The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Lung carcinogenesis by tobacco smoke
Open accessAbstract
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts, leading to miscoding and mutations in critical growth control genes, applies to this mixture but some aspects are difficult to establish because of the complexity of the exposure. This article discusses certain features of this mechanism including the role of nicotine and its receptors; lung carcinogens, co‐carcinogens and related substances in cigarette smoke; structurally characterized DNA adducts in the lungs of smokers; the mutational consequences of DNA adduct formation in smokers' lungs; and biomarkers of nicotine and carcinogen uptake as related to lung cancer. While there are still uncertainties which may never be fully resolved, the general mechanisms by which cigarette smoking causes lung cancer are well understood and provide insights relevant to prevention of lung cancer, the number one cancer killer in the world, causing 1.37 million deaths per year.
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Cites
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Somatic mutations affect key pathways in lung adenocarcinoma
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Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523
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Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics
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“These genes had been shown previously to be strongly associated with selfassessed nicotine dependence.(19) Multiple studies have confirmed and extended the association of variants in these and related genes with lung cancer.”
BackgroundSaccone, N. L., Culverhouse, R. C., Schwantes-An, T.-H., Cannon, D. S., Chen, X., Cichon, S., Giegling, I., Han, S., Han, Y., Keskitalo-Vuokko, K., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001053 · Cited by 395
Cited by
Wang, G.-Z., Zhang, L., Zhao, X.-C., Gao, S.-H., Qu, L.-W., Yu, H., Fang, W.-F., Zhou, Y.-C., Liang, F., Zhang, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08887-7 · Cited by 213
Stress is a principal factor that promotes tobacco use in females
Torres, O. V., & O'Dell, L. E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.005 · Cited by 164
Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung
Nyunoya, T., Mebratu, Y., Contreras, A., Delgado, M., Chand, H. S., & Tesfaigzi, Y. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0348tr · Cited by 110
Metadata
- Authors
- Hecht, S. S.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2012-10-03
- Volume
- 131
- Issue
- 12
- Pages
- 2724-2732
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2083832226
- Cited by
- 480
- References
- 8
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
