Condom use promotes regression of human papillomavirus-associated penile lesions in male sexual partners of women with cervical intraepithelial neoplasia.
Open accessAbstract
Penile HPV-associated lesions are frequently seen in male sexual partners of women with CIN. The natural course and clinical significance of these lesions are unclear. Women with CIN and their male sexual partners were randomized for condom use (condom group n = 68, noncondom group n = 68). Males were screened for the presence of penile lesions, i.e., flat lesions, papular lesions and condylomata acuminata, and of HPV in their penile swabs by PCR testing. Median follow-up time was 13.1 months (range 2.9-57.4). The outcome of our study was clinical regression of penile lesions defined as disappearance of lesions at penoscopy. Potentially prognostic factors, i.e., HPV status, lesion type and age, were studied as well. Outcomes were assessed in 57 men of the condom group and in 43 men of the noncondom group. Condom use shortened the median time to regression of flat penile lesions (7.4 months condom group vs. 13.9 months noncondom group; HR = 2.1, 95% CI 1.2-3.7). This effect was not found for papular lesions (HR = 0.5, 95% CI 0.1-2.8). HPV-negative men showed a significantly shorter median time to regression of flat lesions (3.8 months) compared to men with either HPV-positive status (8.5 months; HR = 0.4, 95% CI 0.2-0.9) or inconsistent HPV status (13.1 months; HR = 0.2, 95% CI 0.1-0.6). Regression of flat penile lesions is HPV-dependent and accelerated by condom use. This effect is probably the result of blocking viral transmission between sexual partners.
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Consistent and correct use of latex condoms reduces the risk for HPV infection and HPV-associated diseases, genital herpes, syphilis, and chancroid when the infected area or site of potential exposure is covered.
“In addition, consistent and correct use of latex condoms reduces the risk for HPV infection and HPV-associated diseases, genital herpes, syphilis, and chancroid when the infected area or site of potential exposure is covered (23–27).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [25]
The Discussion reports that condom use shortened the time to regression of HPV-associated flat penile lesions and recommends condoms to reduce HPV infections and possible complications. It does not address genital herpes, syphilis, or chancroid, or establish the claim's conditions of correct latex-condom use and coverage of the exposure site. Page numbers are not available in the supplied copy. (LLM, conf=0.87)
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“About 50–55% of men whose partners have cervical HPV disease have HPV-associated penile lesions ( 21 ).”
BackgroundCondom Acquisition, Errors, and Breakage among U.S. Cisgender College Students
Butler, S. M., Oswalt, S. B., Hughes, C. M. L., Robbins, C. P., & Sundstrom, B. L. (2024) · Archives of Sexual Behavior · doi:10.1007/s10508-024-02998-z · Cited by 6 · see citing works
“Condoms reduce the risk of unintended pregnancy and sexually transmitted infections (STIs) when used consistently and correctly (Bleeker et al., 2003; Homes et al., 2004; Centers for Disease Control and Prevention [CDC], 2022; Warner & Steiner, 2018).”
HPV-induzierte Erkrankungen bei HIV-positiven Patienten
Wienecke, R., Brockmeyer, N. H., & Kreuter, A. (2006) · Der Hautarzt · doi:10.1007/s00105-006-1236-2 · Cited by 6 · see citing works
The potential of plants for the production and delivery of human papillomavirus vaccines
Rosales‐Mendoza, S., & Govea‐Alonso, D. O. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.1037744 · Cited by 5 · see citing works
Frequency of antibodies against E4 and E7 from human papillomavirus type 16 in Mexican soldiers
Plett-Torres, T., Cruz-Valdéz, A., Esquivel-Guadarrama, F. R., Nevarez, P. H., Lazcano-Ponce, E. C., & Gutiérrez‐Xicoténcatl, L. (2006) · Archives of Virology · doi:10.1007/s00705-006-0829-5 · Cited by 4 · see citing works
“Second, it seems that the HPV infection clears rather quickly in men [4], and it is possible that the antibodies do not disappear as fast as the HPV DNA, making their simultaneous detection difficult.”
BackgroundAntunes, A. A., Lyra, R., Calado, A. A., Antunes, M. A., & Falcão, E. (2004) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-72032004000700008 · Cited by 4 · see citing works
Alfonso-Trujillo, I., Medina, D. L. A., Labrada, M. Á., Quesada, M. R., & García, M. A. R. (2009) · Piel · doi:10.1016/s0213-9251(09)72017-9 · Cited by 4 · see citing works
Stefanaki, C., Stefanaki, I., Verra, P., Hadjivassiliou, M., Caroni, C., Bethimoutis, G., Papadogeorgaki, H., Stavropoulos, P., Kostaki, M., Antoniou, C., et al. (2010) · International Journal of STD & AIDS · doi:10.1258/ijsa.2010.010225 · Cited by 4 · see citing works
Bonnez, W., & Reichman, R. C. (2010) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-0-443-06839-3.00144-2 · Cited by 4 · see citing works
Diagnosis and Prevalence of High-Risk Human Papillomavirus Infection in Heterosexual Men
López-Diez, E., Pérez‐Castro, S., & Iñarrea, A. (2016) · InTech eBooks · doi:10.5772/62948 · Cited by 3 · see citing works
“Studies over the past 20 years evaluating HPV infection concordance among heterosexual partners have shown many inconsistencies, reporting concordances of type-specific infection between 2 and 87% [20, 42–44].”
BackgroundInfections of the Genital Tract: Human Papillomavirus–Related Infections
Yap, T., WATKIN, N. A., & Minhas, S. (2016) · European Urology Supplements · doi:10.1016/j.eursup.2016.08.005 · Cited by 3 · see citing works
Clinical and epidemiological patterns of ano-genital warts among male patients in Erbil city, Iraq
Ismael, S. A., Al-Soudani, A.-J. M. A., & Ali, K. M. (2012) · Annals of the College of Medicine Mosul/Annals of the College of Medecine · doi:10.33899/mmed.2012.64497 · Cited by 2 · see citing works
“In addition, condoms have been shown to reduce the risk of HPV-associated disease, including genital warts, cervical intraepithelial neoplasia and invasive cervical cancer (31) as well as promote the regression of HPV-associated cervical disease and flat penile lesions and the clearance of HPV infection ((30,31)).”
Enhancing Women’s Sexual Health: Prevention Measures in Diverse Populations of Women
Marrazzo, J. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4526-5_11 · Cited by 2 · see citing works
“Use of condoms has been associated with regression of cervical intraepithelial neoplasia (CIN) [ 83 ] and clearance of HPV infection in women, and with regression of HPV-associated penile lesions in men [ 84 ] .”
MethodTopical Treatment of Anogenital Human Papillomavirus Infection in Male Patients
Ankerst, D. P., Diepolder, H. M., & Horster, S. (2009) · Future Virology · doi:10.2217/fvl.09.57 · Cited by 2 · see citing works
“9 months when not using condoms [31], indicating that repeated infec tions with HPV are necessary to maintain an infection.”
BackgroundThe application of laparoscopy in abdominal trauma at Al-Jumhoori Teaching Hospital in Mosul
Asaad, M., Al-Dabbagh, K. A., Ali, M. S., Attash, S. M., & Al-Khyatt, M. K. (2012) · Annals of the College of Medicine Mosul/Annals of the College of Medecine · doi:10.33899/mmed.2012.64399 · Cited by 2 · see citing works
Bonnez, W. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369408-9.00026-3 · Cited by 2 · see citing works
Genital Warts (Anogenital warts)
Akhavan, S., Mousavi, A., Modares-Gilani, M., & Alibakhshi, A. (2017) · Journal of Obstetrics Gynecology and Cancer Research · doi:10.5812/ogcr.11440 · Cited by 2 · see citing works
“Sexual activities may be initiated whenever a patient feels comfortable; however, this usually takes a few weeks (33).”
Warner, L., & Stone, K. M. (2007) · Springer eBooks · doi:10.1007/978-0-387-48740-3_10 · Cited by 2 · see citing works
Bonnez, W. (2015) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-1-4557-4801-3.00146-6 · Cited by 2 · see citing works
Human Papillomavirus and Genital Warts
Goldman, L. (2006) · Humana Press eBooks · doi:10.1007/978-1-59745-040-9_2 · Cited by 2 · see citing works
Human Papillomavirus History and Epidemiology
Rosenblatt, A., & Guidi, H. G. D. C. (2009) · Springer eBooks · doi:10.1007/978-3-540-70974-9_1 · Cited by 2 · see citing works
Pereira, B. J., Graça, B., Palmas, A., Eufrásio, P., Lebre, A., Andrade, P., Louro, N., Azinhais, P., Cardoso, P., Tomada, N., et al. (2020) · Revista Internacional de Andrología · doi:10.1016/j.androl.2020.01.007 · Cited by 2 · see citing works
Human papillomavirus DNA in premenopausal and postmenopausal women
Koçtürk, S. A., & Gul, M. (2020) · Obstetrics & Gynecology International Journal · doi:10.15406/ogij.2020.11.00480 · Cited by 2 · see citing works
Genitoanal HPV Infection and Associated Neoplasias in the Male
Gross, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-14663-3_37 · Cited by 1 · see citing works
Afonso, L. A. (2010) · Jornal Brasileiro de Doenças Sexualmente Transmissíveis · doi:10.5533/2177-8264-201022307 · Cited by 1 · see citing works
Diez, E. L., Pérez, S., Iñarrea, A., de la Orden, A., Castro, M., Almuster, S., Tortolero, L., Rodríguez, M. S., Montero, R., & Ojea, A. (2017) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2017.03.019 · Cited by 1 · see citing works
Colignatus, T. (2004) · RePEc: Research Papers in Economics
Mastrolorenzo, A., Supuran, C. T., & Zuccati, G. (2007) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.17.2.173
“Indeed, two studies reported that condom use was associated with higher rates of regression of CIN and clearance of cervical HPV infection in women, with regression of HPV-associated penile lesions in men [137,138].”
BackgroundHuman Papillomavirus and Squamous Cell Carcinoma of the Penis
Horenblas, S. (2009) · Springer eBooks · doi:10.1007/978-3-540-70974-9_6
Effectiveness of condoms in preventing sexually transmitted
Levine, R., & Weaver, M. R. (2004)
Carvalho, J. J. M. D., Moreira, R. D. J., Vedovato, B. C., & Silva, D. B. (2011)
Human papillomavirus infection and transmission among couples through heterosexual activity
Burchell, A. N. (2009) · eScholarship@McGill (McGill) · doi:10.82308/17001
Human Papillomavirus and External Genital Lesions
Rosenblatt, A., & Guidi, H. G. D. C. (2009) · Springer eBooks · doi:10.1007/978-3-540-70974-9_3
Epidemiology and Risk Factors for Penile Cancer
Hegarty, P. K. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-367-1_1
Natural history of human papillomavirus infection among young men from Kisumu, Kenya
Backes, D. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/03sp-g659
Wainscott, M. (2013) · ThinkTech (Texas Tech University)
Castells, X., Sala, M., Salas, D., Ascunce, N., Zubizarreta, R., & Casamitjana, M. (2009) · DOAJ (DOAJ: Directory of Open Access Journals)
- Authors
- Bleeker, M. C. G., Hogewoning, C. J. A., Voorhorst, F. J., van den Brule, A. J. C., Snijders, P. J. F., Starink, T. M., Berkhof, J., & Meijer, C. J. L. M.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Corresponding author
- Meijer, Chris J.L.M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2003-09-12
- Volume
- 107
- Issue
- 5
- Pages
- 804-810
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1989124603
- Cited by
- 113
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Vrije Universiteit Amsterdam
- Topics
- Health Sciences › Medicine › Surgery › Genital Health and Disease
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- condom use, human papillomavirus, penile lesions, genital warts, papular skin lesions, cervical intraepithelial neoplasia, male sexual partners, lesion regression, HPV transmission, sexual transmission prevention
- MeSH terms
- Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Penile Diseases, Time Factors, Tumor Virus Infections, Condoms, Papillomaviridae, Papillomavirus Infections
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