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Cited by 106Childhood Cancer Survivors' Quality of LifeCancer survivorship and careAcute Lymphoblastic Leukemia research

Health‐status of adult survivors of childhood cancer: A large‐scale population‐based study from the British childhood cancer survivor study

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Reulen, Raoul C., Winter, David L., Lancashire, Emma R., Zeegers, Maurice P., Jenney, Meriel E., Walters, Stephen J., Jenkinson, Crispin, Hawkins, Mike M.·2007·International Journal of Cancer
DOI 10.1002/ijc.22658
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Abstract

The purpose of this study was to investigate the effect of childhood cancer and its treatment on self‐reported health‐status in 10,189 adult survivors of childhood cancer in Britain. Age‐ and sex‐adjusted scores on the SF‐36 Mental and Physical Component Summary scales (MCS, PCS, respectively) were compared between survivors and UK norms, and between subgroups of survivors, by multiple regression. Survivors had comparable scores to UK‐norms on the MCS scale (difference (D) = −0.1, 99% CI: −0.5, 0.3). The difference in scores between survivors and UK‐norms on the PCS scale varied by age (p heterogeneity < 0.001). Young survivors (16–19 years) scored similarly to UK‐norms (D = 0.5, (−1.1, 2.2), whereas the age groups of 25 and older scored statistically and clinically significantly below UK‐norms (all p‐values < 0.0001), with Ds ranging between −2.3 (−3.5, −1.2) and −3.7 (−5.0, −2.4). Survivors of central nervous system (CNS) and bone tumors scored significantly (p‐value at all ages <0.003) below UK‐norms on the PCS scale. Specifically, these survivors were substantially more limited in specific daily activities such as, for example, walking a mile (40, 63%, respectively) when compared to UK‐norms (16%). In conclusion, childhood cancer survivors rate their mental health broadly similarly to those in the general population. Survivors of CNS and bone tumors report their physical health‐status to be importantly below population norms. Although self‐reported physical health is at least as good as in the general population among young survivors, this study suggests that perceived physical health declines more rapidly over time than in the general population. © 2007 Wiley‐Liss, Inc.

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Authors
Reulen, R. C., Winter, D. L., Lancashire, E. R., Zeegers, M. P., Jenney, M. E., Walters, S. J., Jenkinson, C., & Hawkins, M. M.
Affiliations
  • University of Birmingham (GB)
  • University of Sheffield (GB)
  • University of Oxford (GB)
Corresponding author
Reulen, Raoul C.
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
2007-05-25
Volume
121
Issue
3
Pages
633-640
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.22658
OpenAlex
W1997593651
Cited by
106
References
27
Citations by year
2025: 2 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 12 · 2015: 9 · 2014: 12 · 2013: 7 · 2012: 8
FWCI
5.71
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
childhood cancer survivors, adult survivors, health-related quality of life, self-rated health, physical function, mental health, central nervous system tumors, bone tumors, cancer treatment effects, SF-36, age differences
MeSH terms
Activities of Daily Living, Adolescent, Adult, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Neoplasms, Retrospective Studies, Self-Assessment, Cohort Studies, Survivors

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