressants and menstruation disorders in women: a cross-sectional study in three centers
Uğuz, F., Şahingöz, M., Köse, S. A., Ozbebit, O., Şengül, C., Selvı, Y., Şengül, C. B., Ayhan, M. G., Dagistanli, A., & Aşkın, R. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.03.014 · Cited by 27 · see citing works
Carbamazepine-induced hypogammaglobulinemia
Özaras, N., Göksügür, N., Eroglu, S., Tabak, Ö., Canbakan, B., & Özaras, R. (2012) · Seizure · doi:10.1016/j.seizure.2011.12.013 · Cited by 27 · see citing works
Verbelen, M., Collier, D. A., Cohen, D., MacCabe, J. H., & Lewis, C. M. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.5 · Cited by 26 · see citing works
A systems biology pipeline identifies regulatory networks for stem cell engineering
Kinney, M. A., Vo, L. T., Frame, J. M., Barragan, J., Conway, A. J., Li, S., Wong, K., Collins, J. J., Cahan, P., North, T. E., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0159-2 · Cited by 26 · see citing works
Ozolua (2010) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2010.145.151 · Cited by 25 · see citing works
Antipsychotic drug-associated gene–miRNA interaction in T-lymphocytes
Gardiner, E. J., Carroll, A. P., Tooney, P. A., & Cairns, M. J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001752 · Cited by 23 · see citing works
Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
Silva, E., Higgins, M., Hammer, B., & Stephenson, P. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02592-2 · Cited by 22 · see citing works
Clozapine-induced blood dyscrasias in Saudi Arab patients
Abanmy, N. O., Al-Jaloud, A., Al-Jabr, A., Al-Ruwaisan, R., Al-Saeed, W., & Fatani, S. (2014) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-014-9967-0 · Cited by 22 · see citing works
Capannolo, M., Fasciani, I., Romeo, S., Aloisi, G., Rossi, M., Bellio, P., Celenza, G., Cinque, B., Cifone, M. G., Scarselli, M., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.12.002 · Cited by 21 · see citing works
von Wilmsdorff, M., Bouvier, M.-L., Henning, U., Schmitt, A., Schneider-Axmann, T., & Gäebel, W. (2012) · Pharmacopsychiatry · doi:10.1055/s-0032-1321907 · Cited by 21 · see citing works
Oral Health Is a Challenging Problem for Patients with Schizophrenia: A Narrative Review
Denis, F., Pelletier, J., Chauvet‐Gélinier, J., Rude, N., & Trojak, B. (2018) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.8062 · Cited by 20 · see citing works
Paliperidone-induced leukopenia and neutropenia: A case report
Kim, J.-N., Lee, B., Choi, I.-G., Jon, D., & Jung, M. H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.09.018 · Cited by 19 · see citing works
Clozapine—A dangerous drug in a clozapine-naïve subject
Stanworth, D., Hunt, N., & Flanagan, R. J. (2011) · Forensic Science International · doi:10.1016/j.forsciint.2011.07.032 · Cited by 19 · see citing works
Self-citationCepaityte, D., Siafis, S., Egberts, T. C. G., Leucht, S., Kouvelas, D., & Papazisis, G. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa163 · Cited by 18 · see citing works
Clozapine Is Cytotoxic to Primary Cultures of Human Bone Marrow Mesenchymal Stromal Cells
Lahdelma, L., Oja, S., Korhonen, M. O., & Andersson, L. C. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181e6a082 · Cited by 18 · see citing works
A Case with Neutropenia Related with the Use of Various Atypical Antipsychotics
Lim, M. H., Park, J., & Park, T. W. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.4.428 · Cited by 18 · see citing works
Matsuura, H., Kimoto, S., Harada, I., Naemura, S., Yamamuro, K., & Kishimoto, T. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0874-x · Cited by 18 · see citing works
Atypical Antipsychotic Drugs and Ethanol Withdrawal Syndrome: A Review
Uzbay, T. I. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr142 · Cited by 17 · see citing works
Çoşar, B., Taner, E., Eser, H. Y., Altınöz, A. E., & Tarhan, R. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31820e3d9d · Cited by 17 · see citing works
Goto, A., Mouri, A., Nagai, T., Yoshimi, A., Ukigai, M., Tsubai, T., Hida, H., Ozaki, N., & Noda, Y. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.028 · Cited by 16 · see citing works
Risperidone- and Aripiprazole-Induced Leukopenia
Qureshi, S. U., & Rubin, E. (2008) · The Primary Care Companion to The Journal of Clinical Psychiatry · doi:10.4088/pcc.v10n0612c · Cited by 17 · see citing works
Yağcioğlu, A. E. A., Yoca, G., Ayhan, Y., Karaca, R. Ö., Cevik, L., Müderrisoğlu, A., Göktaş, M. T., Eni, N., Yazici, M. K., Bozkurt, A., et al. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000495 · Cited by 16 · see citing works
Changes for clozapine monitoring in the United States
Bastiampillai, T. J., Gupta, A., Chan, S. K. W., & Allison, S. C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.66 · Cited by 16 · see citing works
Simoons, M., Ruhé, H. G., van Roon, E. N., Schoevers, R. A., Bruggeman, R., Cath, D. C., Muis, D., Arends, J., Doornbos, B., & Mulder, H. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-3951-2 · Cited by 16 · see citing works
Fatal agranulocytosis associated with psychotropic medication use
Nazer, L. H., Shankar, G. S., Ali, B. A.-H., & Alnajjar, T. (2012) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp110195 · Cited by 16 · see citing works
Risperidone/paliperidone induced neutropenia and lymphopenia
Raj, V., Druitt, T., Purushothaman, S., & Dunsdon, J. E. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412460594 · Cited by 16 · see citing works
Definitions and mechanisms of drug hypersensitivity
Wedi, B. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.32 · Cited by 16 · see citing works
Immunotherapy of Neuromyelitis Optica
Bienia, B., & Balabanov, R. (2013) · Autoimmune Diseases · doi:10.1155/2013/741490 · Cited by 15 · see citing works
Ostuzzi, G., Papola, D., Gastaldon, C., Schoretsanitis, G., Bertolini, F., Amaddeo, F., Cuomo, A., Emsley, R. A., Fagiolini, A. M., Imperadore, G., et al. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.18308 · Cited by 15 · see citing works
Huguet, G., Louët, A. L., Darnige, L., Lôo, H., & Krebs, M. (2013) · L Encéphale · doi:10.1016/j.encep.2013.02.003 · Cited by 15 · see citing works
Ratanajamit, C., Musakopas, C., Vasiknanonte, S., & Reanmongkol, W. (2009) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651500903402450 · Cited by 15 · see citing works
Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone
Sood, S. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.4.413 · Cited by 15 · see citing works
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., McLoughlin, R. M., Silva, E., Park, B. K., Pirmohamed, M., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000646 · Cited by 15 · see citing works
Voulgari, C., Giannas, R., Paterakis, G. S., Kanellou, A., Anagnostopoulos, N. I., & Pagoni, S. (2015) · Case Reports in Medicine · doi:10.1155/2015/703218 · Cited by 14 · see citing works
Silva, E., Higgins, M., Hammer, B., & Stephenson, P. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253211015070 · Cited by 14 · see citing works
Olanzapine-induced neutropenia
Malhotra, K., Vu, P., Wang, D. H., Lai, H., & Faziola, L. R. (2015) · Mental Illness · doi:10.4081/mi.2015.5871 · Cited by 14 · see citing works
Gharab, K. M. K., Onmaz, D. E., Abuşoğlu, S., Aydın, M., Sivrikaya, A., Tok, O., Abuşoğlu, G., & Ünlü, A. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.113056 · Cited by 13 · see citing works
Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study
Chen, J., Yang, P., Zhang, Q., Chen, R., Wang, P., Liu, B., Sun, W., Jian, X., Xiang, S., Zhou, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01470-z · Cited by 13 · see citing works
Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case
Avinash, A. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/23748.9065 · Cited by 13 · see citing works
Olanzapine-induced and Risperidone-induced Leukopenia: A Case of Synergistic Adverse Reaction?
Woon, L. S., TEE, C. K., Gan, L. L. Y., Deang, K. T., & Chan, L. F. (2018) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000292 · Cited by 12 · see citing works
Antipsychotic drugs and risk of newly diagnosed tuberculosis in schizophrenia
Liu, H., Hung, G. C., Yang, S., Liao, Y., Pan, C., Chen, C., & Kuo, C. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12736 · Cited by 13 · see citing works
Aripiprazole-Induced Neutropenia: Case Report and Literature Review
Felin, T., Naveed, S., & Chaudhary, A. M. D. (2018) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20180419-02 · Cited by 11 · see citing works
Güllich, A. A. D. C., Coelho, R. P., Pilar, B. C., Ströher, D. J., Galarça, L. L., Vieira, S. M., Piccoli, J. D. C. E., Haas, S. E., & Manfredini, V. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9621-5 · Cited by 11 · see citing works
Decoding Clozapine-Induced Agranulocytosis: Unraveling Interactions and Mitigation Strategies
Alalawi, A. M., Albalawi, E., Aljohani, A., Almutairi, A., Alrehili, A., Albalawi, A., & Aldhafiri, A. J. (2024) · Pharmacy · doi:10.3390/pharmacy12030092 · Cited by 10 · see citing works
Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine
Jung, G. H., & You, S. J. (2019) · Korean Journal of Pediatrics · doi:10.3345/kjp.2019.00017 · Cited by 10 · see citing works
Obukohwo, O. M., Ben‐Azu, B., Nwangwa, E. K., Ejiro, O. P., Igweh, J. C., & Adeogun, A. E. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.04.004 · Cited by 10 · see citing works
Jovanović, N., Lovretić, V., & Kuzman, M. R. (2014) · PubMed · Cited by 10 · see citing works
Safety of a Clozapine Trial Following Quetiapine-Induced Leukopenia: A Case Report
Almaghrebi, A. H. (2018) · Current Drug Safety · doi:10.2174/1574886313666180807094654 · Cited by 10 · see citing works
Late Onset Clozapine Induced Agranulocytosis
Velayudhan, R., & Kakkan, S. (2014) · Indian Journal of Psychological Medicine · doi:10.4103/0253-7176.140738 · Cited by 10 · see citing works
Matłoka, M., Janowska, S., Pankiewicz, P., Kokhanovska, S., Kos, T., Hołuj, M., Rutkowska-Włodarczyk, I., Abramski, K. M., Janicka, M., Jakubowski, P., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.999685 · Cited by 9 · see citing works
Lin, A., Forsyth, J. K., Hoftman, G. D., Kushan, L., Jalbrzikowski, M., Dokuru, D. R., Coppola, G., Fiksinski, A., Zinkstok, J., Vorstman, J. A. S., et al. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100386 · Cited by 9 · see citing works
Bouvier, M.-L., Fehsel, K., Schmitt, A., Meisenzahl‐Lechner, E., Gäebel, W., & von Wilmsdorff, M. (2022) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00544-4 · Cited by 9 · see citing works
Crépeau‐Gendron, G., & L’Heureux, S. (2014) · Early Intervention in Psychiatry · doi:10.1111/eip.12134 · Cited by 9 · see citing works
Physical health algorithms for mental health care
Stanley, S. H., & Laugharne, J. D. E. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414548903 · Cited by 9 · see citing works
Medical Complications of Psychiatric Treatment
Lahijani, S. C., & Harris, K. A. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.03.008 · Cited by 8 · see citing works
Simon, L., & Cazard, F. (2016) · L Encéphale · doi:10.1016/j.encep.2016.03.005 · Cited by 8 · see citing works
A granulocytosis associated with rufinamide: A case report
Ide, M., Kato, T., Nakata, M., Saito, K., Yoshida, T., Awaya, T., & Heike, T. (2015) · Brain and Development · doi:10.1016/j.braindev.2014.12.010 · Cited by 8 · see citing works
Perphenazine and trifluoperazine induce mitochondria-mediated cell death in SH-SY5Y cells
Hong, S., Lee, M.-Y., Shin, K. S., & Kang, S. J. (2011) · Animal Cells and Systems · doi:10.1080/19768354.2011.611256 · Cited by 8 · see citing works
Aliyu, H. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp2013.3611 · Cited by 8 · see citing works
Management of Systemic Medical Emergencies Associated with Psychotropic Medications
Grover, S., Sarkar, S., & Avasthi, A. (2022) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_1014_21 · Cited by 7 · see citing works
Acute agranulocytosis when switching from risperidone to paliperidone
Wakuda, T., Suzuki, A., Hasegawa, M., Ichikawa, D., & Yamasue, H. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418821441 · Cited by 7 · see citing works
Coban, N., Gökçen, C., Akbayram, S., & Çalışgan, B. (2019) · Autism Research · doi:10.1002/aur.2122 · Cited by 7 · see citing works
Tinospora cordifolia attenuates antipsychotic drug induced hyperprolactinemia in Wistar rats
Tiwari, P. K., Dubey, S. K., & Sahu, P. K. (2019) · Asian Pacific Journal of Reproduction · doi:10.4103/2305-0500.259171 · Cited by 7 · see citing works
- Authors
- Flanagan, R. J., & Dunk, L.
- Affiliations
- King's College Hospital NHS Foundation Trust (GB)
- Leicester Royal Infirmary (GB)
- Corresponding author
- Flanagan, Robert J.
- ORCID
- Flanagan, Robert J.
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2007
- Volume
- 23
- Issue
- S1
- Pages
- S27-S41
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W2081866209
- Cited by
- 236
- References
- 100
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 14 · 2019: 12 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 19 · 2013: 10 · 2012: 13
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- drug-induced agranulocytosis, drug-induced neutropenia, clozapine, phenothiazines, chlorpromazine, carbamazepine, antipsychotic drugs, atypical antipsychotics, olanzapine, antiepileptic drugs, hematologic toxicity, myelosuppression, infection risk, hematological monitoring
- MeSH terms
- Animals, Mental Disorders, Hematologic Diseases, Humans, Psychotropic Drugs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
