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Cited by 200Cervical Cancer and HPV ResearchReproductive tract infections researchGenital Health and Disease

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial.

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Hogewoning, Cornelis J.A., Bleeker, Maaike C.G., van den Brule, Adriaan J.C., Voorhorst, Feja J., Snijders, Peter J.F., Berkhof, Johannes, Westenend, Pieter J., Meijer, Chris J.L.M.·2003·International Journal of Cancer
DOI 10.1002/ijc.11474
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Abstract

Women with persistent HPV infections have increased risk of progressive CIN lesions. Transmission of HPV between sexual partners might maintain viral infection and, consequently, may influence the clinical course of CIN. We investigated the effect of condom use on regression of CIN lesions and on clearance of HPV. Women with CIN and their male sexual partners were randomized for condom use (condom group n = 72 and noncondom group n = 76). They were conservatively managed and followed every 3-6 months by colposcopy, cytology and HPV testing by GP5+/6+ PCR. Baseline cervical biopsy specimens were taken. Median follow-up time for women was 15.2 months (range 3.0-85.4). Outcomes of interest were clinical regression of CIN at colposcopy and clearance of HPV. Outcomes were assessed in 64 women of the condom group and 61 women of the noncondom group. Women in the condom group showed a 2-year cumulative regression rate of 53% vs. 35% in the noncondom group (p = 0.03). The 2-year cumulative rates of HPV clearance were 23% vs. 4%, respectively (p = 0.02). Although lower regression rates were found if women were HPV-positive and had > or =CIN2 lesions at baseline, effects of condom use were found both in women with CIN1 and in women with > or =CIN2 lesions. Condom use promotes regression of CIN lesions and clearance of HPV.

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Metadata

Authors
Hogewoning, C. J. A., Bleeker, M. C. G., van den Brule, A. J. C., Voorhorst, F. J., Snijders, P. J. F., Berkhof, J., Westenend, P. J., & Meijer, C. J. L. M.
Affiliations
  • Albert Schweitzer Ziekenhuis (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Meijer, Chris J.L.M.
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
2003-09-12
Volume
107
Issue
5
Pages
811-816
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.11474
OpenAlex
W2006826127
Cited by
200
References
23
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 11 · 2012: 18
FWCI
9.35
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Surgery › Genital Health and Disease
Keywords
condom use, cervical intraepithelial neoplasia, human papillomavirus, HPV clearance, CIN regression, sexually transmitted infections, male sexual partners, conservative treatment, colposcopy, HPV genotyping
MeSH terms
Adult, Uterine Cervical Dysplasia, Colposcopy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Netherlands, Sexual Behavior, Time Factors, Tumor Virus Infections, Condoms, Papillomaviridae, Papillomavirus Infections

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