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Human papillomavirus 16 load in normal and abnormal cervical scrapes: An indicator of CIN II/III and viral clearance
Open accessAbstract
The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high‐grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case‐control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16 DNA load was determined using a quantitative real‐time PCR assay. In group A, case women (women with CIN II/III, n = 12) had a significantly higher viral load than control women (women with CIN ≤ I, n = 47). This resulted in an increased relative risk of women with the 50% highest viral load for development of CIN II/III (OR 7.7; CI 1.6–33). In group B, women with CIN II/III (n = 38) had a significantly higher viral load than women with CIN ≤ I (n = 25). Women with the 50% highest viral load had an increased relative risk of CIN II/III (OR 3.2; CI 1.1–9.3) and a decreased chance of both viral clearance and cytologic regression. Our data suggest that in women with normal cytology an increased HPV 16 load confers an increased risk of developing a CIN lesion. A sustained high viral load is subsequently informative for progression to a high‐grade CIN lesion. © 2002 Wiley‐Liss, Inc.
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Cited by
Dalstein, V., Riethmuller, D., Prétet, J., Le Bail Carval, K., Sautière, J., Carbillet, J., Kantelip, B., Schaal, J., & Mougin, C. (2003) · International Journal of Cancer · doi:10.1002/ijc.11222 · Cited by 435
Petry, K.-U., Menton, S., Menton, M., van Loenen-Frosch, F., de Carvalho Gomes, H., Holz, B., Schopp, B., Garbrecht-Buettner, S., Davies, P., Boehmer, G., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600918 · Cited by 300
Hogewoning, C. J. A., Bleeker, M. C. G., van den Brule, A. J. C., Voorhorst, F. J., Snijders, P. J. F., Berkhof, J., Westenend, P. J., & Meijer, C. J. L. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11474 · Cited by 200
Self-citationBleeker, M. C. G., Hogewoning, C. J. A., Voorhorst, F. J., van den Brule, A. J. C., Snijders, P. J. F., Starink, T. M., Berkhof, J., & Meijer, C. J. L. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11473 · Cited by 113
Metadata
- Authors
- van Duin, M., Snijders, P. J. F., Schrijnemakers, H. F. J., Voorhorst, F. J., Rozendaal, L., Nobbenhuis, M. A. E., van den Brule, A. J. C., Verheijen, R. H. M., Helmerhorst, T. J., & Meijer, C. J. L. M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2002-01-24
- Volume
- 98
- Issue
- 4
- Pages
- 590-595
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2026712887
- Cited by
- 260
- References
- 0
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van Duin, M., Snijders, P. J. F., Schrijnemakers, H. F. J., Voorhorst, F. J., Rozendaal, L., Nobbenhuis, M. A. E., van den Brule, A. J. C., Verheijen, R. H. M., Helmerhorst, T. J., & Meijer, C. J. L. M. (2002). Human papillomavirus 16 load in normal and abnormal cervical scrapes: An indicator of CIN II/III and viral clearance. International Journal of Cancer. https://doi.org/10.1002/ijc.10232
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