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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
Open accessAbstract
Arginine, a semi‐essential amino acid in humans, is critical for the growth of human cancers, particularly those marked by de novo chemoresistance and a poor clinical outcome. In addition to protein synthesis, arginine is involved in diverse aspects of tumour metabolism, including the synthesis of nitric oxide, polyamines, nucleotides, proline and glutamate. Tumoural downregulation of the enzyme argininosuccinate synthetase (ASS1), a recognised rate‐limiting step in arginine synthesis, results in an intrinsic dependence on extracellular arginine due to an inability to synthesise arginine for growth. This dependence on extracellular arginine is known as arginine auxotrophy. Several tumours are arginine auxotrophic, due to variable loss of ASS1, including hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer. Importantly, targeting extracellular arginine for degradation in the absence of ASS1 triggers apoptosis in arginine auxotrophs. Several phase I/II clinical trials of the arginine‐lowering drug, pegylated arginine deiminase, have shown encouraging evidence of clinical benefit and low toxicity in patients with ASS1‐negative tumours. In part, ASS1 loss is due to epigenetic silencing of the ASS1 promoter in various human cancer cell lines and tumours, and it is this silencing that confers arginine auxotrophy. In relapsed ovarian cancer, this is associated with platinum refractoriness. In contrast, several platinum sensitive tumours, including primary ovarian, stomach and colorectal cancer, are characterised by ASS1 overexpression, which is regulated by proinflammatory cytokines. This review examines the prospects for novel approaches in the prevention, diagnosis and treatment of malignant disease based on ASS1 pathophysiology and its rate‐limiting product, arginine.
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“For example, some melanoma, lymphoma, glioma, and prostate cancers reduce or lose the expression of the urea cycle enzyme argininosuccinate synthase 1 (ASS1) (Delage et al., 2010).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Delage et al., 2010
In the citing paper
“Accordingly, the auxotrophy of tumors for arginine is being exploited in the development of anticancer therapies (Delage et al., 2010).”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Delage et al., 2010
In the citing paper
“Succination is a hallmark of FH-deficient tumours and an antibody against succinate protein has been proposed as a diagnostic marker for HLRCC89.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [89]
In the citing paper
“Succination is a hallmark of FH-deficient tumours and an antibody against succinate protein has been proposed as a diagnostic marker for HLRCC89.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [89]
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Citations
Cites
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Tumor cell metabolism: cancer's Achilles' heel
Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337
Regulation of immune responses by L-arginine metabolism
Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775
The role of nitric oxide in tumour progression
Fukumura, D., Kashiwagi, S., & Jain, R. K. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1910 · Cited by 1,279
Polyamines and cancer: old molecules, new understanding
Gerner, E. W., & Meyskens, F. L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1454 · Cited by 1,163
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018
Rodrı́guez, P. C., & Ochoa, A. C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00608.x · Cited by 743
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
Xia, Y., & Zweier, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6954 · Cited by 691
Meyskens, F. L., McLaren, C. E., Pelot, D., Fujikawa-Brooks, S., Carpenter, P. M., Hawk, E. T., Kelloff, G. J., Lawson, M. J., Kidao, J., McCracken, J., et al. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0042 · Cited by 518
Recent advances in arginine metabolism: roles and regulation of the arginases
Morris Jr, S. M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00278.x · Cited by 485
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Kung, H.-J., Changou, C. A., Nguyen, H. G., Yang, J. C., Evans, C. P., Bold, R. J., & Chuang, F. Y. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6828-8_19 · Cited by 8
Ma, C., Xu, Y., Yin, G., Wang, Y., Hu, S., Xia, W., Chen, Y., Liu, X., Chen, J., & Li, X. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.10.037 · Cited by 8
Al-Shahari, E. A., Barky, A. R. E., Mohamed, T. M., & Alm-Eldeen, A. A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13177-1 · Cited by 8
Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells
Xia, J., Liu, W., Ni, Y., Shahzad, A., Cui, K., Xu, Z., Zhang, J., Wei, Z., Teng, Z., Yang, Z., et al. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111593 · Cited by 7
Shi, J., Mui, S., Yan, Y., Liu, S., Wen, K., He, C., Li, H., Liao, H., Meng, T., Wen, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202503851 · Cited by 9
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy
Zhang, J., Wang, S., Liu, H., Luo, L., & You, J. (2025) · Medicinal Research Reviews · doi:10.1002/med.70015 · Cited by 9
Gulati, K., Manukonda, R., Kairamkonda, M., Kaliki, S., & Poluri, K. M. (2023) · ACS Omega · doi:10.1021/acsomega.3c07424 · Cited by 7
Cellular Signaling of Amino Acid Metabolism in Prostate Cancer
Yao, P., Cao, S., Zhu, Z., Wen, Y., Guo, Y., Liang, W., & Xie, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020776 · Cited by 7
Rona, G. B., de Almeida, N. P., dos Santos, G. C., Fidalgo, T. K. D. S., Almeida, F. C. L., Eleuthério, E. C. A., & Pinheiro, A. S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27816 · Cited by 7
Zhou, L., Wang, Q., Mao, L., Chen, S., Yang, Z., Liu, X., Gao, Y., Li, X., Zhou, Z., & He, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.875324 · Cited by 7
The exploitation of enzyme-based cancer immunotherapy
Chandan, G., Saini, A. K., Kumari, R., Chakrabarti, S., Mittal, A., Sharma, A. K., & Saini, R. V. (2022) · Human Cell · doi:10.1007/s13577-022-00821-2 · Cited by 7
Zhang, X., Wu, L., Jia, L., Hu, X., Yao, Y., Liu, H., Ma, J., Wang, W. J., Li, L., Chen, K., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108897 · Cited by 7
Non-Mutational Key Features in the Biology of Thymomas
Küffer, S., Müller, D., Marx, A., & Ströbel, P. (2024) · Cancers · doi:10.3390/cancers16050942 · Cited by 7
Metabolic Frugality Marks Cancer Cells for Immune Targeting
Sullivan, L. B. (2018) · Cell · doi:10.1016/j.cell.2018.08.023 · Cited by 7
Precision Therapy for Mesothelioma: Feasibility and New Opportunities
Dulloo, S., Bzura, A., & Fennell, D. A. (2021) · Cancers · doi:10.3390/cancers13102347 · Cited by 7
Self-citationRole of the anti-glioma drug AT13148 in the inhibition of Notch signaling pathway
Min, W., Li, Y., Zhang, Y., Dai, D., Cao, Y., Yue, Z., & Liu, J. (2015) · Gene · doi:10.1016/j.gene.2015.07.033 · Cited by 7
Immobilization of engineered arginase on gold-carbon nanotubes
Lee, G. K.-C., Kwok, S.-Y., Yu, C. H., Tam, K. Y., Chong, H.-C., Leung, Y., & Tsang, S. C. E. (2012) · Chemical Communications · doi:10.1039/c2cc32863a · Cited by 7
Tishler, H., Ziman, S., Cheng, K., Wang, K., Sanghvi, N., Adler, L. N., Stelzer, G., Maniriho, H., Dassa, B., Bab-Dinitz, E., et al. (2025) · Cells · doi:10.3390/cells15010025 · Cited by 6
Arginine Transporters in Human Cancers: Emerging Mechanisms and Clinical Implications
Cai, X., Shang, L., Li, Y., Cao, Y., & Shi, F. (2026) · Biomolecules · doi:10.3390/biom16010132 · Cited by 6
Feng, W., Zuo, M., Li, W., Chen, S., Wang, Z., Yuan, Y., Yang, Y., & Liu, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1145828 · Cited by 6
Application of Metabolic Biomarkers in Breast Cancer: A Literature Review
Lee, A., & Lam, C. (2025) · Annals of Laboratory Medicine · doi:10.3343/alm.2024.0482 · Cited by 7
Improvements in Systemic Therapies for Advanced Malignant Mesothelioma
Deiana, C., Fabbri, F., Tavolari, S., Palloni, A., & Brandi, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310415 · Cited by 6
Site of breast cancer metastasis is independent of single nutrient levelsPreprint
Abbott, K. L., Subudhi, S., Ferreira, R., Gültekin, Y., Steinbuch, S. C., Munim, M. B., Honeder, S. E., Kumar, A. S., Ramesh, D. L., Wu, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.24.616714 · Cited by 6
The Mechanism of TRIM21 Inhibiting the Invasion and Migration of ccRCC by Stabilizing ASS1
Yang, Z., Cai, J., Li, J., Liu, X., Liu, W., Cui, K., Bai, Z., Dong, Y., Peng, D., Duan, Q., et al. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23840 · Cited by 5
Mitochondria and tumorigenesis: Molecular basis and therapeutic implications
Huang, C. Y., Xie, Z., Li, J., & Zhang, C. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101806 · Cited by 6
Exploring Metabolic Approaches for Epithelial Ovarian Cancer Therapy
Kumari, S., Gupta, S., Jamil, A., Tabatabaei, D., & Karakashev, S. V. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31495 · Cited by 5
Chu, Y.-D., Liu, H.-F., Chen, Y.-C., Chou, C.-H., & Yeh, C.-T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.996820 · Cited by 7
Phillips, M. M., Pavlyk, I., Allen, M. D., Ghazaly, E. A., Cutts, R. J., Carpentier, J., Berry, J. S., Nattress, C. B., Feng, S., Halldén, G., et al. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00480-6 · Cited by 5
Self-citationDevelopment and characterization of fused human arginase I for cancer therapy
Jawalekar, S. S., Kawathe, P. S., Sharma, N., Anakha, J., Tikoo, K., & Pande, A. H. (2023) · Investigational New Drugs · doi:10.1007/s10637-023-01387-y · Cited by 5
Kulkarni, V., Tsigelny, I. F., & Kouznetsova, V. L. (2024) · Metabolites · doi:10.3390/metabo14090501 · Cited by 5
Tang, Z., Wei, C., Deng, X., Lin, Q., Hu, Q., Li, S., Wang, J., Wu, Y., Liu, D., Fang, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1489077 · Cited by 5
Altered metabolic profiles in colon and rectal cancer
Wu, X., Yang, Q., Leng, L., Yang, P., & Zhu, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-96004-8 · Cited by 5
Therapeutic interventions to disrupt the protein synthetic machinery in melanoma
Kardos, G. R., & Robertson, G. P. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12391 · Cited by 5
Ibana, J. A., Cutay, S. J., Romero, M., & Schust, D. J. (2015) · Reproductive Sciences · doi:10.1177/1933719115602762 · Cited by 5
Exploring conserved mRNA-miRNA interactions in colon and lung cancers.
Izadi, F., Azodi, M. Z., Mansouri, V., Khodadoostan, M., & Naderi, N. (2017) · Gastroenterology and hepatology from bed to bench. · Cited by 5
Szyszko, T. A., Dunn, J., Phillips, M. M., Bomalaski, J. S., Sheaff, M. T., Ellis, S., Pike, L. C., Goh, V., Cook, G., & Szlosarek, P. W. (2022) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2022.100382 · Cited by 5
Self-citationEffect of nitric oxide donor on viability of human leukemic cells upon arginine deprivation
Chen, O. I., Lyniv, L., Igumentseva, N. I., Barska, M., Sybirna, N. O., & Stasyk, O. V. (2011) · Studia Biologica · doi:10.30970/sbi.0502.155 · Cited by 5
Zheng, C., Yu, L., Zhao, L., Guo, M., Feng, M., Li, H., Zhou, X., Fan, Y., Liu, L., Ma, Z., et al. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.124387 · Cited by 4
Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes
Zhou, Y., Yu, S., Zhu, L., Wang, Y., Duan, C., Li, D., Du, J., Zhang, J., Zhang, J., Ma, R., et al. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01088-5 · Cited by 4
Amino Acids Supplementation in Cancer: What Do We Feed, the Patient or the Tumor?
Corsetti, G., Pasini, E., Romano, C., & Dioguardi, F. S. (2025) · Nutrients · doi:10.3390/nu17172813 · Cited by 4
Nagel, R., Kochavi, A., Karlsen, K. F., Adhikary, M., Gal-On, Y., Klaoudatou, M. G., Champagne, J., Valcanover, L., Palashati, H., Nielsen, M. M., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-4773 · Cited by 4
Szymańska, P., Wójcik, A. M., Bazaliński, D., & Leppert, W. (2021) · Medycyna Paliatywna · doi:10.5114/mp.2021.108688 · Cited by 4
Pan, W., Huang, W., Zheng, J., Meng, Z., & Pan, X. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-922 · Cited by 4
Kim, J. S., Choi, W., Kim, H. I., Chung, S. W., Choi, J., Lee, D., & Kim, K. M. (2025) · Journal of Liver Cancer · doi:10.17998/jlc.2024.12.27 · Cited by 6
Jin, K., Chu, X., & Qian, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114146 · Cited by 4
Chiaviello, A., Paciello, I., Veneziani, B. M., Palumbo, G. A., & Aloj, S. M. (2011) · Medical Oncology · doi:10.1007/s12032-011-0130-7 · Cited by 4
A Novel Network Modelling for Metabolite Set Analysis: A Case Study on CRC Metabolomics
Liu, Y., Xu, X., Deng, L., Cheng, K., Xu, J., Raftery, D., & Dong, J. (2020) · IEEE Access · doi:10.1109/access.2020.3000432 · Cited by 4
Bremmer, F., Bohnenberger, H., Findeisen, P., Welter, S., von Hammerstein-Equord, A. F., Hinterthaner, M., Müller, D., Küffer, S., Okada, S., Marx, A., et al. (2023) · Histopathology · doi:10.1111/his.14972 · Cited by 4
Kührer, N., Huebner-Resch, I., Mayr, R., Agaimy, A., Kronbichler, A., Hartmann, A., Schmidinger, M., & Pichler, R. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10368-9 · Cited by 3
Aydın, H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1638108 · Cited by 3
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
Gao, X.-Z., Qin, Y., Wan, H., Lu, G. X., & Shen, H. (2026) · MedComm – Oncology · doi:10.1002/mog2.70064 · Cited by 3
Mesothelioma: is chemotherapy alone a thing of the past?
Bibby, A. C., Blyth, K. G., Sterman, D. H., & Scherpereel, A. (2020) · European Respiratory Society eBooks · doi:10.1183/2312508x.10024219 · Cited by 3
Hajjari, M., Khoshnevisan, A., & Behmanesh, M. (2014) · Gene · doi:10.1016/j.gene.2014.10.011 · Cited by 3
Avtandilyan, N. V., Javrushyan, H., Karapetyan, A. F., & Trchоunian, A. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09428-0 · Cited by 3
RetractedNovel and Promising Systemic Treatment Approaches in Mesothelioma
Dudnik, E., Reinhorn, D. J., & Holtzman, L. (2021) · Current Treatment Options in Oncology · doi:10.1007/s11864-021-00883-8 · Cited by 3
Enhancement of anti-tumor activity in melanoma using arginine deiminase fused with 30Kc19α protein
Lee, H., Park, G., Kim, S., Son, B., Joo, J., Park, H. H., & Park, T. H. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12218-0 · Cited by 3
Multiple-matrix metabolomics analysis for the distinct detection of colorectal cancer and adenoma
Zhang, Y., Ni, M., Tao, Y., Shen, M., Xu, W., Fan, M., Shan, J., & Cheng, H. (2024) · Metabolomics · doi:10.1007/s11306-024-02114-1 · Cited by 3
Albaugh, V. L., & Barbul, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.06082-9 · Cited by 3
3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival
Broaddus, V. C., Follo, C., & Barbone, D. (2017) · Current cancer research · doi:10.1007/978-3-319-53560-9_11 · Cited by 3
Combination of Arginine Depletion and Chemotherapy in Thoracic Malignancies
Ho, J., & Lam, S. K. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.7305 · Cited by 3
Tobolski, D., Zwierzchowski, G., Wójcik, R., Haxhiaj, K., Wishart, D. S., & Ametaj, B. N. (2024) · Metabolites · doi:10.3390/metabo14110624 · Cited by 2
Qian, X., Xie, C., Zhang, B., Cao, H., Lu, Z., Liu, L., Dai, S., Wang, X., Zhang, X., Han, F., et al. (2025) · Advanced Science · doi:10.1002/advs.202505291 · Cited by 2
Zhang, M., Zhang, X., Song, X., Bai, R., Qiao, Q., Wei, M., & Zhao, L. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02598-6 · Cited by 3
Emerging therapies for malignant pleural mesothelioma
Quispel-Janssen, J. M. M. F., & Baas, P. (2012) · Current Respiratory Care Reports · doi:10.1007/s13665-012-0010-4 · Cited by 2
Tumor starvation by L-arginine deprivation
Fried, R., Carlton, R. M., & Fried, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824013-7.00005-5 · Cited by 2
Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma
Carpentier, J., Freitas, M., Morales, V., Bianchi, K., Bomalaski, J. S., Szlosarek, P. W., & Martin, S. A. (2024) · iScience · doi:10.1016/j.isci.2024.111525 · Cited by 2
Self-citationStarvation in cancer cells: circulating arginine is good for cancer but bad for patients
Sharma, N. K., Sarode, S. C., Sarode, G. S., & Patil, S. V. (2019) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2019.1620606 · Cited by 2
Arginine Metabolism and Tumour-Associated Macrophages
Phillips, M., & Szlosarek, P. W. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0662-4_6 · Cited by 2
Self-citationNovel Therapeutic Targets for Hepatocellular Carcinoma Treatment
Chen, Y., & Han, C. (2012) · InTech eBooks · doi:10.5772/28894 · Cited by 2
Danielsson, F., Fasterius, E., Sullivan, D. P., Hases, L., Sanli, K., Zhang, C., Mardinoğlu, A., Szigyarto, C. A., Huss, M., Uhlén, M., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24808 · Cited by 2
Microbial enzymes: the role of enzyme in cancer therapy
Zbar, N. S. (2022) · International Journal of Research in Engineering and Innovation · doi:10.36037/ijrei.2021.6204 · Cited by 1
Metabolic dysregulation in cancer progression
Arfin, S., Agrawal, K., Kumar, A., Kumar, A. J., Rathi, B., & Kumar, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00008-0 · Cited by 2
l-Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy
Lee, H.-Y., Mohammed, K. A., & Nasreen, N. (2016) · Springer eBooks · doi:10.1007/978-3-319-26009-9_41 · Cited by 2
Jamehdor, S., Farivar, S., Sangtarash, M. H., Amini, R., Pajouhanfar, S., & Teimoori, A. (2021) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.101957 · Cited by 2
Chang, S. M., Munim, M. B., Trojan, S., Cox, H., Shevzov-Zebrun, A., Abbott, K. L., Chang, R., & Heiden, M. G. V. (2025) · eLife · doi:10.7554/elife.107123 · Cited by 2
Offin, M. D., Fitzgerald, B. G., Zauderer, M. G., & Doroshow, D. B. (2023) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2022.140 · Cited by 1
Zhao, C., & Chang, T. M. S. (2025) · Cancers · doi:10.3390/cancers17162698 · Cited by 1
Tatar, C., & Erdemir, A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107499 · Cited by 1
Cecil, A., Gentschev, I., Prehn, C. P., Hauck, S. M., Witting, M. A., Petrov, I. S., Ye, M., Othman, E. M., & Szalay, A. A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118750 · Cited by 1
Matsumoto, M., Shiotani, A., Osawa, M., Handa, O., Matsumoto, H., Umegaki, E., Yonezawa, H., & Osaki, T. (2026) · Gastric Cancer · doi:10.1007/s10120-026-01720-3 · Cited by 1
Wang, H., Wang, X., Zhang, W., Hu, S., Chen, H., Liu, J., Xue, H., Yang, J., Li, Y., Dan, W. A. N. G., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218582 · Cited by 1
Thelagathoti, R. K., Jiang, C., Chandel, D. S., Tom, W. A., Sarmiento, C., Olou, A. A., Krzyzanowski, G. D., & Fernando, M. R. (2026) · Bioengineering · doi:10.3390/bioengineering13060597 · Cited by 1
Subramani, E., Pilie, P. G., Slack-Tidwell, R., Viscuse, P. V., Kuang, X., Kandasamy, T., Awad, D., Han, J. J., Huang, L., Peterson, C. B., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116184 · Cited by 1
Triumph or tragedy: progress in cancer
Erenler, A. Ş., & Geçkil, H. (2014) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1407-41 · Cited by 1
München, M.-U. (2014) · Cited by 1
Innovations in the Management of Hepatocellular Carcinoma
Rafiullah, R., Ali, A., Mohiuddin, H., Zahid, U., & Abushahin, L. I. (2018) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000713 · Cited by 1
Kunz‐Schughart, L. A., Mueller-Klieser, W., & Vaupel, P. W. (2012) · Strahlentherapie und Onkologie · doi:10.1007/s00066-012-0203-3 · Cited by 1
Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy
Xing, Z., Jiang, X., Wu, Y., & Yu, Z. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096273730231206054104 · Cited by 1
Sumida, Y., & Tsunoda, M. (2024) · Molecules · doi:10.3390/molecules29030700 · Cited by 1
Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma
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Metadata
- Authors
- Delage, B., Fennell, D. A., Nicholson, L., McNeish, I., Lemoine, N. R., Crook, T., & Szlosarek, P. W.
- Affiliations
- Queen Mary University of London (GB)
- Queen's University Belfast (GB)
- King's College London (GB)
- St Bartholomew's Hospital (GB)
- Imperial College London (GB)
- Corresponding author
- Szlosarek, Peter W.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2010-04-09
- Volume
- 126
- Issue
- 12
- Pages
- 2762-2772
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2027449497
- Cited by
- 441
- References
- 86
- Citations by year
- 2026: 26 · 2025: 38 · 2024: 28 · 2023: 30 · 2022: 32 · 2021: 51 · 2020: 26 · 2019: 35 · 2018: 32 · 2017: 26 · 2016: 25 · 2015: 20 · 2014: 25 · 2013: 17 · 2012: 12
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Cancer Research UK (C12522/A8632, 12008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- arginine deprivation, argininosuccinate synthetase, ASS1, arginine auxotrophy, pegylated arginine deiminase, epigenetic silencing, chemoresistance, platinum resistance, ovarian cancer, tumor microenvironment, inflammatory cytokines, hepatocellular carcinoma, melanoma, malignant pleural mesothelioma, prostate cancer, kidney cancer, cancer therapy
- MeSH terms
- Animals, Arginine, Argininosuccinate Synthase, Humans, Neoplasms, Prognosis
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