Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
Open accessAbstract
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
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The estimated lifetime risk of pancreatic cancer for an individual with two first-degree relatives with pancreatic cancer is about 8%.
“the estimated lifetime risk of developing pancreatic cancer for an individual with two first-degree relatives with pancreatic cancer is ~8%.”
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References 36 · Cited by 151
Research works printed but not linked: 1
- [26]Hosmer DW Lemeshow S Applied Logistic Regression 1989 John Wiley and Sons New York
- Authors
- Jacobs, E. J., Chanock, S. J., Fuchs, C. S., LaCroix, A., McWilliams, R. R., Steplowski, E., Stolzenberg‐Solomon, R. Z., Arslan, A. A., Bueno‐de‐Mesquita, H. B., Gross, M., Helzlsouer, K., Petersen, G., Zheng, W., Agalliu, I., Allen, N. E., Amundadottir, L., Boutron‐Ruault, M., Buring, J. E., Canzian, F., Clipp, S., Dorronsoro, M., Gaziano, J. M., Giovannucci, E. L., Hankinson, S. E., Hartge, P., Hoover, R. N., Hunter, D. J., Jacobs, K. B., Jenab, M., Kraft, P., Kooperberg, C., Lynch, S. M., Sund, M., Mendelsohn, J. B., Mouw, T., Newton, C. C., Overvad, K., Palli, D., Peeters, P. H. M., Rajkovic, A., Shu, X., Thomas, G., Tobias, G. S., Trichopoulos, D., Virtamo, J., Wactawski‐Wende, J., Wolpin, B. M., Yu, K., & Zeleniuch‐Jacquotte, A.
- Affiliations
- American Cancer Society (US)
- National Institutes of Health (US)
- Brigham and Women's Hospital (US)
- Fred Hutch Cancer Center (US)
- Mayo Clinic (US)
- Information Management Services (US)
- New York University (US)
- University of Minnesota (US)
- Mercy Medical Center (US)
- Vanderbilt University (US)
- Albert Einstein College of Medicine (US)
- University of Oxford (GB)
- Inserm (FR)
- German Cancer Research Center (DE)
- Centre international de recherche sur le cancer (FR)
- Harvard University (US)
- Umeå University (SE)
- Imperial College London (GB)
- Aalborg University Hospital (DK)
- Istituto per lo Studio e la Prevenzione Oncologica (IT)
- Utrecht University (NL)
- University of Pittsburgh (US)
- Finnish Institute for Health and Welfare (FI)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Jacobs, Eric J.
- ORCID
- Jacobs, Eric J.
- Chanock, Stephen J.
- Fuchs, Charles S.
- LaCroix, Andrea
- McWilliams, Robert R.
- Stolzenberg‐Solomon, Rachael Z.
- Arslan, Alan A.
- Zheng, Wei
- Agalliu, Ilir
- Allen, Naomi E.
- Amundadottir, Laufey
- Boutron‐Ruault, Marie‐Christine
- Buring, Julie E.
- Canzian, Federico
- Gaziano, J. Michael
- Giovannucci, Edward L.
- Hankinson, Susan E.
- Hoover, Robert N.
- Jacobs, Kevin B.
- Jenab, Mazda
- Kraft, Peter
- Kooperberg, Charles
- Lynch, Shannon M.
- Sund, Malin
- Newton, Christina C.
- Overvad, Kim
- Palli, Domenico
- Peeters, Petra H.M.
- Rajkovic, Aleksandar
- Shu, Xiao‐Ou
- Thomas, Gilles
- Tobias, Geoffrey S.
- Wactawski‐Wende, Jean
- Wolpin, Brian M.
- Yu, Kai
- Zeleniuch‐Jacquotte, Anne
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2010-07-19
- Volume
- 127
- Issue
- 6
- Pages
- 1421-1428
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- PMC
- PMC2926939
- OpenAlex
- W1279187214
- Cited by
- 151
- References
- 36
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 5 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 14 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- National Cancer Institute (R01CA124908, R37CA070867, U01CA098710, R01CA082729, R01CA097193, P50CA102701)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- pancreatic cancer, family history of cancer, hereditary cancer predisposition, prostate cancer, ovarian cancer, breast cancer, colorectal cancer, familial cancer risk
- MeSH terms
- Humans, Pancreatic Neoplasms, Cohort Studies, Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study
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