Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

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Items 101–200 of 441

1. Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
   Marco Sciacovelli, Aurélien J. F. Dugourd, Lorea Valcárcel-Jiménez, Ming Hui Yang, Efterpi Nikitopoulou, Ana S.H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt et al. · 2022 · Nature Communications
2. Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy
   Yilin Yu, Jie Yu, Shengfang Ge, Yun Su, Xianqun Fan · 2023 · International Journal of Biological Sciences
3. Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells
   Rita F. Tanios, Amira Bekdash, Elias Kassab, Everett M Stone, George Georgiou, Arthur Edward Frankel, Ralph Joseph Abi‐Habib · 2013 · Leukemia Research
4. PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration
   Elena Brin, Katherine Wu, Hsin-Tze Lu, Yudou He, Zhaoming Dai, Wei He · 2017 · Oncotarget
5. Metabolic regulation in the immune response to cancer
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6. Proteomic analysis of oropharyngeal carcinomas reveals novel HPV‐associated biological pathways
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7. Red Blood Cell-Encapsulated L-Asparaginase: Potential Therapy of Patients with Asparagine Synthetase Deficient Acute Myeloid Leukemia
   Vaidehi Agrawal, Jung Hee Woo, Gautham Borthakur, Hagop M. Kantarjian, Arthur Edward Frankel · 2013 · Protein and Peptide Letters
8. Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination
   Yu Zhang, Sai‐Fung Chung, Suet-Ying Tam, Yun‐Chung Leung, Xiao Guan · 2021 · Cancer Letters
9. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
   Tingting Li, Xian Wang, Enguo Ju, Suzane Ramos da Silva, Luping Chen, Xinquan Zhang, Shan Wei, Shou‐Jiang Gao · 2021 · Nature Communications
10. Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin’s lymphoma cells
    Xian Liang Zeng, Yubin Li, Jiajun Fan, Hu Zhao, Zongshu Xian, Yun Sun, Zhijun Wang, Shao-Gang Wang, Genhao Zhang, Dianwen Ju · 2013 · Cell Death and Disease
11. Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation
    Iuliia Pavlyk, Yuriy Rzhepetskyy, Adam Konrad Jagielski, Jakub Drożak, Anna Wasik, Galyna Pereverzieva, Marta Brewińska‐Olchowik, Leoni A. Kunz‐Schughart, Oleh V. Stasyk, Maria Jolanta Rędowicz · 2014 · Amino Acids
12. Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity
    Leslie A. Bateman, Wan-min Ku, Martin J. Heslin, Carlo M. Contreras, Christine F. Skibola, Daniel K. Nomura · 2017 · ACS Chemical Biology
13. Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation
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14. Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma
    Barbone, Dario, Van Dam, Loes, Follo, Carlo, Jithesh, Puthen V., Zhang, Shu-Dong, Richards, William G., Bueno, Raphael, Fennell, Dean A., Broaddus, V. Courtney · 2016 · PLOS ONE
15. Metabolic Rewiring and Redox Alterations in Malignant Pleural Mesothelioma
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16. A cluster of long non-coding RNAs exhibit diagnostic and prognostic values in renal cell carcinoma
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17. A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
    Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter Karl Sorger · 2024 · Nature Cell Biology
18. Argininosuccinate lyase is a potential therapeutic target in breast cancer
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19. Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy
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20. The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer
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21. Arginine deprivation and autophagic cell death in cancer
    Peter Wojciech Szlosarek · 2014 · Proceedings of the National Academy of Sciences
22. Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent
    Ghenwa Nasreddine, Mirvat El‐Sibai, Ralph Joseph Abi‐Habib · 2019 · Investigational New Drugs
23. The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials
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24. Novel Proteomic Biomarker Panel for Prediction of Aggressive Metastatic Hepatocellular Carcinoma Relapse in Surgically Resectable Patients
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25. Expression of argininosuccinate synthetase in patients with hepatocellular carcinoma
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26. Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug
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27. Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma
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28. Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability
    Anke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen Ildicho Closs, Markus Munder · 2019 · Frontiers in Oncology
29. ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism
    Sanika Khare, Laura C. Kim, Graham P. Lobel, Paschalis‐Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith, Marie Celeste Simon · 2021 · Cancer & Metabolism
30. Graphene Functionalized with Arginine Decreases the Development of Glioblastoma Multiforme Tumor in a Gene-Dependent Manner
    Ewa Sawosz, Sławomir Jaworski, Marta Kutwin, Krishna Prasad Vadalasetty, Marta Grodzik, Mateusz Wierzbicki, Natalia Kurantowicz, Barbara Strojny, Anna Hotowy, L. Lipińska et al. · 2015 · International Journal of Molecular Sciences
31. Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis
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32. Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment
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33. Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis
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34. Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
    Rouzbeh Daylami, Diego J. Muilenburg, Subbulakshmi Virudachalam, Richard J. Bold · 2014 · Journal of Experimental & Clinical Cancer Research
35. Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion
    Houssam Al-Koussa, Maria Al Haddad, Ralph Joseph Abi‐Habib, Mirvat El‐Sibai · 2019 · International Journal of Molecular Sciences
36. OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer
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37. Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer Treatment
    Yu‐De Chu, Ming‐Wei Lai, Chau‐Ting Yeh · 2023 · International Journal of Molecular Sciences
38. Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling
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39. Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC
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40. Arginine deprivation as a new treatment strategy for head and neck cancer
    Cheng‐Chih Huang, Sen‐Tien Tsai, Ching‐Chuan Kuo, Jeffrey Shu-Ming Chang, Ying‐Tai Jin, Jang‐Yang Chang, Jenn‐Ren Hsiao · 2012 · Oral Oncology
41. Extensive Decoupling of Metabolic Genes in Cancer
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42. Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
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43. Recombinant arginine‐degrading enzymes in metabolic anticancer therapy and bioanalytics
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44. NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells
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45. Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization
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47. Expression status of candidate genes in mesothelioma tissues and cell lines
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49. Attenuation of Argininosuccinate Lyase Inhibits Cancer Growth via Cyclin A2 and Nitric Oxide
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50. Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling
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51. 13C and 15N natural isotope abundance reflects breast cancer cell metabolism
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52. Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
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53. Metabolic Strategies for Inhibiting Cancer Development
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54. Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer
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55. MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis
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56. Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma
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57. Medicinal chemistry perspectives on anticancer drug design based on clinical applications (2015–2025)
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58. Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma
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59. Identification of metabolites in plasma for predicting survival in glioblastoma
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60. Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1
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61. Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway
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62. Bench-to-Bedside Studies of Arginine Deprivation in Cancer
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63. Purification and immobilization of l-arginase from thermotolerant Penicillium chrysogenum KJ185377.1; with unique kinetic properties as thermostable anticancer enzyme
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64. Cancer cell sensitivity to arginine deprivation in vitro is not determined by endogenous levels of arginine metabolic enzymes
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65. L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells
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66. The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer—Understanding the Basis of a Rapidly Evolving Disease
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67. 5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction
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68. Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
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69. Nitric Oxide Synthase Inhibition Enhances the Antitumor Effect of Radiation in the Treatment of Squamous Carcinoma Xenografts
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70. Mesothelioma treatment: Are we on target? A review
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71. Silencing of argininosuccinate lyase inhibits colorectal cancer formation
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72. Targeted Arginine Metabolism Therapy: A Dilemma in Glioma Treatment
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73. ASS1 enhances anoikis resistance via AMPK/CPT1A-mediated fatty acid metabolism in ovarian cancer
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74. Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence
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75. Pleural mesothelioma
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76. Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment
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77. A simultaneously quantitative profiling method for 40 endogenous amino acids and derivatives in cell lines using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry
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78. PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP / AMPK / CEBPB pathway
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79. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion
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80. ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis
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82. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3
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84. Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM
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85. Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
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86. Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Upregulates Argininosuccinate Synthase 1, a Rate-Limiting Enzyme of the Citrulline-Nitric Oxide Cycle, To Activate the STAT3 Pathway and Promote Growth Transformation
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87. Multimodal convolutional neural networks based on the Raman spectra of serum and clinical features for the early diagnosis of prostate cancer
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88. Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts
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89. Nutrient requirements of organ-specific metastasis in breast cancer
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92. Identification of arginine and its “Downstream” molecules as potential markers of breast cancer
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93. The importance of plasma arginine level and its downstream metabolites in diagnosing prostate cancer
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94. Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1
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95. Differential expression of argininosuccinate synthetase in serous and non‐serous ovarian carcinomas
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96. Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells
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97. L-arginine/5-fluorouracil combination treatment approaches cells selectively: Rescuing endothelial cells while killing MDA-MB-468 breast cancer cells
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98. Pharmacologic approaches to amino acid depletion for cancer therapy
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99. Metabolite biomarker discovery for human gastric cancer using dried blood spot mass spectrometry metabolomic approach
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100. Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA
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