Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Hoffmann, Patrick, Hofmeister, Robert, Brischwein, Klaus, Brandl, Christian, Crommer, Sandrine, Bargou, Ralf, Itin, Christian, Prang, Nadja +1 more·2005·International Journal of Cancer

DOI 10.1002/ijc.20908

Cited by (348)

Items 301–348 of 348

Antibodies in Phase I/II/III: Cancer Therapy
Peter Markus Deckert · 2007
Wirkmechanismus des bispezifischen anti-CD19 x anti-CD3 BiTE-Antikörpers MT103 in Patienten mit rezidivem indolenten B-Zell-Non-Hodgkin-Lymphom
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Treating Adults with Acute Lymphoblastic Leukemia: It is Time to Grow Up
Partow Kebriaei, Farhad Ravandi · 2013 · International Journal of Hematologic Oncology
Médicaments de haute technologie en oncologie
Marie-Christine Étienne-Grimaldi, Patrick Couvreur, Jean‐Pierre Benoît, Raphaëlle Fanciullino, Jacques‐Aurélien Sergent, Erik Van Miert, Bertrand Pourroy, Patrick Meshaka, A. Brescianini, Nathalie Corvaı̈a et al. · 2014 · ONCOLOGIE
Immunology of the Lymphomas
Carla D. Kurkjian, Howard Ozer · 2012 · Springer eBooks
ANTI-CD19 MONOCLONAL ANTIBODIES: A NEW APPROACH TO LYMPHOMA THERAPY (REVIEW ARTICLE)
Fatemeh Naddafi, Fatemeh Davami · 2015
Passive immunotherapy by T cell–engaging bispecific antibodies
Patrick A. Baeuerle, Benno Rattel · 2011 · Informa Healthcare eBooks
Immunotherapy for High-Grade Gliomas
Teilo H. Schaller, John Howard Sampson · 2016 · Springer eBooks
Updates in Adult Acute Lymphoblastic Leukemia—Current Status of Antigen-targeted Treatments and Immunotherapy
Xavier Thomas · 2017 · touchREVIEWS in Oncology & Haematology
Stimulus-Response Mechanisms: An Overview
Mohammad A. Tabrizi, Shraddha Sadekar, Isabel Figueroa, Ayse Meric Ovacik · 2018 · Springer eBooks
Development of T cell based therapeutic strategies for childhood cancer neuroblastoma
Aysha Patel · 2017 · UCL Discovery (University College London)
Relapsed Pediatric ALL
Ayumu Arakawa · 2019 · Springer eBooks
Late Effects After Treatment of Acute Lymphoblastic Leukemia in Childhood and Adolescence
Franziska Cuntz, Gabriele Escherich · 2020 · Springer eBooks
Les nouvelles immunothérapies (hors CAR-T cells) dans les leucémies aiguës pédiatriques
Benoît Brethon · 2021 · Perfectionnement en Pédiatrie
A Comparative Investigation of the Bispecific Antibody: Expression in Expi293F Cells and E.coli
Reza Moazzami, Hasan Mirzahosaini, Fatemeh Naddafi, Fatemeh Davami · 2021 · Quarterly of Horizon of Medical Sciences
Optimal Timing of Blinatumomab for the Treatment of B-Lymphoblastic Leukemia
Sumit Gupta, Stacy Cooper, Rachel E. Rau · 2021 · Clinical Lymphoma Myeloma & Leukemia
ACUTE LEUKEMIAS XV
M. Mossner, J. Jann, W. Hofmann, A. Trumpp, D. Nowak · 2015 · Annals of Hematology
An Oncolytic Vaccinia Virus Expressing EpCAM Bispecific T-Cell Engager Enhances Immune Response in Solid Tumors
Min Wei, Shuguang Zuo, Peng Qian, Yenan Zhang, Chuning Xu, Lingkai Kong, Jie Dong, Jiwu Wei · 2022 · SSRN Electronic Journal
Biologics in rectal cancer
Alexandre Andrade dos Anjos Jacome, Renata D’Alpino Peixoto, Mariana Vargas Gil, Juliana Ominelli, Gabriel Prolla, Rodrigo Dienstmann, Cathy Eng · 2022 · Expert Opinion on Biological Therapy
New therapeutic modalities in the treatment of childhood acute lymphoblastic leukemia
Lucie Šrámková · 2022 · Česko-slovenská pediatrie
Antibody‐Based Targeted T ‐Cell Therapies
Manoj Bansode, Kaushik Deb, Sarmistha Deb · 2022 · Methods and principles in medicinal chemistry
Data from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct
Scott A. Hammond, Ralf Lutterbuese, Shannon R. Roff, Petra Lutterbuese, Bernd Schlereth, Elizabeth Bruckheimer, Michael S. Kinch, Steve Coats, Patrick A. Baeuerle, Peter Kufer et al. · 2023
Data from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct
Scott A. Hammond, Ralf Lutterbuese, Shannon R. Roff, Petra Lutterbuese, Bernd Schlereth, Elizabeth Bruckheimer, Michael S. Kinch, Steve Coats, Patrick A. Baeuerle, Peter Kufer et al. · 2023
Data from A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
Wei Zhang, Aurélie Auguste, Xiaoyun Liao, Christian Walterskirchen, Kathrin Bauer, Yu-Hsi Lin, Ling Yang, Farzaneh H. Sayedian, Markus Fabits, Michael M. Bergmann et al. · 2023
Data from A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
Wei Zhang, Aurélie Auguste, Xiaoyun Liao, Christian Walterskirchen, K. H. Bauer, Yu-Hsi Lin, Ling Yang, Farzaneh H. Sayedian, Markus Fabits, Michael M. Bergmann et al. · 2023
[Clinical advances in bispecific antibodies for hematological malignancies].
Yuepiao Cai, Depei Wu, Yang Y. Xu · 2023 · PubMed Central
Novel Biomarkers and Molecular Targets in ALL
Hong De, Jessica Taft Leonard · 2023 · Current Hematologic Malignancy Reports
Additional file 2 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Yi Huo, Zhen Sheng, Daniel Lu, Daniel Christian Ellwanger, Chi-Ming Li, Oliver R. Homann, Songli Wang, Hong Yin, Ruibao Ren · 2021 · Figshare
Additional file 5 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Yi Huo, Zhen Sheng, Daniel Lu, Daniel Christian Ellwanger, Chi-Ming Li, Oliver R. Homann, Songli Wang, Hong Mei Yin, Ruibao Ren · 2021 · Figshare
Additional file 4 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Yi Huo, Zhen Sheng, Daniel Lu, Daniel Christian Ellwanger, Chi-Ming Li, Oliver R. Homann, Songli Wang, Hong Yin, Ruibao Ren · 2021 · Figshare
Additional file 6 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Yi Huo, Zhen Sheng, Daniel Lu, Daniel Christian Ellwanger, Chi-Ming Li, Oliver R. Homann, Songli Wang, Hong Mei Yin, Ruibao Ren · 2021 · Figshare
Other Forms of Immunotherapy
Elaine Vickers · 2024
High-Throughput Centrifuge Force Microscopy Reveals Dynamic Immune-Cell Avidity at the Single-Cell Level
Hans Bergal, Koji Kinoshita, Wesley P. Wong · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Survival Benefits of Early Treatment With Blinatumomab in Adult Patients With Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
Dong Won Baek, Sang Kyun Sohn, Sung‐Hoon Jung, Ga‐Young Song, Ik‐Chan Song, Jeong Suk Koh, Ho‐Jin Shin, Do Young Kim, Sung‐Hyun Kim, Ji‐Hyun Lee et al. · 2025 · Clinical Lymphoma Myeloma & Leukemia
Umprogrammierte T-Zellen zur Behandlung der rheumatoiden Arthritis
Patrick A. Baeuerle, Ricardo Grieshaber‐Bouyer · 2025 · rheuma plus
Treatment-free interval duration during T-cell engager conditioning shapes simulated T-cell exhaustion and post-transfer tumor control
Nina Obertopp, Matthew Froid, Shari Pilon‐Thomas, David Basanta · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Antibody-Redirected T-Cell Immunotherapy for Brain Tumors
Bryan D. Choi · 2014 · DukeSpace (Duke University)
Additional file 3 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Huo, Yi, Sheng, Zhen, Daniel Lu, Daniel Christian Ellwanger, Li, Chi-Ming, Oliver R. Homann, Wang, Songli, Yin, Hong, Ren, Ruibao · 2021 · Figshare
Additional file 1 of Blinatumomab-induced T cell activation at single cell transcriptome resolution
Yi Huo, Sheng, Zhen, Daniel Lu, Daniel Christian Ellwanger, Li, Chi-Ming, Oliver R. Homann, Wang, Songli, Yin, Hong, Ren, Ruibao · 2021 · Figshare
Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: insights from in vitro assays
Miriam Kelm, Nourhan Nasr, Sonja Bendig, Dieter Kabelitz, Marta Lustig, Heiko Trautmann, Anna Laqua, Christian Peters, Daniela Wesch, Hans‐Heinrich Oberg et al. · 2026 · Frontiers in Immunology
Développement et évaluation d'anticorps bispécifiques dans le traitement du Myélome multiple
Maxime Fayon · 2019 · theses.fr (ABES)
Blinatumomab bypasses CD28 blockade to sustain T-cell cytotoxicity and improve survival in a xenograft B-ALL model
Geovana SF Leite, John Sullivan, Dimitrios Filioglou, Matina Kounelis, Helena Batatinha, Richard J. Simpson, Emmanuel Katsanis · 2026 · Journal for ImmunoTherapy of Cancer
Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K + Supramolecular Attack Particles
Jemma H. Larson, Ewoud Bernardus Compeer, Phillip R. Dougherty, Kyle Smith, Michael C. Zaiken, Olga Margaritaki, Benn Kopp, Sujeong Jin, Maria Harkiolaki, Lina Chen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
An In Vitro Quantitative Systems Pharmacology Platform for Characterizing CD3-Bispecific Antibody-Mediated T-Cell Activation and Tumor Cell Cytotoxicity
Xuanzhen Yuan, Craig J. Thalhauser, Nasrin Afzal, Kristel Kemper, Guohua An, Tommy Ruosi Li · 2026 · The AAPS Journal
An Overview on T-Cell Engagers: The Current Position in Both the Biological and Mathematical Context
Jonathan Davies, Liam Brown, Mark W. Jones, Mark Penny, Gibin Powathil · 2026 · Computational and Structural Biotechnology Journal
Generation of a highly versatile TCR bispecific scaffold optimized for targeting tumor-specific peptide-HLA antigens
Martin Hofmann, Felix Unverdorben, M. Gabriele Pszolla, Nadine Aschmoneit, Meike Hutt, Timo Manz, Heiko Schuster, Jens L. Hukelmann, Andreas Acs, Clara Tenkerian et al. · 2026 · mAbs
Prognostic value of early lymphocyte dynamics during blinatumomab therapy in relapsed or refractory B-cell precursor acute lymphoblastic leukemia: A real-world retrospective study
Seonghan Lee, Daehun Kwag, Gi June Min, Sung‐Soo Park, Silvia Park, Sung‐Eun Lee, Byung‐Sik Cho, Ki‐Seong Eom, Yoo‐Jin Kim, Hee-Je Kim et al. · 2026 · Therapeutic Advances in Hematology
Comparative clinical outcomes and single-cell profiling of CD19 CAR-T versus blinatumomab for relapsed/refractory B-ALL
Kexin Wang, Leijin Yu, Xinghua Liang, Fengmei Song, 江松福, Shi Han, Mingming Zhang, Kai Liu, Rui Wen, Lele Jin et al. · 2026 · Journal for ImmunoTherapy of Cancer