The DOI matches its Crossref record.
E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain
Abstract
Human papillomavirus type 16 E5 protein (HPV‐16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I; HLA class I in humans) to the cell surface and retains the complex in the GA. We report that these effects are due, at least in part, to the interaction between E5 and HLA I heavy chain (HC). We also demonstrate that the down‐regulation of surface HLA I and interaction with HC are mediated by the first hydrophobic domain of E5. Although E5 downregulates classical HLA selectively as it does not downregulate non‐classical HLA, the interaction with the HC of classical HLA I is not specific for a particular haplotype of HLA I. This suggests that E5 can interfere with antigen presentation by most, if not all, classical HLA I haplotypes, with potentially serious consequences as the ability of infected cells to present antigenic peptides to effector T cells would be compromised. © 2006 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mechanistically, this has been linked to interaction of HPV-16 E5 with MHC class I through E5’s first helical transmembrane domain (TM1), and to E5’s location in Golgi/ER, possibly interfering with the trafficking of MHC molecules to the cell surface, as dislocation of E5 from Golgi/ER leads to the abrogation of MHC I downregulation [345,346].”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [346]
In the citing paper
“Mechanistically, this has been linked to interaction of HPV-16 E5 with MHC class I through E5’s first helical transmembrane domain (TM1), and to E5’s location in Golgi/ER, possibly interfering with the trafficking of MHC molecules to the cell surface, as dislocation of E5 from Golgi/ER leads to the abrogation of MHC I downregulation [345,346].”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [346]
In the citing paper
“Mechanistically, this has been linked to interaction of HPV-16 E5 with MHC class I through E5’s first helical transmembrane domain (TM1), and to E5’s location in Golgi/ER, possibly interfering with the trafficking of MHC molecules to the cell surface, as dislocation of E5 from Golgi/ER leads to the abrogation of MHC I downregulation [345,346].”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [346]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 31
- 10.1111/j.1600-065X.1999.tb01288.x · DOI
- 10.1038/nrc798 · DOI
- 10.1111/j.1600-065X.1999.tb01353.x · DOI
- 10.1002/ijc.20558 · DOI · Paper page
- 10.1007/BF02256414 · DOI · Paper page
- 10.1099/0022-1317-75-9-2451 · DOI · Paper page
- Suprynowicz FA, 2006, Papillomavirus research: from natural history to vaccines and beyond, 97
- 10.1038/sj.onc.1203718 · DOI
- 10.1038/sj.onc.1205008 · DOI
- 10.1038/sj.onc.1209245 · DOI
- 10.1038/sj.onc.1205885 · DOI
- 10.1016/S1570-9639(02)00408-9 · DOI
- 10.1016/0042-6822(88)90259-0 · DOI
- 10.1007/s00705-004-0325-8 · DOI
- 10.1006/viro.1995.1395 · DOI
- 10.1099/vir.0.80128-0 · DOI
- 10.1128/JVI.67.10.6170-6178.1993 · DOI
- Goldstein DJ, 1992, A glutamine residue in the membrane‐associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)‐ATPase, J Virol, 66, 405, 10.1128/jvi.66.1.405-413.1992 · DOI
- 10.1128/jvi.70.12.9041-9045.1996 · DOI
- 10.1006/viro.2000.0376 · DOI
- 10.1128/JVI.79.9.5839-5846.2005 · DOI · Paper page
- 10.1128/JVI.69.5.3185-3192.1995 · DOI
- 10.1128/JVI.67.8.4521-4532.1993 · DOI · Paper page
- 10.1128/JVI.77.5.3041-3049.2003 · DOI
- 10.1128/JVI.79.1.632-636.2005 · DOI
- 10.1016/S1074-7613(00)80065-5 · DOI
- 10.1016/S1074-7613(00)80569-5 · DOI
- 10.1038/sj.onc.1204010 · DOI
- 10.1016/S1097-2765(01)80005-8 · DOI
- 10.1006/viro.1993.1607 · DOI
- 10.1158/0008-5472.CAN-05-0083 · DOI · Paper page
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Ashrafi, G. H., Haghshenas, M., Marchetti, B., & Campo, M. S.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-07-05
- Volume
- 119
- Issue
- 9
- Pages
- 2105-2112
- ISSN
- 0020-7136
- 1097-0215
- Cited by
- 131
- References
- 0
- Language
- en
- Funders
- Medical Research Council of Great Britain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
